Testing the Protein Leverage Hypothesis in a free-living human population
Abstract
The Protein Leverage Hypothesis (PLH) predicts that humans prioritize protein when regulating food intake. We tested a central prediction of PLH: protein intake will remain more constant than fat or carbohydrate in the face of dietary changes in a free-living population. Data come from a large sample of adult Filipino women participating in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) located in Philippines. Longitudinal data analysis showed that, as predicted, calories of dietary protein remained more constant over time than calories of dietary carbohydrates or fat, even if corrected for the low proportional contribution of protein to dietary energy.
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During amino acid restriction, mammals increase their consumption of diets low in protein to acquire sufficient protein to satisfy organismal requirements, despite increasing their overall caloric intake.
“During amino acid restriction, mammals increase their consumption of diets low in protein to acquire sufficient protein to satisfy organismal requirements, despite increasing their overall caloric intake125–129.”
From Metabolic messengers: FGF21 (2021) · cites this paper as [128]
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Self-citation
- Authors
- Martinez-Cordero, C., Kuzawa, C. W., Sloboda, D. M., Stewart, J., Simpson, S. J., & Raubenheimer, D.
- Affiliations
- Northwestern University (US)
- University of Auckland (NZ)
- The University of Sydney (AU)
- Massey University (NZ)
- Venue
- Appetite
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 59
- Issue
- 2
- Pages
- 312-315
- ISSN
- 0195-6663 (ISSN-L)
- OpenAlex
- W2155286444
- Cited by
- 50
- References
- 28
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 4
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Appetite (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- protein intake, food intake regulation, macronutrient intake, dietary fat, dietary carbohydrates, energy intake, Filipino women, Cebu Longitudinal Health and Nutrition Survey
- MeSH terms
- Adult, Energy Intake, Diet, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Female, Humans, Longitudinal Studies, Middle Aged, Nutrition Surveys, Philippines, Young Adult
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