Geometric analysis of macronutrient selection in the rat
Abstract
A conceptual framework is introduced which has been derived from work on insects. The scheme is intended to integrate studies of diet selection, regulation of amounts eaten, nutrient utilization, body composition and animal performance. Aspects of framework are illustrated with published data on macronutrient selection in the rat. An animal is viewed as moving through a multidimensional nutrient space, which is bounded by axes representing each required nutrient and within which lie optimal points of intake and nutrient allocation ("targets"). The aim is first to estimate the location of these functional optima experimentally, and then to interpret the responses of animals which are constrained from reaching them ("decisions of best compromise"). The framework can then be used to interpret data from animals reared under differing environmental conditions and to compare animals of differing developmental stage, genotype or nutritional state.
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Several studies using the geometric framework suggest that animals eat to a carbohydrate target.
“several studies suggest that animals eat to a carbohydrate target”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [30]
Cites
A multi-level analysis of feeding behaviour: the geometry of nutritional decisions
Simpson, S. J., & Raubenheimer, D. (1993) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1993.0166 · Cited by 452 · see citing works
Self-citationThe geometry of compensatory feeding in the locust
Raubenheimer, D., & Simpson, S. J. (1993) · Animal Behaviour · doi:10.1006/anbe.1993.1114 · Cited by 419 · see citing works
Self-citationAnalysis of covariance: an alternative to nutritional indices
Raubenheimer, D., & Simpson, S. L. (1992) · Entomologia Experimentalis et Applicata · doi:10.1111/j.1570-7458.1992.tb00662.x · Cited by 337 · see citing works
Self-citationA Theory of Feeding and Growth of Animals
Parks, J. R. (1982) · Advanced series in agricultural sciences · doi:10.1007/978-3-642-68330-5 · Cited by 229 · see citing works
The geometric analysis of feeding and nutrition: a user's guide
Simpson, S. J., & Raubenheimer, D. (1995) · Journal of Insect Physiology · doi:10.1016/0022-1910(95)00006-g · Cited by 228 · see citing works
Self-citationFood intake regulation in the weanling rat: self-selection of protein and energy
Musten, B., Peace, D., & Anderson, G. H. (1974) · The Journal of Nutrition · doi:10.1093/jn/104.5.563 · Cited by 189 · see citing works
The central role of the haemolymph in the regulation of nutrient intake in insects
Simpson, S. J., & Raubenheimer, D. (1993) · Physiological Entomology · doi:10.1111/j.1365-3032.1993.tb00613.x · Cited by 170 · see citing works
Self-citationZanotto, F. P., Simpson, S. J., & Raubenheimer, D. (1993) · Physiological Entomology · doi:10.1111/j.1365-3032.1993.tb00617.x · Cited by 158 · see citing works
Self-citationRaubenheimer, D. (1992) · Ecology · doi:10.2307/1940176 · Cited by 140 · see citing works
Self-citationNUTRITIONAL REQUIREMENTS OF PREGNANT AND LACTATING RATS STUDIED BY THE SELFSELECTION METHOD
Richter, C. P., & Barelare, B. (1938) · Endocrinology · doi:10.1210/endo-23-1-15 · Cited by 133 · see citing works
Behavioural mechanisms of nutrient balancing in Locusta migratoria nymphs
Chambers, P. G., Simpson, S. J., & Raubenheimer, D. (1995) · Animal Behaviour · doi:10.1016/0003-3472(95)80007-7 · Cited by 127 · see citing works
Self-citationThe Analysis of Nutrient Budgets
Raubenheimer, D., & Simpson, S. J. (1994) · Functional Ecology · doi:10.2307/2390238 · Cited by 122 · see citing works
Self-citationProblems with Ratio Analysis in Nutritional Studies
Raubenheimer, D. (1995) · Functional Ecology · doi:10.2307/2390086 · Cited by 117 · see citing works
Self-citationFeeding behaviour, sensory physiology and nutrient feedback: a unifying model
Simpson, S. J., & Raubenheimer, D. (1996) · Entomologia Experimentalis et Applicata · doi:10.1111/j.1570-7458.1996.tb00885.x · Cited by 101 · see citing works
Self-citationDiet selection by animals: theory and Experimental Design
Emmans, G. C. (1991) · Proceedings of The Nutrition Society · doi:10.1079/pns19910010 · Cited by 93 · see citing works
The Mechanisms of Nutritional Homeostasis
Simpson, S. J., Raubenheimer, D., & Chambers, P. G. (1995) · Springer eBooks · doi:10.1007/978-1-4615-1775-7_9 · Cited by 92 · see citing works
Self-citationDevelopmental patterns of macronutrient intake in female and male rats from weaning to maturity
LEIBOWITZ, S. F., Lucas, D. J., Leibowitz, K. L., & Jhanwar, Y. S. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90578-c · Cited by 85 · see citing works
Regulation of salt intake by nymphs of Locusta migratoria
Trumper, S., & Simpson, S. J. (1993) · Journal of Insect Physiology · doi:10.1016/0022-1910(93)90118-b · Cited by 74 · see citing works
Self-citationSelf-Selection and Regulation of Protein:Carbohydrate Ratio in Foods Adult Rats Eat
Theall, C. L., Wurtman, J. J., & Wurtman, R. J. (1984) · Journal of Nutrition · doi:10.1093/jn/114.4.711 · Cited by 49 · see citing works
Self-selected intake of carbohydrate, fat, and protein by obese (ob/ob) and lean mice
Romsos, D. R., & Ferguson, D. (1982) · Physiology & Behavior · doi:10.1016/0031-9384(82)90079-8 · Cited by 32 · see citing works
Selective egestion of lysine by locusts fed nutritionally unbalanced foods
Zanotto, F. P., Raubenheimer, D., & Simpson, S. J. (1994) · Journal of Insect Physiology · doi:10.1016/0022-1910(94)90049-3 · Cited by 30 · see citing works
Self-citationRats Treated with Somatotropin Select Diets Higher in Protein
Roberts, T. J., Azain, M. J., White, B. D., & Martin, R. J. (1995) · Journal of Nutrition · doi:10.1093/jn/125.10.2669 · Cited by 29 · see citing works
Raubenheimer, D., & Simpson, S. J. (1995) · Entomologia Experimentalis et Applicata · doi:10.1111/j.1570-7458.1995.tb01990.x · Cited by 29 · see citing works
Self-citationProtein selection by rats adapted to high or moderately low levels of dietary protein
Tews, J. K., Repa, J. J., & Harper, A. E. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90105-b · Cited by 28 · see citing works
Dietary Self-Selection and Meal Patterns of Obese and Lean Zucker Rats
Enns, M. P., & Grinker, J. A. (1983) · Appetite · doi:10.1016/s0195-6663(83)80021-x · Cited by 24 · see citing works
Meeting nutrient requirements: the roles of power and efficiency
Raubenheimer, D., & Simpson, S. J. (1996) · Entomologia Experimentalis et Applicata · doi:10.1111/j.1570-7458.1996.tb00886.x · Cited by 24 · see citing works
Self-citationSelf-selection and the obese Zucker rat: The effect of dietary fat dilution
Castonguay, T. W., Burdick, S. L., Guzman, M. A., COLLIER, G. H., & Stern, J. S. (1984) · Physiology & Behavior · doi:10.1016/0031-9384(84)90022-2 · Cited by 21 · see citing works
Moon, P. H., & Spencer, D. E. (1974) · Journal of Nutrition · doi:10.1093/jn/104.12.1535 · Cited by 9 · see citing works
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Integrative models of nutrient balancing: application to insects and vertebrates
Raubenheimer, D., & Simpson, S. J. (1997) · Nutrition Research Reviews · doi:10.1079/nrr19970009 · Cited by 454 · see citing works
Self-citationFGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism
Hill, C. M., Laeger, T., Dehner, M., Albarado, D. C., Clarke, B., Wanders, D., Burke, S. J., Collier, J. J., Qualls-Creekmore, E., Solon-Biet, S. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.022 · Cited by 229 · see citing works
Self-citationSørensen, A., Mayntz, D., Raubenheimer, D., & Simpson, S. J. (2008) · Obesity · doi:10.1038/oby.2007.58 · Cited by 218 · see citing works
Self-citationThe impact of low-protein high-carbohydrate diets on aging and lifespan
Le Couteur, D. G., Solon-Biet, S., Cogger, V. C., Mitchell, S. J., Senior, A., de Cabo, R., Raubenheimer, D., & Simpson, S. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2120-y · Cited by 209 · see citing works
Self-citationLaeger, T., Albarado, D. C., Burke, S. J., Trosclair, L., Hedgepeth, J. W., Berthoud, H.-R., Gettys, T. W., Collier, J. J., Münzberg, H., & Morrison, C. D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.044 · Cited by 206 · see citing works
Protein-dependent regulation of feeding and metabolism
Morrison, C. D., & Laeger, T. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.02.008 · Cited by 106 · see citing works
Homeostatic regulation of protein intake: in search of a mechanism
Morrison, C. D., Reed, S. D., & Henagan, T. M. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00609.2011 · Cited by 99 · see citing works
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Hill, C. M., Laeger, T., Albarado, D. C., McDougal, D. H., Berthoud, H.-R., Münzberg, H., & Morrison, C. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-07498-w · Cited by 97 · see citing works
Neural and metabolic regulation of macronutrient intake and selection
Berthoud, H.-R., Münzberg, H., Richards, B. K., & Morrison, C. D. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000559 · Cited by 87 · see citing works
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Chaumontet, C., Azzout-Marniche, D., Blais, A., Piedcoq, J., Tomé, D., Gaudichon, C., & Even, P. C. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00316.2018 · Cited by 42 · see citing works
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- Authors
- SIMPSON, S. J., & RAUBENHEIMER, D.
- Affiliations
- University of Oxford (GB)
- Venue
- Appetite
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 28
- Issue
- 3
- Pages
- 201-213
- ISSN
- 0195-6663 (ISSN-L)
- OpenAlex
- W2022982795
- Cited by
- 110
- References
- 28
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 4 · 2012: 8
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Appetite (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- macronutrient selection, diet selection, nutrient partitioning, body composition, animal performance, nutrient utilization, food intake regulation, rats, developmental stages, genotypes, nutritional status
- MeSH terms
- Animals, Body Composition, Dietary Carbohydrates, Dietary Proteins, Feeding Behavior, Food Preferences, Homeostasis, Nutritional Requirements, Nonlinear Dynamics, Rats
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