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Cited by 44Growth Hormone and Insulin-like Growth FactorsPituitary Gland Disorders and TreatmentsHormonal and reproductive studies

Traumatic brain injury as a relevant cause of growth hormone deficiency in adults: A KIMS-based study

Casanueva, Felipe F., Leal, Alfonso, Koltowska-Häggström, Maria, Jonsson, Peter, Góth, Miklós I.·2005·Archives of Physical Medicine and Rehabilitation
DOI 10.1016/j.apmr.2004.05.018
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Abstract

Objectives To characterize further the clinical manifestations and the efficacy of growth hormone (GH) replacement therapy in patients with adult-onset growth hormone deficiency (GHD) reported in the KIMS (Pfizer's international metabolic database) as caused by traumatic brain injury (TBI) and to compare them with nonirradiated patients whose GHD was due to a nonfunctioning pituitary adenoma (NFPA).Design Observational study.Setting Subjects selected from the KIMS database.Participants Fifty-one patients with GHD resulting from TBI and 688 patients with GHD resulting from NFPA. Both groups were selected from the KIMS and had adult-onset GHD with GH replacement therapy only after KIMS entry and before and after KIMS entry.Interventions Not applicable.Main outcome measures Age, body mass index, age at disease onset, age at disease diagnosis, age at KIMS entry, final height, GH peak at testing, GH replacement dose, routine biochemical analysis, clinical manifestations of disease, and quality of life measurements.Results Patients with TBI were significantly younger at study entry and were younger both at pituitary disease onset and at GHD diagnosis, but they showed a significant delay in treatment. When comparing patients not treated with GH before entering in the KIMS, patients with TBI were significantly shorter (167.2+/-1.7 cm) than those with NFPA (171.6+/-0.4 cm) in final height. TBI patients had lower GH reserves than NFPA patients, and although the latter group experienced more positive changes, both groups benefited from GH replacement therapy.Conclusions Patients with GHD due to TBI showed a significant reduction in height and a reduction in pituitary GH reserve and were diagnosed and treated with inappropriate delay.

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  • Acquired GHD in childhood can impair adult height as well as body composition if there is a delay in diagnosis and treatment.

    “Acquired GHD in childhood can impair adult height as well as body composition if there is a delay in diagnosis and treatment [72].”

    From Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury (2015) · cites this paper as [72]

  • TBI has previously been considered a rare cause of hypopituitarism, but an increased prevalence of neuroendocrine dysfunction in patients with TBI has been reported during the last 15 years in most retrospective and prospective studies.

    “TBI has previously been considered as a rare cause of hypopituitarism, but an increased prevalence of neuroendocrine dysfunction in patients with TBI has been reported during the last 15 years in most of the retrospective and prospective studies.”

    From Pituitary dysfunction following traumatic brain injury: clinical perspectives (2015) · cites this paper as [11]

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Authors
Casanueva, F. F., Leal, A., Koltowska-Häggström, M., Jonsson, P., & Góth, M. I.
Affiliations
  • Universidade de Santiago de Compostela (ES)
  • Hospital Universitario Virgen del Rocío (ES)
ORCID
Venue
Archives of Physical Medicine and Rehabilitation
Publisher
Elsevier BV
Published
2005-03
Volume
86
Issue
3
Pages
463-468
ISSN
0003-9993 (ISSN-L)
DOI
10.1016/j.apmr.2004.05.018
OpenAlex
W2094192596
Cited by
44
References
31
Citations by year
2025: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2015: 9 · 2014: 3 · 2012: 2
FWCI
3.32
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Archives of Physical Medicine and Rehabilitation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
traumatic brain injury, adult-onset growth hormone deficiency, growth hormone replacement therapy, non-functioning pituitary adenoma, growth hormone reserve, adult height, treatment delay, quality of life
MeSH terms
Adult, Brain Injuries, Female, Humans, Male, Pituitary Diseases, Quality of Life, Body Mass Index, Databases, Factual, Pharmacoepidemiology, Human Growth Hormone

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