Cited by 244Dietary Effects on HealthNutritional Studies and DietDiet and metabolism studies

Intermittent Fasting: A Heart Healthy Dietary Pattern?

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Dong, Tiffany A., Sandesara, Pratik B., Dhindsa, Devinder S., Mehta, Anurag, Arneson, Laura C., Dollar, Allen L., Taub, Pam R., Sperling, Laurence S.·2020·The American Journal of Medicine

Abstract

Dietary patterns, such as the Dietary Approaches to Stop Hypertension (DASH) and the Mediterranean diet, have been shown to improve cardiac health. Intermittent fasting is another type of popular dietary pattern that is based on timed periods of fasting. Two different regimens are alternative day fasting and time-restricted eating. Although there are no large, randomized control trials examining the relationship between intermittent fasting and cardiovascular outcomes, current human studies that suggest this diet could reduce the risk for cardiovascular disease with improvement in weight control, hypertension, dyslipidemia, and diabetes. Intermittent fasting may exert its effects through multiple pathways, including reducing oxidative stress, optimization of circadian rhythms, and ketogenesis. This review evaluates current literature regarding the potential cardiovascular benefits of intermittent fasting and proposes directions for future research.

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Authors
Dong, T. A., Sandesara, P. B., Dhindsa, D. S., Mehta, A., Arneson, L. C., Dollar, A. L., Taub, P. R., & Sperling, L. S.
Affiliations
  • Emory University (US)
  • Northwestern University (US)
  • University of California San Diego (US)
Corresponding author
Sperling, Laurence S.
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2020-08
Volume
133
Issue
8
Pages
901-907
ISSN
0002-9343 (ISSN-L)
OpenAlex
W3018101566
Cited by
240
References
40
Citations by year
2026: 14 · 2025: 43 · 2024: 50 · 2023: 44 · 2022: 38 · 2021: 47 · 2020: 4
FWCI
4.40
Type
journal article
Language
en
Open access
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK118278)
Topics
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
Keywords
intermittent fasting, cardiovascular disease, time-restricted eating, dietary habits, hypertension, dyslipidemia, diabetes mellitus, weight management, oxidative stress, circadian rhythm, ketogenesis
MeSH terms
Cardiovascular Diseases, Circadian Rhythm, Diabetes Mellitus, Fasting, Humans, Hypertension, Ketone Bodies, Obesity, Risk Factors, Oxidative Stress, Risk Reduction Behavior, Dyslipidemias, Diet, Ketogenic

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