The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio)
Open accessAbstract
Plastic pollution is a critical environmental concern and comprises the majority of anthropogenic debris in the ocean, including macro, micro, and likely nano-scale (less than 100 nm in at least one dimension) plastic particles. While the toxicity of macroplastics and microplastics is relatively well studied, the toxicity of nanoplastics is largely uncharacterized. Here, fluorescent polystyrene nanoparticles (PS NPs) were used to investigate the potential toxicity of nanoplastics in developing zebrafish (Danio rerio), as well as characterize the uptake and distribution of the particles within embryos and larvae. Zebrafish embryos at 6 h post-fertilization (hpf) were exposed to PS NPs (0.1, 1, or 10 ppm) until 120 hpf. Our results demonstrate that PS NPs accumulated in the yolk sac as early as 24 hpf and migrated to the gastrointestinal tract, gallbladder, liver, pancreas, heart, and brain throughout development (48 hpf-120 hpf). Accumulation of PS NPs decreased during the depuration phase (120 hpf-168 hpf) in all organs, but at a slower rate in the pancreas and gastrointestinal tract. Notably, exposure to PS NPs did not induce significant mortality, deformities, or changes to mitochondrial bioenergetics, but did decrease the heart rate. Lastly, exposure to PS NPs altered larval behavior as evidenced by swimming hypoactivity in exposed larvae. Taken together, these data suggest that at least some nanoplastics can penetrate the chorion of developing zebrafish, accumulate in the tissues, and affect physiology and behavior, potentially affecting organismal fitness in contaminated aquatic ecosystems.
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Cites
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Altered Behavior, Physiology, and Metabolism in Fish Exposed to Polystyrene Nanoparticles
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Cited by
Emergence of Nanoplastic in the Environment and Possible Impact on Human Health
Lehner, R., Weder, C., Petri-Fink, A., & Rothen-Rutishauser, B. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b05512 · Cited by 1,242
Micro- and nanoplastic toxicity on aquatic life: Determining factors
Kögel, T., Bjorøy, Ø., Toto, B., Bienfait, A. M., & Sanden, M. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.136050 · Cited by 518
Pitt, J. A., Trevisan, R., Massarsky, A., Kozal, J. S., Levin, E. D., & Di Giulio, R. T. (2018) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.06.186 · Cited by 413
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Metadata
- Authors
- Pitt, J. A., Kozal, J. S., Jayasundara, N., Massarsky, A., Trevisan, R., Geitner, N., Wiesner, M., Levin, E. D., & Di Giulio, R. T.
- Venue
- Aquatic Toxicology
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 194
- Pages
- 185-194
- ISSN
- 0166-445X (ISSN-L)
- OpenAlex
- W2770615613
- Cited by
- 653
- References
- 8
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Pitt, J. A., Kozal, J. S., Jayasundara, N., Massarsky, A., Trevisan, R., Geitner, N., Wiesner, M., Levin, E. D., & Di Giulio, R. T. (2018). Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio). Aquatic Toxicology. https://doi.org/10.1016/j.aquatox.2017.11.017
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