Cited by 216Autophagy in Disease and TherapyCell death mechanisms and regulationCalcium signaling and nucleotide metabolism

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Lysosomal cell death mechanisms in aging

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Gómez-Sintes, Raquel, Ledesma, María Dolores, Boya, Patricia·2016·Ageing Research Reviews

DOI 10.1016/j.arr.2016.02.009

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Abstract

Lysosomes are degradative organelles essential for cell homeostasis that regulate a variety of processes, from calcium signaling and nutrient responses to autophagic degradation of intracellular components. Lysosomal cell death is mediated by the lethal effects of cathepsins, which are released into the cytoplasm following lysosomal damage. This process of lysosomal membrane permeabilization and cathepsin release is observed in several physiopathological conditions and plays a role in tissue remodeling, the immune response to intracellular pathogens and neurodegenerative diseases. Many evidences indicate that aging strongly influences lysosomal activity by altering the physical and chemical properties of these organelles, rendering them more sensitive to stress. In this review we focus on how aging alters lysosomal function and increases cell sensitivity to lysosomal membrane permeabilization and lysosomal cell death, both in physiological conditions and age-related pathologies.

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Authors: Gómez-Sintes, R., Ledesma, M. D., & Boya, P.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
Corresponding author: Boya, Patricia
ORCID: Ledesma, María Dolores
Boya, Patricia
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2016-12
Volume: 32
Pages: 150-168
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2016.02.009
OpenAlex: W2299746178
Cited by: 216
References: 220
Citations by year: 2026: 20 · 2025: 41 · 2024: 23 · 2023: 24 · 2022: 19 · 2021: 20 · 2020: 21 · 2019: 16 · 2018: 13 · 2017: 13 · 2016: 5
FWCI: 2.12
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
Funders: MINECO Consolider (CSD2010-00045, SAF2012-36079, SAF2014-57539-R)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: lysosomal cell death, aging, lysosomal membrane permeabilization, cathepsins, lysosomal function, age-related diseases, autophagy, lysosomal stress, neurodegenerative diseases, tissue remodeling
MeSH terms: Aging, Animals, Autophagy, Cathepsins, Humans, Lysosomes, Cell Death, Apoptosis, Neurodegenerative Diseases

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Lysosomal cell death mechanisms in aging

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