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A Beneficial Role for Immunoglobulin E in Host Defense against Honeybee Venom
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In the citing paper
“They also mediate protection from venoms produced by a range of animals, including snakes and bees. 5 , 6 , 7”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [6]
In the citing paper
“On the other hand, mast cells can also be protective, for example against Staphylococcus, honeybee, and snake venom. 1 , 5 , 6 , 7”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [6]
In the citing paper
“In adults, mast cells have important functions in protective immunity from certain bacteria, 1 helminths 2 , 3 , 4 and animal venoms. 6 , 7”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [6]
In the citing paper
“in mice surviving an initial encounter with venom, acquired type 2 immune responses, IgE antibodies, the high affinity IgE receptor (FcεRI), and mast cells can contribute to acquired resistance to the lethal effects of both honeybee venom and Russell’s”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [96]
In the citing paper
“We also found that genetically IgE-deficient mice [97] could not develop acquired immunity to honeybee venom, even though they developed a robust IgG1 antibody response to the venom [96].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [96]
In the citing paper
“Subsequently, we found that the acquired enhanced resistance to Russell’s viper venom (RVV) which we observed in mice that had developed type 2 immune responses to that venom [96] also was highly dependent on IgE (Fig. 5) and FcεRI (see Fig. 4, A–E in ref. [105]), and could be effectively transferred by immune serum into normal mice (see Fig. 3, F–J in ref. [105]) but not into C57BL/6-Cpa3-Cre;Mcl”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [96]
In the citing paper
“Taken together, these two initial studies [96, 104] support the hypothesis that one physiological function of IgE is to protect the host against noxious substances.”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [96]
In the citing paper
“We also showed that “immune serum” from WT mice could passively transfer enhanced resistance to honeybee venom to naïve IgE-deficient mice, unless such “immune serum” was first treated to neutralize IgE or impair its ability to bind to FcεRI [96].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [96]
In the citing paper
“Finally, we revealed that naïve genetically mast cell-deficient C57BL/6-KitW-sh/KitW-sh or C57BL/6-Cpa3-Cre+-Mcl-1fl/fl mice which received immune serum from honeybee venom-immunized C57BL/6 WT mice actually exhibited worse survival after challenge with a high dose of honeybee venom than did mast cell-deficient mice which had received serum from PBS mock-immunized C57BL/6 WT mice [96].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [96]
In the citing paper
“Our evidence showed that IgE antibodies were the critical elements of the acquired host resistance to honeybee or Russell’s viper venom.”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [96]
In the citing paper
“We found that, in mice, IgE-associated type 2 immune responses against honeybee venom or Russell’s viper venom were able to increase significantly host resistance to challenge with potentially lethal doses of those venoms [96].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [96]
In the citing paper
“We found that most or all of the acquired resistance induced in mice by a single exposure to honeybee venom was transferable to naïve mice with only 250 microliters of serum from honeybee venom-immunized mice [96].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [96]
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Citations
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Cited by
Sorted by citations
Mast cells and IgE in defense against venoms: Possible “good side” of allergy?
Galli, S. J., Starkl, P., Marichal, T., & Tsai, M. (2016) · Allergology International · doi:10.1016/j.alit.2015.09.002 · Cited by 73
Self-citationMast cell ontogeny: From fetal development to life‐long health and disease
Chia, S. L., Kapoor, S., Carvalho, C., Bajénoff, M., & Gentek, R. (2023) · Immunological Reviews · doi:10.1111/imr.13191 · Cited by 60
Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
Galli, S. J., Metz, M., Starkl, P., Marichal, T., & Tsai, M. (2020) · Allergo Journal International · doi:10.1007/s40629-020-00118-6 · Cited by 57
Self-citationUnderstanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases
Jiménez‐Saiz, R., Iborra, S., Blanco, C., González‐Pérez, R., Nuñez‐Borque, E., Zeyneloglu, C., Babayev, H., Göksel, O., Göksel, T., Khaitov, M., et al. (2026) · Allergy · doi:10.1111/all.70512 · Cited by 2
Metadata
- Authors
- Marichal, T., Starkl, P., Reber, L. L., Kalesnikoff, J., Oettgen, H. C., Tsai, M., Metz, M., & Galli, S. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 39
- Issue
- 5
- Pages
- 963-975
- ISSN
- 1074-7613
- PMC
- PMC4164235
- Cited by
- 180
- References
- 2
- Language
- en
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- Marichal, T., Starkl, P., Reber, L. L., Kalesnikoff, J., Oettgen, H. C., Tsai, M., Metz, M., & Galli, S. J. (2013). A Beneficial Role for Immunoglobulin E in Host Defense against Honeybee Venom. Immunity. https://doi.org/10.1016/j.immuni.2013.10.005
