The DOI matches its Crossref record; 114 of the 115 references it cites were found in a registry or an index.
Mast cells and IgE in defense against venoms: Possible “good side” of allergy?
Open accessAbstract
Physicians think of mast cells and IgE primarily in the context of allergic disorders, including fatal anaphylaxis. This 'bad side' of mast cells and IgE is so well accepted that it can be difficult to think of them in other contexts, particularly those in which they may have beneficial functions. However, there is evidence that mast cells and IgE, as well as basophils (circulating granulocytes whose functions partially overlap with those of mast cells), can contribute to host defense as components of adaptive type 2 immune responses to helminths, ticks and certain other parasites. Accordingly, allergies often are conceptualized as "misdirected" type 2 immune responses, in which IgE antibodies are produced against any of a diverse group of apparently harmless antigens, as well as against components of animal venoms. Indeed, certain unfortunate patients who have become sensitized to venoms develop severe IgE-associated allergic reactions, including fatal anaphylaxis, upon subsequent venom exposure. In this review, we will describe evidence that mast cells can enhance innate resistance to reptile or arthropod venoms during a first exposure to such venoms. We also will discuss findings indicating that, in mice which survive an initial encounter with venom, acquired type 2 immune responses, IgE antibodies, the high affinity IgE receptor (FcɛRI), and mast cells can contribute to acquired resistance to the lethal effects of both honeybee venom and Russell's viper venom. These findings support the hypothesis that mast cells and IgE can help protect the host against venoms and perhaps other noxious substances.
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IgE and mast cells in allergic disease
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Self-citationMAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances
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Cited by
Sorted by citations
IgE and mast cells in host defense against parasites and venoms
Mukai, K., Tsai, M. M., Starkl, P. M., Marichal, T., & Galli, S. J. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0565-1 · Cited by 211
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Self-citationThe Metabolic Requirements of Th2 Cell Differentiation
Stark, J. M., Tibbitt, C. A., & Coquet, J. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02318 · Cited by 176
Allergy, Anaphylaxis, and Nonallergic Hypersensitivity: IgE, Mast Cells, and Beyond
Vitte, J., Vibhushan, S., Bratti, M., Montero-Hernández, J. E., & Blank, U. (2022) · Medical Principles and Practice · doi:10.1159/000527481 · Cited by 110
Tryptase as a polyfunctional component of mast cells
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Metadata
- Authors
- Galli, S. J., Starkl, P., Marichal, T., & Tsai, M.
- Affiliations
- Stanford Medicine (US)
- Austrian Academy of Sciences (AT)
- University of Liège (BE)
- Corresponding author
- Galli, Stephen J.
- Venue
- Allergology International
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 65
- Issue
- 1
- Pages
- 3-15
- ISSN
- 1323-8930 (ISSN-L)
- OpenAlex
- W2172671124
- Semantic Scholar
- eda71d375165c803869a1c5383a7b95bef1abaac
- Cited by
- 73
- References
- 115
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 12 · 2016: 7
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Allergology International (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (R37 AI23990, R01 CA072074, R01 AR067145, U19 AI104209)
- National Science Foundation (2013263)
- Department of Pathology at Stanford University
- Max Kade Foundation
- Austrian Academy of Sciences
- Schroedinger Fellowship of the Austrian Science Fund (J3399-B21)
- European Commission (H2020-MSCA–IF–2014)
- European Union's Seventh Framework Programme (FP7-PEOPLE-2011-IOF)
- Belgian National Fund for Scientific Research
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Venomous Animal Envenomation and Studies
- Keywords
- mast cells, IgE, venom resistance, Th2 immune response, helminthiasis, ticks, basophils, FcεRI, honey bee venom, Russell's viper venom, anaphylaxis, innate immunity
- MeSH terms
- Allergens, Anaphylaxis, Animals, Basophils, Bee Venoms, Humans, Hypersensitivity, Immunoglobulin E, Immunity, Innate, Mast Cells, Models, Animal, Disease Resistance
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