Potential Therapeutic Action of Adiponectin in Duchenne Muscular Dystrophy
Open accessAbstract
Adiponectin (ApN) is a hormone that exhibits anti-inflammatory effects on skeletal muscle exposed to acute and chronic inflammation. We have previously tested the implication of ApN in Duchenne muscular dystrophy (DMD) using mdx mice, a model of DMD, and by generating transgenic mdx mice overexpressing ApN. We showed that ApN can act as a preventive agent and delay disease progression by reducing muscle inflammation/injury and improving force/myogenesis. Herein, we took an opposite approach and crossed mdx mice with ApN knockout mice, to obtain mdx mice with ApN depletion. The aims were to test whether ApN deficiency could worsen the mdx phenotype and whether ApN supplementation can reverse several muscle abnormalities once the disease is settled. mdx-knockout mice exhibited lower muscle force/endurance as well as increased muscle damage when compared to regular mdx mice. Local administration of the ApN gene significantly reduced the expression of several oxidative stress/inflammatory markers and increased the expression of myogenic markers in the skeletal muscle. Finally, the presence of ApN markedly reduced the activity of NF-κB, a key player in muscle inflammation and myogenesis. ApN proves to be a powerful protector of the skeletal muscle capable of reversing the disease progression, thus making it a potential therapeutic agent for DMD.
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Replenishment of ApN by transgenesis or gene electro-transfer mitigated the dystrophic phenotype in mdx mice.
“Replenishment of ApN by transgenesis or gene electro-transfer mitigated the dystrophic phenotype in mdx mice [56,102].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [102]
ApN supplementation by muscular gene electro-transfer counteracted all abnormalities even once the disease has been installed.
“However, ApN supplementation by muscular gene electro-transfer counteracted all abnormalities even once the disease has been installed”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [102]
When mdx mice were crossed with ApN-knockout mice, the mdx phenotype worsened.
“When mdx mice were crossed with ApN-knockout mice, the mdx phenotype actually worsened.”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [102]
Enhanced mitochondrial biogenesis and oxidative metabolism will induce a switch towards an oxidative and more resistant fiber phenotype.
“Second, enhanced mitochondrial biogenesis and oxidative metabolism will induce a switch towards an oxidative and more resistant fiber phenotype [56,102].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [102]
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- Authors
- Abou-Samra, M., Boursereau, R., Lecompte, S., Noel, L., & Brichard, S. M.
- Affiliations
- UCLouvain (BE)
- Corresponding author
- Brichard, Sonia M.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 187
- Issue
- 7
- Pages
- 1577-1585
- ISSN
- 0002-9440 (ISSN-L)
- OpenAlex
- W2607679512
- Cited by
- 24
- References
- 35
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 6 · 2018: 2
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Health Sciences › Medicine › Epidemiology › Inflammatory Myopathies and Dermatomyositis
- Keywords
- adiponectin, Duchenne muscular dystrophy, mdx mice, muscle inflammation, oxidative stress, myogenesis, NF-κB, muscle damage, therapeutic target
- MeSH terms
- Animals, Disease Models, Animal, Humans, Inflammation, Male, Metabolism, Inborn Errors, NF-kappa B, Mice, Inbred mdx, Mice, Knockout, Muscle, Skeletal, Muscular Dystrophy, Duchenne, Muscle Development, Mice, Adiponectin
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