Induction of adiponectin in skeletal muscle of type 2 diabetic mice: In vivo and in vitro studies

Delaigle, A. M.; Senou, M.; Guiot, Y.; Many, M. -C.; Brichard, S. M.

doi:10.1007/s00125-006-0210-y

Cited by 79Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismMuscle Physiology and Disorders

Induction of adiponectin in skeletal muscle of type 2 diabetic mice: In vivo and in vitro studies

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Delaigle, A. M., Senou, M., Guiot, Y., Many, M. -C., Brichard, S. M.·2006·Diabetologia

DOI 10.1007/s00125-006-0210-y

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Abstract

Aims/hypothesis Adiponectin is an adipokine that exhibits insulin-sensitising, fat-burning and anti-inflammatory properties as well as modulatory effects on oxidative stress. We examined whether adiponectin could be induced in a non-adipose tissue, skeletal muscle, in response to metabolic or oxidative aggression both in vivo (in a murine model of type 2 diabetes) and in vitro.Methods Obese and diabetic ob/ob mice were used and compared with lean littermates. Some obese mice were treated with the antioxidant probucol for 3 weeks. At the end of the experiment, blood was sampled and tibialis anterior muscles were collected for mRNA measurement and immunohistochemistry. Additional in vitro experiments were performed on C2C12 myotubes cultured for up to 48 h.Results In spite of hypoadiponectinaemia, Adipoq mRNA levels were markedly increased in the skeletal muscle of ob/ob mice and correlated with systemic oxidative stress. Adipoq upregulation was shown in laser-microdissected myocytes of obese mice. Concomitantly, immunoreactivity for adiponectin was enhanced in obese muscle fibres together with lipid infiltration and local markers of oxidative stress. In cultured C2C12 myotubes, a triglyceride mix and reactive oxygen species producers (H2O2 or a lipoperoxidation end-product) upregulated Adipoq expression and adiponectin production. This effect was reversed by an antioxidant. Finally, treatment of obese mice with probucol also attenuated upregulation in muscle.Conclusions/interpretation The paradoxical upregulation of adiponectin in muscle of obese and diabetic mice may result from lipotoxicity and related oxidative stress. This unexpected finding could be viewed as a local protection to counteract ectopic fat deposition and oxidative damage.

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ApN up-regulation was reproduced in cultured murine or human myotubes in response to pro-inflammatory cytokines, ROS inducers or triglycerides.
“ApN up-regulation was also reproduced in cultured murine or human myotubes in response to pro-inflammatory cytokines, reactive oxygen species (ROS) inducers or triglycerides [36,38].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [38]
Although mainly secreted by adipocytes under normal conditions, ApN may be produced in skeletal muscle of mice submitted to stressful challenges.
“Although it is mainly secreted by adipocytes under normal conditions, ApN may be produced in skeletal muscle of mice submitted to stressful challenges.”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [38]
Acute (LPS injection) or low-grade inflammation (genetic or nutritional induced obesity) enhanced ApN expression in muscle of challenged mice.
“Thus, acute (lipopolysaccharides (LPS) injection) or low-grade inflammation (genetic or nutritional induced obesity) enhanced ApN expression in muscle of challenged mice [36,38,39,40].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [38]

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Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works
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Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works
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Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176 · see citing works
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Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133 · see citing works
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Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,139 · see citing works
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Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2094 · Cited by 1,659 · see citing works
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Cnop, M., Havel, P. J., Utzschneider, K. M., Carr, D. B., Sinha, M. K., Boyko, E. J., Retzlaff, B. M., Knopp, R. H., Brunzell, J. D., & Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-003-1074-z · Cited by 1,483 · see citing works
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Havel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575 · see citing works
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Tsuchida, A., Yamauchi, T., Ito, Y., Hada, Y., Maki, T., Takekawa, S., Kamon, J., Kobayashi, M., Suzuki, R., Hara, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402367200 · Cited by 550 · see citing works
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Cani, P. D., Neyrinck, A. M., Maton, N., & Delzenne, N. M. (2005) · Obesity Research · doi:10.1038/oby.2005.117 · Cited by 382 · see citing works
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Ferré, P., Leturque, A., Burnol, A., Pénicaud, L., & Girard, J. R. (1985) · Biochemical Journal · doi:10.1042/bj2280103 · Cited by 337 · see citing works
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Punyadeera, C., Zorenc, A. H. G., Koopman, R., McAinch, A. J., Smit, E., MANDERS, R. J. F., KEIZER, H. A., Cameron‐Smith, D., & van Loon, L. J. C. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01872 · Cited by 112 · see citing works
Effect of leptin deficiency on metabolic rate inob/obmice
Breslow, M. J., Min-Lee, K., Brown, D. R., Chacko, V. P., Palmer, D. J., & Berkowitz, D. E. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.3.e443 · Cited by 109 · see citing works
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Cellular Carbonyl Stress Enhances the Expression of Plasminogen Activator Inhibitor-1 in Rat White Adipocytes via Reactive Oxygen Species-dependent Pathway
Uchida, Y., Ohba, K., Yoshioka, T., Irie, K., Muraki, T., & Maru, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m304222200 · Cited by 74 · see citing works
Stereological methods in cell biology: where are we--where are we going?
Weibel, E. R. (1981) · Journal of Histochemistry & Cytochemistry · doi:10.1177/29.9.7026667 · Cited by 67 · see citing works
A simple method to assess the oxidative susceptibility of low density lipoproteins
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Structural Changes in the Angiofollicular Units between Active and Hypofunctioning Follicles Align with Differences in the Epithelial Expression of Newly Discovered Proteins Involved in Iodine Transport and Organification
Gérard, A.-C., Many, M., Daumerie, C., Costagliola, S., Miot, F. E. L., DEVIJLDER, J., Colin, I. M., & Denef, J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8278 · Cited by 58 · see citing works
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Delporte, M.-L., El Mkadem, S. A., Quisquater, M., & Brichard, S. M. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2003 · Cited by 55 · see citing works
Self-citation
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Harris, R. B. S., Hausman, D. B., & Bartness, T. J. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00339.2002 · Cited by 39 · see citing works
Skeletal muscle accretion and turnover in lean and obese (ob/ob) mice
Trostler, N., Romsos, D. R., Bergen, W. G., & Leveille, G. A. (1979) · Metabolism · doi:10.1016/0026-0495(79)90093-3 · Cited by 37 · see citing works
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Ide, T., Tsunoda, M., Mochizuki, T., & Murakami, K. (2004) · PubMed · Cited by 30 · see citing works
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Bailey, C. J., & Flatt, P. R. (1987) · Diabetologia · doi:10.1007/bf01788904 · Cited by 25 · see citing works
Cytokines d’origine adipocytaire, obésité et développement du diabète
Lacquemant, C., Vasseur, F., Leprêtre, F., & Froguel, P. (2003) · médecine/sciences · doi:10.1051/medsci/20031989809 · Cited by 19 · see citing works
Effect of probucol on serum lipids, atherosclerosis and toxicology in fat-fed LDL receptor deficient mice
Benson, G. M., Schiffelers, R. M., Nicols, C., Latcham, J., Vidgeon-Hart, M., Toseland, C. D. N., Suckling, K. E., & Groot, P. H. E. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00177-4 · Cited by 16 · see citing works

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Margaritis, M., Antonopoulos, A. S., Digby, J. E., Lee, R., Reilly, S. N., Coutinho, P., Shirodaria, C. C., Sayeed, R. A., Petrou, M., Silva, R. D., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.001133 · Cited by 364 · see citing works
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Adiponectin as a tissue regenerating hormone: More than a metabolic function
Fiaschi, T., Magherini, F., Gamberi, T., Modesti, P. A., & Modesti, A. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1537-4 · Cited by 66 · see citing works
Adipose–Muscle Crosstalk in Age-Related Metabolic Disorders: The Emerging Roles of Adipo-Myokines
Fang, P., She, Y., Yu, M., Min, W., Shang, W., & Zhang, Z. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101829 · Cited by 62 · see citing works
Meta-Analysis Approach identifies Candidate Genes and associated Molecular Networks for Type-2 Diabetes Mellitus
Rasche, A., Al‐Hasani, H., & Herwig, R. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-310 · Cited by 58 · see citing works
Microarray Analysis Reveals Novel Features of the Muscle Aging Process in Men and Women
Liu, D., Sartor, M. A., Nader, G. A., Pistilli, E. E., Tanton, L. C., Lilly, C., Gutmann, L., IglayReger, H. B., Visich, P. S., Hoffman, E. P., et al. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt015 · Cited by 58 · see citing works
Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signalling pathways
Meeprom, A., Sompong, W., Suwannaphet, W., Yibchok‐anun, S., & Adisakwattana, S. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001589 · Cited by 56 · see citing works
Adiponectin and Skeletal Muscle
Jortay, J., Senou, M., Abou-Samra, M., Noel, L., Robert, A., Many, M.-C., & Brichard, S. M. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.03.035 · Cited by 52 · see citing works
Self-citation
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Bonetto, A., Penna, F., Muscaritoli, M., Minero, V. G., Fanelli, F. R., Baccino, F. M., & Costelli, P. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.002 · Cited by 52 · see citing works
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Chiarugi, P., & Fiaschi, T. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903530712 · Cited by 52 · see citing works
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Self-citation
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Han, Y., Jung, H. W., & Park, Y. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.059 · Cited by 42 · see citing works
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Stocker, R. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32832aee68 · Cited by 41 · see citing works
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Self-citation
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Potential of Adiponectin as a Cardioprotective Agent
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Relationship between serum adiponectin levels and calcific aortic valve disease
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Dynamic relationships between body fat and circulating adipokine levels from adolescence to young adulthood: The Santiago Longitudinal Study
Kim, D., Howard, A. G., Blanco, E., Burrows, R. A., Correa‐Burrows, P., Memili, A., Cecilia Albala, B., Santos, J. L., Bárbara Angel, B., Lozoff, B., et al. (2022) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.01.001 · Cited by 4 · see citing works
Characterization of Wistar–Kyoto rats showing hyperadiponectinemia
Inoué, T., Takemori, K., Yamamoto, K., & Ito, H. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.01.003 · Cited by 4 · see citing works
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Ono, H., Tanaka, A., Nakazato, K., Hasegawa, Y., Kim, K. I., Kim, S. R., Nakajima, K., & Nagamine, T. (2014) · The Kitakanto Medical Journal · doi:10.2974/kmj.64.13 · Cited by 4 · see citing works
Incretin-induced changes in the transcriptome of skeletal muscles of fa/fa Zucker rat (ZFR) with obesity, without diabetes
Colin, I. M., Knoops, B., & Gérard, A.-C. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01114-2 · Cited by 3 · see citing works
Stress-induced Biomarkers in Liver with Non-alcohol Fatty Liver Diseases and Non-alcohol Steatohepatitis
Ono, H., Tanaka, A., Nakazato, K., Hasegawa, Y., Kim, K. I., Kim, S. R., Nakajima, K., & Nagamine, T. (2016) · The Kitakanto Medical Journal · doi:10.2974/kmj.66.79 · Cited by 1 · see citing works
Determinantes de la fuerza específica de contracción en el músculo esquelético del ratón geronte
Pereyra, A. S. (2015) · doi:10.35537/10915/50513
Regulation of Cardiac Remodelling by Adiponectin in Response to Pressure Overload and Unloading: A Focus on the Extracellular Matrix
Dadson, J. K. E. (2014) · YorkSpace (York University)
Síndrome metabólica e perfil de adipocitocinas séricas em pacientes adultas jovens com dermatomiosite
Silva, M. G. (2016) · doi:10.11606/d.5.2016.tde-05102016-084008
Efeitos das erva-mate (Ilex paraguariensis) na modulação do metabolismo energético mitocondrial associado à obesidade
dos Santos, T. W. (2018) · doi:10.47749/t/unicamp.2018.1051961
Current World Literature
(2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282c3a898
Current World Literature
(2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3280d5f7e9
Current literature in diabetes
(2006) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.720

Adiponectin : muscular regulation during stress and pathophysiological implications
Delaigle, A. (2006) · Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B))
Self-citation
Adiponectin and Skeletal Muscle
Jortay, J., Senou, M., Abou-Samra, M., Noel, L., Robert, A., Many, M.-C., & Brichard, S. M. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.03.035 · Cited by 52 · see citing works
Self-citation
Adiponectin overexpression in C2C12 myocytes increases lipid oxidation and myofiber transition
Lopez‐Yus, M., Lopez-Perez, R., García-Sobreviela, M. P., del Moral, R., Lorente‐Cebrián, S., & Arbonés-Mainar, J. M. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00836-7 · Cited by 13 · see citing works
Impaired Activation of AMP-Kinase and Fatty Acid Oxidation by Globular Adiponectin in Cultured Human Skeletal Muscle of Obese Type 2 Diabetics
Chen, M. B., McAinch, A. J., Macaulay, S. L., Castelli, L. A., O’Brien, P. E., Dixon, J. B., Cameron‐Smith, D., Kemp, B. E., & Steinberg, G. R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1980 · Cited by 200 · see citing works
Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice
Liu, Y., Palanivel, R., Rai, E., Park, M. S., Gabor, T. V., Scheid, M. P., Xu, A., & Sweeney, G. (2014) · Diabetes · doi:10.2337/db14-0267 · Cited by 223 · see citing works

Authors: Delaigle, A. M., Senou, M., Guiot, Y., Many, M. C., & Brichard, S. M.
Affiliations: UCLouvain (BE)
Corresponding author: Brichard, S. M.
ORCID: Guiot, Y.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2006-03-29
Volume: 49
Issue: 6
Pages: 1311-1323
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-006-0210-y
OpenAlex: W2080905500
Cited by: 79
References: 45
Citations by year: 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 10 · 2012: 4
FWCI: 4.90
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
Funders: Fonds De La Recherche Scientifique - FNRS (ARC 05/10-328)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: adiponectin, skeletal muscle, type 2 diabetes, oxidative stress, lipotoxicity, probucol, ob/ob mice, C2C12 myotubes, reactive oxygen species, lipid peroxidation, ectopic fat deposition, insulin resistance, adipokines
MeSH terms: Animals, Antioxidants, Body Weight, Cells, Cultured, Diabetes Mellitus, Type 2, Female, Gene Expression Regulation, Lipids, Mice, Inbred C57BL, Mice, Obese, Obesity, Probucol, RNA, Polymerase Chain Reaction, DNA Primers, Oxidative Stress, Muscle, Skeletal, Mice, Adiponectin

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Induction of adiponectin in skeletal muscle of type 2 diabetic mice: In vivo and in vitro studies

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