The DOI matches its Crossref record; 57 of the 59 references it cites were found in a registry or an index, and 1 are not checked yet.
Cardiovascular disease, its risk factors and treatment and age-related macular degeneration: Women's Health Initiative Sight Exam ancillary Study
Open accessAbstract
Purpose To examine the association of cardiovascular disease (CVD), CVD risk factors, and CVD treatment with age-related macular degeneration (AMD).Design Observational analysis of a randomized clinical trial.Methods Settings The Women's Health Initiative Sight Examination (WHISE), an ancillary study to the Women's Health Initiative's clinical trial of hormone replacement therapy.Study population A total of 4,288 women age 63 years and older.Observation procedures Information on CVD and its risk factors were obtained from a standardized questionnaire and examination.Main outcome measure AMD as determined by standardized grading of fundus photographs.Results Prevalence of any AMD was 21.4% (n = 919). Of those with AMD, 5.8% (n = 53) had signs of exudative AMD (n = 39) or pure geographic atrophy (n = 14), limiting the power to examine associations. Significant associations between late AMD and CVD risk factors were (odds ratio [OR], 95% confidence interval [CI]) older age (1.19, 1.13 to 1.27, P < .0001), more pack years smoked (1.02 per pack-year smoked, 1.003 to 1.03, P = .01), systolic blood pressure (0.84 per 10 mm Hg, 0.71 to 0.995, P = .04), report of taking calcium channel blockers (2.49, 1.21 to 5.12, P = .04), self-reported history of diabetes (2.00, 1.01 to 3.96, P = .05), and greater body mass index (1.05 per 1 kg/m, 1.001 to 1.10, P = .05). History of myocardial infarction, stroke, use of statins, or white blood cell count was not associated with AMD.Conclusions Results suggest that smoking, use of calcium channel blockers, diabetes, and obesity are risk factors for late AMD in women. However, the association of late AMD with systolic blood pressure and the effects of other CVD risk factors on early AMD need to be further explored.
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“These findings were not confirmed in other studies, although these studies included fewer individuals with advanced age-related macular degeneration.77–79”
From Age-related macular degeneration (2008) · cites this paper as [79]
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Cites
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Causes and Prevalence of Visual Impairment Among Adults in the UnitedStates
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Design of the Women’s Health Initiative Clinical Trial and Observational Study
The Women’s Health Initiative Study Group (1998) · Controlled Clinical Trials · doi:10.1016/s0197-2456(97)00078-0 · Cited by 2,580
Prevalence of age-related maculopathy
Klein, R., Klein, B. E. K., & Linton, K. L. P. (1992) · Ophthalmology · doi:10.1016/s0161-6420(92)31871-8 · Cited by 1,845
The Wisconsin Age-related Maculopathy Grading System
Klein, R., Davis, M. D., Magli, Y. L., Segał, P., Klein, R., & Hubbard, L. D. (1991) · Ophthalmology · doi:10.1016/s0161-6420(91)32186-9 · Cited by 1,188
Risk factors for age-related macular degeneration
Smith, W., Assink, J., Klein, R., Mitchell, P., Klaver, C. C. W., Klein, B. E. K., Hofman, A., Jensen, S., Wang, J. J., & de Jong, P. T. V. M. (2001) · Ophthalmology · doi:10.1016/s0161-6420(00)00580-7 · Cited by 1,071
Self-citationThe epidemiology of age-related macular degeneration
Klein, R., Peto, T., Bird, A., & Vannewkirk, M. R. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.11.069 · Cited by 932
The Framingham Eye Study. I. Outline and major prevalence findings.
Kahn, H. A., Leibowitz, H., Ganley, J., Kini, M., Colton, T., Nickerson, R. S., & Dawber, T. (1977) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112428 · Cited by 821
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Age-related macular degeneration
Coleman, H. R., Chan, C.-C., Ferris, F. L., & Chew, E. Y. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61759-6 · Cited by 542
Pennington, K. L., & DeAngelis, M. M. (2016) · Eye and Vision · doi:10.1186/s40662-016-0063-5 · Cited by 499
“A number of subsequent studies also reported no association between AMD and CVD, including the Women’s Health Initiative Sight Exam (WHISE) Ancillary Study [112], the Los Angeles Latino Eye Study (LALES, [113]), a report on a Pennington and DeAngelis Eye and Vision (2016) 3:34 Page 6 of 20”
BackgroundMethodInfluentialMyopic maculopathy: Current status and proposal for a new classification and grading system (ATN)
Ruiz‐Medrano, J., Montero, J. A., Flores‐Moreno, I., Arias, L., García‐Layana, A., & Ruiz‐Moreno, J. M. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.10.005 · Cited by 450
“Bevacizumab Several studies have reported excellent results with intravitreal anti-VEGF agents for the treatment of CNV secondary to AMD (Brown et al., 2006; Rosenfeld et al., 2006).”
InfluentialAge-Related Macular Degeneration Preferred Practice Pattern®
Flaxel, C. J., Adelman, R. A., Bailey, S. T., Fawzi, A. A., Lim, J. I., Vemulakonda, G. A., & Ying, G. (2019) · Ophthalmology · doi:10.1016/j.ophtha.2019.09.024 · Cited by 367
Miller, J. W. (2012) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2012.10.018 · Cited by 254
“Inolder eyes, this gradient is reversed: cells in the macular area become narrower and higher, whereas cells in the periphery become broader and lower with little change in the equatorial zone.(55)”
Background
Metadata
- Authors
- Klein, R., Deng, Y., Klein, B. E. K., Hyman, L., Seddon, J., Frank, R. N., Wallace, R. B., Hendrix, S. L., Kuppermann, B. D., Langer, R. D., Kuller, L., Brunner, R., Johnson, K. C., Thomas, A. M., & Haan, M.
- Affiliations
- University of Michigan (US)
- Stony Brook University (US)
- Massachusetts Eye and Ear Infirmary (US)
- Wayne State University (US)
- University of Iowa (US)
- University of California, Irvine (US)
- Geisinger Medical Center (US)
- University of Pittsburgh (US)
- University of Nevada, Reno (US)
- University of Tennessee Health Science Center (US)
- MedStar Health Research Institute (US)
- ORCID
- Venue
- American Journal of Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 143
- Issue
- 3
- Pages
- 473-483.e2
- ISSN
- 0002-9394 (ISSN-L)
- PMC
- PMC2812860
- OpenAlex
- W1994945285
- Cited by
- 142
- References
- 59
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 13 · 2013: 8 · 2012: 8
- FWCI
- 12.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01wh22110-38-0-0, N01 WH022110)
- National Eye Institute (R01EY011309)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- age-related macular degeneration, cardiovascular disease, cardiovascular risk factors, calcium channel blockers, smoking, diabetes mellitus, obesity, body mass index, systolic blood pressure, exudative AMD, geographic atrophy, late AMD, women's health
- MeSH terms
- Aged, Calcium Channel Blockers, Cardiovascular Diseases, Humans, Macular Degeneration, Middle Aged, Obesity, Surveys and Questionnaires, Risk Factors, Smoking, Estrogen Replacement Therapy, Body Mass Index, Women's Health, Diabetes Complications
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