Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A 1 receptors
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Significance: Modern work environments favor working around the clock, at the cost of insufficient sleep and increased risk for fatigue-related human error. Performance impairments caused by sleep loss show great variability among individuals and resemble the effects of ethanol intoxication. We found that there are individual trait characteristics that make individuals either vulnerable or resilient to both alcohol and to sleep deprivation. We also provide evidence by molecular brain imaging that ethanol induces an up-regulation of cerebral A 1 adenosine receptors, reminiscent of the effects of sleep deprivation. Targeting the brain’s adenosine system might help to identify countermeasures for fatigue- and alcohol-related human error.
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The degree of performance impairment in response to sleep loss is subject to substantial inter-individual differences that are stable and trait-like.
“The degree of performance impairment in response to sleep loss is subject to substantial inter-individual differences that are stable and trait-like36,51–54.”
From Effects of total sleep deprivation on performance in a manual spacecraft docking task (2024) · cites this paper as [36]
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Jaqua, E. E. (2023) · The Journal of Family Practice · doi:10.12788/jfp.0674 · Cited by 1 · see citing works
Pills or Sleep Deprivation? Sleep-Deprivation as a Therapeutic Option Intervention in Psychiatry
Antsyborov, A. V., Dubatova, I. V., & Kalinchuk, A. V. (2020) · Interactive science · doi:10.21661/r-551967
Imaging of Adenosine Receptors
Elmenhorst, D., Bier, D. D., Holschbach, M. H., & Bauer, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-53176-8_8
Self-citationPapież, Ł. S., Dołęga, J., Zabawa, B., Krzykawski, K., Maciejczyk, T., Sieńko, A., Hudzińska, P., Sadowski, J., Mól, P., & Łabuś, M. (2024) · Quality in Sport · doi:10.12775/qs.2024.34.56223
Sauerstoffmangel im Gehirn: Perfusion und Verfügbarkeit von A1-Adenosinrezeptoren
Weis, H., Elmenhorst, E.-M., Elmenhorst, D., Michno, M., Schmitz, J., Foerges, A. L., Beer, S., Jordan, J., Neumaier, B., Drzezga, A. E., et al. (2025) · Flugmedizin · Tropenmedizin · Reisemedizin - FTR · doi:10.1055/a-2547-3678
Self-citationWirkungen von Alkohol und hypobarer Hypoxie auf Schlaf, SpO₂ und Herzfrequenz
Trammer, R. A., Rooney, D., Benderoth, S., Wittkowski, M., Wenzel, J., & Elmenhorst, E. (2025) · Flugmedizin · Tropenmedizin · Reisemedizin - FTR · doi:10.1055/a-2541-9147
Self-citationKaifie, A., Reugels, M., Kraus, T., & Kursawe, M. (2021) · Figshare · doi:10.6084/m9.figshare.16584251
Analysis of sleep quality and its influencing factors among residents in Chengguan District of Lhasa
Zhang, L., Zhao, H., Xu, M., Jiang, Y., Zhang, B., Zhou, D., Wang, F., Cuomu, G., Ren, Y., Yang, N., et al. (2026) · BMC Public Health · doi:10.1186/s12889-026-27686-6
Motoi, M., Shin, N., Hama, M., Yasuda, Y., Nishimura, T., Nishimura, E., Toyoshima, H., Araki, Y., Katsumura, T., Xia, Y., et al. (2026) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-026-00434-w
- Authors
- Elmenhorst, E.-M., Elmenhorst, D., Benderoth, S., Kroll, T., Bauer, A., & Aeschbach, D.
- Affiliations
- Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (DE)
- University of Bonn (DE)
- Forschungszentrum Jülich (DE)
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-07-16
- Volume
- 115
- Issue
- 31
- Pages
- 8009-8014
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6077699
- OpenAlex
- W2883120943
- Cited by
- 51
- References
- 57
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 13 · 2020: 10 · 2019: 8
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion)
- elib (German Aerospace Center) (submittedVersion)
- Funders
- Deutsches Zentrum für Luft- und Raumfahrt
- Forschungszentrum Jülich
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- alcohol intoxication, sleep deprivation, cognitive impairment, adenosine A1 receptor, fatigue, human error, shift work, adenosine system, neuroimaging
- MeSH terms
- Adult, Alcohol Drinking, Brain, Humans, Male, Sleep Deprivation, Quantitative Trait, Heritable, Receptor, Adenosine A1, Positron-Emission Tomography, Cognitive Dysfunction
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