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Omega-3 fatty acids and brain resistance to ageing and stress: Body of evidence and possible mechanisms
Abstract
The increasing life expectancy in the populations of rich countries raises the pressing question of how the elderly can maintain their cognitive function. Cognitive decline is characterised by the loss of short-term memory due to a progressive impairment of the underlying brain cell processes. Age-related brain damage has many causes, some of which may be influenced by diet. An optimal diet may therefore be a practical way of delaying the onset of age-related cognitive decline. Nutritional investigations indicate that the ω-3 poyunsaturated fatty acid (PUFA) content of western diets is too low to provide the brain with an optimal supply of docosahexaenoic acid (DHA), the main ω-3 PUFA in cell membranes. Insufficient brain DHA has been associated with memory impairment, emotional disturbances and altered brain processes in rodents. Human studies suggest that an adequate dietary intake of ω-3 PUFA can slow the age-related cognitive decline and may also protect against the risk of senile dementia. However, despite the many studies in this domain, the beneficial impact of ω-3 PUFA on brain function has only recently been linked to specific mechanisms. This review examines the hypothesis that an optimal brain DHA status, conferred by an adequate ω-3 PUFA intake, limits age-related brain damage by optimizing endogenous brain repair mechanisms. Our analysis of the abundant literature indicates that an adequate amount of DHA in the brain may limit the impact of stress, an important age-aggravating factor, and influences the neuronal and astroglial functions that govern and protect synaptic transmission. This transmission, particularly glutamatergic neurotransmission in the hippocampus, underlies memory formation. The brain DHA status also influences neurogenesis, nested in the hippocampus, which helps maintain cognitive function throughout life. Although there are still gaps in our knowledge of the way ω-3 PUFA act, the mechanistic studies reviewed here indicate that ω-3 PUFA may be a promising tool for preventing age-related brain deterioration.
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“The benefits of ω-3 (n-3) fatty acids for central functioning range from enhanced memory, mood, attention, and cognitive performance to a reduced risk of developing depression and regulation of stress sensitivity (131-138).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [136]
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Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
The importance of the ratio of omega-6/omega-3 essential fatty acids
Simopoulos, A. P. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00253-6 · Cited by 4,286
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,491
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,343
Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
Barnes, C. A. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077579 · Cited by 2,088
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451
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Yates, C. M., Calder, P. C., & Rainger, G. E. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.010 · Cited by 410
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Sun, G. Y., Simonyi, Á., Fritsche, K. L., Chuang, D. Y., Hannink, M., Gu, Z., Greenlief, C. M., Yao, J. K., Lee, J. C., & Beversdorf, D. Q. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.03.006 · Cited by 324
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Bjørklund, G., Shanaida, M., Lysiuk, R., Butnariu, M., Peana, M., Sărac, I., Strus, O., Smetanina, K., & Chirumbolo, S. (2022) · Molecules · doi:10.3390/molecules27207084 · Cited by 234
Di Marco, L. Y., Marzo, A., Muñoz-Ruiz, M., Ikram, M. A., Kivipelto, M., Ruefenacht, D., Venneri, A., Soininen, H., Wanke, I., Ventikos, Y. A., et al. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-132225 · Cited by 215
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Muscaritoli, M. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.656290 · Cited by 233
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Chianese, R., Coccurello, R., Viggiano, A., Scafuro, M., Fiore, M., Coppola, G., Operto, F. F., Fasano, S., Laye, S., Pierantoni, R., et al. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666171017102547 · Cited by 159
Impact of Omega-3 Fatty Acid Supplementation on Memory Functions in Healthy Older Adults
Külzow, N., Witte, A. V., Kerti, L., Grittner, U., Schuchardt, J. P., Hahn, A., & Flöel, A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150886 · Cited by 144
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Mecocci, P., Tinarelli, C., Schulz, R. J., & Polidori, M. C. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00147 · Cited by 144
Köbe, T., Witte, A. V., Schnelle, A., Lesemann, A., Fabian, S., Tesky, V. A., Pantel, J., & Flöel, A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.050 · Cited by 138
n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice
Cutuli, D., Bartolo, P. D., Caporali, P., Laricchiuta, D., Foti, F., Ronci, M., Rossi, C., Neri, C., Spalletta, G., Caltagirone, C., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00220 · Cited by 130
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Ijomone, O. M., Ifenatuoha, C. W., Aluko, O. M., Ijomone, O. K., & Aschner, M. (2020) · Critical Reviews in Toxicology · doi:10.1080/10408444.2020.1838441 · Cited by 121
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Shaffer, J. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01118 · Cited by 133
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Provensi, G., Schmidt, S. D., Boehme, M., Bastiaanssen, T. F. S., Rani, B., Costa, A., Busca, K., Fouhy, F., Strain, C., Stanton, C., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820832116 · Cited by 110
Trindade, A., Dantas, A. F., Lima, D. C., Ferreira, S. L. C., & Teixeira, L. S. G. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.03.118 · Cited by 109
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Lee, J.-Y., Jun, N.-R., Yoon, D. W., Shin, C., & Baik, I. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.58 · Cited by 98
Kleiner, A. C., Cladis, D. P., & Santerre, C. R. (2015) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6816 · Cited by 93
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Sharma, G., Parihar, A., Talaiya, T., Dubey, K., Porwal, B., & Parihar, M. S. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2019-0105 · Cited by 94
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Dobri, A.-M., Dudău, M., Enciu, A., & Hinescu, M. E. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.003 · Cited by 83
Omega-3 polyunsaturated fatty acids and brain aging
Denis, I., Potier, B., Heberden, C., & Vancassel, S. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000141 · Cited by 83
Self-citationFatty Acids, Antioxidants and Physical Activity in Brain Aging
Freitas, H. R., Ferreira, G. C., Trevenzoli, I. H., Oliveira, K. J., & Reis, R. A. D. M. (2017) · Nutrients · doi:10.3390/nu9111263 · Cited by 85
Semba, R. D. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa024 · Cited by 78
Cutuli, D., Pagani, M., Caporali, P., Galbusera, A., Laricchiuta, D., Foti, F., Neri, C., Spalletta, G., Caltagirone, C., Petrosini, L., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00038 · Cited by 79
Zhou, M., Zhu, L., Cui, X., Feng, L., Zhao, X., He, S., Ping, F., Li, W., & Li, Y. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0157-x · Cited by 75
Fatty acid transporting proteins: Roles in brain development, aging, and stroke
Zhang, W., Chen, R., Yang, T., Xu, N., Chen, J., Gao, Y., & Stetler, R. A. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.04.004 · Cited by 79
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Yang, B., Li, R., Greenlief, C. M., Fritsche, K. L., Gu, Z., Cui, J., Lee, J. C., Beversdorf, D. Q., & Sun, G. Y. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1232-3 · Cited by 67
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Petrella, C., Carito, V., Carere, C., Ferraguti, G., Ciafrè, S., Natella, F., Bello, C., Greco, A., Ralli, M., Mancinelli, R., et al. (2020) · Nutrition · doi:10.1016/j.nut.2020.110783 · Cited by 64
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Vecchioli, S. F., Sacchetti, S., di Robilant, N. V., & Cutuli, D. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170912113852 · Cited by 67
Marín, R., & Díaz, M. L. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00128 · Cited by 59
Monaco, A., Ferrandino, I., Boscaino, F., Cocca, E., Cigliano, L., Maurano, F., Luongo, D., Spagnuolo, M. S., Rossi, M., & Bergamo, P. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m079400 · Cited by 57
Jackson, P. A., Forster, J. S., Bell, J. G., Dick, J., Younger, I., & Kennedy, D. O. (2016) · Nutrients · doi:10.3390/nu8020086 · Cited by 55
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Colin, J., Gregory-Pauron, L., Lanhers, M.-C., Claudepierre, T., Corbier, C., Yen, F. T., Malaplate-Armand, C., & Oster, T. (2016) · Biochimie · doi:10.1016/j.biochi.2016.08.014 · Cited by 55
Rahal, N. B., Barba, F. J., Barth, D., & Chevalot, I. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.07.006 · Cited by 52
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Pollard, A. K., Ortori, C. A., Stöger, R. J., Barrett, D. A., & Chakrabarti, L. (2017) · Aging · doi:10.18632/aging.101204 · Cited by 51
McCabe, D., Lisy, K., Lockwood, C. S., & Colbeck, M. (2017) · The JBI Database of Systematic Reviews and Implementation Reports · doi:10.11124/jbisrir-2016-002965 · Cited by 51
Roselló‐Soto, E., Barba, F. J., Lorenzo, J. M., Domínguez, R., Pateiro, M., Mañes, J., & Moltó, J. C. (2018) · Food Research International · doi:10.1016/j.foodres.2018.11.054 · Cited by 48
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Georgy, G. S., Nassar, N. N., Mansour, H. A., & Abdallah, D. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064847 · Cited by 44
Almeida, J. S., dos Santos, G. L., Brandão, G. C., Korn, M. G. A., & Teixeira, L. S. G. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.01.112 · Cited by 42
Lukaschek, K., von Schacky, C., Kruse, J., & Ladwig, K. (2016) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000448805 · Cited by 42
Larsen, J. A., & Farcas, A. K. (2014) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2014.03.003 · Cited by 39
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Loong, S., Barnes, S. R., Gatto, N. M., Chowdhury, S., & Lee, G. J. (2023) · Brain Sciences · doi:10.3390/brainsci13091278 · Cited by 45
Lam, S. M., Chua, G. H., Li, X., Su, B., & Shui, G. (2016) · Oncotarget · doi:10.18632/oncotarget.11190 · Cited by 37
Barros, A. S., Crispim, R. Y. G., Cavalcanti, J. U., Souza, R. B., Lemos, J. C., Filho, G. C., Bezerra, M. M., Pinheiro, T. F. M., Vasconcelos, S. M. M., Macêdo, D. S., et al. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12713 · Cited by 34
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Rossignoli, C. P., Dechandt, C. R. P., Souza, A. D. O., Sampaio, I. H., Vicentini, T. M., Teodoro, B. G., Neto, M. P. C., Ferrari, G. D., Lima, C. A. C., & Alberici, L. C. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.001 · Cited by 33
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Bainbridge, M. L., Lock, A. L., & Kraft, J. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b00857 · Cited by 29
Cutuli, D., Landolfo, E., Nobili, A., Bartolo, P. D., Sacchetti, S., Chirico, D., Marini, F., Pieroni, L., Ronci, M., D’Amelio, M., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00705-3 · Cited by 30
Effects of Mediterranean Diet Components on Neurodegenerative Diseases
Farooqui, A. A., & Farooqui, T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811959-4.00001-8 · Cited by 28
Létondor, A., Buaud, B., Vaysse, C., Fonseca, L., Herrouin, C., Servat, B., Layé, S., Pallet, V., & Alfos, S. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514002529 · Cited by 31
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Heberden, C. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000081 · Cited by 27
Self-citationLifetime cognition and late midlife blood metabolites: findings from a British birth cohort
Proitsi, P., Kuh, D. J., Wong, A., Maddock, J., Bendayan, R., Wulaningsih, W., Hardy, R., & Richards, M. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0253-0 · Cited by 26
Jaureguiberry, M., Tricerri, M. A., Sánchez, S. A., Finarelli, G. S., Montanaro, M. A., Prieto, E. D., & Rimoldi, O. J. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmt155 · Cited by 25
Neto, J., Jantsch, J., de Oliveira, S., Braga, M. F., Castro, L. F. D. S., Diniz, B. F., Moreira, J. C. F., Giovenardi, M., Porawski, M., & Guedes, R. P. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521003998 · Cited by 26
Champeil‐Potokar, G., Hennebelle, M., Latour, A., Vancassel, S., & Denis, I. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13510 · Cited by 24
Self-citationCabré, R., Naudí, A., Domínguez-González, M., Jové, M., Ayala, V., Mota‐Martorell, N., Pradas, I., Nogueras, L., Rué, M., Portero‐Otín, M., et al. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx164 · Cited by 26
Li, M., Li, Z., & Fan, Y. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1598588 · Cited by 34
Cutuli, D., Landolfo, E., Decandia, D., Nobili, A., Viscomi, M. T., Barbera, L. L., Sacchetti, S., Bartolo, P. D., Curci, A., D’Amelio, M., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051741 · Cited by 25
Mašek, T., Filipović, N., Hamzić, L. F., Puljak, L., & Starčević, K. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.10.015 · Cited by 22
Oleson, S., Gonzales, M. M., Tarumi, T., Davis, J. N., Cassill, C., Tanaka, H., & Haley, A. P. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1186341 · Cited by 20
The effect of omega-3 on cognition in hypothyroid adult male rats
Allah, E. S. H. A., Gomaa, A. M. S., & Sayed, M. M. (2014) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.101.2014.3.11 · Cited by 22
n-3 PUFA Improve Emotion and Cognition during Menopause: A Systematic Review
Decandia, D., Landolfo, E., Sacchetti, S., Gelfo, F., Petrosini, L., & Cutuli, D. (2022) · Nutrients · doi:10.3390/nu14091982 · Cited by 18
Businaro, R. (2022) · F1000Research · doi:10.12688/f1000research.75856.1 · Cited by 16
Turczyn, P., Wojdasiewicz, P., Poniatowski, Ł. A., Purrahman, D., Maślińska, M., Żurek, G., Romanowska‐Próchnicka, K., Żuk, B., Kwiatkowska, B., Piechowski‐Jóźwiak, B., et al. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07762-x · Cited by 15
Haley, A. P., Oleson, S., Pasha, E. P., Birdsill, A. C., Kaur, S., Thompson, J., & Tanaka, H. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13673 · Cited by 14
Bojar, I., Wierzbińska-Stępniak, A., Witczak, M., Raczkiewicz, D., & Owoc, A. (2015) · Annals of Agricultural and Environmental Medicine · doi:10.5604/12321966.1141391 · Cited by 15
Wu, D., Jia, Y., Liu, Y., & Shang, M. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1424156 · Cited by 14
McCall, N. M., Mahadevia, D., Corriveau, J. A., & Glenn, M. J. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.03.004 · Cited by 11
Haidary, M., Ahmadi‐Soleimani, S. M., Ghofraninezad, M., Azhdari‐Zarmehri, H., & Beheshti, F. (2024) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10336 · Cited by 13
Does Argan Oil Supplementation Affect Metabolic Parameters and Behavior in Wistar Rats?
Bousalham, R., Rhazali, L. J., Harmouch, A., Lotfi, H., Benazzouz, B., Hessni, A. E., Ouichou, A., Akhouayri, O., & Mesfioui, A. (2015) · Food and Nutrition Sciences · doi:10.4236/fns.2015.69085 · Cited by 12
Negative Impacts on the Environment and People From Simplification of Crop and Livestock Production
Kronberg, S. L., & Ryschawy, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811050-8.00005-4 · Cited by 16
Kar, R., Panchali, T., Das, P., Dutta, A., Phoujdar, M., & Pradhan, S. (2024) · Physiological Reports · doi:10.14814/phy2.70019 · Cited by 10
Molz, S., Olescowicz, G., Kraus, J. R., Ludka, F. K., & Tasca, C. I. (2014) · Purinergic Signalling · doi:10.1007/s11302-014-9438-z · Cited by 11
Whole transcriptome sequencing analyses of DHA treated glioblastoma cells
Ruan, M., Liu, J., Ren, X., Chu, L., Zhao, A. Z., Li, L., Yang, H., Dai, Y., & Wang, Y. (2018) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2018.11.027 · Cited by 11
Chen, L., Chou, Y., Lee, M., Chiou, J., Chen, J., & Chen, Y. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.04.002 · Cited by 12
Dietary interventions for prevention of dementia in people with mild cognitive impairment
Tang, E. Y. H., Harrison, S. L., Albanese, E., Gorman, T. J., Rutjes, A. W., Siervo, M., & Stephan, B. C. M. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011909 · Cited by 10
Nemeth, M., Millesi, E., Puehringer-Sturmayr, V., Kaplan, A., Wagner, K., Quint, R. M., & Wallner, B. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0107-5 · Cited by 11
Hu, Y., Zhang, X., Lian, F., Yang, J. J., & Xu, X. (2021) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.67.234 · Cited by 9
He, X., Yu, H., Fang, J., Qi, Z., Pei, S., Yan, B., Liu, R., Wang, Q., Szeto, I. M., Liu, B., et al. (2023) · Food & Function · doi:10.1039/d3fo02959j · Cited by 10
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Metadata
- Authors
- Denis, I., Potier, B., Vancassel, S., Heberden, C., & Lavialle, M.
- Affiliations
- Institut National de la Recherche Agronomique (FR)
- Inserm (FR)
- Corresponding author
- Denis, I.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 12
- Issue
- 2
- Pages
- 579-594
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2119356619
- Cited by
- 150
- References
- 260
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 8 · 2021: 4 · 2020: 15 · 2019: 6 · 2018: 15 · 2017: 16 · 2016: 15 · 2015: 17 · 2014: 16 · 2013: 3
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- omega-3 fatty acids, docosahexaenoic acid, brain aging, cognitive decline, stress, hippocampus, glutamatergic neurotransmission, neurogenesis, synaptic transmission, memory, senile dementia
- MeSH terms
- Aged, Aging, Animals, Cognition, Cognition Disorders, Docosahexaenoic Acids, Hippocampus, Humans, Memory, Short-Term, Synaptic Transmission, Stress, Physiological, Stress, Psychological, Fatty Acids, Omega-3, Neuroprotective Agents, Dietary Supplements
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