WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325

Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors

Gordon, M. D., & Nusse, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600015200 · Cited by 1,333

The evolution of sex-biased genes and sex-biased gene expression

Ellegren, H., & Parsch, J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2167 · Cited by 925

Tissue-specific expression and regulation of sexually dimorphic genes in mice

Yang, X., Schadt, E. E., Wang, S., Wang, H., Arnold, A. P., Ingram-Drake, L., Drake, T. A., & Lusis, A. J. (2006) · Genome Research · doi:10.1101/gr.5217506 · Cited by 922

Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis

Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E., & Millar, S. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00452-x · Cited by 489

Autosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locus.

Vikkula, M., Madman, E. C. M., Lui, V., Zhidkova, N. I., Tiller, G., Goldring, M., van Beersum, S. V., Malefijt, M. C. D. W., van den Hoogen, F. V. D., Ropers, H., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90493-x · Cited by 387

Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling

Järvinen, E., Salazar‐Ciudad, I., Birchmeier, W., Taketo, M. M., Jernvall, J., & Thesleff, I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607289103 · Cited by 379

Nonindependence of mammalian dental characters.

Kangas, A. T., Evans, A. R., Thesleff, I., & Jernvall, J. (2004) · Nature · doi:10.1038/nature02927 · Cited by 337

Analysis of Epithelial–Mesenchymal Interactions in the Initial Morphogenesis of the Mammalian Tooth

Dassule, H. R., & McMahon, A. P. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8992 · Cited by 311

Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: The odonto-onycho-dermal dysplasia

Adaimy, L., Chouery, E., Mégarbané, H., Mroueh, S., Delague, V., Nicolas, E., Belguith, H., de Mazancourt, P., & Mégarbané, A. (2007) · The American Journal of Human Genetics · doi:10.1086/520064 · Cited by 248

Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

Shungin, D., Haworth, S. J., Divaris, K., Agler, C. S., Kamatani, Y., Lee, M. K., Grinde, K. E., Hindy, G., Alaraudanjoki, V., Pesonen, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10630-1 · Cited by 372

Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases

Cluzeau, C., Hadj-Rabia, S., Jambou, M., Mansour, S., Guigue, P., Masmoudi, S., Bal, E., Chassaing, N., Vincent, M.-C., Viot, G., et al. (2011) · Human Mutation · doi:10.1002/humu.21384 · Cited by 311

Wnt Signaling in Skin Development, Homeostasis, and Disease

Lim, X., & Nusse, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008029 · Cited by 268

Wnt/β-catenin Signaling in Oral Tissue Development and Disease

Liu, F., & Millar, S. E. (2010) · Journal of Dental Research · doi:10.1177/0022034510363373 · Cited by 252

Wnt and the Wnt signaling pathway in bone development and disease

Wang, Y. (2014) · Frontiers in bioscience · doi:10.2741/4214 · Cited by 255

Mutations in WNT10A are present in more than half of isolated hypodontia cases

van den Boogaard, M. H., Créton, M. A., Bronkhorst, Y., van der Hout, A. H., Hennekam, E. A. M., Lindhout, D., Cune, M. S., & van Amstel, H. K. P. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-100750 · Cited by 214

Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells

Castellana, D., Paus, R., & Pérez‐Moreno, M. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1002002 · Cited by 189

Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders

Vlashi, R., Zhang, X., Wu, M., & Chen, G. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.07.011 · Cited by 165

WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation

Xu, M., Horrell, J., Snitow, M. E., Cui, J., Gochnauer, H. R., Syrett, C. M., Kallish, S., Seykora, J. T., Liu, F., Gaillard, D., et al. (2017) · Nature Communications · doi:10.1038/ncomms15397 · Cited by 133

A targeted next-generation sequencing assay for the molecular diagnosis of genetic disorders with orodental involvement

Prasad, M. K., Geoffroy, V., Vicaire, S., Jost, B., Dumas, M., Gras, S. L., Switala, M., Gasse, B., Laugel-Haushalter, V., Paschaki, M., et al. (2015) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103302 · Cited by 137

A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice

Maupin, K. A., Droscha, C. J., & Williams, B. O. (2013) · Bone Research · doi:10.4248/br201301004 · Cited by 133

Androgenetic Alopecia: Identification of Four Genetic Risk Loci and Evidence for the Contribution of WNT Signaling to Its Etiology

Heilmann‐Heimbach, S., Kiefer, A. K., Fricker, N., Drichel, D., Hillmer, A. M., Herold, C., Tung, J. Y., Eriksson, N., Redler, S., Betz, R. C., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.43 · Cited by 130

From molecules to mastication: the development and evolution of teeth

Jheon, A. H., Seidel, K., Biehs, B., & Klein, O. D. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.63 · Cited by 115

Candidate Gene Analysis of Tooth Agenesis Identifies Novel Mutations in Six Genes and Suggests Significant Role for WNT and EDA Signaling and Allele Combinations

Arte, S., Parmanen, S., Pirinen, S., Alaluusua, S., & Nieminen, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073705 · Cited by 112

Intersection of AHR and Wnt Signaling in Development, Health, and Disease

Schneider, A. J., Branam, A. M., & Peterson, R. E. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151017852 · Cited by 109

Diseases of the tooth: the genetic and molecular basis of inherited anomalies affecting the dentition

Cobourne, M. T., & Sharpe, P. T. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.66 · Cited by 112

iSyTE : I ntegrated Sy stems T ool for E ye Gene Discovery

Lachke, S. A., Ho, J. W. K., Kryukov, G. V., O'Connell, D. J., Aboukhalil, A., Bulyk, M. L., Park, P. J., & Maas, R. L. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8839 · Cited by 103

WNT10A and isolated hypodontia

Kantaputra, P. N., & Sripathomsawat, W. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33840 · Cited by 99

Mutations in WNT10B Are Identified in Individuals with Oligodontia

Yu, P., Yang, W., Han, D. K., Wang, X., Guo, S., Li, J., Li, F., Zhang, X., Wong, S., Bai, B., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.05.012 · Cited by 95

Taurodontism, variations in tooth number, and misshapened crowns inWnt10anull mice and human kindreds

Yang, J., Wang, S., Choi, M., Reid, B. M., Hu, Y., Lee, Y., Herzog, C. R., Kim‐Berman, H., Lee, M., Benke, P. J., et al. (2014) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.111 · Cited by 100

WNT10A variants are associated with non-syndromic tooth agenesis in the general population

Song, S., Zhao, R., He, H., Zhang, J., Feng, H., & Lin, L. (2013) · Human Genetics · doi:10.1007/s00439-013-1360-x · Cited by 94

Genetic skin diseases predisposing to basal cell carcinoma

Castori, M., Morrone, A., Kanitakis, J., & Grammatico, P. (2012) · European Journal of Dermatology · doi:10.1684/ejd.2011.1633 · Cited by 93

WNT10A mutations account for ¼ of population‐based isolated oligodontia and show phenotypic correlations

Shaiq, P. A., Klar, J., Bergendal, B., Norderyd, J., & Dahl, N. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36243 · Cited by 81

Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh

Hermans, F., Hemeryck, L., Lambrichts, I., Bronckaers, A., & Vankelecom, H. E. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.758203 · Cited by 81

Patterns of Dental Agenesis Highlight the Nature of the Causative Mutated Genes

Fournier, B., Bruneau, M. H., Toupenay, S., Kerner, S. P., Berdal, A., Cormier‐Daire, V., Hadj-Rabia, S., Coudert, A. E., & Dure‐Molla, M. D. L. (2018) · Journal of Dental Research · doi:10.1177/0022034518777460 · Cited by 81

Mutations in Frizzled 6 Cause Isolated Autosomal-Recessive Nail Dysplasia

Fröjmark, A.-S., Schuster, J., Sobol, M., Entesarian, M., Kilander, M. B. C., Gabriková, D., Nawaz, S., Baig, S. M., Schulte, G., Klar, J., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.05.013 · Cited by 78

Genetic Basis of Nonsyndromic and Syndromic Tooth Agenesis

Ye, X., & Attaie, A. (2016) · Journal of Pediatric Genetics · doi:10.1055/s-0036-1592421 · Cited by 78

Nucleotide variants of genes encoding components of the Wnt signalling pathway and the risk of non‐syndromic tooth agenesis

Mostowska, A., Biedziak, B., Zadurska, M., Dunin‐Wilczyńska, I., Lianeri, M., & Jagodziński, P. P. (2012) · Clinical Genetics · doi:10.1111/cge.12061 · Cited by 74

WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma

Long, A., Giroux, V., Whelan, K. A., Hamilton, K. E., Tétreault, M.-P., Tanaka, K., Lee, J., Klein–Szanto, A. J., Nakagawa, H., & Rustgi, A. K. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv025 · Cited by 76

Small-molecule Wnt agonists correct cleft palates in Pax9 mutant mice in utero

Jia, S., Zhou, J., Fanelli, C., Wee, Y., Bonds, J., Schneider, P., MUES, G. I., & D’Souza, R. N. (2017) · Development · doi:10.1242/dev.157750 · Cited by 71

Etiology and pathogenesis of ectodermal dysplasias

Itin, P. H. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36550 · Cited by 69

Role of the Wnt signaling molecules in the tooth

Tamura, M., & Nemoto, E. (2016) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2016.04.001 · Cited by 70

Involvement of and Interaction between WNT10A and EDA Mutations in Tooth Agenesis Cases in the Chinese Population

He, H., Han, D. K., Feng, H., Qu, H., Song, S., Bai, B., & Zhang, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080393 · Cited by 66

Orodental manifestations in ectodermal dysplasia—A review

Bergendal, B. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36571 · Cited by 71

Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne

Petridis, C., Navarini, A. A., Dand, N., Saklatvala, J. R., Baudry, D., Duckworth, M., Allen, M. H., Curtis, C. J. C., Lee, S. H., Burden, A. D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07459-5 · Cited by 66

Circadian Disruption Accelerates Tumor Growth and Angio/Stromagenesis through a Wnt Signaling Pathway

Yasuniwa, Y., Izumi, H., Wang, K., Shimajiri, S., Sasaguri, Y., Kawai, K., Kasai, H., Shimada, T., Miyake, K., Kashiwagi, E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015330 · Cited by 66

Mutations in WNT10A are frequently involved in oligodontia associated with minor signs of ectodermal dysplasia

Plaisancié, J., Bailleul‐Forestier, I., Gaston, V., Vaysse, F., Lacombe, D., Holder‐Espinasse, M., Abramowicz, M. J., Coubes, C., Plessis, G., Faivre, L. O., et al. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.35747 · Cited by 61

Genetic background of nonsyndromic oligodontia: a systematic review and meta-analysis

Ruf, S., Klimas, D., Hönemann, M., & Jabir, S. (2013) · Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie · doi:10.1007/s00056-013-0138-z · Cited by 58

The Changing Landscape in the Genetic Etiology of Human Tooth Agenesis

Williams, M. A., & Letra, A. (2018) · Genes · doi:10.3390/genes9050255 · Cited by 59

WNT10A , dermatology and dentistry

Doolan, B. J., Onoufriadis, A., Kantaputra, P., & McGrath, J. A. (2021) · British Journal of Dermatology · doi:10.1111/bjd.20601 · Cited by 56

To grow or not to grow: Hair morphogenesis and human genetic hair disorders

Duverger, O., & Morasso, M. I. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2013.12.006 · Cited by 57

Differential expression of canonical and non‐canonical Wnt ligands in ameloblastoma

Siar, C. H., Nagatsuka, H., Han, P. P., Buery, R. R., Tsujigiwa, H., Nakano, K., Ng, K. H., & Kawakami, T. (2011) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2011.01104.x · Cited by 56

Mutant DLX 3 disrupts odontoblast polarization and dentin formation

Choi, S. J., Song, I., Feng, J. Q., Gao, T., Haruyama, N., Gautam, P., Robey, P. G., & Hart, T. C. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.05.499 · Cited by 54

The WNT10A gene in ectodermal dysplasias and selective tooth agenesis

MUES, G. I., Bonds, J., Xiang, L., Vieira, A. R., Seymen, F., Klein, O. D., & D’Souza, R. N. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36520 · Cited by 54

Sweating ability and genotype in individuals with X-linked hypohidrotic ectodermal dysplasia

Schneider, H., Hammersen, J. E., Preisler-Adams, S., Huttner, K. M., Rascher, W., & Bohring, A. (2011) · Journal of Medical Genetics · doi:10.1136/jmg.2010.084012 · Cited by 57

Autosomal Recessive Congenital Ichthyosis

Richard, G. (2014) · Europe PMC (PubMed Central) · Cited by 52

Hereditary palmoplantar keratodermas. Part II : syndromic palmoplantar keratodermas – Diagnostic algorithm and principles of therapy

Guerra, L., Castori, M., Didona, B., Castiglia, D., & Zambruno, G. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14834 · Cited by 53

Expression patterns of WNT/β-CATENIN signaling molecules during human tooth development

Wang, B., Li, H., Liu, Y., Lin, X. T., Lin, Y., Wang, Y., Hu, X., & Zhang, Y. (2014) · Journal of Molecular Histology · doi:10.1007/s10735-014-9572-5 · Cited by 50

Common polymorphisms in WNT10A affect tooth morphology as well as hair shape

Kimura, R., Watanabe, C., Kawaguchi, A., Kim, Y., Park, S., Maki, K., Ishida, H., & Yamaguchi, T. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv014 · Cited by 50

Ectodysplasin research—Where to next?

Lefebvre, S., & Mikkola, M. L. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.05.002 · Cited by 45

Variability in dentofacial phenotypes in four families with WNT10A mutations

Vink, C. P., Ockeloen, C. W., ten Kate, S., Koolen, D. A., van Amstel, H. K. P., Kuijpers‐Jagtman, A. M., van Heumen, C. C. M., Kleefstra, T., & Carels, C. E. L. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2013.300 · Cited by 41

EDA, EDAR, EDARADD and WNT10A allelic variants in patients with ectodermal derivative impairment in the Spanish population

Martínez‐Romero, M. D. C., Ballesta‐Martínez, M. J., López‐González, V., Sánchez-Soler, M. J., Serrano-Antón, A. T., Barreda‐Sánchez, M., Rodríguez-Peña, L., Martínez-Menchón, M. T., Frías-Iniesta, J., Sánchez‐Pedreño, P., et al. (2019) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-019-1251-x · Cited by 43

Displasias ectodérmicas: revisión clínica y molecular

García‐Martín, P., Hernández‐Martín, A., & Torrelo, A. (2012) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2012.07.012 · Cited by 42

Wnt Signaling in Adult Epithelial Stem Cells and Cancer

Tan, S. H., & Barker, N. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.017 · Cited by 42

Ectodermal Dysplasias: A Clinical and Molecular Review

García‐Martín, P., Hernández‐Martín, A., & Torrelo, A. (2013) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2013.05.001 · Cited by 45

Tricho‐odonto‐onycho‐dermal dysplasia and WNT10A mutations

Kantaputra, P. N., Kaewgahya, M., Jotikasthira, D., & Kantaputra, W. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36388 · Cited by 37

Distinct impacts of bi‐allelic WNT10A mutations on the permanent and primary dentitions in odonto‐onycho‐dermal dysplasia

Yu, M., Liu, Y., Liu, H., Wong, S., He, H., Zhang, X., Wang, Y., Han, D. K., & Feng, H. (2018) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.60682 · Cited by 38

Novel PAX9 Mutations Cause Non-syndromic Tooth Agenesis

Mitsui, S., Yasue, A., Masuda, K., Watanabe, K., Horiuchi, S., Imoto, I., & Tanaka, E. I. (2014) · Journal of Dental Research · doi:10.1177/0022034513519801 · Cited by 37

Eight Mutations of Three Genes (EDA, EDAR, and WNT10A) Identified in Seven Hypohidrotic Ectodermal Dysplasia Patients

Zeng, B., Xiao, X., Li, S., Lu, H., Lu, J., Zhu, L., Yu, D., & Zhao, W. (2016) · Genes · doi:10.3390/genes7090065 · Cited by 37

Sweat gland regeneration: Current strategies and future opportunities

Chen, R., Zhu, Z., Ji, S., Geng, Z., Hou, Q., Sun, X., & Fu, X. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120201 · Cited by 38

Diagnosis and Management of Inherited Palmoplantar Keratodermas

Thomas, B., & O’Toole, E. A. (2020) · Acta Dermato Venereologica · doi:10.2340/00015555-3430 · Cited by 36

Novel EDA or EDAR Mutations Identified in Patients with X-Linked Hypohidrotic Ectodermal Dysplasia or Non-Syndromic Tooth Agenesis

Zeng, B., Zhao, Q., Li, S., Lu, H., Lu, J., Ma, L., Zhao, W., & Yu, D. (2017) · Genes · doi:10.3390/genes8100259 · Cited by 37

Is there a link between ovarian cancer and tooth agenesis?

Bonds, J., Pollan-White, S., Xiang, L., MUES, G. I., & D’Souza, R. N. (2014) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2014.02.013 · Cited by 36

Schöpf-Schulz-Passarge syndrome resulting from a homozygous nonsense mutation in WNT10A

Nagy, N., Wedgeworth, E. K., Hamada, T., White, J. M. L., Hashimoto, T., & McGrath, J. A. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.03.012 · Cited by 35

Wnt Pathway Extracellular Components and Their Essential Roles in Bone Homeostasis

Martínez‐Gil, N., Ugartondo, N., Grinberg, D., & Balcells, S. (2022) · Genes · doi:10.3390/genes13010138 · Cited by 31

Physiological inhibitors of Wnt signaling

Filipovich, A., Gehrke, I., Poll‐Wolbeck, S. J., & Kreuzer, K. (2011) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2011.01592.x · Cited by 34

A 190 base pair, TGF-β responsive tooth and fin enhancer is required for stickleback Bmp6 expression

Erickson, P. A., Cleves, P. A., Ellis, N. A., Schwalbach, K. T., Hart, J. C., & Miller, C. T. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.02.006 · Cited by 32

WNT10A mutations also associated with agenesis of the maxillary permanent canines, a separate entity

Kantaputra, P. N., Kaewgahya, M., & Kantaputra, W. (2013) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36280 · Cited by 32

Mutation of KREMEN1, a modulator of Wnt signaling, is responsible for ectodermal dysplasia including oligodontia in Palestinian families

Issa, Y. A., Kamal, L., Rayyan, A. A., Dweik, D., Pierce, S. B., Lee, M. K., King, M., Walsh, T., & Kanaan, M. N. (2016) · European Journal of Human Genetics · doi:10.1038/ejhg.2016.29 · Cited by 32

Dental and extra‐oral clinical features in 41 patients with WNT10A gene mutations: A multicentric genotype–phenotype study

Tardieu, C., Jung, S., Niederreither, K., Prasad, M. K., Hadj-Rabia, S., Philip, N., Mallet, A., Consolino, É., Sfeir, E., Noueiri, B., et al. (2017) · Clinical Genetics · doi:10.1111/cge.12972 · Cited by 32

Deleterious Variants in WNT10A, EDAR, and EDA Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations

Parveen, A., Khan, S. A., Mirza, M. U., Bashir, H., Arshad, F., Iqbal, M., Ahmad, W., Wahab, A., Fiaz, A., Naz, S., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215282 · Cited by 31

Role of WNT 10A in failure of tooth development in humans and zebrafish

Yuan, Q., Zhao, M., Tandon, B., Maili, L., Liu, X., Zhang, A., Baugh, E. H., Tran, T., Silva, R. M., Hecht, J. T., et al. (2017) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.332 · Cited by 30

Phenotypic variability associated withWNT10Anonsense mutations

Steensel, M. A. M. V., Gattas, M. R., Kesler, Y., Tong, P., Yan, H., Tran, K. L., Steijlen, P. M., Murrell, D. F., & Steensel, M. A. M. V. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09703.x · Cited by 29

Wnt signaling in skin homeostasis and pathology

Augustin, I. (2015) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12620 · Cited by 29

A novel WNT10A mutation causes non-syndromic hypodontia in an Egyptian family

Abdalla, E. M., Mostowska, A., Jagodziński, P. P., Dwidar, K., & Ismail, S. R. (2014) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2014.04.004 · Cited by 27

Using WGCNA (weighted gene co-expression network analysis) to identify the hub genes of skin hair follicle development in fetus stage of Inner Mongolia cashmere goat

Wu, Z., Hai, E., Di, Z., Ma, R., Shang, F., Wang, Y., Wang, M., Liang, L., Rong, Y., Pan, J., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243507 · Cited by 28

Clinical features and WNT 10A mutations in seven unrelated cases of Schöpf–Schulz–Passarge syndrome

Tziotzios, C., Petrof, G., Liu, L., Verma, A., Wedgeworth, E. K., Mellerio, J. E., & McGrath, J. A. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13158 · Cited by 27

Tooth agenesis patterns and phenotype variation in a cohort of Belgian patients with hypodontia and oligodontia clustered in 79 families with their pedigrees

Dreesen, K., Swinnen, S., Devriendt, K., & Carels, C. E. L. (2013) · European Journal of Orthodontics · doi:10.1093/ejo/cjt021 · Cited by 26

Acquired and Developmental Disturbances of the Teeth and Associated Oral Structures

Hartsfield, J. K., & Cameron, A. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-28745-6.00003-x · Cited by 25

Identification of likely pathogenic and known variants in TSPEAR, LAMB3, BCOR, and WNT10A in four Turkish families with tooth agenesis

Du, R., Dinçkan, N., Song, X., Coban‐Akdemir, Z., Jhangiani, S. N., Güven, Y., Aktören, O., Kayserili, H., Petty, L. E., Muzny, D. M., et al. (2018) · Human Genetics · doi:10.1007/s00439-018-1907-y · Cited by 26

KDF1 is a novel candidate gene of non-syndromic tooth agenesis

Zeng, B., Lu, H., Xiao, X., Yu, X., Li, S., Zhu, L., Yu, D., & Zhao, W. (2018) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2018.10.025 · Cited by 26

Synergistic Mutations of LRP6 and WNT10A in Familial Tooth Agenesis

Chu, K.-Y., Wang, Y., Chou, Y.-R., Chen, J., Wang, Y., Simmer, J. P., Hu, J. C. ‐., & Wang, S. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11111217 · Cited by 25

WNT10A variants isolated from Japanese patients with congenital tooth agenesis

Machida, J., Goto, H., Tatematsu, T., Shibata, A., Miyachi, H., Takahashi, K., Izumi, H., Nakayama, A., Shimozato, K., & Tokita, Y. (2017) · Human Genome Variation · doi:10.1038/hgv.2017.47 · Cited by 25

Abnormal primary and permanent dentitions with ectodermal symptoms predict WNT10A deficiency

Bergendal, B., Norderyd, J., Zhou, X., Klar, J., & Dahl, N. (2016) · BMC Medical Genetics · doi:10.1186/s12881-016-0349-4 · Cited by 25

Two families confirm Schöpf-Schulz-Passarge syndrome as a discrete entity within the WNT10A phenotypic spectrum

Castori, M., Castiglia, D., Brancati, F., Foglio, M. H., Heath, S. C., Floriddia, G., Madonna, S., Fischer, J., & Zambruno, G. (2010) · Clinical Genetics · doi:10.1111/j.1399-0004.2010.01513.x · Cited by 24

Functional analysis of a novel missense mutation in AXIN 2 associated with non‐syndromic tooth agenesis

Yue, H., Liang, J., Yang, K., Hua, B., & Bian, Z. (2016) · European Journal Of Oral Sciences · doi:10.1111/eos.12273 · Cited by 24

Inherited Disorders of Cornification

Oji, V., Metze, D., & Traupe, H. (2016) · Wiley eBooks · doi:10.1002/9781118441213.rtd0066 · Cited by 24

Schöpf-Schulz-Passarge syndrome resulting from a homozygous nonsense mutation, p.Cys107X, in WNT10A

Petrof, G., Fong, K., Lai‐Cheong, J. E., Cockayne, S. E., & McGrath, J. A. (2011) · Australasian Journal of Dermatology · doi:10.1111/j.1440-0960.2011.00788.x · Cited by 23

Dento-maxillo-facial phenotype and implants-based oral rehabilitation in Ectodermal Dysplasia with WNT10A gene mutation: Report of a case and literature review

Clauss, F., Waltmann, E., Barrière, P., Hadj-Rabia, S., Manière, M., & Schmittbuhl, M. (2014) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2014.01.037 · Cited by 23

WNT10A mutations causing oligodontia

Park, H., Song, J., Shin, T. J., Hyun, H., Kim, Y., & Kim, J. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.05.007 · Cited by 23

Down-regulation of Wnt10a affects odontogenesis and proliferation in mesenchymal cells

Liu, Y., Han, D. K., Wang, L., & Feng, H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.03.088 · Cited by 21

Novel PAX 9 mutation associated with syndromic tooth agenesis

Mostowska, A., Zadurska, M., Rakowska, A., Lianeri, M., & Jagodziński, P. P. (2013) · European Journal Of Oral Sciences · doi:10.1111/eos.12071 · Cited by 21

WNT10A coding variants and maxillary lateral incisor agenesis with associated dental anomalies

Mostowska, A., Biedziak, B., Zadurska, M., Matuszewska‐Trojan, S., & Jagodziński, P. P. (2014) · European Journal Of Oral Sciences · doi:10.1111/eos.12165 · Cited by 21

Oligodontia and Curly Hair Occur with Ectodysplasin-A Mutations

Lee, K. E., Ko, J. S., Shin, T. J., Hyun, H., Lee, S. H., & Kim, J. W. (2014) · Journal of Dental Research · doi:10.1177/0022034514522059 · Cited by 21

Screening PAX9, MSX1 and WNT10A Mutations in 4 Iranian Families with Non-Syndromic Tooth Agenesis.

Safari, S., Ebadifar, A., Najmabadi, H., Kamali, K., & Abedini, S. S. (2020) · PubMed Central · Cited by 20

A genome-wide association meta-analysis links hidradenitis suppurativa to common and rare sequence variants causing disruption of the Notch and Wnt/β-catenin signaling pathways

Andersen, R. K., Stefánsdóttir, L., Riis, P. T., Halldorsson, G. H., Ferkingstad, E., Oddsson, Á., Walters, G. B., Olafsdottir, T. A., Rutsdottir, G., Zachariae, C. O. C., et al. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2024.11.050 · Cited by 24

WNT10A/β-catenin pathway in tumorigenesis of papillary thyroid carcinoma

Dong, T., Zhang, Z., Zhou, W., Zhou, X., Geng, C., Chang, L. K., Tian, X., & Liu, S. (2017) · Oncology Reports · doi:10.3892/or.2017.5777 · Cited by 20

Novel mutations identified in patients with tooth agenesis by whole‐exome sequencing

Zhao, K., Lian, M., Zou, D., Huang, W., Zhou, W., Shen, Y., Wang, F., & Wu, Y. (2018) · Oral Diseases · doi:10.1111/odi.13002 · Cited by 20

The fundamentals of WNT10A

Benard, E. L., & Hammerschmidt, M. (2025) · Differentiation · doi:10.1016/j.diff.2025.100838 · Cited by 20

Novel missense mutation in the RSPO4 gene in congenital hyponychia and evidence for a polymorphic initiation codon (p.M1I)

Khan, T. N., Klar, J., Nawaz, S., Jameel, M., Tariq, M., Malik, N. A., Baig, S. M., & Dahl, N. (2012) · BMC Medical Genetics · doi:10.1186/1471-2350-13-120 · Cited by 19

Odonto-onycho-dermal dysplasia in a patient homozygous for a WNT10A nonsense mutation and mild manifestations of ectodermal dysplasia in carriers of the mutation

Krøigård, A. B., Clemmensen, O. J., Gjørup, H., Hertz, J. M., & Bygum, A. (2016) · BMC Dermatology · doi:10.1186/s12895-016-0040-7 · Cited by 15

Phenotypic variability associated withWNT10Anonsense mutations

Steensel, M. A. M. V., Gattas, M. R., Kesler, Y., Tong, P., Yan, H., Tran, K. L., Steijlen, P. M., Murrell, D. F., & Steensel, M. A. M. V. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09703.x · Cited by 29

WNT10A missense mutation associated with a complete Odonto-Onycho-Dermal Dysplasia syndrome

Nawaz, S., Klar, J., Wajid, M., Aslam, M. Q., Tariq, M., Schuster, J., Baig, S. M., & Dahl, N. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.81 · Cited by 69

BG07: The protean impact of WNT10A mutations on ectodermal structure and function

(2021) · British Journal of Dermatology · doi:10.1111/bjd.20166

Novel genetic findings

Bohring, A. (2012) · Head & Face Medicine · doi:10.1186/1746-160x-8-s1-i10