Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter

Bello, Nicholas T.; Sweigart, Kristi L.; Lakoski, Joan M.; Norgren, Ralph; Hajnal, Andras

doi:10.1152/ajpregu.00716.2002

Cited by 112Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityEating Disorders and Behaviors

Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter

Bello, Nicholas T., Sweigart, Kristi L., Lakoski, Joan M., Norgren, Ralph, Hajnal, Andras·2003·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00716.2002

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Abstract

Recent studies suggest that the mesoaccumbens dopamine system undergoes neurochemical alterations as a result of restricted feeding conditions with access to sugars. This effect appears to be similar to the neuroadaptation resulting from drugs of abuse and may underlay some pathological feeding behaviors. To further investigate the cellular mechanisms of these alterations, the present study used quantitative autoradiography and in situ hybridization to assess dopamine membrane transporter (DAT) protein density and mRNA expression in restricted-fed and free-fed adult male rats. The restricted feeding regimen consisted of daily limited access to either a normally preferred sucrose solution (0.3 M) or a less preferred chow in a scheduled (i.e., contingent) fashion for 7 days. Restricted-fed rats with the contingent sucrose access lost less body weight, ate more total food, and drank more fluid than free-fed, contingent food, or noncontingent controls. In addition, these animals had selectively higher DAT binding in the nucleus accumbens and ventral tegmental area. This increase in protein binding also was accompanied by an increase in DAT mRNA levels in the ventral tegmental area. In contrast to the restricted-fed groups, no differential effect in DAT regulation was observed across free-fed groups. The observed alteration in behavior and DAT regulation suggest that neuroadaptation in the mesoaccumbens dopamine system develops in response to repeated feeding on palatable foods under dietary constraints. This supports the notion that similar cellular changes may be involved in restrictive eating disorders and bingeing.

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Repeated sucrose access can upregulate dopamine release and dopamine transporter, and change dopamine D1 and D2 receptor availability in the nucleus accumbens.
“The limited information available suggests that repeated sucrose access can upregulate dopamine release ([5](#B5)) and dopamine transporter ([9](#B9)), and change dopamine D1 and D2 receptor availability ([5](#B5), [8](#B8)) in the nucleus accumbens.”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [9]

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Authors: Bello, N. T., Sweigart, K. L., Lakoski, J. M., Norgren, R., & Hajnal, A.
Affiliations: Departments of Behavioral Science and of
Pennsylvania State University (US)
Pharmacology,
ORCID: Bello, Nicholas T.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2003-05-01
Volume: 284
Issue: 5
Pages: R1260-R1268
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00716.2002
OpenAlex: W2151216707
Cited by: 112
References: 59
Citations by year: 2025: 2 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 4 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 11 · 2014: 10 · 2013: 4 · 2012: 3
FWCI: 2.32
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders: National Institute on Aging (AG 17477, R01AG017477)
National Institute on Deafness and Other Communication Disorders (R03DC004751, DC 04751)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-00240)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: feed restriction, sucrose, dopamine transporter, nucleus accumbens, ventral tegmental area, neural adaptation, palatable food, binge eating, eating disorders
MeSH terms: Animals, Blood Glucose, Corticosterone, Diet, Drinking, Eating, Food Deprivation, Insulin, Male, Membrane Glycoproteins, Nerve Tissue Proteins, RNA, Messenger, Sucrose, Time Factors, Up-Regulation, Rats, Sprague-Dawley, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Rats

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Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter

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