Cited by 128Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Phagocytic NADPH Oxidase Overactivity Underlies Oxidative Stress in Metabolic Syndrome

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Fortuño, Ana, San José, Gorka, Moreno, María U., Beloqui, Oscar, Díez, Javier, Zalba, Guillermo·2006·Diabetes

Abstract

Oxidative stress plays a critical role in the pathogenesis of atherosclerosis in patients with metabolic syndrome. This study aimed to investigate whether a relationship exists between phagocytic NADPH oxidase activity and oxidative stress and atherosclerosis in metabolic syndrome patients. The study was performed in 56 metabolic syndrome patients (metabolic syndrome group), 99 patients with one or two cardiovascular risk factors (cardiovascular risk factor group), and 28 healthy subjects (control group). NADPH oxidase expression and activity was augmented (P < 0.05) in metabolic syndrome compared with cardiovascular risk factor and control groups. Insulin was enhanced (P < 0.05) in metabolic syndrome patients compared with cardiovascular risk factor and control groups and correlated with NADPH oxidase activity in the overall population. Insulin stimulated NADPH oxidase activity; this effect was abolished by a specific protein kinase C inhibitor. Oxidized LDL and nitrotyrosine levels and carotid intima-media thickness were increased (P < 0.05) in the metabolic syndrome group compared with cardiovascular risk factor and control groups and correlated with NADPH oxidase activity in the overall population. These findings suggest that phagocytic NADPH oxidase overactivity is involved in oxidative stress and atherosclerosis in metabolic syndrome patients. Our findings also suggest that hyperinsulinemia may contribute to oxidative stress in metabolic syndrome patients through activation of NADPH oxidase.

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Crossref · 10.2337/diabetes.55.01.06.db05-0751

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Authors
Fortuño, A., San José, G., Moreno, M. U., Beloqui, O., Díez, J., & Zalba, G.
Affiliations
  • Division of Cardiovascular Sciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
  • Department of Internal Medicine, University Clinic, University of Navarra, Pamplona, Spain
  • Centro de Investigación Médica Aplicada (ES)
Venue
Diabetes
Published
2006-01-01
Volume
55
Issue
1
Pages
209-215
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
OpenAlex
W2120390713
Cited by
128
References
48
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 9 · 2020: 7 · 2019: 5 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 8
FWCI
8.91
Type
journal article
Language
en
Open access
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
  • UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
  • Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion)
Funders
  • Gobierno de Navarra
  • Instituto de Salud Carlos III (C03/01)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
NADPH oxidase, phagocytes, oxidative stress, metabolic syndrome, atherosclerosis, hyperinsulinemia, protein kinase C, oxidized LDL, nitrotyrosine, carotid intima-media thickness, cardiovascular risk factors
MeSH terms
Female, Humans, Lymphocytes, Male, Middle Aged, Monocytes, Phagocytes, Tetradecanoylphorbol Acetate, Biomarkers, Gene Expression Regulation, Enzymologic, Oxidative Stress, NADPH Oxidases, Metabolic Syndrome, Atherosclerosis

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