Discovery of a novel biomarker in the urine in women with endometriosis
Open accessAbstract
Objective To investigate whether proteins secreted in urine differ between women with and without endometriosis.Design Laboratory study using human urine.Setting University-based laboratory.Patient(s) Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage.Intervention(s) Urine collection from women with and without endometriosis.Main outcome measure(s) Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis.Result(s) On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis.Conclusion(s) Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.
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Cytokeratin-19 (CK19) is uniquely expressed in urine samples from women with histologically proven endometriosis relative to women free of disease.
“Using an immunoblot technique, Tokushige et al. demonstrated cytokeratin-19 (CK19) to be uniquely expressed in 11 urine samples from women with histologically proven endometriosis relative to samples from 6 women free of disease [102].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [102]
Several groups have reported differential peptide profiles in the urine of women with endometriosis relative to women without endometriosis at surgery using MALDI-TOF MS.
“Using matrix assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS), several groups have reported differential peptide profiles in the urine of women with endometriosis relative to that of women without endometriosis at surgery [102, 106].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [102]
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- Authors
- Tokushige, N., Markham, R., Crossett, B., Ahn, S. B., Nelaturi, V. L., Khan, A., & Fraser, I. S.
- Affiliations
- The University of Sydney (AU)
- Macquarie University (AU)
- Corresponding author
- Tokushige, Natsuko
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 95
- Issue
- 1
- Pages
- 46-49
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2093966693
- Cited by
- 61
- References
- 19
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 2
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- Funders
- University of Sydney
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, urinary biomarkers, urinary proteome, cytokeratin 19, protein secretion, diagnostic biomarkers, women
- MeSH terms
- Adult, Endometriosis, Female, Humans, Blotting, Western, Biomarkers, Up-Regulation, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Proteomics, Keratin-19
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