Cited by 177Asthma and respiratory diseasesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesChronic Obstructive Pulmonary Disease (COPD) Research

The impact of anxiety and depression on outpatients with asthma

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Ciprandi, Giorgio, Schiavetti, Irene, Rindone, Elena, Ricciardolo, Fabio L.M.·2015·Annals of Allergy, Asthma & Immunology

Abstract

Background Anxiety and depression may frequently affect patients with asthma. However, the findings of several studies are partially conflicting and conducted in selected cohorts. Objective To investigate the effect of anxiety and depression in a group of outpatients with asthma. Methods This cross-sectional, real-life study included 263 patients (109 males; mean age, 39.2 years) with asthma. Clinical examination, lung function, fractional exhaled nitric oxide measurement, Asthma Control Test (ACT) score, asthma control grade, perception of symptoms by visual analog scale, and Hospital Anxiety and Depression Scale (HADS) questionnaires were evaluated. Results Globally, 97 patients (36.9%) had anxiety, and 29 (11%) had depression. Of these patients, 71 had combined anxiety and depression. Anxiety and depression were associated with poor asthma control (P =.007 and .02, respectively). Patients with depression had higher body mass indexes (P =.002). Anxiety and depression were associated with lower ACT scores (P < .001 for both). The scores on the anxiety and depression subscales of HADS were moderately related (r = 0.57). Conclusions The present real-life study indicates that anxiety and depression are common and relevant comorbidities in asthmatic outpatients and are associated with uncontrolled asthma and lower ACT scores. Thus, assessment of comorbid mental disorders should be performed in common practice.

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  • Some features of asthma overlap with symptoms of anxiety, and the association between asthma and anxiety has been reported extensively in the scientific literature.

    “Some of the features of asthma overlap with symptoms of anxiety and the association between asthma and anxiety has been reported extensively in the scientific literature (Brew, Lundholm, Gong, Larsson & Almqvist, 2018;Brew, Lundholm, Viktorin, Lichtenstein, Larsson & Almqvist, 2018;Ciprandi, Schiavetti, Rindone & Ricciardolo, 2015).”

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  1. Dweik RA, Boggs PB, Erzurum SC, et al. American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applica- tions. Am J Respir Crit Care Med. 2011;184:602e615.

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Authors
Ciprandi, G., Schiavetti, I., Rindone, E., & Ricciardolo, F. L. M.
Affiliations
  • Ospedale Policlinico San Martino (IT)
  • University of Genoa (IT)
  • University of Turin (IT)
Corresponding author
Ciprandi, Giorgio
Venue
Annals of Allergy, Asthma & Immunology
Publisher
Elsevier BV
Published
2015-11
Volume
115
Issue
5
Pages
408-414
ISSN
1081-1206 (ISSN-L)
OpenAlex
W2097414539
Cited by
177
References
47
Citations by year
2026: 7 · 2025: 12 · 2024: 15 · 2023: 11 · 2022: 17 · 2021: 21 · 2020: 53 · 2019: 14 · 2018: 10 · 2017: 8 · 2016: 8 · 2015: 1
FWCI
6.63
Type
journal article
Language
en
Open access
Locations
  • Annals of Allergy Asthma & Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
asthma, anxiety, depression, comorbidities, asthma control, Asthma Control Test, outpatients, body mass index, mental health screening
MeSH terms
Adult, Anxiety, Asthma, Cross-Sectional Studies, Depression, Depressive Disorder, Female, Humans, Male, Outpatients, Severity of Illness Index, Visual Analog Scale

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