INTERMITTENT FASTING AND HUMAN METABOLIC HEALTH

Patterson, Ruth E.; Laughlin, Gail A.; LaCroix, Andrea Z.; Hartman, Sheri J.; Natarajan, Loki; Senger, Carolyn M.; Martínez, María Elena; Villaseñor, Adriana; Sears, Dorothy D.; Marinac, Catherine R.; Gallo, Linda C.

doi:10.1016/j.jand.2015.02.018

Cited by 393Dietary Effects on HealthNutritional Studies and DietDiet and metabolism studies

INTERMITTENT FASTING AND HUMAN METABOLIC HEALTH

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Patterson, Ruth E., Laughlin, Gail A., LaCroix, Andrea Z., Hartman, Sheri J., Natarajan, Loki, Senger, Carolyn M., Martínez, María Elena, Villaseñor, Adriana +3 more·2015·Journal of the Academy of Nutrition and Dietetics

DOI 10.1016/j.jand.2015.02.018PMC PMC4516560

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This process has the potential to be reversible following changes in diet quantity and quality, as shown with calorie restriction, fasting, time-restricted eating, gastric bypass surgery, low saturated fat and low glycemic diets.
“This process has the potential to be reversible following changes in diet quantity and quality, as has been shown to occur with calorie restriction, fasting, time-restricted eating, gastric bypass surgery, low saturated fat and low glycemic diets [168,170,173].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [173]
The Human Intervention Trials sections report weight loss and some improved metabolic markers with fasting, time-restricted feeding, and calorie restriction. They do not establish reversal of the unspecified process, and the paper does not address gastric bypass surgery, low-saturated-fat diets, or low-glycemic diets as ways to reverse it. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Alternate-day fasting alternates fasting or calorie-restricted days with ad libitum feeding days, whereas whole-day fasting restricts caloric intake on two nonconsecutive days per week while permitting unrestricted eating on the remaining 5 days.
“ADF alternates fasting or calorie-restricted days with ad libitum feeding days, whereas WDF restricts caloric intake on two nonconsecutive days per week while permitting unrestricted eating on the remaining 5 days (11, 13, 14).”
From Intermittent fasting versus continuous energy restriction in MASLD: a systematic review and meta-analysis (2026) · cites this paper as [14]

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Prolonged Nightly Fasting and Breast Cancer Prognosis
Marinac, C. R., Nelson, S. H., Breen, C. I., Hartman, S. J., Natarajan, L., Pierce, J. P., Flatt, S. W., Sears, D. D., & Patterson, R. E. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.0164 · Cited by 181 · see citing works
Self-citation
Energy Metabolism and Intermittent Fasting: The Ramadan Perspective
Lessan, N. G., & Ali, T. (2019) · Nutrients · doi:10.3390/nu11051192 · Cited by 169 · see citing works
Effects of time-restricted feeding on body weight and metabolism. A systematic review and meta-analysis
Pellegrini, M., Cioffi, I., Evangelista, A., Ponzo, V., Goitre, I., Ciccone, G., Ghigo, E., & Bo, S. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09524-w · Cited by 168 · see citing works
Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders
Zhang, X., Zou, Q., Zhao, B., Zhang, J., Zhao, W., Li, Y., Liu, R., Liu, X., & Liu, Z. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101535 · Cited by 166 · see citing works
Effect of diurnal fasting on sleep during Ramadan: a systematic review and meta-analysis
Faris, M. E., Jahrami, H., Alhayki, F. A., Alkhawaja, N. A., Ali, A. M., Aljeeb, S. H., Abdulghani, I. H., & BaHammam, A. S. (2019) · Sleep And Breathing · doi:10.1007/s11325-019-01986-1 · Cited by 159 · see citing works
Intermittent fasting in the prevention and treatment of cancer
Clifton, K., Ma, C. X., Fontana, L., & Peterson, L. L. (2021) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21694 · Cited by 160 · see citing works
Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity
Chung, H., Chou, W., Sears, D. D., Patterson, R. E., Webster, N. J. G., & Ellies, L. G. (2016) · Metabolism · doi:10.1016/j.metabol.2016.09.006 · Cited by 149 · see citing works
Self-citation
Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L., Patel, D., Ma, Y., Brocker, C. N., Yan, T., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.007 · Cited by 144 · see citing works
“In contrast, intermittent fasting (including EODF) has been practiced in humans, especially in certain religious groups (Patterson et al., 2015), for centuries and has been proven to benefit body composition and health (Eshghinia and Mohammadzadeh, 2013; López-Bueno et al., 2014; Patterson et al.,…”
Influential
Frequency and Circadian Timing of Eating May Influence Biomarkers of Inflammation and Insulin Resistance Associated with Breast Cancer Risk
Marinac, C. R., Sears, D. D., Natarajan, L., Gallo, L. C., Breen, C. I., & Patterson, R. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136240 · Cited by 144 · see citing works
Self-citation
Impact of intermittent fasting on the lipid profile: Assessment associated with diet and weight loss
Santos, H. O., & Macedo, R. C. O. (2018) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2018.01.002 · Cited by 139 · see citing works
Impact of Ramadan diurnal intermittent fasting on the metabolic syndrome components in healthy, non-athletic Muslim people aged over 15 years: a systematic review and meta-analysis
Faris, M. E., Jahrami, H., Alsibai, J., & Obaideen, A. A. (2019) · British Journal Of Nutrition · doi:10.1017/s000711451900254x · Cited by 129 · see citing works
Precision (Personalized) Nutrition: Understanding Metabolic Heterogeneity
Zeisel, S. H. (2020) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-032519-051736 · Cited by 130 · see citing works
Unravelling the health effects of fasting: a long road from obesity treatment to healthy life span increase and improved cognition
de Toledo, F. W., Grundler, F., Sirtori, C. R., & Ruscica, M. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1770849 · Cited by 119 · see citing works
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases
Fontana, L., Ghezzi, L., Cross, A. H., & Piccio, L. M. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190086 · Cited by 116 · see citing works
Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock
Charlot, A., Hutt, F., Sabatier, E., & Zoll, J. (2021) · Nutrients · doi:10.3390/nu13051405 · Cited by 119 · see citing works
A systematic review, meta-analysis, and meta-regression of the impact of diurnal intermittent fasting during Ramadan on body weight in healthy subjects aged 16 years and above
Jahrami, H., Alsibai, J., Clark, C. C. T., & Faris, M. E. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02216-1 · Cited by 116 · see citing works
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
parker, J., O'Brien, C., Hawrelak, J., & Gersh, F. (2021) · doi:10.20944/preprints202112.0088.v1 · Cited by 113 · see citing works
Ramadan diurnal intermittent fasting modulates SOD2, TFAM, Nrf2, and sirtuins (SIRT1, SIRT3) gene expressions in subjects with overweight and obesity
Madkour, M. I., El-Serafi, A. T., Jahrami, H., Sherif, N. M., Hassan, R. E., Awadallah, S. M., & Faris, M. E. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107801 · Cited by 112 · see citing works
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
Parker, J., O’Brien, C., Hawrelak, J., & Gersh, F. L. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031336 · Cited by 114 · see citing works
“This process has the potential to be reversible following changes in diet quantity and quality, as has been shown to occur with calorie restriction, fasting, timerestricted eating, gastric bypass surgery, low saturated fat and low glycaemic diets (167,169,172).”
Background
Diet, Gut Microbiota and COVID-19
Rishi, P., Thakur, K., Vij, S., Rishi, L., Singh, A., Kaur, I. P., Patel, S. K. S., Lee, J.-K., & Kalia, V. C. (2020) · Indian Journal of Microbiology · doi:10.1007/s12088-020-00908-0 · Cited by 108 · see citing works
Associations between circadian disruption and cardiometabolic disease risk: A review
Ansu, V., & Knutson, K. L. (2023) · Obesity · doi:10.1002/oby.23666 · Cited by 110 · see citing works
Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis
Crudele, L., Piccinin, E., & Moschetta, A. (2021) · Nutrients · doi:10.3390/nu13062101 · Cited by 109 · see citing works
A systematic review, meta-analysis, and meta-regression of the impact of diurnal intermittent fasting during Ramadan on glucometabolic markers in healthy subjects
Faris, M. E., Jahrami, H., BaHammam, A. S., Kalaji, Z., Madkour, M. I., & Hassanein, M. M. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108226 · Cited by 103 · see citing works
Extending Methods in Dietary Patterns Research
Reedy, J., Subar, A. F., George, S. M., & Krebs‐Smith, S. M. (2018) · Nutrients · doi:10.3390/nu10050571 · Cited by 103 · see citing works
Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials
Sun, M., Yao, W., Wang, X., Gao, S., Varady, K. A., Forslund, S. K., Zhang, M., Shi, Z.-Y., Cao, F., Zou, B.-J., et al. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102519 · Cited by 103 · see citing works
Meal timing, aging, and metabolic health
Kessler, K., & Pivovarova-Ramich, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081911 · Cited by 95 · see citing works
The Role of Mitochondria in Diabetic Kidney Disease
Hallan, S. I., & Sharma, K. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0748-0 · Cited by 94 · see citing works
Effect of alternate-day fasting on obesity and cardiometabolic risk: A systematic review and meta-analysis
Park, J., Seo, Y.-G., Paek, Y.-J., Song, H. J., Park, K. H., & Noh, H.-M. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154336 · Cited by 93 · see citing works
Effects of Intermittent Fasting on the Circulating Levels and Circadian Rhythms of Hormones
Kim, B. H., Joo, Y., Kim, M., Choe, H. K., Tong, Q., & Kwon, O. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2021.405 · Cited by 98 · see citing works
The Role of Exercise, Diet, and Cytokines in Preventing Obesity and Improving Adipose Tissue
ATAKAN, M. M., Koşar, Ş. N., Güzel, Y., Tin, H. T., & Yan, X. (2021) · Nutrients · doi:10.3390/nu13051459 · Cited by 94 · see citing works
The effect of intermittent compared with continuous energy restriction on glycaemic control in patients with type 2 diabetes: 24-month follow-up of a randomised noninferiority trial
Carter, S., Clifton, P. M., & Keogh, J. B. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.03.022 · Cited by 88 · see citing works
Effect of Various Types of Intermittent Fasting (IF) on Weight Loss and Improvement of Diabetic Parameters in Human
Nowosad, K., & Sujka, M. (2021) · Current Nutrition Reports · doi:10.1007/s13668-021-00353-5 · Cited by 87 · see citing works
Effects of Intermittent Fasting on Brain Metabolism
Brocchi, A., Rebelos, E., Dardano, A., Mantuano, M., & Daniele, G. (2022) · Nutrients · doi:10.3390/nu14061275 · Cited by 91 · see citing works
Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
Das, M., Ellies, L. G., Kumar, D., Sauceda, C., Oberg, A., Gross, E. T. E., Mandt, T., Newton, I. G., Kaur, M., Sears, D. D., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20743-7 · Cited by 87 · see citing works
Self-citation
Dietary Patterns and Interventions to Alleviate Chronic Pain
Dragan, S. R., Șerban, M.-C., Damian, G., Buleu, F. N., Valcovici, M. D., & Christodorescu, R. (2020) · Nutrients · doi:10.3390/nu12092510 · Cited by 81 · see citing works
Effects of intermittent fasting on cognitive health and Alzheimer’s disease
Elias, A., Padinjakara, N., & Lautenschlager, N. T. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad021 · Cited by 81 · see citing works
Making progress on the global crisis of obesity and weight management
Lean, M. E. J., Astrup, A. V., & Roberts, S. B. (2018) · BMJ · doi:10.1136/bmj.k2538 · Cited by 75 · see citing works
Time-restricted feeding influences immune responses without compromising muscle performance in older men
Gasmi, M., Sellami, M., Denham, J., Padulo, J., Kuvačić, G., Selmi, W., & Khalıfa, R. (2018) · Nutrition · doi:10.1016/j.nut.2017.12.014 · Cited by 68 · see citing works
Brain–Gut–Microbiome Interactions and Intermittent Fasting in Obesity
Frank, J., Gupta, A., Osadchiy, V., & Mayer, E. A. (2021) · Nutrients · doi:10.3390/nu13020584 · Cited by 68 · see citing works
Dietary Management of Obesity: A Review of the Evidence
Hwalla, N., & Jaafar, Z. (2020) · Diagnostics · doi:10.3390/diagnostics11010024 · Cited by 66 · see citing works
Top 10 dietary strategies for atherosclerotic cardiovascular risk reduction
Sikand, G., & Severson, T. (2020) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2020.100106 · Cited by 68 · see citing works
Chrononutrition—When We Eat Is of the Essence in Tackling Obesity
Ahluwalia, M. K. (2022) · Nutrients · doi:10.3390/nu14235080 · Cited by 72 · see citing works
PROFAST: A Randomized Trial Assessing the Effects of Intermittent Fasting and Lacticaseibacillus rhamnosus Probiotic among People with Prediabetes
Tay, A., Pringle, H., Penning, E., Plank, L. D., & Murphy, R. (2020) · Nutrients · doi:10.3390/nu12113530 · Cited by 62 · see citing works
Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials
Xie, F., Fu, R., Hong, J., Ni, H., Yu, K., & Gu, L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.871682 · Cited by 66 · see citing works
Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia
Balasubramanian, P., DelFavero, J., Ungvari, A., Papp, M., Tarantini, A., Price, N. L., de Cabo, R., & Tarantini, S. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101189 · Cited by 60 · see citing works
Efficacy of Popular Diets Applied by Endurance Athletes on Sports Performance: Beneficial or Detrimental? A Narrative Review
Devrim-Lanpir, A., Hill, L., & Knechtle, B. (2021) · Nutrients · doi:10.3390/nu13020491 · Cited by 57 · see citing works
Maternal Circadian Eating Time and Frequency Are Associated with Blood Glucose Concentrations during Pregnancy
Loy, S. L., Chan, J. K. Y., Wee, P. H., Colega, M., Cheung, Y. B., Godfrey, K. M., Kwek, K. Y. C., Saw, S., Chong, Y. S., Padmapriya, N., et al. (2016) · Journal of Nutrition · doi:10.3945/jn.116.239392 · Cited by 55 · see citing works
Dietary Energy Modulation and Autophagy: Exploiting Metabolic Vulnerabilities to Starve Cancer
Cozzo, A. J., Coleman, M. F., Pearce, J. B., Pfeil, A. J., Etigunta, S. K., & Hursting, S. D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590192 · Cited by 55 · see citing works
Intermittent Energy Restriction Is a Feasible, Effective, and Acceptable Intervention to Treat Adolescents with Obesity
Jebeile, H., Gow, M. L., Lister, N. B., Haghighi, M. M., Ayer, J. G., Cowell, C. T. C. T., Baur, L. A., & Garnett, S. P. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz049 · Cited by 54 · see citing works
Intermittent fasting reduces body fat but exacerbates hepatic insulin resistance in young rats regardless of high protein and fat diets
Park, S., Yoo, K. M., Hyun, J. S., & Kang, S. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.10.003 · Cited by 52 · see citing works
Nutrition modulation of human aging: The calorie restriction paradigm
Das, S. K., Balasubramanian, P., & Weerasekara, Y. K. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.04.011 · Cited by 51 · see citing works
Intermittent Fasting: Physiological Implications on Outcomes in Mice and Men
Lee, J. H., Verma, N., Thakkar, N., Yeung, C., & Sung, H. (2020) · Physiology · doi:10.1152/physiol.00030.2019 · Cited by 53 · see citing works
Fasting: How to Guide
Attinà, A., Leggeri, C., Paroni, R., Pivari, F., Dei Cas, M., Mingione, A., Dri, M., Marchetti, M., & Di Renzo, L. (2021) · Nutrients · doi:10.3390/nu13051570 · Cited by 47 · see citing works
AACR White Paper: Shaping the Future of Cancer Prevention – A Roadmap for Advancing Science and Public Health
Lippman, S. M., Abate-Shen, C. T., Maresso, K. C., Colditz, G. A., Dannenberg, A. J., Davidson, N. E., Disis, M. L., DuBois, R. N., Szabo, E. M., Giuliano, A. R., et al. (2018) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-18-0421 · Cited by 47 · see citing works
Self-citation
Thermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice
Kim, Y. H., Lee, J. H., Yeung, J. L.-H., Das, E., Kim, R. Y., Jiang, Y., Moon, J. H., Jeong, H., Thakkar, N., Son, J. E., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39380-2 · Cited by 46 · see citing works
Obesity-Mediated Immune Modulation: One Step Forward, (Th)2 Steps Back
Schmidt, V., Hogan, A. E., Fallon, P. G., & Schwartz, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.932893 · Cited by 45 · see citing works
The Effects of Intermittent Fasting on Glycemic Control and Body Composition in Adults with Obesity and Type 2 Diabetes: A Systematic Review
Vitale, R., & Kim, Y. (2020) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2020.0048 · Cited by 43 · see citing works
Impact of prolonged fasting on insulin secretion, insulin action, and hepatic versus whole body insulin secretion disposition indices in healthy young males
Jørgensen, S. W., Hjort, L., Gillberg, L., Justesen, L., Madsbad, S., Brøns, C., & Vaag, A. A. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00433.2020 · Cited by 42 · see citing works
Effect of Time-Restricted Feeding on Anthropometric, Metabolic, and Fitness Parameters: A Systematic Review
Kang, J., Ratamess, N. A., Faigenbaum, A. D., Bush, J. A., Beller, N. A., Vargas, A., Fardman, B., & Andriopoulos, T. (2021) · Journal of the American Nutrition Association · doi:10.1080/07315724.2021.1958719 · Cited by 42 · see citing works
Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic metabolic effects of fasting
Zhang, Y., Higgins, C. B., Fortune, H. M., Chen, P., Stothard, A. I., Mayer, A. L., Swarts, B. M., & DeBosch, B. J. (2019) · Nature Communications · doi:10.1038/s41467-019-09642-8 · Cited by 40 · see citing works
The Implication of Physiological Ketosis on The Cognitive Brain: A Narrative Review
Altayyar, M., Nasser, J. A., Thomopoulos, D., & Bruneau, M. L. (2022) · Nutrients · doi:10.3390/nu14030513 · Cited by 39 · see citing works
SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase
Higgins, C. B., Mayer, A. L., Zhang, Y., Franczyk, M. P., Ballentine, S. J., Yoshino, J., & DeBosch, B. J. (2022) · Nature Communications · doi:10.1038/s41467-022-28717-7 · Cited by 38 · see citing works
Effects of Intermittent Fasting on Regulation of Metabolic Homeostasis: A Systematic Review and Meta-Analysis in Health and Metabolic-Related Disorders
Silva, A. I., Direito, M., Pinto‐Ribeiro, F., Ludovico, P., & Sampaio‐Marques, B. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12113699 · Cited by 38 · see citing works
Circadian rhythm disrupting behaviours and cancer outcomes in breast cancer survivors: a systematic review
D’cunha, K., Park, Y., Protani, M. M., & Reeves, M. M. (2022) · Breast Cancer Research and Treatment · doi:10.1007/s10549-022-06792-0 · Cited by 36 · see citing works
Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice
Zhang, Y., Shaikh, N., Ferey, J. L. A., Wankhade, U. D., Chintapalli, S. V., Higgins, C. B., Crowley, J. R., Heitmeier, M. R., Stothard, A. I., Mihi, B., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.11.295 · Cited by 36 · see citing works
Effects of Ramadan intermittent fasting on leptin and adiponectin: a systematic review and meta-analysis
Gaeini, Z., Mirmiran, P., & Bahadoran, Z. (2021) · HORMONES · doi:10.1007/s42000-021-00285-3 · Cited by 36 · see citing works
Effects of an Intermittent Fasting 5:2 Plus Program on Body Weight in Chinese Adults with Overweight or Obesity: A Pilot Study
Kang, J., Shi, X., Fu, J., Li, H., Ma, E., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14224734 · Cited by 35 · see citing works
Adaptation to Fasting in Crucian Carp (Carassius auratus): Gut Microbiota and Its Correlative Relationship with Immune Function
Li, T., Qi, M., Gatesoupe, F.-J., Tian, D., Jin, W., Li, J., Lin, Q., Wu, S., & Li, H. (2018) · Microbial Ecology · doi:10.1007/s00248-018-1275-0 · Cited by 35 · see citing works
Fasting mimicking diets: A literature review of their impact on inflammatory arthritis
Venetsanopoulou, A. I., Voulgari, P. V., & Drosos, A. A. (2019) · Mediterranean Journal of Rheumatology · doi:10.31138/mjr.30.4.201 · Cited by 35 · see citing works
Christian Orthodox fasting in practice: A comparative evaluation between Greek Orthodox general population fasters and Athonian monks
Karras, S. Ν., Koufakis, T., Petróczi, A., Folkerts, D., Kypraiou, M., Mulrooney, H. M., Naughton, D. P., Persynaki, A., Zebekakis, P. E., Skoutas, D., et al. (2018) · Nutrition · doi:10.1016/j.nut.2018.07.003 · Cited by 34 · see citing works
Dietary fasting and time-restricted eating in Huntington’s disease: therapeutic potential and underlying mechanisms
Wells, R. G., Neilson, L. E., McHill, A. W., & Hiller, A. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00406-z · Cited by 35 · see citing works
Intermittent Fasting Reshapes the Gut Microbiota and Metabolome and Reduces Weight Gain More Effectively Than Melatonin in Mice
Liu, J., Zhong, Y., Luo, X., Ma, Y., Liu, J., & Wang, H. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.784681 · Cited by 33 · see citing works
Refeeding Syndrome in Pediatric Age, An Unknown Disease: A Narrative Review
Corsello, A., Trovato, C. M., Dipasquale, V., Bolasco, G., Labriola, F., Gottrand, F., Verduci, E., Diamanti, A., & Romano, C. (2023) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000003945 · Cited by 32 · see citing works
The Effects of Different Dietary Patterns on Bone Health
Liu, X., Wu, Y., Bennett, S., Zou, J., Xu, J., & Zhang, L. (2024) · Nutrients · doi:10.3390/nu16142289 · Cited by 32 · see citing works
Diet Therapy in the Management of Chronic Pain: Better Diet Less Pain?
Philpot, U., & Johnson, M. I. (2019) · Pain Management · doi:10.2217/pmt-2019-0014 · Cited by 32 · see citing works
A Prospective Clinical Trial of Prolonged Fasting in Healthy Young Males and Females—Effect on Fatigue, Sleepiness, Mood and Body Composition
Nugraha, B., Riat, A., Ghashang, S. K., Eljurnazi, L., & Gutenbrunner, C. M. (2020) · Nutrients · doi:10.3390/nu12082281 · Cited by 32 · see citing works
Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha
Li, G., Brocker, C. N., Yan, T., Xie, C., Krausz, K. W., Xiang, R., & Gonzalez, F. J. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.10.011 · Cited by 32 · see citing works
Protein restriction, epigenetic diet, intermittent fasting as new approaches for preventing age-associated diseases
Vafa, M., & Hanjani, N. (2018) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_397_16 · Cited by 32 · see citing works
Modulatory Effect of Intermittent Fasting on Adipose Tissue Inflammation: Amelioration of Cardiovascular Dysfunction in Early Metabolic Impairment
Dwaib, H. S., AlZaim, I., Eid, A. H., Obeid, O., & EL‐Yazbi, A. F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.626313 · Cited by 32 · see citing works
Effect of Carbohydrate-Restricted Diets and Intermittent Fasting on Obesity, Type 2 Diabetes Mellitus, and Hypertension Management: Consensus Statement of the Korean Society for the Study of Obesity, Korean Diabetes Association, and Korean Society of Hypertension
Choi, J. H., Cho, Y. J., Kim, H., Ko, S., Chon, S., Kang, J., Kim, E. M., Kim, H. J., Kim, H. J., Song, K., et al. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2022.0038 · Cited by 32 · see citing works
Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation
Han, H.-M., Kim, S.-Y., & Kim, D. (2025) · APL Bioengineering · doi:10.1063/5.0263236 · Cited by 29 · see citing works
Intermittent fasting, fatty acid metabolism reprogramming, and neuroimmuno microenvironment: mechanisms and application prospects
Zhang, A., Wang, J., Zhao, Y., He, Y., & Sun, N. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1485632 · Cited by 31 · see citing works
From Fad to Fact: Evaluating the Impact of Emerging Diets on the Prevention of Cardiovascular Disease
D'Souza, M. S., Dong, T. A., Ragazzo, G., Dhindsa, D. S., Mehta, A., Sandesara, P. B., Freeman, A. M., Taub, P. R., & Sperling, L. S. (2020) · The American Journal of Medicine · doi:10.1016/j.amjmed.2020.05.017 · Cited by 27 · see citing works
Effects of intermittent fasting on liver physiology and metabolism in mice
Ma, J., Cheng, Y., Su, Q., Ai, W., Gong, L., Wang, Y., Li, L., Ma, Z., Pan, Q., Qiao, Z., et al. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10382 · Cited by 29 · see citing works
Dietary patterns affect Parkinson's disease via the microbiota-gut-brain axis
Chu, C., Yu, L., Chen, W., Tian, F., & Zhai, Q. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.07.004 · Cited by 26 · see citing works
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Authors: Patterson, R. E., Laughlin, G. A., LaCroix, A. Z., Hartman, S. J., Natarajan, L., Senger, C. M., Martínez, M. E., Villaseñor, A., Sears, D. D., Marinac, C. R., & Gallo, L. C.
Affiliations: University of California San Diego (US)
University of California System (US)
San Diego State University (US)
ORCID: Patterson, Ruth E.
LaCroix, Andrea Z.
Hartman, Sheri J.
Natarajan, Loki
Sears, Dorothy D.
Marinac, Catherine R.
Gallo, Linda C.
Venue: Journal of the Academy of Nutrition and Dietetics
Publisher: Elsevier BV
Published: 2015-08
Volume: 115
Issue: 8
Pages: 1203-1212
ISSN: 2212-2672 (ISSN-L)
DOI: 10.1016/j.jand.2015.02.018
PMC: PMC4516560
OpenAlex: W2071766083
Cited by: 390
References: 69
Citations by year: 2026: 24 · 2025: 55 · 2024: 47 · 2023: 42 · 2022: 54 · 2021: 51 · 2020: 47 · 2019: 30 · 2018: 19 · 2017: 11 · 2016: 7 · 2015: 2
FWCI: 9.58
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Academy of Nutrition and Dietetics (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health
National Cancer Institute (F31CA183125, K07CA181323, U54CA155435, U54CA132379, U54CA132384)
National Institute on Minority Health and Health Disparities
Topics: Health Sciences › Medicine › Physiology › Dietary Effects on Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Physiology › Diet and metabolism studies
Keywords: intermittent fasting, metabolic health, food abstinence, caloric restriction, dietary recommendations
MeSH terms: Animals, Energy Intake, Disease Models, Animal, Energy Metabolism, Fasting, Humans, Life Style, Obesity, Risk Factors, Health Behavior, Randomized Controlled Trials as Topic, Observational Studies as Topic

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