Lysosomal cell death mechanisms in aging

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The role of autophagy in neurodegenerative disease

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Signals from the lysosome: a control centre for cellular clearance and energy metabolism

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Developmental cell death: morphological diversity and multiple mechanisms

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Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

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Termination of autophagy and reformation of lysosomes regulated by mTOR

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Lysosomal membrane permeabilization in cell death

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Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

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Autophagy is required to maintain muscle mass.

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Lysosomal acidification mechanisms

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

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UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS

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Lysosomal Physiology

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Lipofuscin: mechanisms of age-related accumulation and influence on cell function12 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.

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Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells

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Subcellular Particles

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Pathogenic Lysosomal Depletion in Parkinson's Disease

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Lysosomal cysteine proteases: facts and opportunities

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Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

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Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease

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Lysosomal cell death at a glance

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Age-related decline in chaperone-mediated autophagy

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Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor

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Autophagy failure in Alzheimer's disease—locating the primary defect

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The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

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An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

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Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

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Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

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Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

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Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

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Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion

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Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

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Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

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Silica binding and toxicity in alveolar macrophages

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Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

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Lysosomal involvement in cell death and cancer

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Altered lipid content inhibits autophagic vesicular fusion

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Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine

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Sphingosine-induced apoptosis is dependent on lysosomal proteases

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RIPK1 and RIPK3: critical regulators of inflammation and cell death

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Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification

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Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

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Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre‐clinical AD, amnestic mild cognitive impairment and late‐stage AD

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Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

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At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy

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Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.

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Damage control: cellular mechanisms of plasma membrane repair

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Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

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Autophagy: a druggable process that is deregulated in aging and human disease

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Stat3 controls lysosomal-mediated cell death in vivo

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Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species

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Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration

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NLRP3 Inflammasome Activation in Retinal Pigment Epithelial Cells by Lysosomal Destabilization: Implications for Age-Related Macular Degeneration

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Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

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The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium

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Exploring Cells with a Centrifuge

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AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

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Sphingosine-induced apoptosis is dependent on lysosomal proteases

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Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF)

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Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease.

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Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

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Effective Tumor Cell Death by σ-2 Receptor Ligand Siramesine Involves Lysosomal Leakage and Oxidative Stress

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Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

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Induction of cell death by the lysosomotropic detergent MSDH

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Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

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Cysteine cathepsins are essential in lysosomal degradation of α-synuclein

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Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae

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Inhibitory effect of dietary lipids on chaperone-mediated autophagy

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Lysosome: regulator of lipid degradation pathways

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Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders

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Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation

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Lysosome membrane lipid microdomains: novel regulators of chaperone‐mediated autophagy

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Vincristine Induces Dramatic Lysosomal Changes and Sensitizes Cancer Cells to Lysosome-Destabilizing Siramesine

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Progressive decline of glucocerebrosidase in aging and P arkinson's disease

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Lysosomal Function and Dysfunction: Mechanism and Disease

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V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

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Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age

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The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release

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Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease

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Combating apoptosis and multidrug resistant cancers by targeting lysosomes

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Cystatin C Rescues Degenerating Neurons in a Cystatin B-Knockout Mouse Model of Progressive Myoclonus Epilepsy

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Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein-induced Lysosomal Translocation of Proapoptotic Effectors Is Mediated by Phosphofurin Acidic Cluster Sorting Protein-2 (PACS-2)

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Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis

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Glycogen Synthase Kinase-3β Mediates Endoplasmic Reticulum Stress-Induced Lysosomal Apoptosis in Leukemia

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Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model

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Host-derived, pore-forming toxin–like protein and trefoil factor complex protects the host against microbial infection

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Oxidative Stress Protection by Exogenous Delivery of rhHsp70 Chaperone to the Retinal Pigment Epithelium (RPE), a Possible Therapeutic Strategy Against RPE Degeneration

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Lysosomes as the target of yessotoxin in invertebrate and vertebrate cell lines

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Age-related changes in ultrastructural features of cathepsin B- and D-containing neurons in rat cerebral cortex

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Alteration of Lysosome Fusion and Low-grade Inflammation Mediated by Super-low-dose Endotoxin

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The autophagic lysosomal system in outflow pathway physiology and pathophysiology

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Altered distribution and levels of cathepsinD and cystatins in amyotrophic lateral sclerosis transgenic mice: Possible roles in motor neuron survival

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Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells

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Cystatin C in cerebrospinal fluid as a biomarker of ALS

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Chelation of lysosomal iron protects against ionizing radiation

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Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress

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Squamous Cell Carcinoma Antigen 1 Promotes Caspase-8-Mediated Apoptosis in Response to Endoplasmic Reticulum Stress While Inhibiting Necrosis Induced by Lysosomal Injury

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3‐Aminopropanal is a lysosomotropic aldehyde that causes oxidative stress and apoptosis by rupturing lysosomes

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The molecular machinery of regulated cell death

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Autophagy in healthy aging and disease

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Selective neuronal vulnerability in Parkinson disease

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Lysosomal membrane permeabilization and cell death

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Lysosomes and lysosomal cathepsins in cell death

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Lysosomes in senescence and aging

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Lysosomal cell death at a glance

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Autophagy – The Liaison between the Lysosomal System and Cell Death

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