Bingeing rats: A model of intermittent excessive behavior?
Open accessAbstract
Intermittent excessive behaviors (IEB) characterize a variety human disorders including binge eating, drug abuse, alcoholism, aberrant sexual conduct, and compulsive gambling. Clinical co-morbidity exists among IEB, and limited treatment options are available. The use of behavioral models of bingeing and other feeding protocols is beginning to clarify neural similarities and differences that exist between IEB directed toward obtaining and consuming food and IEB directed toward obtaining and consuming drugs of abuse. Research from this laboratory using a limited access binge-type eating protocol may provide new insight into IEB.
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For nonsweet palatable foods (typically high-fat foods), there is less convincing evidence for development of dependence, although intermittent access to corn oil can stimulate dopamine release in the nucleus accumbens.
“For nonsweet palatable foods (typically high-fat foods), there is less convincing evidence for development of dependence ([21](#B21), [31](#B31)), although intermittent access to corn oil can stimulate dopamine release in the nucleus accumbens ([106](#B106)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [31]
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- Authors
- Corwin, R. L.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Corwin, Rebecca L.
- Venue
- Appetite
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 46
- Issue
- 1
- Pages
- 11-15
- ISSN
- 0195-6663 (ISSN-L)
- PMC
- PMC1769467
- OpenAlex
- W2061438151
- Cited by
- 134
- References
- 63
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 46 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 1 · 2013: 7 · 2012: 8
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Appetite (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH067943)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- binge eating, compulsive behavior, drug abuse, alcoholism, gambling addiction, behavioral models, neural mechanisms
- MeSH terms
- Animals, Bulimia, Disease Models, Animal, Feeding Behavior, Humans, Neurobiology, Comorbidity, Substance-Related Disorders, Rats
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