Cited by 51Sleep and Work-Related FatigueSleep and Wakefulness ResearchAdenosine and Purinergic Signaling

Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A 1 receptors

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Elmenhorst, Eva-Maria, Elmenhorst, David, Benderoth, Sibylle, Kroll, Tina, Bauer, Andreas, Aeschbach, Daniel·2018·Proceedings of the National Academy of Sciences

Abstract

Significance: Modern work environments favor working around the clock, at the cost of insufficient sleep and increased risk for fatigue-related human error. Performance impairments caused by sleep loss show great variability among individuals and resemble the effects of ethanol intoxication. We found that there are individual trait characteristics that make individuals either vulnerable or resilient to both alcohol and to sleep deprivation. We also provide evidence by molecular brain imaging that ethanol induces an up-regulation of cerebral A 1 adenosine receptors, reminiscent of the effects of sleep deprivation. Targeting the brain’s adenosine system might help to identify countermeasures for fatigue- and alcohol-related human error.

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  • The degree of performance impairment in response to sleep loss is subject to substantial inter-individual differences that are stable and trait-like.

    “The degree of performance impairment in response to sleep loss is subject to substantial inter-individual differences that are stable and trait-like36,51–54.”

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  1. Rupp TL, Wesensten NJ, Newman R, & Balkin TJ (2013) PER3 and ADORA2A polymorphisms impact neurobehavioral performance during sleep restriction. J Sleep Res. 22(2):160-165.

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Authors
Elmenhorst, E.-M., Elmenhorst, D., Benderoth, S., Kroll, T., Bauer, A., & Aeschbach, D.
Affiliations
  • Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (DE)
  • University of Bonn (DE)
  • Forschungszentrum Jülich (DE)
  • Brigham and Women's Hospital (US)
Venue
Proceedings of the National Academy of Sciences
Published
2018-07-16
Volume
115
Issue
31
Pages
8009-8014
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2883120943
Cited by
51
References
57
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 13 · 2020: 10 · 2019: 8
FWCI
10.15
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • JuSER (Forschungszentrum Jülich) (submittedVersion)
  • elib (German Aerospace Center) (submittedVersion)
Funders
  • Deutsches Zentrum für Luft- und Raumfahrt
  • Forschungszentrum Jülich
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Keywords
alcohol intoxication, sleep deprivation, cognitive impairment, adenosine A1 receptor, fatigue, human error, shift work, adenosine system, neuroimaging
MeSH terms
Adult, Alcohol Drinking, Brain, Humans, Male, Sleep Deprivation, Quantitative Trait, Heritable, Receptor, Adenosine A1, Positron-Emission Tomography, Cognitive Dysfunction

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