Cited by 443DNA Repair MechanismsEvolution and Genetic DynamicsDNA and Nucleic Acid Chemistry

Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations

Friedberg, Errol C., Wagner, Robert, Radman, Miroslav·2002·Science

Abstract

Cell death caused by arrested replication of damaged or structurally altered DNA can be avoided in prokaryotic and eukaryotic cells by multiple DNA polymerases that are specialized to bypass DNA damage. Some of these polymerases perform such translesion DNA synthesis of specific types of damage with high genetic fidelity. However, they exhibit greatly reduced fidelity when they operate on undamaged DNA or on DNA with lesions that are (apparently) not cognate substrates. The low fidelity of some of these specialized polymerases when copying undamaged DNA may be physiologically functional, including generating immunoglobulin diversity.

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Crossref · 10.1126/science.1070236

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54 of 54 references verified0 citation errors · 0 not checkable

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  • Translesion synthesis (TLS) polymerases copy past lesions in DNA that block the major replicative polymerases.

    “Translesion synthesis (TLS) polymerases copy past lesions in DNA that block the major replicative polymerases (7)(8)(9)(10)(11).”

    From DNA Replication Fidelity (2004) · cites this paper as [9]

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Authors
Friedberg, E. C., Wagner, R., & Radman, M.
Affiliations
  • The University of Texas Southwestern Medical Center (US)
  • Gene Check (United States) (US)
  • Inserm (FR)
Corresponding author
Friedberg, Errol C.
Venue
Science
Published
2002-05-31
Volume
296
Issue
5573
Pages
1627-1630
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2102334286
Cited by
443
References
54
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 9 · 2022: 3 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 13 · 2017: 13 · 2016: 11 · 2015: 15 · 2014: 22 · 2013: 9 · 2012: 17
FWCI
4.14
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords
translesion synthesis, DNA damage bypass, replication fidelity, mutagenesis, cell survival, immunoglobulin diversity, V(D)J recombination, prokaryotic and eukaryotic cells
MeSH terms
Animals, Bacteria, Cell Survival, DNA, DNA Damage, DNA-Directed DNA Polymerase, DNA Replication, Genes, Immunoglobulin, Humans, Templates, Genetic, Yeasts, Mutagenesis, Evolution, Molecular, Somatic Hypermutation, Immunoglobulin

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