The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Tear Cytokine Profiles in Dysfunctional Tear Syndrome
Open accessAbstract
Purpose to compare tear cytokine and chemokine concentrations in asymptomatic control and dysfunctional tear syndrome (DTS) patients and determine the correlations between tear inflammatory mediators and clinical severity. Design Prospective observational cohort study Methods Concentrations of epidermal growth factor (EGF), interleukin (IL) - 1α, 1β, 6, 10, 12 and 13, interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α) and chemokines: IL-8 (CXC), MIP-1α (CCL3) and RANTES (CCL5) were measured by a multiplex immunobead assay in an asymptomatic control group and DTS patients with and without MGD. Spearman correlations between tear cytokines and severity of irritation symptoms and ocular surface signs were calculated. Results Tear concentrations of IL-6, IL-8 and TNF-α were significantly higher in DTS with and without MGD and EGF was significantly reduced in the DTS without MGD group compared to the control group. MIP-1α was greater in entire DTS and DTS without MGD groups than the control group and RANTES was greater in DTS with MGD than the control and DTS without MGD groups. IL-12 was significantly higher in the DTS with MGD than the DTS without MGD subgroup. Significant correlations were observed between IL-6 and irritation symptoms and between a number of cytokines and chemokines and clinical parameters. Conclusions As predicted, patients with DTS have higher levels of inflammatory mediators in their tears that show correlation with clinical disease parameters. Furthermore, different tear cytokine/chemokine profiles were observed in DTS patients with and without MGD groups.
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Cites
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Self-citation(2007) · The Ocular Surface · doi:10.1016/s1542-0124(12)70085-x · Cited by 565
Dysfunctional Tear Syndrome: A Delphi Approach to Treatment Recommendations
Behrens, A., Doyle, J. J., Stern, L., Chuck, R. S., McDonnell, P. J., Azar, D. T., Dua, H. S., Hom, M., Karpecki, P. M., Laibson, P. R., et al. (2006) · Cornea · doi:10.1097/01.ico.0000214802.40313.fa · Cited by 511
Self-citationVitali, C., Bombardieri, S., Moutsopoulos, H. M., Coll, J., Gerli, R., Hatron, P. Y., Kater, L., Konttinen, Y. T., Manthorpe, R., Meyer, O., et al. (1996) · Annals of the Rheumatic Diseases · doi:10.1136/ard.55.2.116 · Cited by 464
Antiinflammatory therapy for dry eye
Pflugfelder, S. C. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.10.036 · Cited by 418
Self-citationDesiccating Stress Induces T Cell-Mediated Sjögren’s Syndrome-Like Lacrimal Keratoconjunctivitis
Niederkorn, J. Y., Stern, M. E., Pflugfelder, S. C., De Paiva, C. S., Corrales, R. M., Gao, J., & Siemasko, K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.3950 · Cited by 338
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TFOS DEWS II Management and Therapy Report
Jones, L., Downie, L. E., Korb, D., Benitez-del-Castillo, J. M., Dana, R., Deng, S. X., Dong, P. N., Geerling, G., Hida, R. Y., Liu, Y., et al. (2017) · The Ocular Surface · doi:10.1016/j.jtos.2017.05.006 · Cited by 1,422
Tear Osmolarity in the Diagnosis and Management of Dry Eye Disease
Lemp, M. A., Bron, A. J., Baudouin, C., Benítez del Castillo, J. M., Geffen, D., Tauber, J., Foulks, G. N., Pepose, J. S., & Sullivan, B. D. (2011) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2010.10.032 · Cited by 653
Dry Eye Disease: An Immune-Mediated Ocular Surface Disorder
Stevenson, W. (2012) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2011.364 · Cited by 583
IL-17 disrupts corneal barrier following desiccating stress
De Paiva, C. S., Chotikavanich, S., Pangelinan, S. B., Pitcher, J. D., Fang, B., Zheng, X., Ma, P., Farley, W. J., Siemasko, K. F., Niederkorn, J. Y., et al. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.5 · Cited by 422
Self-citationIn-depth analysis of the human tear proteome
Zhou, L., Zhao, S. Z., Koh, S. K., Chen, L., Vaz, C., Tanavde, V., Li, X. R., & Beuerman, R. W. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.04.053 · Cited by 379
Metadata
- Authors
- Lam, H., Bleiden, L., de Paiva, C. S., Farley, W., Stern, M. E., & Pflugfelder, S. C.
- Venue
- American Journal of Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 147
- Issue
- 2
- Pages
- 198-205.e1
- ISSN
- 0002-9394 (ISSN-L)
- OpenAlex
- W2052808939
- Cited by
- 498
- References
- 24
- FWCI
- 15.19
- Type
- journal article
- Language
- en
- Open access
- green
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