Sodium intake and physical activity impact cognitive maintenance in older adults: the NuAge Study
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Abstract
This study examines the association between sodium intake and its interaction with physical activity on cognitive function over 3 years in older adults residing in Québec, Canada. We analyzed a subgroup from the NuAge cohort (aged 67-84 years) with nutrient intake data, including sodium, from a food frequency questionnaire administered at baseline. Baseline physical activity was assessed using the Physical Activity Scale for the Elderly (PASE; high-low). Modified Mini Mental State Examination (3MS) was administered at baseline and annually for 3 additional years. Controlling for age, sex, education, waist circumference, diabetes, and dietary intakes, analyses showed an association between sodium intake and cognitive change over time in the low PASE group only. Specifically, in the low PASE group, elders in the low sodium intake tertile displayed better cognitive performance over time (mean decline in 3MS over years: mean [M] = -0.57, standard error [SE] = 0.002) compared with the highest (M = -1.72, SE = 0.01) and mid sodium intake (M = -2.07, SE = 0.01) groups. This finding may have significant public health implications, emphasizing the importance of addressing multiple lifestyle factors rather than a single domain effect on brain health.
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High dietary salt is a risk factor for dementia.
“High dietary salt is a risk factor for dementia [598, 599].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [598]
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- Authors
- Fiocco, A. J., Shatenstein, B., Ferland, G., Payette, H., Belleville, S., Kergoat, M.-J., Morais, J. A., & Greenwood, C. E.
- Affiliations
- Institut Universitaire de Gériatrie de Montréal (CA)
- Université de Sherbrooke (CA)
- McGill University (CA)
- University of Toronto (CA)
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 33
- Issue
- 4
- Pages
- 829.e21-829.e28
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2091449083
- Cited by
- 84
- References
- 47
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 11 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- CIHR (MOP-62842, MOP-81217)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- sodium intake, physical activity, cognitive function, cognitive decline, older adults, dietary salt, brain health, lifestyle factors
- MeSH terms
- Aged, Aged, 80 and over, Aging, Energy Intake, Canada, Cognition Disorders, Female, Humans, Male, Mental Status Schedule, Motor Activity, Neuropsychological Tests, Surveys and Questionnaires, Sodium, Cohort Studies, Chi-Square Distribution
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