Lactation and maternal subclinical cardiovascular disease among premenopausal women
Open accessAbstract
Objective The objective of the study was to examine the association between lactation and maternal subclinical cardiovascular disease.Study design The Women and Infants Study of Healthy Hearts enrolled 607 mothers who delivered a singleton between 1997 and 2002. In 2007, participating mothers underwent measurements of carotid intima-media thickness, lumen diameter, adventitial diameter, and carotid-femoral pulse wave velocity. Multivariable linear and logistic regressions were used to estimate the associations between lactation and subclinical cardiovascular disease.Results Compared with mothers who breastfed for 3 or more months after every birth, mothers who never breastfed exhibited a 0.13 mm larger lumen diameter (95% confidence interval, 0.04-0.22) and a 0.12 mm larger adventitial diameter (95% confidence interval, 0.02-0.22) in models adjusting for age, parity, birth outcome, sociodemographic variables, health-related behaviors, family history, gestational weight gain, early adult body mass index, current body mass index, C-reactive protein, blood pressure, cholesterol, triglyceride, high-density lipoprotein, glucose, and insulin levels.Conclusion Mothers who do not breastfeed have vascular characteristics associated with a greater risk of cardiovascular disease.
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Never breastfed was associated with vascular characteristics (larger arterial lumen and adventitial diameters) linked to a higher risk of cardiovascular disease independent of sociodemographic characteristics, health related behaviour, family history, and body mass index.
“never breastfed was associated with vascular characteristics (larger arterial lumen and adventitial diameters) linked to a higher risk of cardiovascular disease independent of sociodemographic characteristics, health related behaviour, family history, and body mass index”
From Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review (2020) · cites this paper as [117]
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- Authors
- McClure, C. K., Catov, J. M., Ness, R. B., & Schwarz, E. B.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- McClure, Candace K.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 207
- Issue
- 1
- Pages
- 46.e1-46.e8
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC3383628
- OpenAlex
- W2143357438
- Cited by
- 68
- References
- 48
- Citations by year
- 2024: 3 · 2023: 9 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL076532)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD051585)
- Topics
- Health Sciences › Medicine › Epidemiology › Breastfeeding Practices and Influences
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- lactation, breastfeeding, subclinical cardiovascular disease, premenopausal women, carotid intima-media thickness, carotid lumen diameter, pulse wave velocity, maternal cardiovascular risk
- MeSH terms
- Adult, Blood Flow Velocity, Breast Feeding, Cardiovascular Diseases, Carotid Arteries, Female, Humans, Lactation, Risk Factors, Cohort Studies, Linear Models, Logistic Models, Premenopause, Carotid Intima-Media Thickness
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