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Cited by 143Dietary Effects on HealthReligion, Spirituality, and PsychologyNutritional Studies and Diet

Usefulness of Routine Periodic Fasting to Lower Risk of Coronary Artery Disease in Patients Undergoing Coronary Angiography

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Horne, Benjamin D., May, Heidi T., Anderson, Jeffrey L., Kfoury, Abdallah G., Bailey, Beau M., McClure, Brian S., Renlund, Dale G., Lappé, Donald L. +6 more·2008·The American Journal of Cardiology
DOI 10.1016/j.amjcard.2008.05.021PMC PMC2572991
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Abstract

Coronary artery disease (CAD) is common and multifactorial. Members of the Church of Jesus Christ of Latter-day Saints (LDS, or Mormons) in Utah may have lower cardiac mortality than other Utahns and the US population. Although the LDS proscription of smoking likely contributes to lower cardiac risk, it is unknown whether other shared behaviors also contribute. This study evaluated potential CAD-associated effects of fasting. Patients (n(1) = 4,629) enrolled in the Intermountain Heart Collaborative Study registry (1994 to 2002) were evaluated for the association of religious preference with CAD diagnosis (> or = 70% coronary stenosis using angiography) or no CAD (normal coronaries, <10% stenosis). Consequently, another set of patients (n(2) = 448) were surveyed (2004 to 2006) for the association of behavioral factors with CAD, with routine fasting (i.e., abstinence from food and drink) as the primary variable. Secondary survey measures included proscription of alcohol, tea, and coffee; social support; and religious worship patterns. In population 1 (initial), 61% of LDS and 66% of all others had CAD (adjusted [including for smoking] odds ratio [OR] 0.81, p = 0.009). In population 2 (survey), fasting was associated with lower risk of CAD (64% vs 76% CAD; OR 0.55, 95% confidence interval 0.35 to 0.87, p = 0.010), and this remained after adjustment for traditional risk factors (OR 0.46, 95% confidence interval 0.27 to 0.81, p = 0.007). Fasting was also associated with lower diabetes prevalence (p = 0.048). In regression models entering other secondary behavioral measures, fasting remained significant with a similar effect size. In conclusion, not only proscription of tobacco, but also routine periodic fasting was associated with lower risk of CAD.

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  • Of the 13 most rigorous CHD studies, nine (69%) found inverse relationships with CHD and one found a positive one.

    “Of the 13 studies with the most rigorous methodology, nine (69%) found inverse relationships with CHD [357–365] and one found a positive one [366].”

    From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [359]

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Research works printed but not linked: 2

  1. [3]Williams RR Lyon JL Brockert JE Maness AT Havlik RJ Feinleib M Decline in coronary mortality rates: Utah vs. United States Proceedings of the Conference on the Decline in CHD Mortality Washington, D.C.: U.S. Department of Health and Human Services 1979:48-57 NIH publication No. 79-1610
  2. [7]Berkman L Glass T Berkman L Kawachi I Social integration, social networks, social support, and health Social epidemiology 2000 137 73 Oxford University Press New York, NY

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Authors
Horne, B. D., May, H. T., Anderson, J. L., Kfoury, A. G., Bailey, B. M., McClure, B. S., Renlund, D. G., Lappé, D. L., Carlquist, J. F., Fisher, P. W., Pearson, R. R., Bair, T. L., Adams, T. D., & Muhlestein, J. B.
Affiliations
  • University of Utah (US)
  • Intermountain Medical Center (US)
Corresponding author
Horne, Benjamin D.
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
2008-10
Volume
102
Issue
7
Pages
814-819.e1
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/j.amjcard.2008.05.021
PMC
PMC2572991
OpenAlex
W2051879843
Cited by
143
References
29
Citations by year
2026: 2 · 2025: 7 · 2024: 7 · 2023: 47 · 2022: 10 · 2021: 13 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 6 · 2015: 4 · 2014: 2 · 2013: 9 · 2012: 8
FWCI
2.71
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (HL 071878, R01HL071878)
Topics
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Social Sciences › Health › Religion, Spirituality, and Psychology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
intermittent fasting, coronary artery disease, coronary angiography, religious preference, Church of Jesus Christ of Latter-day Saints, Latter-day Saints, smoking abstinence, social support, diabetes prevalence, cardiovascular risk factors
MeSH terms
Aged, Alcohol Drinking, Coronary Disease, Diabetes Mellitus, Fasting, Female, Humans, Hyperlipidemias, Hypertension, Life Style, Male, Middle Aged, Registries, Religion, Risk Factors, Social Support, Utah, Body Mass Index, Prevalence, Chi-Square Distribution, Logistic Models, Coronary Angiography

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