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Cited by 73Mast cells and histamineFood Allergy and Anaphylaxis ResearchVenomous Animal Envenomation and Studies

The DOI matches its Crossref record; 114 of the 115 references it cites were found in a registry or an index.

Mast cells and IgE in defense against venoms: Possible “good side” of allergy?

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Galli, Stephen J., Starkl, Philipp, Marichal, Thomas, Tsai, Mindy·2016·Allergology International
DOI 10.1016/j.alit.2015.09.002
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Abstract

Physicians think of mast cells and IgE primarily in the context of allergic disorders, including fatal anaphylaxis. This 'bad side' of mast cells and IgE is so well accepted that it can be difficult to think of them in other contexts, particularly those in which they may have beneficial functions. However, there is evidence that mast cells and IgE, as well as basophils (circulating granulocytes whose functions partially overlap with those of mast cells), can contribute to host defense as components of adaptive type 2 immune responses to helminths, ticks and certain other parasites. Accordingly, allergies often are conceptualized as "misdirected" type 2 immune responses, in which IgE antibodies are produced against any of a diverse group of apparently harmless antigens, as well as against components of animal venoms. Indeed, certain unfortunate patients who have become sensitized to venoms develop severe IgE-associated allergic reactions, including fatal anaphylaxis, upon subsequent venom exposure. In this review, we will describe evidence that mast cells can enhance innate resistance to reptile or arthropod venoms during a first exposure to such venoms. We also will discuss findings indicating that, in mice which survive an initial encounter with venom, acquired type 2 immune responses, IgE antibodies, the high affinity IgE receptor (FcɛRI), and mast cells can contribute to acquired resistance to the lethal effects of both honeybee venom and Russell's viper venom. These findings support the hypothesis that mast cells and IgE can help protect the host against venoms and perhaps other noxious substances.

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Crossref · 10.1016/j.alit.2015.09.002

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Citations

Cites

Research works printed but not linked: 2

  1. Portier, 1902, De l'action anaphylactique de certains venims, C R Soc Biol, 54, 170
  2. Galli SJ. The 2014 Rous-Whipple Award Lecture. The mast cell-IgE paradox: from homeostasis to anaphylaxis. Am J Pathol. In press.

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Metadata

Authors
Galli, S. J., Starkl, P., Marichal, T., & Tsai, M.
Affiliations
  • Stanford Medicine (US)
  • Austrian Academy of Sciences (AT)
  • University of Liège (BE)
Corresponding author
Galli, Stephen J.
ORCID
Venue
Allergology International
Publisher
Elsevier BV
Published
2016-01
Volume
65
Issue
1
Pages
3-15
ISSN
1323-8930 (ISSN-L)
DOI
10.1016/j.alit.2015.09.002
OpenAlex
W2172671124
Semantic Scholar
eda71d375165c803869a1c5383a7b95bef1abaac
Cited by
73
References
115
Citations by year
2026: 1 · 2025: 5 · 2024: 2 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 12 · 2016: 7
FWCI
0.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Allergology International (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
Funders
  • National Institutes of Health (R37 AI23990, R01 CA072074, R01 AR067145, U19 AI104209)
  • National Science Foundation (2013263)
  • Department of Pathology at Stanford University
  • Max Kade Foundation
  • Austrian Academy of Sciences
  • Schroedinger Fellowship of the Austrian Science Fund (J3399-B21)
  • European Commission (H2020-MSCA–IF–2014)
  • European Union's Seventh Framework Programme (FP7-PEOPLE-2011-IOF)
  • Belgian National Fund for Scientific Research
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Venomous Animal Envenomation and Studies
Keywords
mast cells, IgE, venom resistance, Th2 immune response, helminthiasis, ticks, basophils, FcεRI, honey bee venom, Russell's viper venom, anaphylaxis, innate immunity
MeSH terms
Allergens, Anaphylaxis, Animals, Basophils, Bee Venoms, Humans, Hypersensitivity, Immunoglobulin E, Immunity, Innate, Mast Cells, Models, Animal, Disease Resistance

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