Optimizing Non-Pharmacologic Management of Hypertriglyceridemia
Open accessAbstract
The cornerstone of initial management for hypertriglyceridemia (HTG) is lifestyle modification. The combination of weight loss through caloric restriction, alteration in macronutrient composition and increased energy expenditure reduces TG levels by approximately 50%. The addition of cinnamon, cacao products and isocaloric substitution of 1 serving of nuts may contribute another 5-15% lowering of TG. This can be particularly beneficial in patients with HTG who are at increased risk of cardiovascular disease.
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Triglycerides may be lowered by at least 50% to 70% in response to weight loss; however, the response may be variable.
“Triglycerides may be lowered by at least 50% to 70% in response to weight loss; however, the response may be variable (54,56).”
From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [54]
The Weight Loss/Dietary Change/Exercise section says weight loss lowers triglycerides, but estimates a 20% decrease after 5–10% body-weight loss. The Conclusions report a 50% reduction with weight loss, dietary changes and exercise together. The paper does not support a 50–70% reduction from weight loss alone, although it notes that the extent of lowering depends on several factors. (LLM, conf=0.86)
Experimental — accuracy not yet measuredOverall, a 5% to 10% reduction in body weight is associated with a 20% decrease in triglycerides.
“For patients with elevated triglycerides, weight loss is considered the most effective lifestyle intervention to lower triglyceride levels; overall, a 5% to 10% reduction in body weight is associated with a 20% decrease in triglycerides (54,55).”
From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [54]
For patients with elevated triglycerides, weight loss is considered the most effective lifestyle intervention to lower triglyceride levels.
“For patients with elevated triglycerides, weight loss is considered the most effective lifestyle intervention to lower triglyceride levels; overall, a 5% to 10% reduction in body weight is associated with a 20% decrease in triglycerides (54,55).”
From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [54]
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“This can serve as a useful education tool for patients with prediabetes or T2DM in whom hypertriglyceridemia (HTG) is common and where an associated 5–10% reduction in body weight may also help to normalize blood glucose levels in a subgroup of patients (8).”
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- Authors
- Byrne, A., Makadia, S., Sutherland, A., & Miller, M.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Miller, Michael
- Venue
- Archives of Medical Research
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 48
- Issue
- 6
- Pages
- 483-487
- ISSN
- 0066-6769 (ISSN-L)
- 0188-4409
- PMC
- PMC6089214
- OpenAlex
- W2773451767
- Cited by
- 27
- References
- 48
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 3
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Medical Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (T35DK095737)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- hypertriglyceridemia, non-pharmacological treatment, lifestyle modification, weight loss, caloric restriction, macronutrient composition, energy expenditure, cinnamon, cacao products, nuts, triglyceride lowering, cardiovascular risk
- MeSH terms
- Cardiovascular Diseases, Diet, Diet Therapy, Humans, Life Style, Triglycerides, Hypertriglyceridemia, Weight Loss, Exercise, Risk Reduction Behavior
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