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Cited by 215Coffee research and impactsNutritional Studies and DietAlcohol Consumption and Health Effects

Coffee Consumption and Coronary Heart Disease in Men and Women: A Prospective Cohort Study

Lopez-Garcia, Esther, van Dam, Rob M., Willett, Walter C., Rimm, Eric B., Manson, JoAnn E., Stampfer, Meir J., Rexrode, Kathryn M., Hu, Frank B.·2006·Circulation
DOI 10.1161/circulationaha.105.598664
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Abstract

Background— We examined the association between long-term habitual coffee consumption and risk of coronary heart disease (CHD). Methods and Results— We performed a prospective cohort study with 44 005 men and 84 488 women without history of cardiovascular disease or cancer. Coffee consumption was first assessed in 1986 for men and in 1980 for women and then repeatedly every 2 to 4 years; the follow-up continued through 2000. We documented 2173 incident cases of coronary heart disease (1449 nonfatal myocardial infarctions and 724 fatal cases of CHD) among men and 2254 cases (1561 nonfatal myocardial infarctions and 693 fatal cases of CHD) among women. Among men, after adjustment for age, smoking, and other CHD risk factors, the relative risks (RRs) of CHD across categories of cumulative coffee consumption (<1 cup/mo, 1 cup/mo to 4 cups/wk, 5 to 7 cups/wk, 2 to 3 cups/d, 4 to 5 cups/d, and ≥6 cups/d) were 1.0, 1.04 (95% confidence interval 0.91 to 1.17), 1.02 (0.91 to 1.15), 0.97 (0.86 to 1.11), 1.07 (0.88 to 1.31), and 0.72 (0.49 to 1.07; P for trend=0.41); among women, the RRs were 1.0, 0.97 (0.83 to 1.14), 1.02 (0.90 to 1.17), 0.84 (0.74 to 0.97), 0.99 (0.83 to 1.17), and 0.87 (0.68 to 1.11; P for trend=0.08). Stratification by smoking status, alcohol consumption, history of type 2 diabetes mellitus, and body mass index gave similar results. Similarly, we found no effect when the most recent coffee consumption was examined. RRs for quintiles of caffeine intake varied from 0.97 (0.84 to 1.10) in the second quintile to 0.97 (0.84 to 1.11) in the highest quintile ( P for trend=0.82) in men and from 1.02 (0.90 to 1.16) to 0.97 (0.85 to 1.11; P for trend=0.37) in women. Conclusions— These data do not provide any evidence that coffee consumption increases the risk of CHD.

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Authors
Lopez-Garcia, E., van Dam, R. M., Willett, W. C., Rimm, E. B., Manson, J. E., Stampfer, M. J., Rexrode, K. M., & Hu, F. B.
Affiliations
  • From the Departments of Nutrition (E.L.-G., R.M.v.D., W.C.W., E.B.R., M.J.S., F.B.H.) and Epidemiology (W.C.W., E.B.R., J.E.M., M.J.S., F.B.H.), Harvard School of Public Health; the Channing Laboratory (W.C.W., E.B.R., J.E.M., M.J.S., F.B.H.) and Division of Preventive Medicine (J.E.M., M.J.S., K.M.R.), Harvard Medical School, Boston, Mass.
  • Harvard University (US)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-05-02
Volume
113
Issue
17
Pages
2045-2053
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.105.598664
OpenAlex
W2001333137
Cited by
215
References
46
Citations by year
2026: 5 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 14 · 2015: 12 · 2014: 14 · 2013: 18 · 2012: 15
FWCI
12.12
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL34594, R01HL034594)
  • National Cancer Institute (CA-87969, P01CA087969)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 55523, R01DK058845, R01DK055523, DK58845)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
coffee consumption, coronary artery disease, myocardial infarction, caffeine consumption, sex differences, cardiovascular risk
MeSH terms
Caffeine, Coffee, Coronary Disease, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Prospective Studies, Risk Factors, Smoking, Cohort Studies

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