The road ahead for health and lifespan interventions

Resveratrol improves muscle atrophy by modulating mitochondrial quality control in STZ-induced diabetic mice.

Wang, D., Sun, H., Song, G., Yang, Y., Zou, X., Han, P., & Li, S. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700941 · Cited by 102

Anti-Hsp90 therapy in autoimmune and inflammatory diseases: a review of preclinical studies

Tukaj, S., & Węgrzyn, G. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0670-z · Cited by 100

The Sirt1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress

Ren, Y., Du, C., Shi, Y., Wei, J., Wu, H., & Cui, H. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2931 · Cited by 100

The NHR-8 Nuclear Receptor Regulates Cholesterol and Bile Acid Homeostasis in C. elegans

Magner, D. B., Wollam, J., Shen, Y., Hoppe, C., Li, D., Latza, C., Rottiers, V., Hutter, H., & Antebi, A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.007 · Cited by 98

Cardiovascular Protective Effects and Clinical Applications of Resveratrol

Cho, S. H., Namkoong, K., Shin, M., Park, J., Yang, E., Ihm, J., Thu, V. T., Kim, H. K., & Han, J. (2017) · Journal of Medicinal Food · doi:10.1089/jmf.2016.3856 · Cited by 98

Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import

He, C. Z., Tsuchiyama, S. K., Nguyen, Q. T. T., Proshkina, E., Terrill, S. R., Sahibzada, S., Patel, B., Faulkner, A. R., Shaposhnikov, M. V., Tian, R., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004860 · Cited by 97

A phase II , randomized, placebo‐controlled, double‐blind, multi‐dose study of SRT2104 , a SIRT1 activator, in subjects with type 2 diabetes

Baksi, A., Крайдашенко, О. В., Zalevkaya, A., Stets, R., Elliott, P. J., Haddad, J., Hoffmann, E. C., Vlasuk, G. P., & Jacobson, E. W. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12327 · Cited by 96

Spermidine delays aging in humans

Madeo, F., Carmona‐Gutiérrez, D., Kepp, O., & Kroemer, G. (2018) · Aging · doi:10.18632/aging.101517 · Cited by 95

Protein Homeostasis as a Therapeutic Target for Diseases of Protein Conformation

Calamini, B., & Morimoto, R. I. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026611212220014 · Cited by 94

Sulindac improves memory and increases NMDA receptor subunits in aged Fischer 344 rats

Mesches, M. H., Gemma, C., Veng, L., Allgeier, C. A., Young, D. A., Browning, M. D., & Bickford, P. C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00116-7 · Cited by 91

Postprandial hyperglycemia is a determinant of platelet activation in early type 2 diabetes mellitus

Santilli, F., Formoso, G., Sbraccia, P., Averna, M. R., Miccoli, R., Fulvio, P. D., Ganci, A., Pulizzi, N., Lattanzio, S., Ciabattoni, G., et al. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03742.x · Cited by 91

Hsp90: Friends, clients and natural foes

Verma, S., Goyal, S., Jamal, S., Singh, A. P., & Grover, A. (2016) · Biochimie · doi:10.1016/j.biochi.2016.05.018 · Cited by 91

Resveratrol distinctively modulates the inflammatory profiles of immune and endothelial cells

Schwager, J., Richard, N., Widmer, F., & Raederstorff, D. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1823-z · Cited by 90

UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity

Wanders, D., Burk, D. H., Cortez, C. C., Van, N. T., Stone, K. P., Baker, M., Mendoza, T. M., Mynatt, R. L., & Gettys, T. W. (2015) · The FASEB Journal · doi:10.1096/fj.14-270348 · Cited by 88

Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice

Allard, J. S., Perez, E. J., Fukui, K., Carpenter, P., Ingram, D. K., & Cabo, R. D. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.012 · Cited by 88

Development of 17α‐Estradiol as a Neuroprotective Therapeutic Agent: Rationale and Results from a Phase I Clinical Study

DYKENS, J. A., MOOS, W. H., & HOWELL, N. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1347.008 · Cited by 87

Matrix effects on the bioavailability of resveratrol in humans

Ortuño, J., Covas, M., Farré, M., Pujadas, M., Fitó, M., Khymenets, O., Andrés‐Lacueva, C., Roset, P. N., Joglar, J., Lamuela-Raventós, R. M., et al. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.11.032 · Cited by 87

The Effect of the Creatine Analogue Beta-guanidinopropionic Acid on Energy Metabolism: A Systematic Review

Oudman, I., Clark, J. F., & Brewster, L. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052879 · Cited by 86

FK506 and rapamycin: novel pharmacological probes of the immune response

CHANG, J. Y., Sehgal, S. N., & Bansbach, C. C. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90555-7 · Cited by 85

Resveratrol and Lifespan in Model Organisms

Pallauf, K., Rimbach, G. H., Rupp, P. M., Chin, D., & Wolf, I. M. A. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666161024151233 · Cited by 84

Spermidine-triggered autophagy ameliorates memory during aging

Sigrist, S. J., Carmona-Gutierrez, D., Gupta, V. K., Bhukel, A., Mertel, S., Eisenberg, T., & Madeo, F. (2014) · Autophagy · doi:10.4161/auto.26918 · Cited by 82

Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise

Uddin, G. M., Youngson, N. A., Doyle, B. M., Sinclair, D. A., & Morris, M. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-14866-z · Cited by 82

Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury

Ambade, A., Catalano, D. E., Lim, A., Kopoyan, A., Shaffer, S. A., & Mandrekar, P. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.05.024 · Cited by 80

Dietary Protein, Life-span, and Biochemical Variables in Female Mice

Leto, S., Kokkonen, G. C., & Barrows, C. H. (1976) · Journal of Gerontology · doi:10.1093/geronj/31.2.144 · Cited by 79

Translating the Science of Aging into Therapeutic Interventions

Kirkland, J. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025908 · Cited by 78

Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats

da Luz, P. L., Tanaka, L. Y., Brum, P. C., Dourado, P. M. M., Favarato, D., Krieger, J. E., & Laurindo, F. R. M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.06.007 · Cited by 77

Double-blind, placebo-controlled pilot trial of L-Leucine-enriched amino-acid mixtures on body composition and physical performance in men and women aged 65–75 years

Ispoglou, T., White, H., Preston, T., McElhone, S., McKenna, J., & Hind, K. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.91 · Cited by 76

Growth Factors, Nutrient Signaling, and Cardiovascular Aging

Fontana, L., Vinciguerra, M., & Longo, V. D. (2012) · Circulation Research · doi:10.1161/circresaha.111.246470 · Cited by 76

The human gut microbiota and its interactive connections to diet

Milani, C., Ferrario, C., Turroni, F., Duranti, S., Mangifesta, M., van Sinderen, D., & Ventura, M. (2016) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12371 · Cited by 76

Effect of Resveratrol on Walking Performance in Older People With Peripheral Artery Disease

McDermott, M. M., Leeuwenburgh, C., Guralnik, J. M., Tian, L., Sufit, R. L., Zhao, L., Criqui, M. H., Kibbe, M. R., Stein, J. H., Lloyd‐Jones, D. M., et al. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2017.0538 · Cited by 72

Lack of evidence for GDF 11 as a rejuvenator of aged skeletal muscle satellite cells

Hinken, A. C., Powers, J. M., Luo, G., Holt, J. A., Billin, A. N., & Russell, A. J. (2016) · Aging Cell · doi:10.1111/acel.12475 · Cited by 71

Health benefits of late-onset metformin treatment every other week in mice

Alfaras, I., Mitchell, S. J., Mora, H., Lugo, D. R., Warren, A., Navas-Enamorado, I., Hoffmann, V., Hine, C., Mitchell, J. R., Le Couteur, D. G., et al. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0018-7 · Cited by 68

Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice

Cho, S., Kim, J., Lee, J. H., Sim, J. H., Cho, D.-H., Bae, I., Lee, H., Seol, M. A., Shin, H. M., Kim, T.-J., et al. (2016) · Scientific Reports · doi:10.1038/srep39026 · Cited by 67

Advanced glycation end products and lipopolysaccharides stimulate interleukin‑6 secretion via the RAGE/TLR4‑NF‑κB‑ROS pathways and resveratrol attenuates these inflammatory responses in mouse macrophages

Ohtsu, A., Shibutani, Y., Seno, K., Iwata, H., Kuwayama, T., & Shirasuna, K. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5045 · Cited by 67

Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF)

Hare, A. A., Leng, L., Gandavadi, S., Du, X., Cournia, Z., Bucala, R., & Jorgensen, W. L. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.07.129 · Cited by 63

Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span

Kumar, S., Dietrich, N., & Kornfeld, K. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005866 · Cited by 63

Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet

Bernier, M., Wahl, D., Ali, A., Allard, J. S., Faulkner, S., Wnorowski, A., Sanghvi, M., Moaddel, R., Alfaras, I., Mattison, J. A., et al. (2016) · Aging · doi:10.18632/aging.100942 · Cited by 63

Resveratrol improves alcoholic fatty liver disease by downregulating HIF-1α expression and mitochondrial ROS production

Ma, Z., Zhang, Y., Li, Q., Xu, M. M., Bai, J., & Wu, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183426 · Cited by 61

Allostatic load and ageing: linking the microbiome and nutrition with age-related health

Shiels, P. G., Buchanan, S. J., Selman, C., & Stenvinkel, P. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190110 · Cited by 60

Methionine and cystine double deprivation stress suppresses glioma proliferation via inducing ROS/autophagy

Liu, H., Zhang, W., Wang, K., Wang, X., Yin, F., Li, C., Wang, C., Zhao, B., Chen, Z., Zhang, J., et al. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.11.011 · Cited by 59

From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span

McIsaac, R. S., Lewis, K. N., Gibney, P. A., & Buffenstein, R. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13032 · Cited by 59

Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology

Shavlakadze, T., Zhu, J., Wang, S., Zhou, W., Morin, B., Egerman, M. A., Fan, L., Wang, Y., Iartchouk, O., Meyer, A., et al. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx249 · Cited by 59

Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin

Anisimov, V. N., Popovich, I. G., Zabezhinski, M. A., Egormin, P. A., Yurova, M. N., Semenchenko, A. V., Тындык, М. Л., Панченко, А. В., Trashkov, A. P., Vasiliev, A. G., et al. (2014) · Cell Cycle · doi:10.4161/15384101.2014.973308 · Cited by 58

Macrophage migration inhibitory factor‐knockout mice are long lived and respond to caloric restriction

Harper, J. M., Wilkinson, J. E., & Miller, R. A. (2010) · The FASEB Journal · doi:10.1096/fj.09-152223 · Cited by 58

Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase

Chung, B.-H., Kim, S., Kim, J.-D., Lee, J. J., Baek, Y.-Y., Jeoung, D., Lee, H., Choe, J., Ha, K., Won, M., et al. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.3.014 · Cited by 57

Precision medicine: The future in diabetes care?

Scheen, A. J. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.04.033 · Cited by 57

Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model

Jeong, B. Y., Uddin, M. J., Park, J. H., Lee, J. H., Lee, H. B., Miyata, T., & Ha, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157012 · Cited by 57

Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes

Reifsnyder, P. C., Flurkey, K., Te, A. G., & Harrison, D. E. (2016) · Aging · doi:10.18632/aging.101117 · Cited by 57

β‐Guanidinopropionic acid extends the lifespan of D rosophila melanogaster via an AMP ‐activated protein kinase‐dependent increase in autophagy

Yang, S., Long, L., Li, D., Zhang, J., Jin, S., Wang, F., & Chen, J. (2015) · Aging Cell · doi:10.1111/acel.12371 · Cited by 55

Sirtuin 1 activator SRT 2104 protects Huntington's disease mice

Jiang, M., Zheng, J., Peng, Q., Hou, Z., Zhang, J., Mori, S., Ellis, J. L., Vlasuk, G. P., Fries, H. E., Suri, V., et al. (2014) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.135 · Cited by 54

A systems biology analysis of the unique and overlapping transcriptional responses to caloric restriction and dietary methionine restriction in rats

Ghosh, S., Wanders, D., Stone, K. P., Van, N. T., Cortez, C. C., & Gettys, T. W. (2014) · The FASEB Journal · doi:10.1096/fj.14-249458 · Cited by 54

Exceptional Parental Longevity Associated with Lower Risk of Alzheimer's Disease and Memory Decline

Lipton, R. B., Hirsch, J. S., Katz, M. J., Wang, C., Sanders, A. E., Verghese, J., Barzilai, N., & Derby, C. A. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02868.x · Cited by 54

Healthy ageing: Evidence that improvement is possible at every age

Michel, J., DREUX, C., & Vacheron, A. (2016) · European Geriatric Medicine · doi:10.1016/j.eurger.2016.04.014 · Cited by 54

The effects of 17 alpha-estradiol to inhibit inflammation in vitro

Santos, R. D. S., de Fátima, L. A., Frank, A. P., Carneiro, E. M., & Clegg, D. J. (2017) · Biology of Sex Differences · doi:10.1186/s13293-017-0151-9 · Cited by 51

Fibroblast growth factor 21 delayed endothelial replicative senescence and protected cells from H2O2-induced premature senescence through SIRT1.

Yan, J., Wang, J., Huang, H., Huang, Y., Mi, T., Zhang, C., & Zhang, L. (2017) · PubMed Central · Cited by 48

Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans

McCormack, S. E., Polyák, E., Ostrovsky, J., Dingley, S. D., Rao, M., Kwon, Y. J., Xiao, R., Zhang, Z., Nakamaru‐Ogiso, E., & Falk, M. J. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.02.005 · Cited by 47

Suppression of Alzheimer’s Disease-Related Phenotypes by Geranylgeranylacetone in Mice

Hoshino, T., Suzuki, K., Matsushima, T., Yamakawa, N., Suzuki, T., & Mizushima, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076306 · Cited by 45

SRT2104 attenuates diabetes-induced aortic endothelial dysfunction via inhibition of P53

Wu, H., Wu, J., Zhou, S., Huang, W., Li, Y., Zhang, H., Wang, J., & Jia, Y. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0672 · Cited by 45

Mitochondrial membrane lipidome defines yeast longevity

Beach, A., Richard, V. R., Leonov, A., Burstein, M. T., Bourque, S. D., Koupaki, O., Juneau, M., Feldman, R., Iouk, T. L., & Titorenko, V. I. (2013) · Aging · doi:10.18632/aging.100578 · Cited by 43

Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

Gómez, A. G., Gómez, J., Torres, M. L., Naudí, A., Mota‐Martorell, N., Pamplona, R., & Barja, G. (2015) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-015-9608-x · Cited by 43

Frailty as a Nexus Between the Biology of Aging, Environmental Conditions and Clinical Geriatrics

Ferrucci, L., Hesdorffer, C., Bandinelli, S., & Simonsick, E. M. (2010) · Public health reviews · doi:10.1007/bf03391612 · Cited by 42

The Rapamune era of immunosuppression 2003: the journey from the laboratory to clinical transplantation

Camardo, J. S. (2003) · Transplantation Proceedings · doi:10.1016/s0041-1345(03)00356-7 · Cited by 42

Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with irinotecan: results of an open-label, phase 1 study

Tolcher, A. W., LoRusso, P. M., Arzt, J. A., Busman, T. A., Lian, G., Rudersdorf, N. S., Vanderwal, C. A., Waring, J. F., Yang, J., Holen, K. D., et al. (2015) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-015-2882-9 · Cited by 40

Methionine restriction improves renal insulin signalling in aged kidneys

Grant, L., Lees, E. K., Forney, L. A., Mody, N., Gettys, T. W., Brown, P. A., Wilson, H. M., & Delibegović, M. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.07.003 · Cited by 40

SRT1720 promotes survival of aged human mesenchymal stem cells via FAIM: a pharmacological strategy to improve stem cell-based therapy for rat myocardial infarction

Liu, X., Hu, D., Zeng, Z., Zhu, W., Zhang, N., Yu, H., Chen, H., Wang, K., Wang, Y., Wang, L., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.107 · Cited by 40

Effect of inhibition of α-glucosidase on age-related glucose intolerance and pancreatic atrophy in rats

Yamamoto, M., & Otsuki, M. (2006) · Metabolism · doi:10.1016/j.metabol.2005.11.007 · Cited by 39

Genetics of coronary heart disease: towards causal mechanisms, novel drug targets and more personalized prevention

Orho‐Melander, M. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12407 · Cited by 39

Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome

Beach, A., Richard, V. R., Bourque, S. D., Boukh‐Viner, T., Kyryakov, P., Gomez-Perez, A., Arlia‐Ciommo, A., Feldman, R., Leonov, A., Piano, A., et al. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1026493 · Cited by 38

The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells

Gurt, I., Artsi, H., Cohen‐Kfir, E., Hamdani, G., Ben-Shalom, G., Feinstein, B., El-Haj, M., & Dresner–Pollak, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134391 · Cited by 37

Dietary methionine restriction modulates renal response and attenuates kidney injury in mice

Cooke, D., Ouattara, A., & Ables, G. P. (2017) · The FASEB Journal · doi:10.1096/fj.201700419r · Cited by 37

Dietary Tryptophan Restriction Dose‐Dependently Modulates Energy Balance, Gut Hormones, and Microbiota in Obesity‐Prone Rats

Zapata, R. C., Singh, A., Ajdari, N. M., & Chelikani, P. K. (2018) · Obesity · doi:10.1002/oby.22136 · Cited by 37

Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues

Miller, B. F., Pharaoh, G. A., Hamilton, K. L., Peelor, F. F., Kirkland, J. L., Freeman, W. M., Mann, S. N., Kinter, M. T., Price, J. C., & Stout, M. B. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz113 · Cited by 37

Low dose resveratrol ameliorates mitochondrial respiratory dysfunction and enhances cellular reprogramming

Mizuguchi, Y., Hatakeyama, H., Sueoka, K., Tanaka, M., & Goto, Y.-I. (2017) · Mitochondrion · doi:10.1016/j.mito.2016.12.006 · Cited by 35

Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury

Yu, L., Liu, X., Li, X., Yuan, Z., Yang, H., Zhang, L., & Jiang, Z. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.10.016 · Cited by 34

Circulating Concentrations of Growth Differentiation Factor 11 Are Heritable and Correlate With Life Span

Zhou, Y., Jiang, Z., Harris, E. C., Reeves, J. H., Chen, X., & Pazdro, R. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv308 · Cited by 33

Effects of lifelong intervention with an oligofructose-enriched inulin in rats on general health and lifespan

Rozan, P., Nejdi, A., Hidalgo, S., Bisson, J., Desor, D., & Messaoudi, M. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508975607 · Cited by 32

Fibroblast Growth Factor-21 Is a Promising Dietary Restriction Mimetic

Mendelsohn, A. R., & Larrick, J. W. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1392 · Cited by 32

The ASCVD Risk Estimator App

Gluckman, T. J., Kovacs, R. J., Stone, N. J., Damalas, D., Mullen, J. B., & Oetgen, W. J. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.10.068 · Cited by 32

A novel plasminogen activator inhibitor‐1 inhibitor, TM5441, protects against high‐fat diet‐induced obesity and adipocyte injury in mice

Piao, L., Jung, I., Huh, J. Y., Miyata, T., & Ha, H. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13541 · Cited by 31

Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus

Noh, R. M., Venkatasubramanian, S., Daga, S., Langrish, J. P., Mills, N. L., Lang, N. N., Hoffmann, E. C., Waterhouse, B. R., Newby, D. E., & Frier, B. M. (2017) · Open Heart · doi:10.1136/openhrt-2017-000647 · Cited by 30

The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice

Zhang, Q., Deater, M., Schubert, K. M., Loza, L. I. M., Pelz, C., Sinclair, D. A., & Grompe, M. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.05.007 · Cited by 29

Minocycline effect on life and health span of Drosophila melanogaster.

Oxenkrug, G. F., Navrotskaya, V., Vorobyova, L., & D, P. S. M. (2012) · Europe PMC (PubMed Central) · Cited by 29

The oligosaccharide α-cyclodextrin has modest effects to slow gastric emptying and modify the glycaemic response to sucrose in healthy older adults

Gentilcore, D., Vanis, L., Teng, J. C., Wishart, J. M., Buckley, J. D., Rayner, C. K., Horowitz, M., & Jones, K. L. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511000444 · Cited by 29

Identification of a small molecule activator of SIRT1 gene expression

Cho, S., Cho, M., Seo, D. B., Lee, S. J., & Suh, Y. (2013) · Aging · doi:10.18632/aging.100539 · Cited by 28

Macrophage Migration Inhibitory Factor Is Detrimental in Pneumococcal Pneumonia and a Target for Therapeutic Immunomodulation

Weiser, J. N., Roche, A. M., Hergott, C. A., LaRose, M. I., Connolly, T., Jorgensen, W. L., Leng, L., Bucala, R., & Das, R. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv262 · Cited by 28

Nutritional Tryptophan Restriction and the Role of Serotonin in Development and Plasticity of Central Visual Connections

Serfaty, C. A., Oliveira-Silva, P., Faria‐Melibeu, A. D. C., & Campello‐Costa, P. (2008) · NeuroImmunoModulation · doi:10.1159/000153421 · Cited by 28

NIA’s intervention testing program at 10 years of age

Warner, H. R. (2015) · AGE · doi:10.1007/s11357-015-9761-5 · Cited by 25

Angiotensin II AT1 Receptor Blockade Prolongs the Lifespan of Spontaneously Hypertensive Rats and Reduces Stress‐Induced Release of Catecholamines, Glucocorticoids, and Vasopressin

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