Neurotrophines et douleur : étude d’expression et de corrélation dans l’endométriose
Abstract
Objectives To evaluate the expression of five members of the neurotrophins family in ovarian endometriotic cyst (endometrioma) (OMA), compared to eutopic endometrium (EE) and to examine the correlation between the levels of induction and the pain intensity.Patients and methods Twelve Caucasian women in luteal phase, operated for painful stage IV endometriosis were assigned to 2 groups according to a total Visual Analog Scale (tVAS) score above 15 or below 10. tVAS takes into account all VAS scores for dysmenorrhea, deep dyspareunia, non cyclic chronic pelvic pain, gastrointestinal and lower urinary symptoms. Samples of OMA and EE were processed by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for NGF, BDNF, NT-3, NT-4/5 and NTRK2 mRNA expression. Expression levels in OMA were compared to those in EE on one hand and between two groups of 6 mild painful and 6 highly painful patients on the other.Results All neurotrophins were significantly higher expressed in OMA than in EE, in particular NGF and BDNF (induction ratios: 20.6 and 9.7, respectively). In contrast, no correlation was observed between induction ratios and pain intensity.Conclusion and discussion This is the first study reporting an over-expression of all neurotrophins in endometriosis, as only NGF was previously documented. It confirms the central role of this family in the genesis and modulation of pain in endometriosis. Anti-neurotrophin selective therapy might be a promising way of analgesia in the future.
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Ectopic and eutopic endometrium produce neurotrophic factors, some of which are differentially expressed in cases of endometriosis and could serve as minimally invasive endometriosis biomarkers.
“Not surprisingly, ectopic and eutopic endometrium produce neurotrophic factors, 83 some of which are differentially expressed in cases of endometrioisis 84 and could serve as minimally invasive endometriosis biomarkers.85”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [83]
Cites
Mechanisms of neuropathic pain
Campbell, J. N., & Meyer, R. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.021 · Cited by 1,471 · see citing works
NEUROTROPHINS: Mediators and Modulators of Pain
Pezet, S., & McMahon, S. B. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112929 · Cited by 877 · see citing works
Immune and inflammatory mechanisms in neuropathic pain
Moalem‐Taylor, G., & Tracey, D. J. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.11.004 · Cited by 772 · see citing works
Chapron, C., Fauconnier, A., Vieira, M., Barakat, H., Dousset, B. E., Pansini, V., Vacher‐Lavenu, M., & Dubuisson, J. B. (2003) · Human Reproduction · doi:10.1093/humrep/deg009 · Cited by 584 · see citing works
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Fauconnier, A., & Chapron, C. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi029 · Cited by 522 · see citing works
Self-citationBerkley, K. J., Rapkin, A. J., & Papka, R. E. (2005) · Science · doi:10.1126/science.1111445 · Cited by 455 · see citing works
Relationship between endometriotic foci and nerves in rectovaginal endometriotic nodules
Anaf, V. (2000) · Human Reproduction · doi:10.1093/humrep/15.8.1744 · Cited by 333 · see citing works
Self-citationAnaf, V., Simon, P., El Nakadi, I., Fayt, I., Simonart, T., Buxant, F., & Noel, J.-C. (2002) · Human Reproduction · doi:10.1093/humrep/17.7.1895 · Cited by 317 · see citing works
Self-citationDeep infiltrating endometriosis: relation between severity of dysmenorrhoea and extent of disease
Chapron, C. (2003) · Human Reproduction · doi:10.1093/humrep/deg152 · Cited by 311 · see citing works
Self-citationNerve fibres in peritoneal endometriosis
Tokushige, N., Markham, R., Russell, P., & Fraser, I. S. (2006) · Human Reproduction · doi:10.1093/humrep/del260 · Cited by 299 · see citing works
Use of a levonorgestrel-releasing intrauterine device in the treatment of rectovaginal endometriosis
Fedele, L., Bianchi, S., Zanconato, G., Portuese, A., & Raffaelli, R. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01759-3 · Cited by 290 · see citing works
Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis
Anaf, V., Chapron, C., El Nakadi, I., De Moor, V., Simonart, T., & Noël, J.-C. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.03.057 · Cited by 258 · see citing works
Self-citationEndometriosis is associated with central sensitization: a psychophysical controlled study
Bajaj, P. (2003) · The Journal of Pain · doi:10.1016/s1526-5900(03)00720-x · Cited by 247 · see citing works
Tokushige, N., Markham, R., Russell, P., & Fraser, I. S. (2006) · Human Reproduction · doi:10.1093/humrep/dei368 · Cited by 236 · see citing works
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Wang, G., Tokushige, N., Markham, R., & Fraser, I. S. (2008) · Human Reproduction · doi:10.1093/humrep/den464 · Cited by 232 · see citing works
A life shaped by pain: women and endometriosis
Huntington, A., & Gilmour, J. A. (2005) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2005.01231.x · Cited by 208 · see citing works
Vercellini, P., Pietropaolo, G., De Giorgi, O., Pasin, R., Chiodini, A., & Crosignani, P. G. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.03.083 · Cited by 197 · see citing works
Al-Jefout, M., Dezarnaulds, G., Cooper, M., Tokushige, N., Luscombe, G. M., Markham, R., & Fraser, I. S. (2009) · Human Reproduction · doi:10.1093/humrep/dep275 · Cited by 151 · see citing works
Endometriosis: current and future medical therapies
Vercellini, P., Somigliana, E., Viganò, P., Abbiati, A., Daguati, R., & Crosignani, P. G. (2007) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2007.10.001 · Cited by 136 · see citing works
Mereu, L., Ruffo, G., Landi, S., Barbieri, F., Zaccoletti, R., Fiaccavento, A., Stepniewska, A. K., Pontrelli, G., & Minelli, L. (2007) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2007.02.008 · Cited by 102 · see citing works
The Diagnostic Workup of Patients with Neuropathic Pain
Horowitz, S. H. (2007) · Medical Clinics of North America · doi:10.1016/j.mcna.2006.10.002 · Cited by 79 · see citing works
Zhang, G., Dmitrieva, N., Liu, Y., McGinty, K. A., & Berkley, K. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00649.2007 · Cited by 78 · see citing works
Al-Jefout, M., Andreadis, N., Tokushige, N., Markham, R., & Fraser, I. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.04.032 · Cited by 68 · see citing works
Evans, S., Moalem‐Taylor, G., & Tracey, D. J. (2007) · Pain · doi:10.1016/j.pain.2007.07.006 · Cited by 68 · see citing works
Liver Gene Expression Profiles of Rats Treated with Clofibric Acid
Michel, C., Desdouets, C., Sacre-Salem, B., Gautier, J., Roberts, R. A., & Boitier, E. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63577-8 · Cited by 32 · see citing works
Ovarian endometrioma vascularization in women with pelvic pain
Alcázar, J. L., & García-Manero, M. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.106 · Cited by 32 · see citing works
García-Manero, M., Alcázar, J. L., & Toledo, G. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.117 · Cited by 28 · see citing works
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Scheerer, C. (2016) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-10823
Proteomic identification of neurotrophins in the eutopic endometrium of women with
Browne, S., Yu, J., & Huang, R. (2012)
- Authors
- Borghese, B., Vaiman, D., Mondon, F., Mbaye, M., Anaf, V., Noël, J.-C., de Ziegler, D., & Chapron, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Hôpital Cochin (FR)
- Université Libre de Bruxelles (BE)
- Corresponding author
- Borghese, B.
- Venue
- Gynécologie Obstétrique & Fertilité
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 38
- Issue
- 7-8
- Pages
- 442-446
- ISSN
- 1297-9589 (ISSN-L)
- OpenAlex
- W1985559165
- Cited by
- 39
- References
- 27
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 6
- FWCI
- 4.55
- Type
- journal article
- Language
- fr
- Open access
- closed
- Locations
- Gynécologie Obstétrique & Fertilité (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- neurotrophins, endometriosis-associated pain, nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, neurotrophin-4/5, NTRK2, endometrioma, eutopic endometrium, dysmenorrhea, dyspareunia, chronic pelvic pain, gene expression, neuropathic pain, targeted therapy
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Humans, Nerve Growth Factors, Ovarian Cysts, Pain, RNA, Messenger, Gene Expression, Brain-Derived Neurotrophic Factor, Reverse Transcriptase Polymerase Chain Reaction, Nerve Growth Factor, Neurotrophin 3
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