Endometrial cells derived from donor stem cells in bone marrow transplant recipients
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CONTEXT: Regeneration of the endometrium in each menstrual cycle is required for reproduction. Endogenous endometrial stem cells reside in the basalis layer and serve as a source of cells that differentiate to form the endometrium. Bone marrow-derived cells have been shown to take on functions outside the hematopoietic system. OBJECTIVE: To investigate the possibility that cells of extrauterine origin could repopulate the endometrium. DESIGN, SETTING, AND PATIENTS: Endometrium from 4 HLA-mismatched bone marrow transplant recipients (1998-2002) was evaluated for donor HLA expression. Each recipient had a bone marrow donor with an HLA type that enabled determination of the origin of any cell. Endometrial biopsies also were obtained from 4 healthy control women. MAIN OUTCOME MEASURE: HLA type was determined by immunohistochemistry and by reverse transcription-polymerase chain reaction. RESULTS: Donor-derived endometrial cells were detected in endometrial biopsy samples from all bone marrow recipients and accounted for 0.2% to 48% of epithelial cells and 0.3% to 52% of stromal cells. None of the controls demonstrated HLA mismatch in endometrial samples. CONCLUSION: These findings demonstrate that endometrial cells can originate from donor-derived bone marrow cells and suggest that nonuterine stem cells contribute to the regeneration of endometrial tissue.
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Endometrial biopsy of HLA-mismatched bone marrow donor recipients demonstrated donor-derived cells in the stroma and the epithelium.
“Endometrial biopsy of HLA-mismatched bone marrow donor recipients demonstrated donor-derived cells in the stroma and the epithelium (Taylor, 2004;Ikoma et al., 2009).”
From Endometriosis and nuclear receptors (2019) · cites this paper as Taylor, 2004
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“On the other hand, there are some studies that suggest that the bone marrow-derived stem cells may play a role in the development of the disease [15,39].”
BackgroundBone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis
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- Authors
- Taylor, H. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Taylor, Hugh S.
- ORCID
- Taylor, Hugh S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2004-07-07
- Volume
- 292
- Issue
- 1
- Pages
- 81
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2048412962
- Cited by
- 510
- References
- 29
- Citations by year
- 2026: 10 · 2025: 23 · 2024: 19 · 2023: 29 · 2022: 34 · 2021: 32 · 2020: 37 · 2019: 39 · 2018: 28 · 2017: 21 · 2016: 17 · 2015: 23 · 2014: 29 · 2013: 24 · 2012: 25
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Sciences (ES10610, R01ES010610)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD36887)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- endometrium, endometrial regeneration, bone marrow-derived cells, donor-derived cells, HLA mismatch, bone marrow transplantation, endometrial stem cells, endometrial epithelium, endometrial stroma, cell of origin
- MeSH terms
- Adult, Cell Differentiation, Endometrium, Epithelial Cells, Female, Histocompatibility, Histocompatibility Testing, HLA Antigens, Humans, Regeneration, Stem Cells, Tissue Donors, Transplantation, Homologous, Bone Marrow Transplantation, Stromal Cells, Reverse Transcriptase Polymerase Chain Reaction
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