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The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy
Open accessAbstract
While the elderly segment of the population continues growing in importance, neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition, exercise, and education, among others, influence ageing progression, throughout life. Notably, the Central Nervous System (CNS) can benefit from nutritional strategies and dietary interventions that prevent signs of senescence, such as cognitive decline or neurodegenerative diseases such as Alzheimer's disease and Parkinson's Disease. The dietary polyphenol Resveratrol (RV) possesses antioxidant and cytoprotective effects, producing neuroprotection in several organisms. The oxidative stress (OS) occurs because of Reactive oxygen species (ROS) accumulation that has been proposed to explain the cause of the ageing. One of the most harmful effects of ROS in the cell is DNA damage. Nevertheless, there is also evidence demonstrating that OS can produce other molecular changes such as mitochondrial dysfunction, inflammation, apoptosis, and epigenetic modifications, among others. Interestingly, the dietary polyphenol RV is a potent antioxidant and possesses pleiotropic actions, exerting its activity through various molecular pathways. In addition, recent evidence has shown that RV mediates epigenetic changes involved in ageing and the function of the CNS that persists across generations. Furthermore, it has been demonstrated that RV interacts with gut microbiota, showing modifications in bacterial composition associated with beneficial effects. In this review, we give a comprehensive overview of the main mechanisms of action of RV in different experimental models, including clinical trials and discuss how the interconnection of these molecular events could explain the neuroprotective effects induced by RV.
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“Prevention of cognitive decline and cellular neurodegeneration has been related to the antioxidant properties of resveratrol (Grinan-Ferre et al. 2021).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Grinan-Ferre et al. 2021
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Metadata
- Authors
- Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., & Pallàs, M.
- Affiliations
- Universitat de Barcelona (ES)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- Universitat Autònoma de Barcelona (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Semmelweis University (HU)
- ORCID
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 67
- Pages
- 101271
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W3126884725
- Cited by
- 208
- References
- 483
- Citations by year
- 2026: 15 · 2025: 33 · 2024: 52 · 2023: 47 · 2022: 38 · 2021: 22
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Ageing Research Reviews (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- Funders
- European Regional Development Fund (PCIN-2015-229, PID2019-106285RB)
- Spain Ministry of Science and Innovation
- Hungarian Science Foundation
- Semmelweis Egyetem (STIA-KFI-2020/132257/AOMBT/2020)
- Ministry of Economic Affairs and Digital Transformation
- Government of Catalonia (2017 SGR 106)
- Agencia Estatal de Investigación
- Ministerio de Economía y Competitividad
- Hungarian Scientific Research Fund (K 116525)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- resveratrol, neuroprotection, cognitive decline, Alzheimer's disease, Parkinson's disease, oxidative stress, reactive oxygen species, epigenetic modifications, aging, gut microbiota, dietary polyphenols, mitochondrial dysfunction, neuroinflammation, apoptosis, DNA damage, antioxidant activity
- MeSH terms
- Resveratrol, Aged, Alzheimer Disease, Antioxidants, Humans, Oxidative Stress, Neuroprotective Agents, Epigenesis, Genetic, Cognitive Dysfunction
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