Identification of cells with colony-forming activity, self-renewal capacity, and multipotency in ovarian endometriosis
Open accessAbstract
Endometriosis, the growth of endometrial tissue outside the uterine cavity, is a common gynecological disorder affecting 10% to 15% of women in their reproductive years. Retrograde menstrual shedding containing endometrial stem/progenitor cells has been postulated to be involved in its pathogenesis. In this study, we identified putative endometriotic stem/progenitor cells by their colony-forming potential, self-renewal capacity, and multipotency. Purified epithelial and stromal cells isolated from ovarian endometriotic cysts formed large and small colony-forming units (CFUs) in clonogenic assay. The colony-forming activity of epithelial and stromal cells was found to differ greatly between autologous endometrium and ovarian endometrioma samples. The large CFUs could propagate more than the small CFUs. The endometriotic epithelial small CFUs expressed epithelial markers (epithelial cell adhesion molecule, cytokeratin, and α6 integrin); only occasional large CFUs expressed α6 integrin. Aside from the expression of fibroblast markers, stromal CFUs also expressed three somatic stem cell markers: sal-like 4, CD133, and Musashi-1. Endometriotic stromal cells derived from large CFUs could differentiate into four mesenchymal lineages when cultured in the respective inducing-media, as determined by histochemical staining and RT-PCR of lineage specific markers. These findings demonstrate that ovarian endometrioma contains a subset of cells displaying somatic stem cell properties.
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MSCs and epithelial progenitor cells isolated from ovarian endometriomas do not show increased clonogenicity or self-renewal compared to endometrial stem cells.
“Remarkably, MSCs and epithelial progenitor cells isolated from ovarian endometriomas do not show increased clonogenicity or self-renewal compared to endometrial stem cells, which might have explained the increased survival capacity in endometriosis (Chan et al., 2011;Li et al., 2014).”
From Endometriosis and nuclear receptors (2019) · cites this paper as Chan et al., 2011
The Clonogenicity section reports significantly lower colony-forming efficiency for both epithelial and stromal cells from ovarian endometriomas than from normal endometrium. The Serial Cloning section measures self-renewal within endometrioma-derived colonies, comparing large with small colonies, but does not compare their self-renewal with endometrial stem cells. The proposed link to increased survival capacity is not established by these passages. (LLM, conf=0.87)
Experimental — accuracy not yet measuredEndometriotic lesions harbor multipotent, colony-forming MSCs.
“Similar to endometrium, endometriotic lesions also harbor multipotent, colony-forming MSCs (Chan et al., 2011).”
From Endometriosis and nuclear receptors (2019) · cites this paper as Chan et al., 2011
The Abstract reports colony-forming cells isolated from ovarian endometriotic cysts, and the Cellular Phenotypes and Multipotency section reports that stromal large CFUs differentiated into four mesenchymal lineages. The study describes these as putative stem/progenitor cells and examines ovarian endometriomas, so it does not establish the claim for endometriotic lesions generally or definitively identify the cells as MSCs. (LLM, conf=0.85)
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- Authors
- Chan, R. W. S., Ng, E. H. Y., & Yeung, W. S. B.
- Affiliations
- University of Hong Kong (HK)
- Corresponding author
- Chan, Rachel Wah Shan
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 178
- Issue
- 6
- Pages
- 2832-2844
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC3123988
- OpenAlex
- W2083418262
- Cited by
- 98
- References
- 65
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 4 · 2015: 12 · 2014: 8 · 2013: 12 · 2012: 4
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- General Research Fund of Shanghai Normal University
- Research Grants Council, University Grants Committee (HKU 7822/09M)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- endometrioma, colony-forming units, self-renewal, multipotency, mesenchymal differentiation, epithelial cells, stromal cells, CD133, Musashi-1, endometriosis pathogenesis
- MeSH terms
- Adult, Cell Differentiation, Clone Cells, Endometriosis, Endometrium, Epithelial Cells, Female, Humans, Immunohistochemistry, Mesoderm, Middle Aged, Ovary, Phenotype, Stem Cells, Stromal Cells, Cell Lineage, Multipotent Stem Cells, Cell Shape, Cell Proliferation, Young Adult
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