Cited by 155Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

Dyslipidemia in the metabolic syndrome and type 2 diabetes mellitus.

Brunzell, John D, Ayyobi, Amir F·2003·The American Journal of Medicine

Abstract

Patients with type 2 diabetes mellitus or the metabolic syndrome have a unique dyslipidemia characterized by hypertriglyceridemia; elevated blood levels of apolipoprotein B; small, dense low-density lipoprotein (LDL) cholesterol; and low levels of high-density lipoprotein (HDL) cholesterol, in particular HDL(2)-C. Treatment of the dyslipidemia associated with these disorders should focus on correcting the abnormal lipoprotein levels as well as LDL and HDL heterogeneity. Statins and fibrates are useful for treating elevated LDL in patients with and without diabetes or the metabolic syndrome. In addition, thiazolidinediones or niacin in combination with a statin show promise for correcting defects in LDL and HDL heterogeneity. The ultimate goal of treatment in this patient population is to prevent the development and progression of coronary artery disease.

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Crossref · 10.1016/j.amjmed.2003.08.011

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Authors
Brunzell, J. D., & Ayyobi, A. F.
Affiliations
University of Washington (US)
Corresponding author
Ayyobi, Amir F
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2003-12
Volume
115
Issue
8
Pages
24-28
ISSN
0002-9343 (ISSN-L)
OpenAlex
W2030751874
Cited by
155
References
63
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 12 · 2013: 10 · 2012: 12
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
dyslipidemia, metabolic syndrome, type 2 diabetes, hypertriglyceridemia, apolipoprotein B, small dense LDL, HDL cholesterol, HDL2-C, lipoprotein heterogeneity, statins, fibrates, thiazolidinediones, nicotinic acid, coronary heart disease prevention
MeSH terms
Coronary Artery Disease, Diabetes Mellitus, Type 2, Humans, Hyperlipidemias, Lipase, Cholesterol, HDL, Cholesterol, LDL, Receptor, Insulin, Risk Factors, Metabolic Syndrome

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