Pulsed electric field assisted extraction of intracellular valuables from microalgae
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Mechanical methods do not contaminate the environment but impose higher costs due to energy consumption.
“They do not contaminate the environment, but they do impose higher costs, due to the consumption of energy [116, 117].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [116]
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“They do not contaminate the environment, but they do impose higher costs, due to the consumption of energy [116, 117].”
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“…as microwaves, supercritical fluid extraction, enzymatic extractions, ultrasonic-assisted extraction, pulsed electric field technology and osmotic shock are used to enhance the extraction of cellular lipids bodies by solvents (Mercer and Armenta, 2011; Zheng et al., 2011; Goettel et al., 2012).”
MethodCell disruption and lipid extraction for microalgal biorefineries: A review
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“protothecoides, pre-concentrated to 100 gdw/l, with rectangular 1 μs pulses of an electric field strength of 34 kV/cm, 15 % of the total biomass could be released into the extracellular medium right after PEF treatment [124].”
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“[18], which also reported that 79% of the total released ions from Auxenochlorella protothecoides already occurred in the first hour after treatment.”
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“In fact, the electric field created induces a power differential through the cellular membrane and electroporation occurs when a certain threshold value is exceeded (between 0.5 – 1.5 V) (Goettel et al., 2013; Vorobiev and Lebovka, 2015).”
BackgroundInfluentialPulsed electric field (PEF): Avant-garde extraction escalation technology in food industry
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BackgroundMethodC-phycocyanin extraction assisted by pulsed electric field from Artrosphira platensis
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“The application of PEF for improving microalgal lipid extraction has been previously observed (Goettel et al. 2013; Grimi et al. 2014; Sheng et al. 2011; Zbinden et al. 2013).”
MethodExtraction of valuable compounds from Arthrospira platensis using pulsed electric field treatment
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“In microalgae, it was initially used to extract lipids for biofuel production, but it is now also applied for extracting other metabolites, such as carbohydrates, carotenoids, and chlorophyll [41,51].”
MethodResearch advances and application of pulsed electric field on proteins and peptides in food
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“The degree of pore formation is dependent on electric field strength, shape/type of pulse, treatment time, and number or pulses (Zbinden et al. 2013; Goettel et al. 2013).”
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Pulsed electric field assisted extraction of natural food pigments and colorings from plant matrices
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Techniques of lipid extraction from microalgae for biofuel production: a review
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“From the three types, the red and green algae contain the highest protein contents (Harnedy and FitzGerald 2011) as well as the highest areal yields (20 t DM ha−1) for green macroalgae (van den Burg et al. 2012); therefore, the green macroalgae Ulva lactuca was selected as the model species in this…”
BackgroundContinuous cultivation of photosynthetic microorganisms: Approaches, applications and future trends
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“Nevertheless, the utilization of pulsed electric fields in this photosynthetic microorganisms is not fully established (Coustets et al., 2013; Goettel et al., 2013) and thus more research studies need to be performed and should include scale-up and economic evaluation.”
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“(El-belghiti et al., 2005; Goettel et al., 2013; Pourzaki et al., 2013; Zbinden et al., 2013; Parniakov et al., 2014; Eduardo et al., 2015).”
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“An irreversible cell membrane permeabilization leads to an effective extraction by rupture of membrane and intracellular structures, making easier the solvent access into the cell and thus the release of valuable compounds [132,138].”
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“These include hydrothermal liquefaction [99,100], microwave assisted extraction [101,102], enzymatic extraction [103,104], osmotic shock [21,105], oxidative stress [106], ultrasound assisted extraction [107,108] and pulsed electric field technology [109,110].”
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Self-citationEmerging non-thermal technologies for decontamination of Salmonella in food
Kaavya, R., Pandiselvam, R., Abdullah, S., Sruthi, N. U., Jayanath, Y., Ashokkumar, C., Chandra Khanashyam, A., Kothakota, A., & Ramesh, S. V. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.04.011 · Cited by 107 · see citing works
Li, X., Liu, J., Chen, G., Zhang, J., Wang, C., & Liu, B. (2019) · Algal Research · doi:10.1016/j.algal.2019.101619 · Cited by 105 · see citing works
Lafarga, T. (2019) · Food Reviews International · doi:10.1080/87559129.2019.1655572 · Cited by 108 · see citing works
“One of the main advantages of this technology is that it could be potentially used in a biorefinery concept, where soluble ingredients are extracted before solvent extraction of lipids is performed.([9]) Table 3 summarizes the main outcomes observed after utilizing PEFs and other novel processing techniques to improve…”
BackgroundWicker, R. J., Kumar, G., Khan, E., & Bhatnagar, A. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.128932 · Cited by 104 · see citing works
Fratelli, C., Burck, M., Amarante, M. C. A., & Braga, A. R. C. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.10.043 · Cited by 100 · see citing works
Machado, L. F., Carvalho, G., & Pereira, R. N. (2022) · Biomass · doi:10.3390/biomass2020006 · Cited by 100 · see citing works
“These values of protein release with PEF technology corroborate previous studies with other species of microalgae [95,111].”
ResultLuengo, E., Martínez, J. M., Coustets, M., Álvarez, I., Teissié, J., Rols, M., & Raso, J. (2015) · The Journal of Membrane Biology · doi:10.1007/s00232-015-9796-7 · Cited by 98 · see citing works
“Goettel et al. (2013) investigated the extraction of intracellular compounds from the microalgae Auxenochlorella protothecoides; they also observed that increasing the electric field strength from 23 to 43 kV/cm did not have a great influence on the amount of intracellular compounds that were released.”
BackgroundBrien, R. O. O., Hayes, M., Sheldrake, G. N., Tiwari, B. K., & Walsh, P. J. (2022) · Foods · doi:10.3390/foods11040571 · Cited by 100 · see citing works
“This process has several advantages including that it is energy efficient, environmentally friendly, and can be operated at low temperatures, meaning undesirable change to potentially heat-sensitive target components [47,81,82] such as peptides and proteins can be avoided, resulting in easier downstream purification f…”
BackgroundJaeschke, D. P., Menegol, T., Rech, R., Mercali, G. D., & Marczak, L. D. F. (2016) · Process Biochemistry · doi:10.1016/j.procbio.2016.07.016 · Cited by 96 · see citing works
Han, S.-F., Jin, W., Yang, Q., Abomohra, A., Zhou, X., Tu, R., Chen, C., Xie, G.-J., & Wang, Q. (2018) · Renewable Energy · doi:10.1016/j.renene.2018.10.034 · Cited by 96 · see citing works
Purcell, D., Packer, M. A., Wheeler, T. T., & Hayes, M. (2021) · Molecules · doi:10.3390/molecules26051306 · Cited by 96 · see citing works
Lai, Y. S., Parameswaran, P., Li, A., Baez, M., & Rittmann, B. E. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.09.124 · Cited by 96 · see citing works
Progress in the physicochemical treatment of microalgae biomass for value-added product recovery
Costa, J. A. V., de Freitas, B. B., Moraes, L., Zaparoli, M., & de Morais, M. G. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2019.122727 · Cited by 93 · see citing works
Flisar, K., Meglič, S. H., Morelj, J., Golob, J., & Damijan Miklavčič, A. (2014) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2014.03.008 · Cited by 91 · see citing works
“org/ from bacterial cells [11,32], sugar from sugar beet cells [33–35] and oil for biodiesel from oil-producing microalgae [31,36–46].”
BackgroundCarullo, D., Pataro, G., Donsì, F., & Ferrari, G. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.551272 · Cited by 71 · see citing works
“Moreover, in agreement with previous research (Goettel et al., 2013; Postma et al., 2016; Pataro et al., 2017; ‘t Lam et al., 2017a; Carullo et al., 2018), results of the present work seem to highlight the capacity of PEF to efficiently release small components, such as CH and WSP of small molecular weight, while most…”
BackgroundResultSilve, A., Leray, I., Poignard, C., & Mir, L. M. (2016) · Scientific Reports · doi:10.1038/srep19957 · Cited by 90 · see citing works
Mild and Selective Protein Release of Cell Wall Deficient Microalgae with Pulsed Electric Field
Lam, G. P. ‘., van der Kolk, J. A., Chordia, A., Vermuë, M. H., Olivieri, G., Eppink, M. H. M., & Wijffels, R. H. (2017) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.7b00892 · Cited by 89 · see citing works
Pulsed electric field permeabilization and extraction of phycoerythrin from Porphyridium cruentum
Martínez, J. M., Delso, C., Álvarez, I., & Raso, J. (2018) · Algal Research · doi:10.1016/j.algal.2018.11.005 · Cited by 84 · see citing works
Gene transfer to plants by electroporation: methods and applications
Özyiğit, İ. İ. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05343-4 · Cited by 84 · see citing works
Ansari, F. A., Shriwastav, A., Gupta, S. K., Rawat, I., & Bux, F. (2017) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.6b04814 · Cited by 83 · see citing works
Physical Cell Disruption Technologies for Intracellular Compound Extraction from Microorganisms
Zhao, F., Wang, Z.-W., & Huang, H. (2024) · Processes · doi:10.3390/pr12102059 · Cited by 82 · see citing works
Liu, Z., Zeng, X., Cheng, J., Liu, D. F., & Aadil, R. M. (2018) · International Journal of Food Science & Technology · doi:10.1111/ijfs.13810 · Cited by 79 · see citing works
“These results were in accordance with the findings on lipid and protein extraction for microalgae (Goettel et al., 2013).”
BackgroundResultScherer, D., Krust, D., Frey, W., Mueller, G., Nick, P., & Gusbeth, C. (2019) · Algal Research · doi:10.1016/j.algal.2019.101536 · Cited by 78 · see citing works
“The continuous flow chamber had a volume of approximately 500 μl enclosed by two planar electrodes with 2mm gap distance as described in [9].”
MethodSelf-citationKokkali, M., Martí-Quijal, F. J., Taroncher, M., Ruiz, M.-J., Kousoulaki, K., & Barba, F. J. (2020) · Molecules · doi:10.3390/molecules25173921 · Cited by 76 · see citing works
“The specific energy input influences the degree of membrane permeabilization [34,35].”
BackgroundFrom Current Algae Products to Future Biorefinery Practices: A Review
Eppink, M. H. M., Olivieri, G., Reith, H., van den Berg, C., Barbosa, M. J., & Wijffels, R. H. (2017) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2016_64 · Cited by 78 · see citing works
Santin, A., Russo, M. T., Ferrante, M. I., Balzano, S., Orefice, I., & Sardo, A. (2021) · Molecules · doi:10.3390/molecules26247697 · Cited by 77 · see citing works
Akaberi, S., Gusbeth, C., Silve, A., Senthilnathan, D. S., López, E. N., Grima, E. M., Müller, G., & Frey, W. (2019) · Algal Research · doi:10.1016/j.algal.2019.101656 · Cited by 73 · see citing works
“Efforts have been made to find methods which are not only energy efficient, but also free of chemical contamination [1].”
BackgroundMethodInfluentialSelf-citationFerreira-Santos, P., Nunes, R., Biasio, F. D., Spigno, G., Gorgoglione, D., Teixeira, J., & Rocha, C. (2020) · LWT · doi:10.1016/j.lwt.2020.109491 · Cited by 61 · see citing works
Castejón, N., Þórarinsdóttir, K. A., Einarsdóttir, R., Kristbergsson, K., & Marteinsdóttir, G. (2021) · Marine Drugs · doi:10.3390/md19120662 · Cited by 70 · see citing works
“A time after treatment is needed for the materials to diffuse out of the cells [87,88], and in this experiment the suspensions waited overnight until separation of the liquid (extract) from the pulp.”
BackgroundPolyphenol Extraction from Food (by) Products by Pulsed Electric Field: A Review
Athanasiadis, V., Chatzimitakos, T. G., Κωτσού, Κ., Kalompatsios, D., Bozinou, E., & Lalas, S. I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115914 · Cited by 71 · see citing works
“The membrane’s disruption is proportional to the frequency and pulse width of the applied high-voltage pulses [62].”
BackgroundMalla, A., Rosales‐Mendoza, S., Phoolcharoen, W., & Vimolmangkang, S. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.650820 · Cited by 67 · see citing works
Timira, V., Meki, K., Li, Z., Lin, H., Xu, M., & Pramod, S. N. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1873734 · Cited by 67 · see citing works
Silve, A., Kian, C. B., Papachristou, I., Kubisch, C., Nazarova, N., Wüstner, R., Leber, K., Sträßner, R., & Frey, W. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.08.060 · Cited by 64 · see citing works
“Moreover, several studies in the literature suggested that an incubation period after PEFtreatment could increase the amount of water-soluble molecules released into the interstitial medium (Coustets et al., 2015, 2013; Goettel et al., 2013).”
BackgroundMethodInfluentialSelf-citationPriority-based multiple products from microalgae: review on techniques and strategies
Sarkar, S., Manna, M. S., Bhowmick, T. K., & Gayen, K. (2020) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2020.1753649 · Cited by 64 · see citing works
Shanmugam, S., Manigandan, S., Sivaramakrishnan, R., Raj, T., Ong, E. S., Rabbani, A. H., Rene, E. R., Mathimani, T., Brindhadevi, K., & Pugazhendhi, A. (2021) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2020.12.083 · Cited by 63 · see citing works
Effect of nanosecond pulsed electric field treatment on cell proliferation of microalgae
Buchmann, L., Frey, W., Gusbeth, C., Ravaynia, P. S., & Mathys, A. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.09.124 · Cited by 60 · see citing works
“…field strength E (kV cm −1 ) was 10 kV cm −1 as experiments were conducted using a plate-plate 1 mm polycarbonate treatment chamber (manufactured at the Karlsruhe Institute of Technology (KIT), Germany), for further information regarding the experimental setup refer to Goettel et al. (2013).”
Self-citationMicroalgae as a Potential Source of Proteins
Matos, Â. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816695-6.00003-9 · Cited by 62 · see citing works
Pulse Electric Field Technology for Wastewater and Biomass Residues’ Improved Valorization
Capodaglio, A. G. (2021) · Processes · doi:10.3390/pr9050736 · Cited by 58 · see citing works
“This makes algal cell disintegration and intracellular compounds extraction difficult and costly and identifies these steps as the main bottlenecks in the industrialization of microalgae exploitation in biorefinery [70].”
BackgroundCarullo, D., Abera, B. D., Scognamiglio, M., Donsı̀, F., Ferrari, G., & Pataro, G. (2022) · Foods · doi:10.3390/foods11030471 · Cited by 57 · see citing works
“Therefore, a progressive permeabilization strategy, which can be tailored for each specific strain, has emerged as the cornerstone front of the full valorization of microalgal biomass through an efficient and sustainable biorefinery process [5,20,24,25].”
BackgroundAkaberi, S., Krust, D., Müller, G., Frey, W., & Gusbeth, C. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123099 · Cited by 47 · see citing works
Self-citationGuo, B., Yang, B., Silve, A., Akaberi, S., Scherer, D., Papachristou, I., Frey, W., Hornung, U., & Dahmen, N. (2019) · Algal Research · doi:10.1016/j.algal.2019.101650 · Cited by 55 · see citing works
Self-citationGaneva, V., Angelova, B., Galutzov, B., Goltsev, V. N., & Zhiponova, M. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.552335 · Cited by 54 · see citing works
“The extraction efficiency depends on the fraction of the irreversibly permeabilized cells and in case of macromolecules such as proteins and NA can vary greatly in dependence of the cell wall structure and the conditions of the post-pulse incubation (Ganeva et al., 2003; Shynkaryk et al., 2009; Liu et al., 2012; Goett…”
BackgroundMethodNunes, E., Odenthal, K., Nunes, N., Fernandes, T., Fernandes, I. A., & Pinheiro de Carvalho, M. A. A. (2024) · Algal Research · doi:10.1016/j.algal.2024.103638 · Cited by 53 · see citing works
Biodiesel production potential of wastewater treatment high rate algal pond biomass
Mehrabadi, A., Craggs, R. J., & Farid, M. M. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.09.028 · Cited by 52 · see citing works
Deashing macroalgae biomass by pulsed electric field treatment
Robin, A., Sack, M., Israel, A. A., Frey, W., Müller, G., & Golberg, A. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.01.089 · Cited by 52 · see citing works
Self-citationUsing Algae for Biofuel Production: A Review
Jabłońska‐Trypuć, A., Wołejko, E., Ernazarovna, M. D., Głowacka, A., Sokołowska, G., & Wydro, U. (2023) · Energies · doi:10.3390/en16041758 · Cited by 52 · see citing works
“They do not pollute the environment because they do not generate large amounts of chemical waste, but they are associated with higher costs due to energy consumption [83,84].”
Background
- Authors
- Goettel, M., Eing, C., Gusbeth, C., Straessner, R., & Frey, W.
- Affiliations
- Karlsruhe Institute of Technology (DE)
- Corresponding author
- Goettel, Martina
- Venue
- Algal Research
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 2
- Issue
- 4
- Pages
- 401-408
- ISSN
- 2211-9264 (ISSN-L)
- OpenAlex
- W2063784194
- Cited by
- 313
- References
- 33
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 28 · 2023: 24 · 2022: 30 · 2021: 32 · 2020: 40 · 2019: 25 · 2018: 22 · 2017: 25 · 2016: 16 · 2015: 20 · 2014: 14
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Algal Research (publishedVersion)
- Funders
- German Helmholtz Association
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Plasma Applications and Diagnostics
- Keywords
- pulsed electric field, Auxenochlorella protothecoides, microalgae, cell disintegration, electric field strength, biomass concentration, biorefinery
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