Cited by 150Fatty Acid Research and HealthDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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Omega-3 fatty acids and brain resistance to ageing and stress: Body of evidence and possible mechanisms

Denis, I., Potier, B., Vancassel, S., Heberden, C., Lavialle, M.·2013·Ageing Research Reviews

DOI 10.1016/j.arr.2013.01.007

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Abstract

The increasing life expectancy in the populations of rich countries raises the pressing question of how the elderly can maintain their cognitive function. Cognitive decline is characterised by the loss of short-term memory due to a progressive impairment of the underlying brain cell processes. Age-related brain damage has many causes, some of which may be influenced by diet. An optimal diet may therefore be a practical way of delaying the onset of age-related cognitive decline. Nutritional investigations indicate that the ω-3 poyunsaturated fatty acid (PUFA) content of western diets is too low to provide the brain with an optimal supply of docosahexaenoic acid (DHA), the main ω-3 PUFA in cell membranes. Insufficient brain DHA has been associated with memory impairment, emotional disturbances and altered brain processes in rodents. Human studies suggest that an adequate dietary intake of ω-3 PUFA can slow the age-related cognitive decline and may also protect against the risk of senile dementia. However, despite the many studies in this domain, the beneficial impact of ω-3 PUFA on brain function has only recently been linked to specific mechanisms. This review examines the hypothesis that an optimal brain DHA status, conferred by an adequate ω-3 PUFA intake, limits age-related brain damage by optimizing endogenous brain repair mechanisms. Our analysis of the abundant literature indicates that an adequate amount of DHA in the brain may limit the impact of stress, an important age-aggravating factor, and influences the neuronal and astroglial functions that govern and protect synaptic transmission. This transmission, particularly glutamatergic neurotransmission in the hippocampus, underlies memory formation. The brain DHA status also influences neurogenesis, nested in the hippocampus, which helps maintain cognitive function throughout life. Although there are still gaps in our knowledge of the way ω-3 PUFA act, the mechanistic studies reviewed here indicate that ω-3 PUFA may be a promising tool for preventing age-related brain deterioration.

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A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
The importance of the ratio of omega-6/omega-3 essential fatty acids
Simopoulos, A. P. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00253-6 · Cited by 4,286
Glutamate uptake
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
THE SYNAPTIC VESICLE CYCLE
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,491
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,343
Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
Barnes, C. A. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077579 · Cited by 2,088
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Neural plasticity in the ageing brain
Burke, S. N., & Barnes, C. A. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1809 · Cited by 1,709
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393
Astrocyte Control of Synaptic Transmission and Neurovascular Coupling
Haydon, P. G., & Carmignoto, G. (2006) · Physiological Reviews · doi:10.1152/physrev.00049.2005 · Cited by 1,371
Synaptic plasticity, memory and the hippocampus: a neural network approach to causality
Neves, G., Cooke, S. F., & Bliss, T. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2303 · Cited by 1,287
Plasticity in the human central nervous system
Cooke, S. F. (2006) · Brain · doi:10.1093/brain/awl082 · Cited by 1,260
Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease
Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.940 · Cited by 1,135
GFAP in health and disease
Middeldorp, J., & Hol, E. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.005 · Cited by 1,080
Synaptic AMPA receptor plasticity and behavior
Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993
The stress system in the human brain in depression and neurodegeneration
Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984
Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus
Encinas, J. M., Michurina, T. V., Peunova, N. I., Park, J.-H., Tordo, J., Peterson, D. A., Fishell, G., Koulakov, A. A., & Enikolopov, G. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.03.010 · Cited by 918
Docosahexaenoic acid: Membrane properties of a unique fatty acid
Stillwell, W., & Wassall, S. R. (2003) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(03)00101-4 · Cited by 872
Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors
Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00259-l · Cited by 863
The tripartite synapse: roles for gliotransmission in health and disease
Halassa, M. M., Fellin, T., & Haydon, P. G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.005 · Cited by 852
Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants
Makrides, M., Neumann, M., Byard, R. W., Simmer, K. N., & Gibson, R. A. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.2.189 · Cited by 787
Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
Warner‐Schmidt, J. L., & Duman, R. S. (2006) · Hippocampus · doi:10.1002/hipo.20156 · Cited by 787
Neuron-glia metabolic coupling and plasticity
Magistretti, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2010.053157 · Cited by 781
Impact of aging on hippocampal function: plasticity, network dynamics, and cognition
Rosenzweig, E. S., & Barnes, C. A. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00126-0 · Cited by 755
Omega-3 Fatty Acids: Evidence Basis for Treatment and Future Research in Psychiatry
Freeman, M. P., Hibbeln, J. R., Wisner, K. L., Davis, J. M., Mischoulon, D., Peet, M., Keck, P. E., Marangell, L. B., Richardson, A. J., Lake, J., et al. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1217 · Cited by 709
Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model
Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Ashe, K. H., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.013 · Cited by 707
Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging
Lugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., Haas, C. A., Kempermann, G., Taylor, V., & Giachino, C. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.017 · Cited by 704
A Diet Enriched with the Omega-3 Fatty Acid Docosahexaenoic Acid Reduces Amyloid Burden in an Aged Alzheimer Mouse Model
Lim, G. P., Calon, F., Morihara, T., Yang, F., Teter, B., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4225-04.2005 · Cited by 697
Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease: The Framingham Heart Study
Schaefer, E. J., Bongard, V., Beiser, A. S., Lamon-Fava, S., Robins, S. J., Au, R., Tucker, K. L., Kyle, D. J., Wilson, P. W. F., & Wolf, P. A. (2006) · Archives of Neurology · doi:10.1001/archneur.63.11.1545 · Cited by 686
Effects of adverse experiences for brain structure and function
McEwen, B. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00964-1 · Cited by 639
The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention
Sheldon, A. L., & Robinson, M. B. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.03.012 · Cited by 593
Role of omega-3 fatty acids in brain development and function: Potential implications for the pathogenesis and prevention of psychopathology
McNamara, R. K., & Carlson, S. E. (2006) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.07.010 · Cited by 572
Chronic stress alters synaptic terminal structure in hippocampus
Magariños, A. M., Verdugo, J. M. G., & McEwen, B. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14002 · Cited by 543
Fish, meat, and risk of dementia: cohort study
Barberger‐Gateau, P. (2002) · BMJ · doi:10.1136/bmj.325.7370.932 · Cited by 486
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus
Mira, H., Andreu, Z., Suh, H., Lie, D. C., Jessberger, S., Consiglio, A., San Emeterio, J., Hortigüela, R., Marqués-Torrejón, M. Á., Nakashima, K., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.04.016 · Cited by 480
Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury
Yi, J., & Hazell, A. S. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.001 · Cited by 477
Temporal changes in dietary fats: Role of n−6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity
Ailhaud, G. P., Massiéra, F., WEILL, P., Legrand, P., Alessandri, J. M. J. M., & Guesnet, P. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.01.003 · Cited by 465
Modulation of inflammation in brain: A matter of fat
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04371.x · Cited by 460
Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function
Cao, D., Kevala, K., Kim, J., Moon, H., Jun, S. B., Lovinger, D. M., & Kim, H. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06335.x · Cited by 432
Fish Consumption and Cognitive Decline With Age in a Large Community Study
Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., & Wilson, R. S. (2005) · Archives of Neurology · doi:10.1001/archneur.62.12.noc50161 · Cited by 428
Docosahexaenoic acid promotes neurite growth in hippocampal neurons
Calderón, F. H., & Kim, H. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02520.x · Cited by 416
GFAP mRNA increases with age in rat and human brain
Nichols, N. R., Day, J. R., Laping, N. J., Johnson, S. A., & Finch, C. E. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90100-p · Cited by 413
Docosahexaenoic acid promotes neurogenesis in vitro and in vivo
Kawakita, E., Hashimoto, M., & Shido, O. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.021 · Cited by 410
A neuroscientist's guide to lipidomics
Piomelli, D., Astarita, G., & Rapaka, R. S. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2233 · Cited by 399
Phospholipase A2 in the central nervous system
Sun, G. Y., Xu, J., Jensen, M. D., & Simonyi, Á. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300016-jlr200 · Cited by 391
Neuroprotectin D1 (NPD1): A DHA-Derived Mediator that Protects Brain and Retina Against Cell Injury-Induced Oxidative Stress
Bazan, N. G. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00513.x · Cited by 380
Glutamatergic neurotransmission in aging: a critical perspective
Segovia, G., Porras, A., Arco, A. D., & Mora, F. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00225-6 · Cited by 375
Cognitive decline and fatty acid composition of erythrocyte membranes—The EVA Study
Heude, B., Ducimetière, P., & Berr, C. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.4.803 · Cited by 363
Glutamate transporters: animal models to neurologic disease
Maragakis, N. J., & Rothstein, J. D. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.007 · Cited by 362
Fish consumption, n−3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study
van Gelder, B. M., Tijhuis, M., Kalmijn, S., & Kromhout, D. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1142 · Cited by 346
Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association
Fotuhi, M., Mohassel, P., & Yaffe, K. (2009) · Nature Reviews Neurology · doi:10.1038/ncpneuro1044 · Cited by 344
Polyunsaturated fatty acids and inflammation
Calder, P. C. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330423 · Cited by 341
An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.
Barnes, C. A., & McNaughton, B. L. (1985) · Behavioral Neuroscience · doi:10.1037//0735-7044.99.6.1040 · Cited by 337
Fish, docosahexaenoic acid and Alzheimer’s disease
Cunnane, S. C., Plourde, M., Pifferi, F., Bégin, M. E., Féart, C., & Barberger‐Gateau, P. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.04.001 · Cited by 336
Glutamate‐mediated glial injury: Mechanisms and clinical importance
Matute, C., Domercq, M., & Sánchez‐Gómez, M. V. (2005) · Glia · doi:10.1002/glia.20275 · Cited by 336
Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling
McEwen, B. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05568.x · Cited by 335
Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice
Murray, F., Smith, D., & Hutson, P. H. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.014 · Cited by 334
Effects of Chronic Stress on Structure and Cell Function in Rat Hippocampus and Hypothalamus
Joëls, M., Karst, H., Alfarez, D., Heine, V. M., Qin, Y., Riel, E. V., Verkuyl, M., Lucassen, P. J., & Krugers, H. J. (2004) · Stress · doi:10.1080/10253890500070005 · Cited by 330
Delivery and turnover of plasma-derived essential PUFAs in mammalian brain
Rapoport, S. I., Chang, M., & Spector, A. A. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31629-1 · Cited by 330
Hippocampal markers of age-related memory dysfunction: Behavioral, electrophysiological and morphological perspectives
Geinisman, Y., deToledo‐Morrell, L., Morrell, F., & Heller, R. E. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00047-l · Cited by 327
Chronic Dietary α-Linolenic Acid Deficiency Alters Dopaminergic and Serotoninergic Neurotransmission in Rats ,
Delion, S., Chalon, S., Hérault, J., Guilloteau, D., Besnard, J., & Durand, G. (1994) · Journal of Nutrition · doi:10.1093/jn/124.12.2466 · Cited by 326
Alterations in the Fatty Acid Composition of Rat Brain Cells (Neurons, Astrocytes, and Oligodendrocytes) and of Subcellular Fractions (Myelin and Synaptosomes) Induced by a Diet Devoid of n‐3 Fatty Acids
Bourre, J. M., Pascal, G., Durand, G., Masson, M., Dumont, O., & Piciotti, M. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb00906.x · Cited by 325
Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
Kotani, S., Sakaguchi, E., Warashina, S., Matsukawa, N., Ishikura, Y., Kiso, Y., Sakakibara, M., Yoshimoto, T., Guo, J., & Yamashima, T. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.06.010 · Cited by 321
Age and gender effects on microglia and astrocyte numbers in brains of mice
Mouton, P. R., Long, J. M., Lei, D.-L., Howard, V., Jucker, M., Calhoun, M. E., & Ingram, D. K. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03475-3 · Cited by 320
Effects of chronic stress on hippocampal long‐term potentiation
Pavlides, C., Nivón, L. G., & McEwen, B. S. (2002) · Hippocampus · doi:10.1002/hipo.1116 · Cited by 316
Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition
Wu, A., Ying, Z., & Gómez‐Pinilla, F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.061 · Cited by 315
Calcium/calmodulin-dependent protein kinase II and synaptic plasticity
Colbran, R. J., & Brown, A. M. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.05.008 · Cited by 311
Polyunsaturated fatty acids in the central nervous system: evolution of concepts and nutritional implications throughout life
Alessandri, J., Guesnet, P., Vancassel, S., Astorg, P., Denis, I., Goustard, B., Aïd, S., Poumès‐Ballihaut, C., Champeil‐Potokar, G., & Lavialle, M. (2004) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2004063 · Cited by 298
Self-citation
Omega-3 fatty acids and rodent behavior
Fedorova, I., & Salem, N. (2006) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.07.006 · Cited by 296
Chronic Administration of Docosahexaenoic Acid Ameliorates the Impairment of Spatial Cognition Learning Ability in Amyloid β–Infused Rats
Hashimoto, M., Tanabe, Y., Fujii, Y., Kikuta, T., Shibata, H., & Shido, O. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.3.549 · Cited by 288
Increased Generation of Neuronal Progenitors after Ischemic Injury in the Aged Adult Human Forebrain
Macas, J., Nern, C., Plate, K. H., & Momma, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4667-06.2006 · Cited by 287
An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.
Barnes, C. A., & McNaughton, B. L. (1985) · Behavioral Neuroscience · doi:10.1037/0735-7044.99.6.1040 · Cited by 286
Effects of chronic mild stress on the oxidative parameters in the rat brain
Lucca, G., Comim, C. M., Valvassori, S. S., Réus, G. Z., Vuolo, F. S., Petronilho, F. C., Dal‐Pizzol, F., Gavioli, E. C., & Quevedo, J. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.01.001 · Cited by 271
Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction
Bachevalier, J., Landis, L. S., Walker, L. C., Brickson, M., Mishkin, M., Price, D. L., & Cork, L. C. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90048-o · Cited by 264
Glia: the fulcrum of brain diseases
Giaume, C., Kirchhoff, F., Matute, C., Reichenbach, A., & Verkhratsky, A. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402144 · Cited by 260
Effect of diet on the fatty acid composition of the major phospholipids of infant cerebral cortex.
Farquharson, J., Jamieson, E. C., Abbasi, K., Patrick, W. J., Logan, R. W., & Cockburn, F. (1995) · Archives of Disease in Childhood · doi:10.1136/adc.72.3.198 · Cited by 257
Effects of omega-3 fatty acids on cognitive performance: a meta-analysis
Mazereeuw, G., Lanctôt, K. L., Chau, S. A., Swardfager, W., & Herrmann, N. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.014 · Cited by 253
Dietary n‐3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease
Calon, F., Lim, G. P., Morihara, T., Yang, F., Ubeda, O. J., Salem, N., Frautschy, S. A., & Cole, G. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04253.x · Cited by 253
Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection
Bazan, N. G. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32802b7030 · Cited by 252
Serotoninergic neurotransmission is affected by n‐3 polyunsaturated fatty acids in the rat
Kodas, E., Galineau, L., Bodard, S., Vancassel, S., Guilloteau, D., Besnard, J., & Chalon, S. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02401.x · Cited by 244
Self-citation
Diminished adult neurogenesis in the marmoset brain precedes old age
Leuner, B., Kozorovitskiy, Y., Gross, C. G., & Gould, E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708228104 · Cited by 240
Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys
Wenk, G. L., Walker, L. C., Price, D. L., & Cork, L. C. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90047-n · Cited by 236
Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids
Mirescu, C., Peters, J. D., Noiman, L., & Gould, E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608644103 · Cited by 233
Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid
He, C., Qu, X., Cui, L., Wang, J., & Kang, J. X. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904835106 · Cited by 233
Effect of brain‐derived neurotrophic factor haploinsufficiency on stress‐induced remodeling of hippocampal neurons
Magariños, A. M., Li, C. J., Gal Toth, J., Bath, K. G., Jing, D., Lee, F. S., & McEwen, B. S. (2011) · Hippocampus · doi:10.1002/hipo.20744 · Cited by 232
Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance
Su, H. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.11.003 · Cited by 231
Aging and the physiology of spatial memory
Barnes, C. A. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80114-3 · Cited by 222
Maternal Dietary (n-3) Fatty Acid Deficiency Alters Neurogenesis in the Embryonic Rat Brain
Bertrand, P. C., OʼKusky, J. R., & Innis, S. M. (2006) · Journal of Nutrition · doi:10.1093/jn/136.6.1570 · Cited by 220
Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory
Trouche, S. G., Bontempi, B., Roullet, P., & Rampon, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811054106 · Cited by 220
The dopamine mesocorticolimbic pathway is affected by deficiency in n−3 polyunsaturated fatty acids
Zimmer, L., Vancassel, S., Cantagrel, S., Breton, P., Delamanche, S., Guilloteau, D., Durand, G., & Chalon, S. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.4.662 · Cited by 218
Self-citation
Effects of Altered Maternal Folic Acid, Vitamin B12 and Docosahexaenoic Acid on Placental Global DNA Methylation Patterns in Wistar Rats
Kulkarni, A. V., Dangat, K. D., Kale, A. A., Sable, P., Chavan, P., & Joshi, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017706 · Cited by 216
Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n–3 polyunsaturated fatty acids
Zimmer, L., Vancassel, S., Durand, G., Guilloteau, D., Bodard, S., Besnard, J., & Chalon, S. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32071-x · Cited by 214
Self-citation
Age-dependent alterations in hippocampal synaptic plasticity: Relation to memory disorders
deToledo‐Morrell, L., Geinisman, Y., & Morrell, F. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80117-9 · Cited by 213
Chronic Administration Of Docosahexaenoic Acid Improves The Performance Of Radial Arm Maze Task In Aged Rats
Gamoh, S., Hashimoto, M., Hossain, S., & Masumura, S. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03437.x · Cited by 213
Age-related decreases of the N-methyl-d-aspartate receptor complex in the rat cerebral cortex and hippocampus
Tamaru, M., Yoneda, Y., Ogita, K., Shimizu, J., & Nagata, Y. (1991) · Brain Research · doi:10.1016/0006-8993(91)91001-h · Cited by 212
Age‐related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild‐type mice
Minkeviciene, R., Ihalainen, J. A., Malm, T., Matilainen, O., Keksa-Goldsteine, V., Goldsteins, G., Iivonen, H., Leguit, N., Glennon, J. C., Koıstınaho, J., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05147.x · Cited by 210
Estrogen, neuroinflammation and neuroprotection in Parkinson’s disease: Glia dictates resistance versus vulnerability to neurodegeneration
Morale, M. C., Serra, P. A., L’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Gennuso, F., Giaquinta, G., Rocchitta, G., Desole, M. S., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.060 · Cited by 207
Prolactin-Induced Mitogenesis in the Subventricular Zone of the Maternal Brain during Early Pregnancy Is Essential for Normal Postpartum Behavioral Responses in the Mother
Larsen, C. M., & Grattan, D. R. (2010) · Endocrinology · doi:10.1210/en.2009-1385 · Cited by 205
Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk
Devore, E. E., Grodstein, F., van Rooij, F. J., Hofman, A., Rosner, B., Stampfer, M. J., Witteman, J. C., & Breteler, M. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27037 · Cited by 205
Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex
Rao, J. S., Ertley, R. N., DeMar, J. C., Рапопорт, С. И., Bazinet, R. P., & Lee, H.-J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001887 · Cited by 203
Fish oil prevents the adrenal activation elicited by mental stress in healthy men
Delarue, J., Matzinger, O., Binnert, C., Schneiter, P., Chioléro, R., & Tappy, L. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70039-3 · Cited by 202
Dynamics of cell proliferation in the adult dentate gyrus of two inbred strains of mice
Hayes, N. L., & Nowakowski, R. S. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00324-8 · Cited by 201
Dietary intakes and food sources of n−6 and n−3 PUFA in french adult men and women
Astorg, P., Arnault, N., Czernichow, S., Noisette, N., Galan, P., & Herçberg, S. (2004) · Lipids · doi:10.1007/s11745-004-1259-6 · Cited by 200
Peripheral astrocyte processes: Monitoring by selective immunostaining for the actin‐binding ERM proteins
Derouiche, A., & Frotscher, M. (2001) · Glia · doi:10.1002/glia.1120 · Cited by 197
Phospholipases A2 and Inflammatory Responses in the Central Nervous System
Sun, G. Y., Shelat, P. B., Jensen, M. B., He, Y., Sun, A. Y., & Simonyi, Á. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8092-z · Cited by 197
Repeated Restraint Stress Induces Oxidative Damage in Rat Hippocampus
Fontella, F. U., Siqueira, I. R., de Vasconcellos, A. P. S., Tabajara, Â. S., Netto, C. A., & Dalmaz, C. (2005) · Neurochemical Research · doi:10.1007/s11064-004-9691-6 · Cited by 195
Half‐lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n‐3 polyunsaturated fatty acids
DeMar, J. C., Ma, K., Bell, J. M., & Rapoport, S. I. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02789.x · Cited by 194
Oral supplementation with docosahexaenoic acid and uridine-5’-monophosphate increases dendritic spine density in adult gerbil hippocampus
Sakamoto, T., Cansev, M., & Wurtman, R. J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.08.089 · Cited by 188
Brief Treatment With the Glucocorticoid Receptor Antagonist Mifepristone Normalises the Corticosterone‐Induced Reduction of Adult Hippocampal Neurogenesis
Mayer, J. L., Klumpers, L. E., Maslam, S., de Kloet, E. R., Joëls, M., & Lucassen, P. J. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01455.x · Cited by 186
A Western-like fat diet is sufficient to induce a gradual enhancement in fat mass over generations
Massiéra, F., Barbry, P., Guesnet, P., Joly‐Amado, A., Luquet, S. H., Moreilhon, C., Mohsen‐Kanson, T., Amri, E., & Ailhaud, G. P. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m006866 · Cited by 186
High Sensitivity of Glutamate Uptake to Extracellular Free Arachidonic Acid Levels in Rat Cortical Synaptosomes and Astrocytes
Volterra, A., Trotti, D., Cassutti, P., Tromba, C., SALVAGGIO, A., Melcangi, R. C., & Racagni, G. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09411.x · Cited by 185
Regulation of brain polyunsaturated fatty acid uptake and turnover
Chen, C. T., Green, J. T., Orr, S. K., & Bazinet, R. P. (2008) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2008.09.003 · Cited by 184
NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus
Nácher, J., Alonso‐Llosà, G., Rosell, D. R., & McEwen, B. S. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00096-9 · Cited by 182
Repeated maternal separation of preweanling rats attenuates behavioral responses to primary and conditioned incentives in adulthood
Matthews, K., Wilkinson, L. S., & Robbins, T. W. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02069-1 · Cited by 179
From Molecules to Mind
McEwen, B. S. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03469.x · Cited by 174
Omega‐3 fatty acids reverse age‐related decreases in nuclear receptors and increase neurogenesis in old rats
Dyall, S. C., Michael, G. J., & Michael-Titus, A. T. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22390 · Cited by 174
Docosahexaenoic acid prevents lipopolysaccharide‐induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization
Smedt, V. D., Sargueil, F., Moranis, A., Harizi, H., Mongrand, S., & Layé, S. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05129.x · Cited by 174
Polyunsaturated fatty acids, neuroinflammation and well being
Layé, S. (2010) · Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) · doi:10.1016/j.plefa.2010.02.006 · Cited by 167
Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women
Vercambre, M.-N., Boutron-Ruault, M.-C., Ritchie, K., Clavel-Chapelon, F., & Berr, C. (2009) · British Journal of Nutrition · doi:10.1017/s0007114508201959 · Cited by 167
Effect of a diet-induced n-3 PUFA depletion on cholinergic parameters in the rat hippocampus
Aïd, S., Vancassel, S., Poumès‐Ballihaut, C., Chalon, S., Guesnet, P., & Lavialle, M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300079-jlr200 · Cited by 167
Self-citation
Regulation of Cellular Plasticity Cascades in the Pathophysiology and Treatment of Mood Disorders
Zarate, C. A., Du, J., Quiroz, J. A., GRAY, N. A., Denicoff, K. D., Singh, J., Charney, D. S., & Manji, H. K. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.017 · Cited by 166
Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids
Barceló‐Coblijn, G., Hőgyes, E., Kitajka, K., Puskás, L. G., Zvara, Á., Hackler, L., Nyakas, C. J., Penke, Z., & Farkas, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734008100 · Cited by 166
Long chain polyunsaturated fatty acids are required for efficient neurotransmission in C. elegans
Lesa, G. M., Palfreyman, M. T., Hall, D. H., Clandinin, M. T., Rudolph, C., Jørgensen, E. M., & Schiavo, G. (2003) · Journal of Cell Science · doi:10.1242/jcs.00918 · Cited by 162
Astrocytes in the aging brain
Cotrina, M. L., & Nedergaard, M. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10121 · Cited by 161
Arachidonic Acid and the Brain
Rapoport, S. I. (2008) · Journal of Nutrition · doi:10.1093/jn/138.12.2515 · Cited by 157
Facilitatory effect of docosahexaenoic acid on N‐methyl‐D‐aspartate response in pyramidal neurones of rat cerebral cortex.
Nishikawa, M., Kimura, S., & Akaike, N. (1994) · Journal of Physiology · doi:10.1113/jphysiol.1994.sp020051 · Cited by 153
The concentration of glial fibrillary acidic protein increases with age in the mouse and rat brain
O'Callaghan, J. P., & Miller, D. B. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90057-q · Cited by 152
Metabolic programming of long‐term outcomes due to fatty acid nutrition in early life
Innis, S. M. (2011) · Maternal and Child Nutrition · doi:10.1111/j.1740-8709.2011.00318.x · Cited by 151
Modification upon aging of the density of presynaptic modulation systems in the hippocampus
Canas, P. M., Duarte, J. M. N., Rodrigues, R. J., Köfalvi, A., & Cunha, R. A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.01.003 · Cited by 150
Alterations in brain antioxidant status, protein oxidation and lipid peroxidation in response to different stress models
Şahın, E., & Gümüşlü, S. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.04.022 · Cited by 149
Eicosapentaenoic acid confers neuroprotection in the amyloid-β challenged aged hippocampus
Lynch, A. M., Loane, D. J., Minogue, A. M., Clarke, R. M., Kilroy, D., Nally, R. E., Roche, Ó. J., O'Connell, F., & Lynch, M. A. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.04.006 · Cited by 149
Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging
Kröger, E., Verreault, R., Carmichael, P.-H., Lindsay, J., Julien, P., Dewailly, É., Ayotte, P., & Laurin, D. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26987 · Cited by 149
Stem Cell Review Series: Role of neurogenesis in age‐related memory disorders
Drapeau, E., & Abrous, D. N. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00369.x · Cited by 148
n−3 Fatty acid proportions in plasma and cognitive performance in older adults
Dullemeijer, C., Durga, J., Brouwer, I. A., van de Rest, O., Kok, F. J., Brummer, R.-J. M., van Boxtel, M. P., & Verhoef, P. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1479 · Cited by 148
Glucose transport and utilization are altered in the brain of rats deficient in n‐3 polyunsaturated fatty acids
Ximenes-da-Silva, A., Lavialle, F., Gendrot, G., Guesnet, P., Alessandri, J., & Lavialle, M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00932.x · Cited by 146
Self-citation
The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat
Kelly, L., Grehan, B., Chiesa, A. D., O’Mara, S. M., Downer, E. J., Sahyoun, G., Massey, K. A., Nicolaou, A., & Lynch, M. A. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.001 · Cited by 140
n-3 Polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice
Vancassel, S., Leman, S., Hanonick, L., Denis, S., Roger, J., Nollet, M., Bodard, S., Kousignian, I., Belzung, C., & Chalon, S. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700328-jlr200 · Cited by 138
Self-citation
Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models
Bosetti, F. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04558.x · Cited by 136
Fatty acid intake and the risk of dementia and cognitive decline: a review of clinical and epidemiological studies.
Kalmijn, S. (2000) · PubMed · Cited by 134
Correlates of regular fish consumption in French elderly community dwellers: data from the Three-City study
Barberger‐Gateau, P., Jutand, M.-A., Letenneur, L., Larrieu, S., Tavernier, B., Berr, C., & for the 3C Study Group (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602145 · Cited by 132
Psychological stress-induced enhancement of brain lipid peroxidation via nitric oxide systems and its modulation by anxiolytic and anxiogenic drugs in mice
Matsumoto, K., Yobimoto, K., Huong, N. T. T., Abdel-Fattah, M., Hien, T. V., & Watanabe, H. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01715-1 · Cited by 130
Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals
Robson, L. G., Dyall, S. C., Sidloff, D. A., & Michael-Titus, A. T. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.027 · Cited by 128
Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer's disease
Boudrault, C., Bazinet, R. P., & David, W. L. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.05.016 · Cited by 126
Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain
Dyall, S. C., Michael, G. J., Whelpton, R., Scott, A. G., & Michael-Titus, A. T. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.01.002 · Cited by 126
Age-related changes in phospholipid fatty acid composition and monoaminergic neurotransmission in the hippocampus of rats fed a balanced or an n-3 polyunsaturated fatty acid-deficient diet
Delion, S., Chalon, S., Guilloteau, D., Lejeune, B., Besnard, J., & Durand, G. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37235-7 · Cited by 124
Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study
Zimmer, L., Hembert, S., Durand, G., Breton, P., Guilloteau, D., Besnard, J., & Chalon, S. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00938-5 · Cited by 124
Dietary fatty acids in dementia and predementia syndromes: Epidemiological evidence and possible underlying mechanisms
Solfrizzi, V., Frisardi, V., Capurso, C. A., D’Introno, A., Colacicco, A. M., Vendemiale, G., Capurso, A., & Panza, F. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.07.005 · Cited by 123
Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice
Moranis, A., Delpech, J.-C., Smedt, V. D., Aubert, A., Guesnet, P., Lavialle, M., Joffre, C., & Layé, S. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.11.001 · Cited by 122
Self-citation
Age-related changes in the protein expression of subunits of the NMDA receptor
Magnusson, K. R., Nelson, S. E., & Young, A. B. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00344-8 · Cited by 122
Region-selective stress-induced increase of glutamate uptake and release in rat forebrain
Gilad, G. M., Gilad, V. H., Wyatt, R. J., & Tizabi, Y. (1990) · Brain Research · doi:10.1016/0006-8993(90)90886-g · Cited by 121
Stress hormones and brain aging: adding injury to insult?
Porter, N. M., & Landfield, P. W. (1998) · Nature Neuroscience · doi:10.1038/196 · Cited by 119
Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats
Hgyes, E., Nyakas, C. J., Kiliaan, A. J., Farkas, T., Penke, B., & Luiten, P. G. M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00198-2 · Cited by 117
Glucocorticoid Prevents Brain-Derived Neurotrophic Factor-Mediated Maturation of Synaptic Function in Developing Hippocampal Neurons through Reduction in the Activity of Mitogen-Activated Protein Kinase
Kumamaru, E., Numakawa, T., Adachi, N., Yagasaki, Y., Izumi, A., Niyaz, M., Kudo, M., & Kunugi, H. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0264 · Cited by 116
Docosahexaenoic acid synthesis from n-3 polyunsaturated fatty acids in differentiated rat brain astrocytes
Williard, D. E., Harmon, S. D., Kaduce, T. L., Preuss, M. A., Moore, S. A., Robbins, M. E. C., & Spector, A. A. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30268-6 · Cited by 116
(n-3) Polyunsaturated Fatty Acid Deficiency Reduces the Expression of Both Isoforms of the Brain Glucose Transporter GLUT1 in Rats
Pifferi, F., Roux, F. S., Goustard, B., Alessandri, J., Vancassel, S., Jouin, M., Lavialle, M., & Guesnet, P. (2005) · Journal of Nutrition · doi:10.1093/jn/135.9.2241 · Cited by 116
Self-citation
Cognitive aging, childhood intelligence, and the use of food supplements: possible involvement of n−3 fatty acids
Whalley, L. J., Fox, H. C., Wahle, K. W. J., Starr, J. M., & Deary, I. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1650 · Cited by 116
Docosahexaenoic Acid-rich Phospholipid Supplementation: Effect on Behavior, Learning Ability, and Retinal Function in Control and n-3 Polyunsaturated Fatty Acid Deficient Old Mice
Carrié, I., Smirnova, M., Clément, M., de Javel, D., Francès, H., & Bourre, J. M. (2002) · Nutritional Neuroscience · doi:10.1080/10284150290007074 · Cited by 113
Effect of ω-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: a randomized, placebo-controlled, double-blind trial
Hamazaki, K., Itomura, M., Huan, M., Nishizawa, H., Sawazaki, S., Tanouchi, M., Watanabe, S., Hamazaki, T., TERASAWA, K., & Yazawa, K. (2005) · Nutrition · doi:10.1016/j.nut.2004.07.020 · Cited by 113
Synaptic Vesicle Ultrastructural Changes in the Rat Hippocampus Induced by a Combination of α‐Linolenate Deficiency and a Learning Task
Yoshida, S., Yasuda, A., Kawazato, H., Sakai, K., Shimada, T., Takeshita, M., Yuasa, S., Kobayashi, T., Watanabe, S., & Okuyama, H. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68031261.x · Cited by 112
Diffusion constraints and neuron–glia interaction during aging
Syková, E., Mazel, T., & Šimonová, Z. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00038-2 · Cited by 110
Phenotypic and gene expression modification with normal brain aging in GFAP-positive astrocytes and neural stem cells
Bernal, G. M., & Peterson, D. A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00694.x · Cited by 109
In vivo approaches to quantifying and imaging brain arachidonic and docosahexaenoic acid metabolism
Rapoport, S. I. (2003) · The Journal of Pediatrics · doi:10.1067/s0022-3476(03)00399-8 · Cited by 109
A potentially critical role of phospholipases in central nervous system ischemic, traumatic, and neurodegenerative disorders
Phillis, J. W., & O’Regan, M. H. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2003.10.002 · Cited by 108
DHA-enriched phospholipid diets modulate age-related alterations in rat hippocampus
Favrelière, S., Perault, M. C., Huguet, F., de Javel, D., Bertrand, N., Piriou, A., & Durand, G. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00064-7 · Cited by 107
Uncoupling of interleukin‐6 from its signalling pathway by dietary n‐3‐polyunsaturated fatty acid deprivation alters sickness behaviour in mice
Mingam, R., Moranis, A., Bluthé, R.-M., Smedt, V. D., Kelley, K. W., Guesnet, P., Lavialle, M., Dantzer, R., & Layé, S. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06470.x · Cited by 106
Self-citation
The Role of Perisynaptic Glial Sheaths in Glutamate Spillover and Extracellular Ca2+ Depletion
Rusakov, D. A. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)75846-8 · Cited by 106
Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats
Potier, B., Billard, J., Rivière, S., Sinet, P., Denis, I., Champeil‐Potokar, G., Grintal, B., Jouvenceau, A., Kollen, M., & Dutar, P. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00593.x · Cited by 105
Self-citation
A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer’s transgenic mice
Arendash, G. W., Jensen, M. T., Salem, N., Hussein, N., Cracchiolo, J. R., Dickson, A., Leighty, R. E., & Potter, H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.08.018 · Cited by 105
The impact of glial activation in the aging brain.
Lynch, A. M., Murphy, K. J., Deighan, B. F., O’Reilly, J.-A., Gun’ko, Y. K., Cowley, T. R., González-Reyes, R. E., & Lynch, M. A. (2010) · Europe PMC (PubMed Central) · Cited by 103
Mixture of essential fatty acids lowers test anxiety
Yehuda, S., Rabinovitz, S., & Mostofsky, D. I. (2005) · Nutritional Neuroscience · doi:10.1080/10284150500445795 · Cited by 103
Learning deficits in aged rats related to decrease in extracellular volume and loss of diffusion anisotropy in hippocampus
Syková, E., Mazel, T., Hasenöhrl, R. U., Harvey, A. R., Šimonová, Z., Mulders, W. H. A. M., & Huston, J. P. (2002) · Hippocampus · doi:10.1002/hipo.1101 · Cited by 102
The aging of the NMDA receptor complex
Magnusson, K. R. (1998) · Frontiers in bioscience · doi:10.2741/a368 · Cited by 100
Induction of oxidative stress by restraint stress and corticosterone treatments in rats.
Zafir, A., & Banu, N. (2009) · PubMed · Cited by 100
Deficits in the expression of the NR2B subunit in the hippocampus of aged Fisher 344 rats
Clayton, D. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00196-2 · Cited by 99
Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy
Païzanis, E., Hamon, M., & Lanfumey, L. (2007) · Neural Plasticity · doi:10.1155/2007/73754 · Cited by 99
Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils
Cansev, M., & Wurtman, R. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.016 · Cited by 98
Exercise contributes to the effects of DHA dietary supplementation by acting on membrane-related synaptic systems
Chytrova, G., Ying, Z., & Gómez‐Pinilla, F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.018 · Cited by 95
Arachidonic acid potentiates exocytosis and allows neuronal SNARE complex to interact with Munc18a
Latham, C. F., Osborne, S. L., Cryle, M. J., & Meunier, F. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04286.x · Cited by 95
Fish consumption and cognitive function among older people in the UK: Baseline data from the OPAL study
Dangour, A. D., Allen, E., Elbourne, D. R., FLETCHER, A. E., Richards, M., & Uauy, R. D. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0057-2 · Cited by 92
Influence of Omega-3 Fatty Acid Status on the Way Rats Adapt to Chronic Restraint Stress
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Authors: Denis, I., Potier, B., Vancassel, S., Heberden, C., & Lavialle, M.
Affiliations: Institut National de la Recherche Agronomique (FR)
Inserm (FR)
Corresponding author: Denis, I.
ORCID: Denis, I.
Potier, B.
Vancassel, S.
Heberden, C.
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2013-03
Volume: 12
Issue: 2
Pages: 579-594
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2013.01.007
OpenAlex: W2119356619
Cited by: 150
References: 260
Citations by year: 2026: 10 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 8 · 2021: 4 · 2020: 15 · 2019: 6 · 2018: 15 · 2017: 16 · 2016: 15 · 2015: 17 · 2014: 16 · 2013: 3
FWCI: 1.91
Type: journal article
Language: en
Open access: closed
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: omega-3 fatty acids, docosahexaenoic acid, brain aging, cognitive decline, stress, hippocampus, glutamatergic neurotransmission, neurogenesis, synaptic transmission, memory, senile dementia
MeSH terms: Aged, Aging, Animals, Cognition, Cognition Disorders, Docosahexaenoic Acids, Hippocampus, Humans, Memory, Short-Term, Synaptic Transmission, Stress, Physiological, Stress, Psychological, Fatty Acids, Omega-3, Neuroprotective Agents, Dietary Supplements

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Omega-3 fatty acids and brain resistance to ageing and stress: Body of evidence and possible mechanisms

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