Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis

Cloning of a novel receptor expressed in rat prostate and ovary.

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Endometriosis

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EPIDEMIOLOGY OF ENDOMETRIOSIS

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Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B

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Global gene profiling in human endometrium during the window of implantation

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Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility

Kao, L. C., Germeyer, A., Tulac, S., Lobo, S., Yang, J. P., Taylor, R. N., Osteen, K., Lessey, B. A., & Giudice, L. C. (2003) · Endocrinology · doi:10.1210/en.2003-0043 · Cited by 696 · see citing works

Endometriosis

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Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment

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Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis

Attia, G. R. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2897 · Cited by 488 · see citing works

Endometriosis and pelvic pain: relation to disease stage and localization

Vercellini, P., Trespidi, L., De Giorgi, O., Cortesi, I., Parazzini, F., & Crosignani, P. G. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58089-3 · Cited by 457 · see citing works

Progesterone resistance in endometriosis: link to failure to metabolize estradiol.

Bulun, S. E., Cheng, Y.-H., Yin, P., Imir, G., Utsunomiya, H., Attar, E., Innes, J., & Julie Kim, J. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.041 · Cited by 397 · see citing works

Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis1

Xue, Q., Lin, Z., Cheng, Y.-H., Huang, C.-C., Marsh, E., Yin, P., Milad, M. P., Confino, E., Reierstad, S., Innes, J., et al. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.061804 · Cited by 346 · see citing works

A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis

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Deficient 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17β-Estradiol¹

Zeitoun, K., Takayama, K., Sasano, H., Suzuki, T., Moghrabi, N., Andersson, S., Johns, A., Meng, L., Putman, M., Carr, B., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.12.5301 · Cited by 308 · see citing works

Increased activation of pelvic macrophages in infertile women with mild endometriosis

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Deficient cellular immunity in endometriosis

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LESSONS IN ESTROGEN BIOLOGY FROM KNOCKOUT AND TRANSGENIC ANIMALS

Hewitt, S. C., Harrell, J. C., & Korach, K. S. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.115914 · Cited by 292 · see citing works

Estrogen Receptor-β: Recent Lessons from in Vivo Studies

Harris, H. A. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0459 · Cited by 278 · see citing works

Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target

Zeitoun, K. M., & Bulun, S. E. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00393-3 · Cited by 256 · see citing works

Immunolocalization and Regulation of the Chemokine RANTES in Human Endometrial and Endometriosis Tissues and Cells

Hornung, D., Ryan, I. P., Chao, V. A., Vigne, J., Schriock, E. D., & Taylor, R. N. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3919 · Cited by 238 · see citing works

Characterization of the hormone responsive element involved in the regulation of the progesterone receptor gene.

Savouret, J., Bailly, A., Misrahi, M., Rauch, C., Redeuilh, G., Chauchereau, A., & Milgröm, E. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07713.x · Cited by 232 · see citing works

Progestins for symptomatic endometriosis: a critical analysis of the evidence

Vercellini, P., Cortesi, I., & Crosignani, P. G. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00193-3 · Cited by 229 · see citing works

Ligand-Modulated Regulation of Progesterone Receptor Messenger Ribonucleic Acid and Protein in Human Breast Cancer Cell Lines

Read, L. D., Snider, C. E., Miller, J. S., Greene, G. L., & Katzeneilenbogen, B. S. (1988) · Molecular Endocrinology · doi:10.1210/mend-2-3-263 · Cited by 211 · see citing works

Regulation of Progesterone Receptor Messenger Ribonucleic Acid and Protein Levels in MCF-7 Cells by Estradiol: Analysis of Estrogen’s Effect on Progesterone Receptor Synthesis and Degradation*

Nardulli, A. M., Greene, G. L., O’Malley, B. W., & Katzenellenbogen, B. S. (1988) · Endocrinology · doi:10.1210/endo-122-3-935 · Cited by 189 · see citing works

Multiple Human Progesterone Receptor Messenger Ribonucleic Acids and Their Autoregulation by Progestin Agonists and Antagonists in Breast Cancer Cells

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Sp1 Binding Sites and An Estrogen Response Element Half-Site Are Involved in Regulation of the Human Progesterone Receptor A Promoter

Petz, L. N., & Nardulli, A. M. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.7.0493 · Cited by 180 · see citing works

Estrogen Receptor (ER) β Modulates ERα-Mediated Transcriptional Activation by Altering the Recruitment of c-Fos and c-Jun to Estrogen-Responsive Promoters

Matthews, J. B., Wihlén, B., Tujague, M., Wan, J., Ström, A., & Gustafsson, J.-Α. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0140 · Cited by 179 · see citing works

Peritoneal Macrophages From Patients With Endometriosis Release Growth Factor Activityin Vitro*

Halme, J. K., WHITE, C., Kauma, S. W., Estes, J. E., & Haskill, S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-5-1044 · Cited by 179 · see citing works

Oestrogen receptor (ER)-alpha and ER- isoforms in normal endometrial and endometriosis-derived stromal cells

Brandenberger, A. W. (1999) · Molecular Human Reproduction · doi:10.1093/molehr/5.7.651 · Cited by 165 · see citing works

Familial endometriosis

Kennedy, S., Mardon, H., & Barlow, D. (1995) · Journal of Assisted Reproduction and Genetics · doi:10.1007/bf02214126 · Cited by 157 · see citing works

Estrogen Receptor (ER) β Regulates ERα Expression in Stromal Cells Derived from Ovarian Endometriosis

Trukhacheva, E., Lin, Z., Reierstad, S., Cheng, Y.-H., Milad, M., & Bulun, S. E. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1466 · Cited by 143 · see citing works

Differential regulation of the human progesterone receptor gene through an estrogen response element half site and Sp1 sites

Petz, L. N., Ziegler, Y., Schultz, J. R., Kim, H., Kemper, J. K., & Nardulli, A. M. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2003.11.008 · Cited by 142 · see citing works

Estrogen Receptor α and Activating Protein-1 Mediate Estrogen Responsiveness of the Progesterone Receptor Gene in MCF-7 Breast Cancer Cells

Petz, L. N., Ziegler, Y., Loven, M. A., & Nardulli, A. M. (2002) · Endocrinology · doi:10.1210/en.2002-220369 · Cited by 133 · see citing works

Expression of oestrogen receptor-alpha and -beta in ovarian endometriomata

Fujimoto, J. (1999) · Molecular Human Reproduction · doi:10.1093/molehr/5.8.742 · Cited by 123 · see citing works

Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis

Osteen, K. G., Bruner-Tran, K. L., & Eisenberg, E. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.11.026 · Cited by 122 · see citing works

Estrogen receptor α and Sp1 regulate progesterone receptor gene expression

Schultz, J. R., Petz, L. N., & Nardulli, A. M. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00415-x · Cited by 121 · see citing works

Up-regulation of the uterine estrogen receptor and its messenger ribonucleic acid during the mouse estrous cycle: the role of estradiol

Bergman, M. D., Schachter, B. S., Karelus, K., Combatsiaris, E. P., Garcia, T., & Nelson, J. F. (1992) · Endocrinology · doi:10.1210/endo.130.4.1547720 · Cited by 105 · see citing works

Cell- and Ligand-specific Regulation of Promoters Containing Activator Protein-1 and Sp1 Sites by Estrogen Receptors α and β

Schultz, J. R., Petz, L. N., & Nardulli, A. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407879200 · Cited by 105 · see citing works

Estrogen target tissue determines alternative promoter utilization of the human estrogen receptor gene in osteoblasts and tumor cell lines

Grandien, K., Bäckdahl, M., Ljunggren, Ö., Gustafsson, J., & Berkenstam, A. L. (1995) · Endocrinology · doi:10.1210/endo.136.5.7720671 · Cited by 103 · see citing works

Determination of transcription start sites in the human estrogen receptor gene and identification of a novel, tissue-specific, estrogen receptor-mRNA isoform

Grandien, K. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03716-0 · Cited by 100 · see citing works

Novel Estrogen Receptor-α Binding Sites and Estradiol Target Genes Identified by Chromatin Immunoprecipitation Cloning in Breast Cancer

Lin, Z., Reierstad, S., Huang, C.-C., & Bulun, S. E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3696 · Cited by 93 · see citing works

Fos and Jun Inhibit Estrogen-Induced Transcription of the Human Progesterone Receptor Gene through an Activator Protein-1 Site

Petz, L. N., Ziegler, Y., Schultz, J. R., & Nardulli, A. M. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0105 · Cited by 81 · see citing works

Selective Promoter Usage of the Human Estrogen Receptor-α Gene and Its Regulation by Estrogen

Donaghue, C., Westley, B. R., & May, F. E. B. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.11.0366 · Cited by 72 · see citing works

Interactions of Estrogen- and Thyroid Hormone Receptors on a Progesterone Receptor Estrogen Response Element (ERE) Sequence: a Comparison with the Vitellogenin A2 Consensus ERE

Scott, R. E. M., Wu-Peng, X. S., Yen, P. M., Chin, W. W., & Pfaff, D. W. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.11.0003 · Cited by 63 · see citing works

Localization of DNase I hypersensitive sites in the human oestrogen receptor gene correlates with the transcriptional activity of two differentially used promoters

Grandien, K., Berkenstam, A. L., Nilsson, S., & Gustafsson, J.-Å. (1993) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0100269 · Cited by 51 · see citing works

Progesterone‐Mediated Endometrial Maturation Limits Matrix Metalloproteinase (MMP) Expression in an Inflammatory‐like Environment

Osteen, K. G., Bruner‐Tran, K. L., Keller, N. R., & Eisenberg, E. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02764.x · Cited by 44 · see citing works

Identification of a Novel Transferable cis Element in the Promoter of an Estrogen-Responsive Gene that Modulates Sensitivity to Hormone and Antihormone

Montano, M. M., Kraus, W. L., & Katzenellenbogen, B. S. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.3.9899 · Cited by 19 · see citing works

Endometriosis is a chronic systemic disease: Clinical challenges and novel innovations

Taylor, H. S., Kotlyar, A. M., & Flores, V. A. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00389-5 · Cited by 1,425 · see citing works

Endometriosis and nuclear receptors

Yilmaz, B. D., & Bulun, S. E. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz005 · Cited by 243 · see citing works

Pathogenetic Mechanisms of Deep Infiltrating Endometriosis

Tosti, C., Pinzauti, S., Santulli, P., Chapron, C., & Petraglia, F. (2015) · Reproductive Sciences · doi:10.1177/1933719115592713 · Cited by 222 · see citing works

Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis

Pirtea, P., Cicinelli, E., Nola, R. D., de Ziegler, D., & Ayoubi, J. M. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.12.010 · Cited by 226 · see citing works

Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills

Casper, R. F. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.003 · Cited by 205 · see citing works

Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics

McKinnon, B. D., Kocbek, V., Nirgianakis, K., Bersinger, N. A., & Mueller, M. D. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmv060 · Cited by 194 · see citing works

Pathogenesis of endometriosis: Interaction between Endocrine and inflammatory pathways

Patel, B. G., Lenk, E. E., Lebovic, D. I., Shu, Y., Yu, J., & Taylor, R. N. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.01.006 · Cited by 195 · see citing works

The role of the peritoneum in the pathogenesis of endometriosis

Young, V. J., Brown, J. K., Saunders, P. T. K., & Horne, A. W. (2013) · Human Reproduction Update · doi:10.1093/humupd/dmt024 · Cited by 177 · see citing works

Oestrogen and progesterone action on endometrium: a translational approach to understanding endometrial receptivity

Young, S. L. (2013) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2013.06.010 · Cited by 177 · see citing works

Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis

Zhao, Y., Gong, P., Chen, Y., Nwachukwu, J. C., Srinivasan, S., Ko, C., Bagchi, M. K., Taylor, R. N., Korach, K. S., Nettles, K. W., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010626 · Cited by 170 · see citing works

Local and Systemic Factors and Implantation: what is the Evidence?

Fox, C., Morin, S., Jeong, J., Scott, R., & Lessey, B. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.02.018 · Cited by 146 · see citing works

Is there an association between autoimmunity and endometriosis?

Eisenberg, V. H., Zolti, M., & Soriano, D. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.01.005 · Cited by 164 · see citing works

Endometrial progesterone resistance and PCOS

Li, X., Feng, Y., Jin-fang, L., Billig, H., & Shao, R. (2014) · Journal of Biomedical Science · doi:10.1186/1423-0127-21-2 · Cited by 155 · see citing works

Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity

Vinketova, К., Mourdjeva, M., & Oreshkova, T. (2016) · Journal of Pregnancy · doi:10.1155/2016/8689436 · Cited by 142 · see citing works

Aromatase inhibitors for the treatment of endometriosis

Pavone, M. E., & Bulun, S. E. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.053 · Cited by 138 · see citing works

Immunological aspects of endometriosis: a review.

Králíčková, M., & Větvička, V. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.06.08 · Cited by 133 · see citing works

Wnt/Β-Catenin and Sex Hormone Signaling In Endometrial Homeostasis and Cancer

Wang, Y., van der Zee, M., Fodde, R., & Blok, L. J. (2010) · Oncotarget · doi:10.18632/oncotarget.201 · Cited by 126 · see citing works

Treatment of pain associated with deep endometriosis: alternatives and evidence

Ferrero, S., Alessandri, F., Racca, A., & Maggiore, U. L. R. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.08.031 · Cited by 124 · see citing works

The Role of the Lymphatic System in Endometriosis: A Comprehensive Review of the Literature1

Jerman, L. F., & Hey-Cunningham, A. J. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.114.124313 · Cited by 122 · see citing works

Elagolix Treatment for Endometriosis-Associated Pain: Results from a Phase 2, Randomized, Double-Blind, Placebo-Controlled Study

Diamond, M. P., Carr, B. R., Dmowski, W. P., Koltun, W. D., O'Brien, C. F., Jiang, P. X., Burke, J., Jimenez, R., Garner, E. I. O., & Chwalisż, K. (2013) · Reproductive Sciences · doi:10.1177/1933719113497292 · Cited by 121 · see citing works

Key to Life: Physiological Role and Clinical Implications of Progesterone

Nagy, B., Szekeres‐Barthó, J., Kovács, G. L., Sulyok, E., Farkas, B., Várnagy, Á., Vértes, V., Kovács, K. A., & Bódis, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011039 · Cited by 123 · see citing works

Progesterone Receptor Status Predicts Response to Progestin Therapy in Endometriosis

Flores, V. A., Vanhie, A., Dang, T., & Taylor, H. S. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01227 · Cited by 118 · see citing works

Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects

Lessey, B., Lebovic, D., & Taylor, R. (2013) · Seminars in Reproductive Medicine · doi:10.1055/s-0032-1333476 · Cited by 113 · see citing works

Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis

Hayashi, A., Tanabe, A., Kawabe, S., Hayashi, M., Yuguchi, H., Yamashita, Y., Okuda, K., & Ohmichi, M. (2012) · Journal of Ovarian Research · doi:10.1186/1757-2215-5-31 · Cited by 111 · see citing works

Histological and Immunohistochemical Characterization of the Similarity and Difference Between Ovarian Endometriomas and Deep Infiltrating Endometriosis

Liu, X., Zhang, Q., & Guo, S.-W. (2018) · Reproductive Sciences · doi:10.1177/1933719117718275 · Cited by 110 · see citing works

G Protein-Coupled Estrogen Receptor (GPER) Expression in Normal and Abnormal Endometrium

Plante, B. J., Lessey, B. A., Taylor, R. N., Wang, W., Bagchi, M. K., Yuan, L., Scotchie, J. G., Fritz, M. A., & Young, S. L. (2012) · Reproductive Sciences · doi:10.1177/1933719111431000 · Cited by 107 · see citing works

An update on the pharmacological management of endometriosis

Streuli, I., de Ziegler, D., Santulli, P., Marcellin, L., Borghese, B., Batteux, F., & Chapron, C. (2013) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2013.767334 · Cited by 105 · see citing works

Identification of cells with colony-forming activity, self-renewal capacity, and multipotency in ovarian endometriosis

Chan, R. W. S., Ng, E. H. Y., & Yeung, W. S. B. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.02.025 · Cited by 98 · see citing works

The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis

Han, S. J., & O’Malley, B. W. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu002 · Cited by 98 · see citing works

ERβ- and Prostaglandin E2-Regulated Pathways Integrate Cell Proliferation via Ras-like and Estrogen-Regulated Growth Inhibitor in Endometriosis

Monsivais, D., Dyson, M. T., Yin, P., Coon, J. S., Navarro, A., Feng, G., Malpani, S. S., Ono, M., Ercan, C. M., Wei, J. J., et al. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1421 · Cited by 91 · see citing works

Targeting oxidative stress to treat endometriosis

Harlev, A., Gupta, S., & Agarwal, A. K. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1077226 · Cited by 90 · see citing works

Molecular and preclinical basis to inhibit PGE 2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis

Arosh, J. A., Lee, J., Balasubbramanian, D., Stanley, J. A., Long, C. R., Meagher, M. W., Osteen, K. G., Bruner‐Tran, K. L., Burghardt, R. C., Starzinski‐Powitz, A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507931112 · Cited by 89 · see citing works

HDAC1 and HDAC2 are Differentially Expressed in Endometriosis

Colón-Díaz, M., Báez, P., García, M., Ruiz, A., Monteiro, J. B., Fourquet, J., Bayona, M., Alvarez-Garriga, C., Achille, A., Seto, E., et al. (2012) · Reproductive Sciences · doi:10.1177/1933719111432870 · Cited by 88 · see citing works

Steroid hormones regulate genome-wide epigenetic programming and gene transcription in human endometrial cells with marked aberrancies in endometriosis

Houshdaran, S., Oke, A., Fung, J. C., Vo, K. C., NEZHAT, C. R., & Giudice, L. C. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008601 · Cited by 87 · see citing works

Novel Therapies Targeting Endometriosis

Taylor, H. S., Osteen, K. G., Bruner‐Tran, K. L., Lockwood, C. J., Krikun, G., Sokalska, A., & Dulęba, A. J. (2011) · Reproductive Sciences · doi:10.1177/1933719111410713 · Cited by 82 · see citing works

Interaction between sex hormones and WNT/β-catenin signal transduction in endometrial physiology and disease

van der Horst, P. H., Wang, Y., van der Zee, M., Burger, C. W., & Blok, L. J. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.010 · Cited by 80 · see citing works

Pathogenesis of Endometriosis and Endometriosis-Associated Cancers

Adilbayeva, A., & Kunz, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147624 · Cited by 88 · see citing works

Minireview: Steroid-Regulated Paracrine Mechanisms Controlling Implantation

Pawar, S., Hantak, A. M., Bagchi, I. C., & Bagchi, M. K. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1074 · Cited by 78 · see citing works

Medical treatment for adenomyosis and/or adenomyoma

Tsui, K., Lee, W.-L., Chen, C.-Y., Sheu, B., Yen, M., Chang, T., & Wang, P. (2014) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2014.04.024 · Cited by 78 · see citing works

Androgens, oestrogens and endometrium: a fine balance between perfection and pathology

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The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis: A Randomized Clinical Trial

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