Metallothionein and the biology of aging

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

A C. elegans mutant that lives twice as long as wild type

Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works

Evidence for Cardiomyocyte Renewal in Humans

Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130 · see citing works

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280 · see citing works

Extension of murine life span by overexpression of catalase targeted to mitochondria

Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724 · see citing works

Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias

Dwan, K., Altman, D. G., Arnaiz, J. A., Bloom, J., Chan, A.-W., Cronin, E., Decullier, E., Easterbrook, P. J., Von Elm, E., Gamble, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003081 · Cited by 1,546 · see citing works

Using FlyAtlas to identify better Drosophila melanogaster models of human disease

Chintapalli, V. R., Wang, J., & Dow, J. A. T. (2007) · Nature Genetics · doi:10.1038/ng2049 · Cited by 1,479 · see citing works

A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

Margoshes, M., & Vallée, B. L. (1957) · Journal of the American Chemical Society · doi:10.1021/ja01574a064 · Cited by 1,313 · see citing works

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works

Dwarf mice and the ageing process

Brown‐Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996) · Nature · doi:10.1038/384033a0 · Cited by 1,091 · see citing works

Overview of caloric restriction and ageing

Masoro, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.012 · Cited by 1,054 · see citing works

Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

Thornalley, P. J., & Vašák, M. (1985) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(85)90098-6 · Cited by 1,041 · see citing works

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

Friedman, D. B., & Johnson, T. E. (1988) · Genetics · doi:10.1093/genetics/118.1.75 · Cited by 1,011 · see citing works

Oxygen free radicals and metallothionein

Sato, M., & Bremner, I. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90029-t · Cited by 855 · see citing works

Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of Carcinogenesis

Dai, C., Whitesell, L. J., Rogers, A. B., & Lindquist, S. L. (2007) · Cell · doi:10.1016/j.cell.2007.07.020 · Cited by 827 · see citing works

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826 · see citing works

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734 · see citing works

Metallothionein protection of cadmium toxicity

Klaassen, C. D., Liu, J., & Diwan, B. A. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.03.026 · Cited by 731 · see citing works

The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegans

Honda, Y., & Honda, S. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.11.1385 · Cited by 730 · see citing works

Is the oxidative stress theory of aging dead?

Pérez, V. I., Bokov, A., Remmen, H. V., Mele, J., Ran, Q., Ikeno, Y., & Richardson, A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.003 · Cited by 604 · see citing works

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

Zid, B. M., Rogers, A. N., Katewa, S. D., Vargas, M. A., Kolipinski, M., Lu, T. A., Benzer, S., & Kapahi, P. (2009) · Cell · doi:10.1016/j.cell.2009.07.034 · Cited by 541 · see citing works

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

Frankel, N., Davis, G. K., Vargas, D., Wang, S., Payre, F., & Stern, D. L. (2010) · Nature · doi:10.1038/nature09158 · Cited by 510 · see citing works

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00533.x · Cited by 501 · see citing works

Stress-Response Hormesis and Aging: “That which Does Not Kill Us Makes Us Stronger”

Gems, D., & Partridge, L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.01.001 · Cited by 496 · see citing works

The transcription factor MTF‐1 is essential for basal and heavy metal‐induced metallothionein gene expression.

Heuchel, R. L., Radtke, F., Georgiev, O., Stark, G., Aguet, M., & Schaffner, W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06581.x · Cited by 492 · see citing works

Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?

Salmon, A. B., Richardson, A. G., & Pérez, V. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.015 · Cited by 444 · see citing works

Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.

Dunn, S. E., Kari, F. W., French, J. E., Leininger, J. R., Travlos, G. S., Wilson, R., & Barrett, J. C. (1997) · PubMed · Cited by 439 · see citing works

Expression analysis of G Protein-Coupled Receptors in mouse macrophages

Lattin, J. E., Schroder, K., Su, A. I., Walker, J. R., Zhang, J., Wiltshire, T., Saijo, K., Glass, C. K., Hume, D. A., Kellie, S., et al. (2008) · Immunome Research · doi:10.1186/1745-7580-4-5 · Cited by 439 · see citing works

Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse.

Michalska, A., & Choo, K. H. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8088 · Cited by 377 · see citing works

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2008.00449.x · Cited by 353 · see citing works

Antioxidant role of metallothioneins: a comparative overview.

Viarengo, A., Burlando, B., Ceratto, N., & Panfoli, I. (2000) · PubMed · Cited by 341 · see citing works

Cellular zinc sensors: MTF-1 regulation of gene expression

Andrews, G. K. (2001) · BioMetals · doi:10.1023/a:1012932712483 · Cited by 325 · see citing works

Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction

Bonkowski, M. S., Rocha, J. S., Masternak, M. M., Al-Regaiey, K., & Bartke, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600161103 · Cited by 311 · see citing works

Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin‐like signals

Walker, G. A., & Lithgow, G. J. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00045.x · Cited by 303 · see citing works

Enhanced Sensitivity to Oxidative Stress in Cultured Embryonic Cells from Transgenic Mice Deficient in Metallothionein I and II Genes

Lazo, J. S., Kondo, Y., Dellapiazza, D., Michalska, A., Choo, K. H. A., & Pitt, B. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5506 · Cited by 301 · see citing works

Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models

Berryman, D. E., Christiansen, J. S., Johannsson, G., Thorner, M. O., & Kopchick, J. J. (2008) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2008.05.005 · Cited by 288 · see citing works

Longevity and heavy metal resistance in daf‐2 and age‐1 long‐lived mutants of Caenorhabditis elegans

Barsyte, D., Lovejoy, D. A., & Lithgow, G. J. (2001) · The FASEB Journal · doi:10.1096/fj.99-0966com · Cited by 270 · see citing works

Temporal linkage between the phenotypic and genomic responses to caloric restriction

Dhahbi, J. M., Kim, H.-J., Mote, P. L., Beaver, R. J., & Spindler, S. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305300101 · Cited by 259 · see citing works

Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity.

Kang, Y. J., Chen, Y.-C., Yu, A., Voss-McCowan, M. E., & Epstein, P. N. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119672 · Cited by 253 · see citing works

Zinc metallothionein imported into liver mitochondria modulates respiration

Ye, B., Maret, W., & Vallée, B. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041619198 · Cited by 253 · see citing works

Longer Life Spans and Delayed Maturation in Wild-Derived Mice

Miller, R. A., Harper, J. M., Dysko, R. C., Durkee, S. J., & Austad, S. N. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700715 · Cited by 248 · see citing works

Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress

Salmon, A. B., Murakami, S., Bartke, A., Kopchick, J. J., Yasumura, K., & Miller, R. A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00575.2004 · Cited by 244 · see citing works

Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin

Kampkötter, A., Timpel, C., Zurawski, R. F., Ruhl, S., Chovolou, Y., Proksch, P., & Wätjen, W. (2007) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2007.10.004 · Cited by 239 · see citing works

Genotype and age influence the effect of caloric intake on mortality in mice

Forster, M. J., Morris, P., & Sohal, R. S. (2003) · The FASEB Journal · doi:10.1096/fj.02-0533fje · Cited by 236 · see citing works

Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia

Yousuf, S., Atif, F., Ahmad, M., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.068 · Cited by 226 · see citing works

Curcumin Extends Life Span, Improves Health Span, and Modulates the Expression of Age-Associated Aging Genes in Drosophila melanogaster

Lee, K., Lee, B.-S., Semnani, S., Avanesian, A., Um, C.-Y., Jeon, H., Seong, K.-M., Yu, K., Min, K., & Jafari, M. (2010) · Rejuvenation Research · doi:10.1089/rej.2010.1031 · Cited by 214 · see citing works

Does caloric restriction extend life in wild mice?

Harper, J. M., Leathers, C. W., & Austad, S. N. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00236.x · Cited by 212 · see citing works

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

Zhang, Y., Ikeno, Y., Qi, W., Chaudhuri, A., Li, Y., Bokov, A., Thorpe, S. R., Baynes, J., Epstein, C. J., Richardson, A. G., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp132 · Cited by 206 · see citing works

Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

Jang, Y. C., Pérez, V., Song, W. J., Lustgarten, M. S., Salmon, A. B., Mele, J., Qi, W., Liu, Y., Liang, H., Chaudhuri, A. R., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp100 · Cited by 201 · see citing works

Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis

Ran, Q., Liang, H., Ikeno, Y., Qi, W., Prolla, T. A., Roberts, L. J., Wolf, N., VanRemmen, H., & Richardson, A. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.9.932 · Cited by 195 · see citing works

The Evolution of the Antiaging Action of Dietary Restriction: A Hypothesis

Masoro, E. J., & Austad, S. N. (1996) · The Journals of Gerontology Series A · doi:10.1093/gerona/51a.6.b387 · Cited by 192 · see citing works

Endocrine signaling in Caenorhabditis elegans controls stress response and longevity

Baumeister, R., Schaffitzel, E., & Hertweck, M. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06856 · Cited by 192 · see citing works

Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse

Swindell, W. R. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-585 · Cited by 171 · see citing works

Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size

Takahashi, M. M., Kamei, Y., & Ezaki, O. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00244.2004 · Cited by 170 · see citing works

Obesity and hyperleptinemia in metallothionein (-I and -II) null mice

Beattie, J. H., Wood, A. M., Newman, A. M., Bremner, I., Choo, K. H. A., Michalska, A., Duncan, J. S., & Trayhurn, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.358 · Cited by 167 · see citing works

Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity.

Schwarz, M. A., Lazo, J. S., Yalowich, J. C., Reynolds, I. J., Kagan, V. E., Tyurin, V. A., Kim, Y. M., Watkins, S. C., & Pitt, B. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36597-3 · Cited by 164 · see citing works

Design of aging intervention studies: the NIA interventions testing program

Nadon, N. L., Strong, R., Miller, R. A., Nelson, J. F., Javors, M. A., Sharp, Z. D., Peralba, J. M., & Harrison, D. E. (2008) · AGE · doi:10.1007/s11357-008-9048-1 · Cited by 156 · see citing works

Accelerated failure time models provide a useful statistical framework for aging research

Swindell, W. R. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.10.005 · Cited by 153 · see citing works

Metallothionein prolongs survival and antagonizes senescence‐associated cardiomyocyte diastolic dysfunction: role of oxidative stress

Yang, X., Doser, T. A., Fang, C. X., Nunn, J. M., Janardhanan, R., Zhu, M. J., Sreejayan, N., Quirin, M. T., Ren, J. T., Yang, X., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5288fje · Cited by 151 · see citing works

Metallothioneins and Cancer

Eckschlager, T., Adam, V., Hraběta, J., Figova, K., & Kizek, R. (2009) · Current Protein and Peptide Science · doi:10.2174/138920309788922243 · Cited by 144 · see citing works

Nrf2 Signaling, a Mechanism for Cellular Stress Resistance in Long-Lived Mice

Leiser, S. F., & Miller, R. A. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01145-09 · Cited by 137 · see citing works

Metallothionein Prevents High-Fat Diet–Induced Cardiac Contractile Dysfunction

Dong, F., Li, Q., Sreejayan, N., Nunn, J. M., & Ren, J. T. (2007) · Diabetes · doi:10.2337/db06-1596 · Cited by 136 · see citing works

Metallothionein as an Anti-Inflammatory Mediator

Inoue, K., Takano, H., Shimada, A., & Satoh, M. (2009) · Mediators of Inflammation · doi:10.1155/2009/101659 · Cited by 132 · see citing works

Effect of Coenzyme Q10 Intake on Endogenous Coenzyme Q Content, Mitochondrial Electron Transport Chain, Antioxidative Defenses, and Life Span of Mice

Sohal, R. S., Kamzalov, S., Sumien, N., Ferguson, M., Rebrin, I., Heinrich, K. R., & Forster, M. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.037 · Cited by 131 · see citing works

Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice

Mocchegiani, E., Santarelli, L., Muzzioli, M., & Fabris, N. (1995) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(95)00059-b · Cited by 127 · see citing works

Delayed development and lifespan extension as features of metabolic lifestyle alteration inC. elegansunder dietary restriction

Szewczyk, N. J., Udranszky, I. A., Kozak, E. M., Sunga, J., Kim, S. K., Jacobson, L. A., & Conley, C. A. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02492 · Cited by 127 · see citing works

Metallothionein and Liver Cell Regeneration

Cherian, M. G., & Kang, Y. J. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100203 · Cited by 125 · see citing works

Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats

Iszard, M. (1995) · Toxicology · doi:10.1016/0300-483x(95)03118-y · Cited by 124 · see citing works

Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination

Papaconstantinou, J. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.11.025 · Cited by 124 · see citing works

The scientific basis of caloric restriction leading to longer life

Fontana, L. (2009) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32831ef1ba · Cited by 124 · see citing works

Chronic food restriction in young rats results in depression- and anxiety-like behaviors with decreased expression of serotonin reuptake transporter

Jahng, J. W., Kim, J. G., Kim, H. J., Kim, B.-T., Kang, D. W., & Lee, J.-H. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.080 · Cited by 121 · see citing works

Metallothionein (MT)-Null Mice Are Sensitive to Cisplatin-Induced Hepatotoxicity

Liu, J., Liu, Y., Habeebu, S. S., et al. (1998) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1997.8325 · Cited by 120 · see citing works

Mitochondrial ROS production correlates with, but does not directly regulate lifespan in drosophila

Sanz, A., Fernández‐Ayala, D. J. M., Stefanatos, R. K. A., & Jacobs, H. T. (2010) · Aging · doi:10.18632/aging.100137 · Cited by 119 · see citing works

Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury

Agarwal, R., Goel, S. K., & Behari, J. R. (2010) · Journal of Applied Toxicology · doi:10.1002/jat.1517 · Cited by 118 · see citing works

Platelet Monoamine Oxidase, Personality and Alcoholism: The Rise, Fall and Resurrection

Oreland, L. (2003) · NeuroToxicology · doi:10.1016/s0161-813x(03)00115-3 · Cited by 113 · see citing works

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

Minor, R. K., Allard, J. S., Younts, C. M., Ward, T. M., & de Cabo, R. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq042 · Cited by 112 · see citing works

Radioresistance in cells with high content of metallothionein

Bakka, A. O., Johnsen, A. S., Endresen, L., et al. (1982) · Cellular and Molecular Life Sciences · doi:10.1007/bf01949406 · Cited by 111 · see citing works

"That which does not kill us makes us stronger"

LaCroix, A. Z. (2009) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181b4bfaa · Cited by 110 · see citing works

Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease

Ebadi, M., Brown‐Borg, H. M., Refaey, H. E., Singh, B. B., Garrett, S. H., Shaik, S., & Sharma, S. K. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.09.011 · Cited by 108 · see citing works

Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells

Reinecke, F., Levanets, O., Olivier, Y., et al. (2006) · Biochemical Journal · doi:10.1042/bj20051253 · Cited by 102 · see citing works

Lifespan extension in genetically modified mice

Ladiges, W., Van Remmen, H., Strong, R., Ikeno, Y., Treuting, P., Rabinovitch, P., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00491.x · Cited by 101 · see citing works

Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells.

van Erk, M. J., Teuling, E., Staal, Y. C. M., Huybers, S., van BLADEREN, P. J., Aarts, J. M. M. J. G., & van Ommen, B. (2004) · Journal of Carcinogenesis · doi:10.1186/1477-3163-3-8 · Cited by 99 · see citing works

Metal‐responsive transcription factor‐1 (MTF‐1) is essential for embryonic liver development and heavy metal detoxification in the adult liver

Wang, Y., Wimmer, U., Lichtlen, P., Inderbitzin, D., Stieger, B., Meier, P. J., Hunziker, L., Stallmach, T., Forrer, R. S., Rülicke, T., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-1282com · Cited by 98 · see citing works

Regulation of Metallothionein Gene Transcription

Moilanen, L. H., Fukushige, T., & Freedman, J. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29655 · Cited by 97 · see citing works

Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.

Kaina, B., Lohrer, H. D., Karin, M., & Herrlich, P. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2710 · Cited by 95 · see citing works

Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet

Sun, X., Seeberger, J., Alberico, T., Wang, C., Wheeler, C. T., Schauss, A. G., & Zou, S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.008 · Cited by 90 · see citing works

Development of high‐fat‐diet‐induced obesity in female metallothionein‐null mice

Sato, M., Kawakami, T., Kondoh, M., Takiguchi, M., Kadota, Y., Himeno, S., & Suzuki, S. S. (2010) · The FASEB Journal · doi:10.1096/fj.09-145466 · Cited by 89 · see citing works

Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression

Lee, D., Carrasco, J., Hidalgo, J., & Andrews, G. K. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3370059 · Cited by 87 · see citing works

Long-Lived Ames Dwarf Mice Are Resistant to Chemical Stressors

Bokov, A. F., Lindsey, M. L., Khodr, C. E., Sabia, M. R., & Richardson, A. G. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp052 · Cited by 87 · see citing works

Program for testing biological interventions to promote healthy aging

Warner, H. R., Ingram, D. K., Miller, R. A., Nadon, N. L., & Richardson, A. G. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00118-4 · Cited by 81 · see citing works

Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging

Swindell, W. R. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-353 · Cited by 80 · see citing works

Metallothionein Induction in Response to Restraint Stress

Ghoshal, K., Wang, Y., Sheridan, J. F., & Jacob, S. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.27904 · Cited by 78 · see citing works

Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population

Cipriano, C., Malavolta, M., Costarelli, L., Giacconi, R., Muti, E., Gasparini, N., Cardelli, M., Monti, D., Mariani, E., & Mocchegiani, E. (2006) · Biogerontology · doi:10.1007/s10522-006-9050-x · Cited by 78 · see citing works

The possible biological role of metallothionein in apoptosis

Dutsch‐Wicherek, M. (2008) · Frontiers in bioscience · doi:10.2741/2991 · Cited by 76 · see citing works

The ATP–metallothionein complex

Jiang, L., Maret, W., & Vallée, B. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9146 · Cited by 74 · see citing works

Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues

Swindell, W. R. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.11.003 · Cited by 70 · see citing works

Induction of metallothionein by stress and its molecular mechanisms.

Jacob, S. T., Ghoshal, K., & Sheridan, J. F. (1999) · Europe PMC (PubMed Central) · Cited by 70 · see citing works

Metallothionein mRNA Expression and Cadmium Tolerance in Metal-stressed and Reference Populations of the Springtail Orchesella cincta

Timmermans, M. J. T. N., Ellers, J., Roelofs, D., et al. (2005) · Ecotoxicology · doi:10.1007/s10646-005-0020-x · Cited by 68 · see citing works

Insulin signaling and life span

Avogaro, A., de Kreutzenberg, S., & Fadini, G. (2009) · Pflügers Archiv: European Journal of Physiology · doi:10.1007/s00424-009-0721-8 · Cited by 67 · see citing works

Overexpression of metallothionein in CHO cells and its effect on cell killing by ionizing radiation and alkylating agents

Lohrer, H. D., & Robson, T. (1989) · Carcinogenesis · doi:10.1093/carcin/10.12.2279 · Cited by 66 · see citing works

Lifelong Calorie Restriction Alleviates Age-Related Oxidative Damage in Peripheral Nerves

Opalach, K., Rangaraju, S., Madorsky, I., Leeuwenburgh, C., & Notterpek, L. M. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.0892 · Cited by 66 · see citing works

Metallothionein induction attenuates the effects of glutathione depletors in rat hepatocytes

Haïdara, K. (1999) · Toxicological Sciences · doi:10.1093/toxsci/49.2.297 · Cited by 65 · see citing works

The Longevity Effect of Tannic Acid in Caenorhabditis elegans: Disposable Soma Meets Hormesis

Saul, N., Pietsch, K., Menzel, R., Stürzenbaum, S. R., & Steinberg, C. E. W. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq051 · Cited by 65 · see citing works

Metallothioneins I and II: Neuroprotective significance during CNS pathology

Stankovic, R. K., Chung, R. S., & Penkowa, M. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.09.010 · Cited by 63 · see citing works

Hormetic Modulation of Aging and Longevity by Mild Heat Stress

Rattan, S. I. S. (2005) · Dose-Response · doi:10.2203/dose-response.003.04.008 · Cited by 62 · see citing works

Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on the survival

Mocchegiani, E., Santarelli, L., Tibaldi, A., et al. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00253-1 · Cited by 60 · see citing works

Metallothionein can function as a chaperone for zinc uptake transport into prostate and liver mitochondria

Costello, L. C., Guan, Z., FRANKLIN, R. B., & Feng, P. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.02.005 · Cited by 60 · see citing works

Identification and expression analysis of leptin-regulated immediate early response and late target genes

Waelput, W., Verhee, A., Broekaert, D., Eyckerman, S., Vandekerckhove, J. S., Beattie, J. H., & Tavernier, J. H. (2000) · Biochemical Journal · doi:10.1042/bj3480055 · Cited by 58 · see citing works

Polyphenol‐Rich Beverages Enhance Zinc Uptake and Metallothionein Expression in Caco‐2 Cells

Kilari, S., Pullakhandam, R., & Nair, K. M. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01582.x · Cited by 57 · see citing works

Effects of atherogenic diet on hepatic gene expression across mouse strains

Shockley, K. R., Witmer, D. R., Burgess-Herbert, S. L., Paigen, B. J., & Churchill, G. A. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.90350.2008 · Cited by 56 · see citing works

Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice

Swindell, W. R., Masternak, M. M., Kopchick, J. J., Conover, C. A., Bartke, A., & Miller, R. A. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.03.004 · Cited by 55 · see citing works

Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease

Hands, S. L., Mason, R. P., Sajjad, M. U., Giorgini, F., & Wyttenbach, A. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380552 · Cited by 55 · see citing works

Longevity in mice: is stress resistance a common factor?

Brown‐Borg, H. M. (2006) · AGE · doi:10.1007/s11357-006-9003-y · Cited by 54 · see citing works

The Balance between Life and Death of Cells: Roles of Metallothioneins.

Nielsen, A. E., Bohr, A., & Penkowa, M. (2007) · PubMed · Cited by 53 · see citing works

Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways

Leung, Y. K., Pankhurst, M. W., Dunlop, S. A., et al. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.10.006 · Cited by 52 · see citing works

Protective role of metallothionein in renal toxicity of cisplatinum

Satoh, M., Aoki, Y., & Tohyama, C. (1997) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800050670 · Cited by 50 · see citing works

Involvement of Oxidative Stress in the Synthesis of Metallothionein Induced by Mitochondrial Inhibitors

Futakawa, N., Kondoh, M., Ueda, S., Higashimoto, M., Takiguchi, M., Suzuki, S., & Sato, M. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.2016 · Cited by 48 · see citing works

Effects of exogenous metallothionein against thallium-induced oxidative stress in rat liver

Kılıç, G., & Kutlu, H. M. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.01.013 · Cited by 48 · see citing works

Zinc supplement greatly improves the condition of parkin mutant Drosophila

Saini, N., & Schaffner, W. (2010) · Biological Chemistry · doi:10.1515/bc.2010.052 · Cited by 48 · see citing works

The Balance between Life and Death of Cells: Roles of Metallothioneins

Nielsen, A. E., Bohr, A., & Penkowa, M. (2006) · Biomarker Insights · doi:10.1177/117727190600100016 · Cited by 48 · see citing works

Novel roles for metallothionein‐I + II (MT‐I + II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: Insights from global gene expression profiling in wild‐type and MT‐I + II knockout mice

Penkowa, M., Cáceres, M., Borup, R., Nielsen, F. C., Poulsen, C. B., Quintana, A., Molinero, A., Carrasco, J., Florit, S., Giralt, M., et al. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21043 · Cited by 47 · see citing works

Effect of preinduction of metallothionein on paraquat toxicity in mice

Satoh, M., Naganuma, A., & Imura, N. (1992) · Archives of Toxicology · doi:10.1007/bf02342510 · Cited by 46 · see citing works

Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity

Bahadorani, S., Mukai, S. T., Egli, D. M., & Hilliker, A. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.001 · Cited by 46 · see citing works

Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice

Satoh, M., Shimada, A., Zhang, B., et al. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00478-0 · Cited by 45 · see citing works

The ATP/Metallothionein Interaction: NMR and STM

Maret, W., Heffron, G. J., Hill, H. A. O., et al. (2002) · Biochemistry · doi:10.1021/bi0116083 · Cited by 45 · see citing works

Copper–metallothionein in the Kidney of Macular Mice: A Model for Menkes Disease

Suzuki–Kurasaki, M., Okabe, M., & Kurasaki, M. (1997) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549704501106 · Cited by 44 · see citing works

Using MT−/− mice to study metallothionein and oxidative stress

Conrad, C. C., Grabowski, D. T., Walter, C. A., Sabia, M., & Richardson, A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00263-4 · Cited by 44 · see citing works

Genetic Modulation of Hormone Levels and Life Span in Hybrids Between Laboratory and Wild-Derived Mice

Harper, J. M., Durkee, S. J., Dysko, R. C., Austad, S. N., & Miller, R. A. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.10.1019 · Cited by 44 · see citing works

Astrocyte cultures from transgenic mice to study the role of metallothionein in cytotoxicity of tert-butyl hydroperoxide

Suzuki, Y., Apostolova, M. D., & Cherian, M. G. (2000) · Toxicology · doi:10.1016/s0300-483x(99)00220-6 · Cited by 38 · see citing works

Zinc, Immune Plasticity, Aging, and Successful Aging: Role of Metallothionein

Mocchegiani, E., Giacconi, R., Muti, E., ROGO, C., Bracci, M., Muzzioli, M., Cipriano, C., & Malavolta, M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.023 · Cited by 38 · see citing works

Involvement of Oxidative Stress in Paraquat-Induced Metallothionein Synthesis Under Glutathione Depletion

Nakagawa, I., Suzuki, M., Imura, N., et al. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00008-2 · Cited by 35 · see citing works

Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2

Wakida, K., Morimoto, N., Shimazawa, M., et al. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.125 · Cited by 33 · see citing works

Study of Trace Elements in Blood of Thyroid Disorder Subjects Before and After 131I Therapy

Zhang, F., Liu, N., Wang, X., et al. (2004) · Biological Trace Element Research · doi:10.1385/bter:97:2:125 · Cited by 32 · see citing works

Exogenous metallothionein‐IIA promotes accelerated healing after a burn wound

Morellini, N. M., Giles, N. L., Rea, S. M., et al. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00418.x · Cited by 31 · see citing works

In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene

Swindell, W. R., Masternak, M. M., & Bartke, A. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.02.009 · Cited by 30 · see citing works

Calcium, magnesium, and zinc status in experimental hyperthyroidism

Şimşek, G., Andican, G., Ünal, E., et al. (1997) · Biological Trace Element Research · doi:10.1007/bf02778196 · Cited by 29 · see citing works

Changes in hepatic gene expression in response to hepatoprotective levels of zinc

Liu, J., Zhou, Z., Zhang, W., Bell, M. W., & Waalkes, M. P. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02007.x · Cited by 29 · see citing works

Heat shock proteins in long-lived worms and mice with insulin/insulin-Like signaling mutations

Swindell, W. R. (2009) · Aging · doi:10.18632/aging.100058 · Cited by 29 · see citing works

Insulin/IGF-1 modulation of the expression of two estrogen-induced genes in MCF-7 cells

El‐Tanani, M., & Green, C. D. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(96)03844-0 · Cited by 28 · see citing works

Genes regulated by caloric restriction have unique roles within transcriptional networks

Swindell, W. R. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.06.001 · Cited by 26 · see citing works

Allelic diversity of metallothionein in Orchesella cincta (L.): traces of natural selection by environmental pollution

Timmermans, M. J. T. N., Ellers, J., & van Straalen, N. M. (2007) · Heredity · doi:10.1038/sj.hdy.6800942 · Cited by 26 · see citing works

Overexpression of Metallothionein Protects Cultured Motor Neurons Against Oxidative Stress, but not Mutant Cu/Zn-Superoxide Dismutase Toxicity

Taylor, D. M., Minotti, S., Agar, J. N., et al. (2004) · NeuroToxicology · doi:10.1016/j.neuro.2004.02.002 · Cited by 24 · see citing works

Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans

Mocchegiani, E., Giacconi, R., Muti, E., Cipriano, C., Costarelli, L., Tesei, S., Gasparini, N., & Malavolta, M. (2007) · Immunity & Ageing · doi:10.1186/1742-4933-4-7 · Cited by 24 · see citing works

Gene expression profiles in the liver and kidney of metallothionein-null mice

Miura, N., & Koizumi, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.043 · Cited by 22 · see citing works

Transgenic mice overexpressing metallothionein are not resistant to adriamycin cardiotoxicity.

Ra, D., Liu, J., & Cd, K. (1996) · PubMed · Cited by 22 · see citing works

Prior Increase in Metallothionein Levels is Required to Prevent Doxorubicin Cardiotoxicity 1

Sun, X., & Kang, Y. J. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700815 · Cited by 21 · see citing works

Publishing Negative Results: The Problem of Publication Bias

Rockwell, S., Kimler, B. F., & Moulder, J. E. (2006) · Radiation Research · doi:10.1667/rr3573.1 · Cited by 18 · see citing works

Over-Expression of Heat Shock Protein 70 in Mice Is Associated with Growth Retardation, Tumor Formation, and Early Death

Vanhooren, V., Liu, X., Desmyter, L., Fan, Y.-D., Vanwalleghem, L., Molle, W. V., Dewaele, S., Praet, M. M., Contreras, R., Libert, C., et al. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0783 · Cited by 18 · see citing works

Induction of metallothionein synthesis by glutathione depletion after trans- and cis-stilbene oxide administration in rats

Sato, M., Sasaki, M., Oguro, T., et al. (1995) · Chemico-Biological Interactions · doi:10.1016/0009-2797(95)03629-z · Cited by 17 · see citing works

Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide glutathione peroxidase-overexpressed cells

Kadota, Y., Suzuki, S., Ideta, S., Fukinbara, Y., Kawakami, T., Imai, H., Nakagawa, Y., & Sato, M. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.09.060 · Cited by 16 · see citing works

Effect of Glutathione Depletion on Metallothionein Synthesis Induced by Paraquat in Mice.

Nakagawa, I., Suzuki, M., Yanagiya, T., et al. (1995) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.177.249 · Cited by 15 · see citing works

Positive Reasons for Publishing Negative Findings

Connor, J. T. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.02028.x · Cited by 14 · see citing works

Re-evaluation of the Binding of ATP to Metallothionein

Zangger, K., Öz, G., & Armitage, I. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7534 · Cited by 13 · see citing works

The changes of hepatic metallothionein synthesis and the hepatic damage induced by starvation in mice

Sogawa, N., Sogawa, C. A., Fukuoka, H., et al. (2003) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2003.25.8.778079 · Cited by 13 · see citing works

A potential role for prolactin in zinc homeostasis

KOPPELMAN, M. C. S. (1988) · Medical Hypotheses · doi:10.1016/0306-9877(88)90020-5 · Cited by 12 · see citing works

Basal expression of metallothionein suppresses butenolide-induced oxidative stress in liver homogenates in vitro

Yang, H., Wang, Y., & Peng, S. (2008) · Toxicon · doi:10.1016/j.toxicon.2008.11.008 · Cited by 10 · see citing works

Enhancement of MT synthesis by leptin in fasted mice

Kondoh, M., Tsukahara, R., Kuronaga, M., et al. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02022-2 · Cited by 9 · see citing works

Protection from aging by small chaperones

Morrow, G., Kim, H., Pécheur, M. L., Kaul, S. C., Wadhwa, R., & Tanguay, R. M. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05413.x · Cited by 7 · see citing works

Effect of Acute and Chronic Oral Zinc Administration inHyperprolactinemic Patients

Madureira, G., BLOISE, W., Mendonca, B. B., et al. (1999) · Metal-Based Drugs · doi:10.1155/mbd.1999.159 · Cited by 3 · see citing works

Aging induces aberrant state transition kinetics in murine muscle stem cells

Kimmel, J. C., Hwang, A. B., Scaramozza, A., Marshall, W. F., & Brack, A. S. (2020) · Development · doi:10.1242/dev.183855 · Cited by 95 · see citing works

Analysis of hepatic copper, zinc, metallothionein and metallothionein‐Ia mRNA in developing sheep

Paynter, J. A., Camakaris, J., & Mercer, J. F. B. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15558.x · Cited by 28 · see citing works

Induction of hepatic metallothionein by feeding zinc to rats of depleted zinc status

McCormick, C. C., Menard, M. P., & Cousins, R. J. (1981) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1981.240.4.e414 · Cited by 56 · see citing works

The Induced Synthesis of Metallothionein in Various Tissues of Rat after Injection of Various Metals

Onosaka, S., YOSHIYA, S., Min, K.-S., et al. (1983) · Eisei kagaku · doi:10.1248/jhs1956.29.4_221 · Cited by 11 · see citing works

Metabolism of parenterally administered zinc and cadmium in livers of newborn rats

Panemangalore, M., & Cherian, M. G. (1983) · Chemico-Biological Interactions · doi:10.1016/0009-2797(83)90079-0 · Cited by 20 · see citing works

Kinetics of cadmium-induced hepatic and renal metallothionein synthesis in the mouse

Probst, G. S., Bousquet, W. F., & Miya, T. S. (1977) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(77)90176-4 · Cited by 65 · see citing works