The DOI matches its Crossref record; 218 of the 220 references it cites were found in a registry or an index.
Lysosomal cell death mechanisms in aging
Open accessAbstract
Lysosomes are degradative organelles essential for cell homeostasis that regulate a variety of processes, from calcium signaling and nutrient responses to autophagic degradation of intracellular components. Lysosomal cell death is mediated by the lethal effects of cathepsins, which are released into the cytoplasm following lysosomal damage. This process of lysosomal membrane permeabilization and cathepsin release is observed in several physiopathological conditions and plays a role in tissue remodeling, the immune response to intracellular pathogens and neurodegenerative diseases. Many evidences indicate that aging strongly influences lysosomal activity by altering the physical and chemical properties of these organelles, rendering them more sensitive to stress. In this review we focus on how aging alters lysosomal function and increases cell sensitivity to lysosomal membrane permeabilization and lysosomal cell death, both in physiological conditions and age-related pathologies.
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“Additional LMP triggers include lysosomotropic agents (e.g., sphingosine), calpains, and ROS [751].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [751]
In the citing paper
“Lysosome-dependent cell death is relevant for several pathophysiological conditions, including inflammation, tissue remodeling (e.g., mammary gland involution after lactation), aging, neurodegeneration, cardiovascular disorders, and intracellular pathogen response [750–752].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [751]
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Metadata
- Authors
- Gómez-Sintes, R., Ledesma, M. D., & Boya, P.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Boya, Patricia
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 32
- Pages
- 150-168
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2299746178
- Cited by
- 216
- References
- 220
- Citations by year
- 2026: 20 · 2025: 41 · 2024: 23 · 2023: 24 · 2022: 19 · 2021: 20 · 2020: 21 · 2019: 16 · 2018: 13 · 2017: 13 · 2016: 5
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
- Funders
- MINECO Consolider (CSD2010-00045, SAF2012-36079, SAF2014-57539-R)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- lysosomal cell death, aging, lysosomal membrane permeabilization, cathepsins, lysosomal function, age-related diseases, autophagy, lysosomal stress, neurodegenerative diseases, tissue remodeling
- MeSH terms
- Aging, Animals, Autophagy, Cathepsins, Humans, Lysosomes, Cell Death, Apoptosis, Neurodegenerative Diseases
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