The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

DNA methylation patterns and epigenetic memory

Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Oxidative stress, aging, and diseases

Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s158513 · Cited by 3,979

Therapeutic potential of resveratrol: the in vivo evidence

Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9498 · Cited by 3,942

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622

Molecular chaperones in protein folding and proteostasis

Hartl, F. U., Bracher, A., & Hayer-Hartl, M. (2011) · Nature · doi:10.1038/nature10317 · Cited by 3,381

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300

CpG islands and the regulation of transcription

Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160

The role of MicroRNAs in human cancer

Peng, Y., & Croce, C. M. (2016) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2015.4 · Cited by 2,566

Role for DNA methylation in genomic imprinting

Li, E., Beard, C., & Jaenisch, R. (1993) · Nature · doi:10.1038/366362a0 · Cited by 2,117

The DNA methyltransferases of mammals

Bestor, T. H. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.16.2395 · Cited by 2,078

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935

An operational definition of epigenetics: Figure 1.Preprint

Berger, S. L., Kouzarides, T., Shiekhattar, R., & Shilatifard, A. (2009) · Genes & Development · doi:10.1101/gad.1787609 · Cited by 1,889

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

Tönnies, E., & Trushina, E. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161088 · Cited by 1,750

MicroRNAs in Cancer

Leva, G. D., Garofalo, M., & Croce, C. M. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104715 · Cited by 1,705

Role for DNA methylation in genomic imprinting

Li, E., Beard, C., & Jaenisch, R. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90228-3 · Cited by 1,698

HDAC2 negatively regulates memory formation and synaptic plasticity

Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Cantó, C., & Auwerx, J. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328328d0a4 · Cited by 1,624

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,370

Inflammation in neurodegenerative diseases

Amor, S., Puentes, F., Baker, D., & Van Der Valk, P. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03225.x · Cited by 1,355

The role of oxidative stress in neurodegenerative diseases

Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

Steffan, J. S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B. L., Kazantsev, A., Schmidt, E., Zhu, Y.-Z., Greenwald, M., et al. (2001) · Nature · doi:10.1038/35099568 · Cited by 1,228

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

Issa, J.-P. J., Ottaviano, Y. L., Celano, P., Hamilton, S. R., Davidson, N. E., & Baylin, S. B. (1994) · Nature Genetics · doi:10.1038/ng0894-536 · Cited by 1,191

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.011 · Cited by 1,162

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

Ficz, G., Branco, M. R., Seisenberger, S., Santos, F., Krueger, F., Hore, T. A., Marques, C. J., Andrews, S., & Reik, W. (2011) · Nature · doi:10.1038/nature10008 · Cited by 1,160

Finding function in novel targets: C. elegans as a model organism

Kaletta, T., & Hengartner, M. O. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2031 · Cited by 1,152

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

Gu, T., Guo, F., Yang, H., Wu, H.-P., Xu, G., Liu, W., Xie, Z.-G., Shi, L., He, X., Jin, S., et al. (2011) · Nature · doi:10.1038/nature10443 · Cited by 1,144

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., Delalle, I., Baur, J. A., Sui, G., Armour, S. M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601758 · Cited by 1,074

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

Hata, K., Okano, M., Lei, H., & Li, E. (2002) · Development · doi:10.1242/dev.129.8.1983 · Cited by 1,073

Bioavailability of resveratrol

Walle, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05842.x · Cited by 1,051

Extended Functional Groups (EFG): An Efficient Set for Chemical Characterization and Structure-Activity Relationship Studies of Chemical Compounds

Salmina, E. S., Haider, N., & Tetko, I. V. (2015) · Molecules · doi:10.3390/molecules21010001 · Cited by 1,037

Role of oxidative stress in Alzheimer’s disease

HUANG, W.-J., ZHANG, X., & CHEN, W.-W. (2016) · Biomedical Reports · doi:10.3892/br.2016.630 · Cited by 1,023

Histone core modifications regulating nucleosome structure and dynamics

Tessarz, P., & Kouzarides, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3890 · Cited by 1,018

Role of neuroinflammation in neurodegenerative diseases (Review)

Chen, W., Zhang, X., & Huang, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4948 · Cited by 961

Epigenetic mechanisms of longevity and aging

Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016) · Cell · doi:10.1016/j.cell.2016.07.050 · Cited by 956

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., et al. (2010) · Science · doi:10.1126/science.1186088 · Cited by 951

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

Min, S.-W., Cho, S.-H., Zhou, Y., Schroeder, S., Haroutunian, V., Seeley, W. W., Huang, E. J., Shen, Y., Masliah, E., Mukherjee, C., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.044 · Cited by 949

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Franceschi, C., Garagnani, P., Morsiani, C., Conte, M., Santoro, A., Grignolio, A., Monti, D., Capri, M., & Salvioli, S. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00061 · Cited by 945

Degradation of misfolded proteins in neurodegenerative diseases: Therapeutic targets and strategies

Ciechanover, A., & Kwon, Y. T. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.117 · Cited by 898

Regulation of heat shock transcription factors and their roles in physiology and disease

Gómez‐Pastor, R., Burchfiel, E. T., & Thiele, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.73 · Cited by 871

Epigenetics and aging

Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860

Impaired Proteasome Function in Alzheimer's Disease

Keller, J. N., Hanni, K. B., & Markesbery, W. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750436.x · Cited by 848

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

Szulwach, K. E., Li, X., Li, Y., Song, C., Wu, H., Dai, Q., Irier, H. A., Upadhyay, A. K., Gearing, M., Levey, A. I., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2959 · Cited by 843

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

Özdal, T., Sela, D. A., Xiao, J., Boyacıoğlu, D., Chen, F., & Çapanoğlu, E. (2016) · Nutrients · doi:10.3390/nu8020078 · Cited by 842

Pathways of cellular proteostasis in aging and disease

Klaips, C. L., Jayaraj, G. G., & Hartl, F. U. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201709072 · Cited by 835

Brain-Gut-Microbiota Axis in Alzheimer’s Disease

Kowalski, K., & Mulak, A. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18087 · Cited by 826

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

Liu, Z., Zhou, T., Ziegler, A. C., Dimitrion, P., & Zuo, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2525967 · Cited by 810

Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate

Valenzano, D. R., Tozzini, E. T., Genade, T., Cattaneo, A., Domenici, L., & Cellerino, A. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.038 · Cited by 804

Oxidative Stress in Neurodegenerative Diseases

Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9337-5 · Cited by 800

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791

Maternal Methyl Supplements in Mice Affect Epigenetic Variation and DNA Methylation of Offspring

Cooney, C. A., Dave, A. A., & Wolff, G. L. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2393s · Cited by 784

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

Turner, R. S., Thomas, R. G., Craft, S., van Dyck, C. H., Mintzer, J. E., Reynolds, B., Brewer, J. B., Rissman, R. A., Raman, R., Aisen, P. S. S., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000002035 · Cited by 769

Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides

Marambaud, P., Zhao, H., & Davies, P. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508246200 · Cited by 766

Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast

Medina, D. A., Jordán‐Pla, A., Millán-Zambrano, G., Chávez, S., Choder, M., & Pérez-Ortín, J. E. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00001 · Cited by 754

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., & Gan, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509329200 · Cited by 740

Sirt1 and the Mitochondria

Luen Tang, B. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2318 · Cited by 740

Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦

Yamamoto, M., Clark, J. D., Pastor, J. V., Gurnani, P., Nandi, A., Kurosu, H., Miyoshi, M., Ogawa, Y., Castrillón, D. H., Rosenblatt, K. P., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509039200 · Cited by 736

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

Moussa, C., Hebron, M. L., Huang, X., Ahn, J., Rissman, R. A., Aisen, P. S. S., & Turner, R. S. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0779-0 · Cited by 712

The role of protein clearance mechanisms in organismal ageing and age-related diseases

Vı́lchez, D., Sáez, I., & Dillin, A. G. (2014) · Nature Communications · doi:10.1038/ncomms6659 · Cited by 710

Neuroinflammation as a common feature of neurodegenerative disorders

Guzman-Martinez, L., Maccioni, R. B., Andrade, V., Navarrete, L. P., Pastor, M. G., & Ramos-Escobar, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01008 · Cited by 702

Epigenetics and aging: the targets and the marks

Fraga, M. F., & Esteller, M. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.05.008 · Cited by 690

miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

Zhou, S., Jin, J.-P., Wang, J., Zhang, Z., Freedman, J. H., Zheng, Y., & Cai, L. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.30 · Cited by 690

Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses

Leonard, S. S., Xia, C., Jiang, B.-H., Stinefelt, B. M., KLANDORF, H., Harris, G. K., & Shi, X. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.105 · Cited by 683

Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation

Orang, A., Safaralizadeh, R., & Kazemzadeh, M. (2014) · International Journal of Genomics · doi:10.1155/2014/970607 · Cited by 675

Histone H4 lysine 16 acetylation regulates cellular lifespan

Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667

DNA Methylation Decreases in Aging But Not in Immortal Cells

Wilson, V. L., & Jones, P. A. (1983) · Science · doi:10.1126/science.6844925 · Cited by 654

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

Vingtdeux, V., Giliberto, L., Zhao, H., Chandakkar, P., Wu, Q., Simon, J. E., Janle, E. M., Lobo, J., Ferruzzi, M. G., Davies, P. J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.060061 · Cited by 654

FOXO transcription factors: key regulators of cellular quality control

Webb, A. E., & Brunet, A. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.003 · Cited by 649

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

Ben-Zvi, A., Miller, E. A., & Morimoto, R. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902882106 · Cited by 649

AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

Um, J.-H., Park, S.-J., Kang, H., Yang, S., Foretz, M., McBurney, M. W., Kim, M. K., Viollet, B., & Chung, J. H. (2010) · Diabetes · doi:10.2337/db09-0482 · Cited by 647

Administration of resveratrol: What formulation solutions to bioavailability limitations?

Amri, A., Chaumeil, J. C., Sfar, S., & Charrueau, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.083 · Cited by 647

Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1

Westerheide, S. D., Anckar, J., Stevens, S. M., Sistonen, L., & Morimoto, R. I. (2009) · Science · doi:10.1126/science.1165946 · Cited by 639

Calorie restriction extends yeast life span by lowering the level of NADH

Lin, S.-J., Ford, E., Haigis, M., Liszt, G., & Guarente, L. (2004) · Genes & Development · doi:10.1101/gad.1164804 · Cited by 632

Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction

Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J. T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602909200 · Cited by 626

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

Morselli, E., Maiuri, M. C., Markaki, M., Megalou, E., Pasparaki, A., Palikaras, K., Criollo, A., Galluzzi, L., Malik, S. A., Vitale, I., et al. (2010) · Cell Death & Disease · doi:10.1038/cddis.2009.8 · Cited by 613

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

Greer, E. L., & Brunet, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00459.x · Cited by 591

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

Hubbard, B. P., & Sinclair, D. A. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.12.004 · Cited by 588

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

Barger, J. L., Kayo, T., Vann, J. M., Arias, E. B., Wang, J., Hacker, T. A., Wang, Y., Raederstorff, D., Morrow, J. D., Leeuwenburgh, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002264 · Cited by 580

The central role of glutathione in the pathophysiology of human diseases

Franco, R., Schoneveld, O., Pappa, A., & Panayiotidis, M. I. (2007) · Archives of Physiology and Biochemistry · doi:10.1080/13813450701661198 · Cited by 554

Biochemistry and biology of mammalian DNA methyltransferases

Hermann, A., Gowher, H., & Jeltsch, A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4201-1 · Cited by 553

α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

Kontopoulos, E., Parvin, J. D., & Feany, M. Β. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl243 · Cited by 553

Environmental enrichment strengthens corticocortical interactions and reduces amyloid-β oligomers in aged mice

Mainardi, M., Garbo, A. D., Caleo, M., Berardi, N., Sale, A., & Maffei, L. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00001 · Cited by 550

Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging

Liu, L., Cheung, T. H., Charville, G. W., Hurgo, B. M. C., Leavitt, T., Shih, J., Brunet, A., & Rando, T. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.043 · Cited by 544

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature · doi:10.1038/nature09195 · Cited by 543

The Impact of Nutrition and Environmental Epigenetics on Human Health and Disease

Tiffon, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113425 · Cited by 534

Resveratrol protects against global cerebral ischemic injury in gerbils

Wang, Q., Xu, J., Rottinghaus, G. E., Simonyi, Á., Lubahn, D. E., Sun, G. Y., & Sun, A. Y. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03543-6 · Cited by 528

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

Parker, J. A., Arango-Lievano, M., Abderrahmane, S., Lambert, E., Tourette, C., Catoire, H., & Néri, C. (2005) · Nature Genetics · doi:10.1038/ng1534 · Cited by 518

SIRT1 in Neurodevelopment and Brain Senescence

Herskovits, A. Z., & Guarente, L. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.028 · Cited by 504

Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

Tsujikawa, H., Kurotaki, Y., Fujimori, T., Fukuda, K., & Nabeshima, Y. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0048 · Cited by 501

Transgenerational response to nutrition, early life circumstances and longevity

Kaati, G., Bygren, L. O., Pembrey, M., & Sjöström, M. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201832 · Cited by 500

Apoptotic cell: linkage of inflammation and wound healing

Wu, Y.-S., & Chen, S.-N. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00001 · Cited by 500

Genetics of longevity in model organisms: debates and paradigm shifts

Gems, D., & Partridge, L. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183712 · Cited by 499

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

Wu, Y., Li, X., Zhu, J. X., Xie, W., Le, W., Fan, Z., Jankovic, J. J., & Pan, T. (2011) · Neurosignals · doi:10.1159/000328516 · Cited by 496

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

Karuppagounder, S. S., Pinto, J. T., Xu, H., Chen, H., Beal, M. F., & Gibson, G. E. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.008 · Cited by 495

Nutraceutical Antioxidants as Novel Neuroprotective Agents

Kelsey, N. A., Wilkins, H., & Linseman, D. A. (2010) · Molecules · doi:10.3390/molecules15117792 · Cited by 488

MicroRNAs in cardiovascular disease: an introduction for clinicians

Romaine, S. P. R., Tomaszewski, M., Condorelli, G., & Samani, N. J. (2015) · Heart · doi:10.1136/heartjnl-2013-305402 · Cited by 479

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

Tan, J. M. M., Wong, E. S. P., Kirkpatrick, D. S., Pletniková, O., Ko, H. S., Tay, S.-P., Ho, M. W. L., Troncoso, J. C., Gygi, S. P., Lee, M. K., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm320 · Cited by 457

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

Witte, A. V., Kerti, L., Margulies, D. S., & Floel, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0385-14.2014 · Cited by 455

A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans

Boehm, M., & Slack, F. J. (2005) · Science · doi:10.1126/science.1115596 · Cited by 451

MicroRNAs in Cardiovascular Disease

Barwari, T., Joshi, A., & Mayr, M. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.09.945 · Cited by 449

Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?

Saiko, P., Szakmary, A., Jaeger, W., & Szekeres, T. (2007) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2007.08.004 · Cited by 448

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., & Partridge, L. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.07.007 · Cited by 447

An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells

Lukiw, W. J., Zhao, Y., & Cui, J. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805371200 · Cited by 441

Elevated histone expression promotes life span extension

Feser, J., Truong, D., Das, C., Carson, J. J., Kieft, J., Harkness, T., & Tyler, J. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.015 · Cited by 435

Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells

Chen, C.-Y., Jang, J.-H., Li, M.-H., & Surh, Y.-J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.237 · Cited by 428

Pharmacokinetic and safety profile oftrans‐resveratrol in a rising multiple‐dose study in healthy volunteers

Almeida, L., Vaz‐da‐Silva, M., Falcão, A. C., Soares, E., Costa, R., Loureiro, A. I., Fernandes‐Lopes, C., Rocha, J., Nunes, T., Wright, L. C., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800177 · Cited by 427

CpG and non-CpG methylation in epigenetic gene regulation and brain function

Jang, H., Shin, W., Lee, J., & Do, J. (2017) · Genes · doi:10.3390/genes8060148 · Cited by 427

Resveratrol Mitigates Lipopolysaccharide- and Aβ-Mediated Microglial Inflammation by Inhibiting the TLR4/NF-Κb/STAT Signaling cascade

Capiralla, H., Vingtdeux, V., Zhao, H., Sankowski, R., Al‐Abed, Y., Davies, P., & Marambaud, P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07594.x · Cited by 426

Neuroprotective action of resveratrol

Bastianetto, S., Ménard, C., & Quirion, R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.09.011 · Cited by 423

Resveratrol regulates microglia M1/M2 polarization via PGC-1α in conditions of neuroinflammatory injury

Yang, X., Xu, S., Qian, Y., & Xiao, Q. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.03.003 · Cited by 421

A Role for SIR-2.1 Regulation of ER Stress Response Genes in Determining C. elegans Life Span

Viswanathan, M., Kim, S. K., Berdichevsky, A., & Guarente, L. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.017 · Cited by 420

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

O'Sullivan, R. J., Kubicek, S., Schreiber, S. L., & Karlseder, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1897 · Cited by 416

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation

Kennedy, D. O., Wightman, E. L., Reay, J. L., Lietz, G., Okello, E. J., Wilde, A., & Haskell, C. F. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28641 · Cited by 415

Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation

Cropley, J. E., Suter, C. M., Beckman, K. B., & Martin, D. I. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607090103 · Cited by 403

Role of resveratrol in regulation of cellular defense systems against oxidative stress

Truong, V., Jun, M., & Jeong, W. (2017) · BioFactors · doi:10.1002/biof.1399 · Cited by 402

Caloric restriction, SIRT1 and longevity

Cantó, C., & Auwerx, J. (2009) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.03.008 · Cited by 395

Protective effect of resveratrol on β-amyloid-induced oxidative PC12 cell death

Jang, J.-H. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00062-5 · Cited by 391

Cohort Profile: The Dutch Hunger Winter Families Study

Lumey, L., Stein, A. D., Kahn, H. S., van der Pal-de Bruin, K. M., Blauw, G., Zybert, P. A., & Susser, E. S. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym126 · Cited by 385

Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats

Jin, F. J., Wu, Q., Lu, Y., Gong, Q., & Shi, J. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.10.005 · Cited by 384

One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease

Tomé‐Carneiro, J., Larrosa, M., Yáñez-Gascón, M. J., Dávalos, A., Gil‐Zamorano, J., Gonzálvez, M., García‐Almagro, F. J., Ros, J. A. R., Tomás-Barberán, F. A., Espı́n, J. C., et al. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.03.011 · Cited by 384

Aβ inhibits the proteasome and enhances amyloid and tau accumulation

Tseng, B. P., Green, K. N., Chan, J. L., Blurton-Jones, M., & LaFerla, F. M. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.014 · Cited by 384

Correction: Corrigendum: Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

Hashizume, O., Ohnishi, S., Mito, T., Shimizu, A., Ishikawa, K., Nakada, K., Soda, M., Mano, H., Togayachi, S., Miyoshi, H., et al. (2015) · Scientific Reports · doi:10.1038/srep14591 · Cited by 381

Resveratrol Attenuates Obesity-Associated Peripheral and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet

Jeon, B. T., Jeong, E. A., Shin, H. J., Lee, Y., Lee, D. H., Kim, H. J., Kang, S. S., Cho, G. J., Choi, W. S., & Roh, G. S. (2012) · Diabetes · doi:10.2337/db11-1498 · Cited by 366

Protein Quality Control by Molecular Chaperones in Neurodegeneration

Ciechanover, A. J., & Kwon, Y. T. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00185 · Cited by 366

Genomic DNA methylation decreases in response to moderate folate depletion in elderly women

Rampersaud, G. C., KAUWELL, G. P. A., Hutson, A. D., Cerda, J. J., & Bailey, L. B. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.4.998 · Cited by 365

Naturally occurring phytochemicals for the prevention of Alzheimer’s disease

Kim, J., Lee, H. J., & Lee, K. W. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06562.x · Cited by 361

Grape-Derived Polyphenolics Prevent A Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

Wang, J., Ho, L., Zhao, W., Ono, K., Rosensweig, C., Chen, L., Humala, N., Teplow, D. B., & Pasinetti, G. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0364-08.2008 · Cited by 360

Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats

Sinha, K., Chaudhary, G., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01691-0 · Cited by 356

Decreased birthweights in infants after maternal in utero exposure to the Dutch famine of 1944–1945

Lumey, L. H. (1992) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.1992.tb00764.x · Cited by 343

Enhancing the bioavailability of resveratrol by combining it with piperine

Johnson, J. J., Nihal, M., Siddiqui, I. A., Scarlett, C. O., Bailey, H. H., Mukhtar, H., & Ahmad, N. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100117 · Cited by 340

Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases

Sun, A. Y., Wang, Q., Simonyi, Á., & Sun, G. Y. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8111-y · Cited by 335

MicroRNAs (miRNAs) in Neurodegenerative Diseases

Nelson, P. T., Wang, W., & Rajeev, B. W. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00120.x · Cited by 335

MicroRNAs and their roles in aging

Smith-Vikos, T., & Slack, F. J. (2012) · Journal of Cell Science · doi:10.1242/jcs.099200 · Cited by 333

Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets

Kameswaran, V., Bramswig, N. C., McKenna, L. B., Penn, M. M. C., Schug, J., Hand, N. J., Chen, Y., Choi, I., Vourekas, A., Won, K., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.016 · Cited by 324

Nutritional influences on brain development

Georgieff, M., Ramel, S. E., & Cusick, S. E. (2018) · Acta Paediatrica · doi:10.1111/apa.14287 · Cited by 323

Edible flowers: A review of the nutritional, antioxidant, antimicrobial properties and effects on human health

Fernandes, L., Casal, S. I. P., Pereira, J. A., Saraiva, J. A., & Ramalhosa, E. (2017) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2017.03.017 · Cited by 321

Resveratrol nanoformulations: Challenges and opportunities

Summerlin, N., Soo, E., Thakur, S. S., Qu, Z., Jambhrunkar, S., & Popat, A. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.01.003 · Cited by 319

Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein 1

Shiraki-Iida, T., Aizawa, H., Matsumura, Y., Sekine, S., Iida, A., Anazawa, H., Nagai, R., Kuro‐o, M., & Nabeshima, Y.-I. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00127-6 · Cited by 313

Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease

Choi, D., Lee, Y., Hong, J. T., & Lee, H. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.11.014 · Cited by 311

Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseases

Alexander, A. G., Marfil, V., & Li, C. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00279 · Cited by 310

Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers

Ladiwala, A. R. A., Lin, J. C., Bale, S. S., Marcelino, A. M. C., Bhattacharya, M., Dordick, J. S., & Tessier, P. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.133108 · Cited by 306

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

Feng, Y. N., Wang, X., Yang, S., Wang, Y., Zhang, X., Du, X., Sun, X., Zhao, M., Huang, L., & Liu, R. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.08.013 · Cited by 306

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

Li, Y., Xu, S., Giles, A. J., Nakamura, K., Lee, J. W., Hou, X., Dönmez, G., Li, J., Luo, Z., Walsh, K. X., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-173492 · Cited by 305

Food for thought: how nutrition impacts cognition and emotion

Spencer, S. J., Kőrösi, A., Layé, S., Shukitt‐Hale, B., & Barrientos, R. M. (2017) · npj Science of Food · doi:10.1038/s41538-017-0008-y · Cited by 304

Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide‐related toxicity in cultured hippocampal neurons

Bastianetto, S., Zheng, W., & Quirion, R. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703626 · Cited by 302

Neuroprotective effects of resveratrol against β‐amyloid‐induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C

Han, Y.-S., Zheng, W., Bastianetto, S., Chabot, J., & Quirion, R. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705688 · Cited by 300

Moderate consumption of Cabernet Sauvignon attenuates A� neuropathology in a mouse model of Alzheimer's disease

Wang, J., Ho, L., Zhao, Z., Seror, I., Humala, N., Dickstein, D. L., Thiyagarajan, M., Percival, S. S., Talcott, S. T., & Pasinetti, G. M. (2006) · The FASEB Journal · doi:10.1096/fj.06-6281com · Cited by 299

Sensory receptors—design principles revisited

Wicher, D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00001 · Cited by 296

Are mitochondria critical in the pathogenesis of Alzheimer's disease?

Reddy, P. H., & Beal, M. F. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.03.004 · Cited by 294

The Daily Oral Administration of High Doses of trans-Resveratrol to Rats for 28 Days Is Not Harmful

Juan, M. E., Vinardell, M. P., & Planas, J. M. (2002) · Journal of Nutrition · doi:10.1093/jn/132.2.257 · Cited by 293

MicroRNAs Both Promote and Antagonize Longevity in C. elegans

de Lencastre, A., Pincus, Z., Zhou, K. I., Kato, M., Lee, S. S., & Slack, F. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.11.015 · Cited by 292

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

McCubrey, J. A., Lertpiriyapong, K., Steelman, L. S., Abrams, S. L., Yang, L. V., Murata, R. M., Rosalen, P. L., Scalisi, A., Neri, L. M., Cocco, L., et al. (2017) · Aging · doi:10.18632/aging.101250 · Cited by 292

Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4).

Spanier, G., Xu, H., Xia, N., Tobias, S., Deng, S., Wojnowski, L., Förstermann, U., & Li, H. (2009) · PubMed · Cited by 288

Resveratrol for Alzheimer's disease

Sawda, C. N., Moussa, C., & Turner, R. S. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13431 · Cited by 287

I’m Eating for Two: Parental Dietary Effects on Offspring Metabolism

Rando, O. J., & Simmons, R. A. (2015) · Cell · doi:10.1016/j.cell.2015.02.021 · Cited by 285

Polyphenols, food and pharma. Current knowledge and directions for future research

Tresserra‐Rimbau, A., Lamuela-Raventós, R. M., & Moreno, J. J. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.050 · Cited by 281

Lifespan and healthspan extension by resveratrol

Bhullar, K. S., & Hubbard, B. P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.01.012 · Cited by 278

Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD

Tili, E., Michaille, J., Adair, B., Alder, H., Limagne, E., Taccioli, C., Ferracin, M., Delmas, D., Latruffe, N., & Croce, C. M. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq143 · Cited by 275

Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia

Bi, X. L., Yang, J., Dong, Y. X., Wang, J., Cui, Y. H., Ikeshima, T., Zhao, Y. Q., & Wu, C. F. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.08.008 · Cited by 274

Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells

Huang, Y., Chávez, L., Chang, X., Wang, X., Pastor, W. A., Kang, J., Zepeda-Martínez, J. A., Pape, U. J., Jacobsen, S. E., Peters, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322921111 · Cited by 272

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

Porquet, D., Casadesús, G., Bayod, S., Vicente, A., Canudas, A. M., Vilaplana, J., Pelegrı́, C., Sanfeliu, C., Camins, A., Pallàs, M., et al. (2012) · AGE · doi:10.1007/s11357-012-9489-4 · Cited by 272

Anti-inflammatory activities of resveratrol in the brain: Role of resveratrol in microglial activation

Zhang, F., Liu, J., & Shi, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.03.043 · Cited by 270

The emerging role of microRNAs in Alzheimer's disease

Femminella, G. D., Ferrara, N., & Rengo, G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00040 · Cited by 270

The microbiome, immunity, and schizophrenia and bipolar disorder.

Dickerson, F., Severance, E., & Yolken, R. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.010 · Cited by 268 · cited 1×

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease

Seo, E.-J., Fischer, N., & Efferth, T. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.11.030 · Cited by 265 · cited 1×

The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy

Wu, M., Yiang, G., Lai, T.-T., & Li, C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3420187 · Cited by 264

The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide

Albani, D., Polito, L., Batelli, S., Mauro, S. D., Fracasso, C., Martelli, G., Colombo, L., Manzoni, C., Salmona, M., Caccia, S., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06228.x · Cited by 263

The involvement of microRNAs in neurodegenerative diseases

Maciotta, S., Meregalli, M., & Torrente, Y. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00265 · Cited by 260

Ageing and neurodegenerative diseases

Hung, C.-W., Chen, Y., Hsieh, W.-L., Chiou, S., & Kao, C.-L. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.006 · Cited by 257

Oxidative stress in vascular dementia and Alzheimer’s disease: a common pathology

Bennett, S., Grant, M. M., & Aldred, S. (2008) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1041 · Cited by 254

The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system

Kietzmann, T., Petry, A., Shvetsova, A., Gerhold, J. M., & Görlach, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13792 · Cited by 253

Postsynthetic Trimethylation of Histone H4 at Lysine 20 in Mammalian Tissues Is Associated with Aging

Sarg, B., Koutzamani, E., Helliger, W., Rundquist, I., & Lindner, H. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205166200 · Cited by 252

Neuroprotective effects of resveratrol in Alzheimer disease pathology

Rege, S. D., Geetha, T., Griffin, G. D., Broderick, T. L., & Babu, J. R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00218 · Cited by 250

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Santoro, A., Ostan, R., Candela, M., Biagi, E., Brigidi, P., Capri, M., & Franceschi, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2674-y · Cited by 250

Regulation of CCL2 and CCL3 expression in human brain endothelial cells by cytokines and lipopolysaccharide

Chui, R. W., & Dorovini‐Zis, K. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-1 · Cited by 249

DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy

Lin, Q., Weidner, C. I., Costa, I. G., Marioni, R. E., Ferreira, M. R. P., Deary, I. J., & Wagner, W. (2016) · Aging · doi:10.18632/aging.100908 · Cited by 247

Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment

Pasinetti, G. M., Wang, J., Ho, L., Zhao, W., & Dubner, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.006 · Cited by 244

Understanding microRNAs in neurodegeneration

Eacker, S. M., Dawson, T. M., & Dawson, V. L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2726 · Cited by 239

Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats

Virgili, M., & Contestabile, A. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00820-x · Cited by 234

An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster

Bauer, J. H., Goupil, S., Garber, G. B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403493101 · Cited by 234

Making Sense of … the Microbiome in Psychiatry

Bastiaanssen, T. F. S., Cowan, C. S. M., Claesson, M. J., Dinan, T. G., & Cryan, J. F. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy067 · Cited by 234

MicroRNAs - Biology and clinical applications

Ranganathan, K., & Sivasankar, V. (2014) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/0973-029x.140762 · Cited by 231

Rapid changes in Atlantic grey seal milk from birth to weaning – immune factors and indicators of metabolic strain

Lowe, A. D., Bawazeer, S., Watson, D. G., McGill, S., Burchmore, R., Pomeroy, P. P., & Kennedy, M. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-16187-7 · Cited by 231

The Neuroprotective Effect of Klotho is Mediated via Regulation of Members of the Redox System

Zeldich, E., Chen, C.-D., Colvin, T. A., Bove‐Fenderson, E., Liang, J. J., Zhou, T. B. T., Harris, D. A., & Abraham, C. R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.567321 · Cited by 229

Nutrition and the Risk of Alzheimer's Disease

Hu, N., Yu, J., Tan, L., Wang, Y., Sun, L., & Tan, L. (2013) · BioMed Research International · doi:10.1155/2013/524820 · Cited by 228

Oxidative Stress and Epigenetic Regulation in Ageing and Age-Related Diseases

Cencioni, C., Spallotta, F., Martelli, F., Valente, S., Mai, A., Zeiher, A. M., & Gaetano, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917643 · Cited by 227

Mechanisms of Mitochondrial Dysfunction in Alzheimer’s Disease

Cadonic, C., Sabbir, M. G., & Albensi, B. C. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9515-5 · Cited by 226

Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

Pajares, M., Cuadrado, A., & Rojo, A. I. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.006 · Cited by 226

Resveratrol and Brain Mitochondria: a Review

Jardim, F. R., de Rossi, F. T., Nascimento, M. X., Barros, R. G. D. S., Borges, P. A., Prescilio, I. C., & de Oliveira, M. R. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0448-z · Cited by 225

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638

Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases

Jiang, S., Liu, H., & Li, C. (2021) · Foods · doi:10.3390/foods10081854 · Cited by 241

Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

Migliore, L., & Coppedè, F. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00714-w · Cited by 217

Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

Feng, J., Zheng, Y., Guo, M., Arés, I., Martínez, M., López-Torres, B., Martínez‐Larrañaga, M., Wang, X., Anadón, A., & Martínez, M. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.07.010 · Cited by 187

Antioxidants and Reactive Oxygen Species: Shaping Human Health and Disease Outcomes

Manful, C. F., Fordjour, E., Subramaniam, D., Sey, A. A., Abbey, L., & Thomas, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157520 · Cited by 193

Therapeutic effects of resveratrol on epigenetic mechanisms in age‐related diseases: A comprehensive review

Zhang, S., & Kiarasi, F. (2024) · Phytotherapy Research · doi:10.1002/ptr.8176 · Cited by 35

Effects of Resveratrol and Other Polyphenols on the Most Common Brain Age-Related Diseases

Sarubbo, F., Moranta, D., Asensio, V. J., Miralles, A., & Esteban, S. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170724102743 · Cited by 71

Dietary antioxidants, epigenetics, and brain aging: A focus on resveratrol

Griñán‐Ferré, C., Izquierdo, V., & Pallàs, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817780-8.00022-0 · Cited by 3

Neuroprotective action of resveratrol

Bastianetto, S., Ménard, C., & Quirion, R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.09.011 · Cited by 423

Chronic resveratrol administration reduces oxidative stress and brain cell loss and improves memory of recognition in old rats

Juárez-Serrano, D., Arteaga, I. C., Cortes, H., Vázquez‐Roque, R. A., López‐López, G., Flores, G., Treviño, S., Guevara, J., & Díaz, A. (2023) · Synapse · doi:10.1002/syn.22271 · Cited by 22