Cited by 205Systemic Lupus Erythematosus ResearchReproductive System and PregnancyPregnancy and preeclampsia studies

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Antiphospholipid antibody profile based obstetric outcomes of primary antiphospholipid syndrome: the PREGNANTS study

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Saccone, Gabriele, Berghella, Vincenzo, Maruotti, Giuseppe Maria, Ghi, Tullio, Rizzo, Giuseppe, Simonazzi, Giuliana, Rizzo, Nicola, Facchinetti, Fabio, Dall’Asta, Andrea, Visentin, Silvia, Sarno, Laura, Xodo, Serena, Bernabini, Dalila, Monari, Francesca, Roman, Amanda, Eke, Ahizechukwu Chigoziem, Hoxha, Ariela, Ruffatti, Amelia, Schuit, Ewoud, Martinelli, Pasquale·2017·American Journal of Obstetrics and Gynecology

DOI 10.1016/j.ajog.2017.01.026

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Abstract

Background Antiphospholipid syndrome is an autoimmune, hypercoagulable state that is caused by antiphospholipid antibodies. Anticardiolipin antibodies, anti-β2 glycoprotein-I, and lupus anticoagulant are the main autoantibodies found in antiphospholipid syndrome. Despite the amassed body of clinical knowledge, the risk of obstetric complications that are associated with specific antibody profile has not been well-established. Objective The purpose of this study was to assess the risk of obstetric complications in women with primary antiphospholipid syndrome that is associated with specific antibody profile. Study design The Pregnancy In Women With Antiphospholipid Syndrome study is a multicenter, retrospective, cohort study. Diagnosis and classification of antiphospholipid syndrome were based on the 2006 International revised criteria. All women included in the study had at least 1 clinical criteria for antiphospholipid syndrome, were positive for at least 1 antiphospholipid antibody (anticardiolipin antibodies, anti-β2 glycoprotein-I, and/or lupus anticoagulant), and were treated with low-dose aspirin and prophylactic low molecular weight heparin from the first trimester. Only singleton pregnancies with primary antiphospholipid syndrome were included. The primary outcome was live birth, defined as any delivery of a live infant after 22 weeks gestation. The secondary outcomes were preeclampsia with and without severe features, intrauterine growth restriction, and stillbirth.…

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Antiphospholipid Syndrome
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Authors: Saccone, G., Berghella, V., Maruotti, G. M., Ghi, T., Rizzo, G., Simonazzi, G., Rizzo, N., Facchinetti, F., Dall’Asta, A., Visentin, S., Sarno, L., Xodo, S., Bernabini, D., Monari, F., Roman, A., Eke, A. C., Hoxha, A., Ruffatti, A., Schuit, E., & Martinelli, P.
Affiliations: University of Naples Federico II (IT)
Thomas Jefferson University (US)
University of Parma (IT)
University of Rome Tor Vergata (IT)
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
University of Modena and Reggio Emilia (IT)
University of Padua (IT)
University of Udine (IT)
Johns Hopkins University (US)
Stanford Medicine (US)
Corresponding author: Saccone, Gabriele
ORCID: Saccone, Gabriele
Berghella, Vincenzo
Maruotti, Giuseppe Maria
Ghi, Tullio
Rizzo, Giuseppe
Simonazzi, Giuliana
Rizzo, Nicola
Facchinetti, Fabio
Dall’Asta, Andrea
Visentin, Silvia
Sarno, Laura
Xodo, Serena
Monari, Francesca
Eke, Ahizechukwu Chigoziem
Hoxha, Ariela
Ruffatti, Amelia
Schuit, Ewoud
Martinelli, Pasquale
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 2017-05
Volume: 216
Issue: 5
Pages: 525.e1-525.e12
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/j.ajog.2017.01.026
OpenAlex: W2580867287
Cited by: 205
References: 31
Citations by year: 2026: 7 · 2025: 17 · 2024: 24 · 2023: 22 · 2022: 31 · 2021: 19 · 2020: 21 · 2019: 35 · 2018: 20 · 2017: 9
FWCI: 20.34
Type: journal article
Language: en
Open access: green
www.sciencedirect.com
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by-nc-nd)
Utrecht University Repository (Utrecht University) (submittedVersion)
IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: primary antiphospholipid syndrome, pregnancy complications, live birth, preeclampsia, fetal growth restriction, stillbirth, anticardiolipin antibodies, anti-beta2-glycoprotein I antibodies, lupus anticoagulant, low-dose aspirin, low molecular weight heparin, pregnancy outcomes
MeSH terms: Adult, Anticoagulants, Aspirin, Female, Fetal Growth Retardation, Heparin, Low-Molecular-Weight, Humans, Italy, Platelet Aggregation Inhibitors, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Retrospective Studies, Cohort Studies, Antiphospholipid Syndrome, Antibodies, Antiphospholipid, Stillbirth, Live Birth, beta 2-Glycoprotein I

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Antiphospholipid antibody profile based obstetric outcomes of primary antiphospholipid syndrome: the PREGNANTS study

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