The DOI matches its Crossref record; 473 of the 483 references it cites were found in a registry or an index.
The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy
Open accessAbstract
While the elderly segment of the population continues growing in importance, neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition, exercise, and education, among others, influence ageing progression, throughout life. Notably, the Central Nervous System (CNS) can benefit from nutritional strategies and dietary interventions that prevent signs of senescence, such as cognitive decline or neurodegenerative diseases such as Alzheimer's disease and Parkinson's Disease. The dietary polyphenol Resveratrol (RV) possesses antioxidant and cytoprotective effects, producing neuroprotection in several organisms. The oxidative stress (OS) occurs because of Reactive oxygen species (ROS) accumulation that has been proposed to explain the cause of the ageing. One of the most harmful effects of ROS in the cell is DNA damage. Nevertheless, there is also evidence demonstrating that OS can produce other molecular changes such as mitochondrial dysfunction, inflammation, apoptosis, and epigenetic modifications, among others. Interestingly, the dietary polyphenol RV is a potent antioxidant and possesses pleiotropic actions, exerting its activity through various molecular pathways. In addition, recent evidence has shown that RV mediates epigenetic changes involved in ageing and the function of the CNS that persists across generations. Furthermore, it has been demonstrated that RV interacts with gut microbiota, showing modifications in bacterial composition associated with beneficial effects. In this review, we give a comprehensive overview of the main mechanisms of action of RV in different experimental models, including clinical trials and discuss how the interconnection of these molecular events could explain the neuroprotective effects induced by RV.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Prevention of cognitive decline and cellular neurodegeneration has been related to the antioxidant properties of resveratrol (Grinan-Ferre et al. 2021).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Grinan-Ferre et al. 2021
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Oxidative stress, aging, and diseases
Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s158513 · Cited by 3,979
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958
Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9498 · Cited by 3,942
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Research works printed but not linked: 5
- Berger, 2009, An operational definition of epigenetics an operational definition of epigenetics an operational definition of epigenetics, DNA Seq., 23
- Berman, 2017, The therapeutic potential of resveratrol: a review of clinical trials. Npj Precis, Oncol., 1
- Gaballah, 2016, Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson’s disease, Chem. Biol. Interact., 251, 10, 10.1016/j.cbi.2016.03.023 · DOI
- López-Otín, 2013, The hallmarks of aging, Cell, 10.1016/j.cell.2013.05.039 · DOI · Paper page
- Zhao, 2013, Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway, Biochem. Biophys. Res. Commun., 435, 597, 10.1016/j.bbrc.2013.05.025 · DOI
Cited by
Sorted by citations
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases
Jiang, S., Liu, H., & Li, C. (2021) · Foods · doi:10.3390/foods10081854 · Cited by 241
Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
Migliore, L., & Coppedè, F. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00714-w · Cited by 217
Feng, J., Zheng, Y., Guo, M., Arés, I., Martínez, M., López-Torres, B., Martínez‐Larrañaga, M., Wang, X., Anadón, A., & Martínez, M. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.07.010 · Cited by 187
Antioxidants and Reactive Oxygen Species: Shaping Human Health and Disease Outcomes
Manful, C. F., Fordjour, E., Subramaniam, D., Sey, A. A., Abbey, L., & Thomas, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157520 · Cited by 193
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145
Antioxidant Therapeutic Strategies in Neurodegenerative Diseases
Morén, C., deSouza, R. M., Giraldo, D. M., & Uff, C. E. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169328 · Cited by 129
Zhang, H., Wang, Y., Wang, Y., Li, X., Wang, S., & Wang, Z. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114606 · Cited by 111
Yang, L., Wang, Y., Li, Z., Wu, X., Mei, J., & Zheng, G. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120714 · Cited by 106
Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis
López-Armada, M. J., Fernández-Rodríguez, J. A., & Blanco, F. J. (2022) · Antioxidants · doi:10.3390/antiox11061151 · Cited by 118
Üremiş, N., & Üremi̇ş, M. M. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70133 · Cited by 103
Velásquez-Jiménez, D., Corella‐Salazar, D. A., Zuñiga-Martínez, B. S., Domínguez-Avila, J. A., Montiel‐Herrera, M., Salazar‐López, N. J., Rodrigo-García, J., Villegas‐Ochoa, M. A., & González-Aguilar, G. A. (2021) · Food & Function · doi:10.1039/d1fo02017j · Cited by 83
Shaito, A. A., Al‐Mansoob, M., Ahmad, S. M. S., Haider, M. Z., Eid, A. H., Posadino, A. M., Pintus, G., & Giordo, R. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666221012122855 · Cited by 88
Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy
Zhang, S., Meng, Y., Zhou, L., Qiu, L., Wang, H., Su, D., Zhang, B., Chan, K. M., & Han, J. (2022) · MedComm · doi:10.1002/mco2.173 · Cited by 85
Xu, W., Zheng, H., Fu, Y., Gu, Y., Zou, H., Yuan, Y., Gu, J., Liu, Z., & Bian, J. (2022) · Toxins · doi:10.3390/toxins14110733 · Cited by 77
Phytochemicals as Regulators of Genes Involved in Synucleinopathies
Surguchov, A. P., Bernal, L., & Surguchev, A. A. (2021) · Biomolecules · doi:10.3390/biom11050624 · Cited by 77
Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding
Grant, W. B., & Blake, S. M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230418 · Cited by 82
Liu, X., Liu, Y., Liu, J., Zhang, H., Shan, C., Guo, Y., Gong, X., Cui, M., Li, X., & Tang, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382223 · Cited by 75
The hormesis principle of neuroplasticity and neuroprotection
Mattson, M. P., & Leak, R. K. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.022 · Cited by 77
Abbas, H., Refai, H., Sayed, N. S. E., Rashed, L., Mousa, M. H., & Zewail, M. (2021) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2021.121244 · Cited by 58
Resveratrol—A Promising Therapeutic Agent with Problematic Properties
Radeva, L., & Yoncheva, K. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17010134 · Cited by 67
The Tragedy of Alzheimer’s Disease: Towards Better Management via Resveratrol-Loaded Oral Bilosomes
Abbas, H., Gad, H. A., Khattab, M. A., & Mansour, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101635 · Cited by 62
Prasanth, M. I., Sivamaruthi, B. S., Cheong, C. S. Y., Verma, K., Tencomnao, T., Brimson, J. M., & Prasansuklab, A. (2024) · Antioxidants · doi:10.3390/antiox13050606 · Cited by 65
Warren, A., Nyavor, Y., Zarabian, N., Mahoney, A., & Frame, L. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1365673 · Cited by 64
Bartra, C., Yuan, Y., Vuraić, K., Valdés-Quiroz, H., Garcia-Baucells, P., SLEVIN, M. A., Pastorello, Y., Sunol, C. E., & Sanfeliu, C. (2024) · Antioxidants · doi:10.3390/antiox13020177 · Cited by 58
Self-citationWang, H., Liu, Y., Li, J., Wang, T., Hei, Y., Li, H., Wang, X., Wang, L., Zhao, R., Baskys, A., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00620-y · Cited by 56
New Mechanisms of Action of Natural Antioxidants in Health and Disease
Hrelia, S., & Angeloni, C. (2020) · Antioxidants · doi:10.3390/antiox9040344 · Cited by 55
Copper, Iron, Selenium and Lipo-Glycemic Dysmetabolism in Alzheimer’s Disease
Aaseth, J., Skalny, A. V., Roos, P. M., Alexander, J., Aschner, M., & Tinkov, A. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179461 · Cited by 58
Oxidative Stress in Tauopathies: From Cause to Therapy
Bartolomé, F. B., Carro, E., & Alquézar, C. (2022) · Antioxidants · doi:10.3390/antiox11081421 · Cited by 59
Phenolic Characterization and Neuroprotective Properties of Grape Pomace Extracts
Chiavaroli, A., Balaha, M. F., Acquaviva, A., Ferrante, C., Cataldi, A., Menghini, L., Rapino, M., Orlando, G., Brunetti, L., Leone, S., et al. (2021) · Molecules · doi:10.3390/molecules26206216 · Cited by 52
Dietary Polyphenols as Anti-Aging Agents: Targeting the Hallmarks of Aging
Liu, Y., Fang, M., Tu, X., Mo, X., Zhang, L., Yang, B., Wang, F., Kim, Y., Huang, C., Chen, L., et al. (2024) · Nutrients · doi:10.3390/nu16193305 · Cited by 62
Webber, E. K., Fivaz, M., Stutzmann, G. E., & Griffioen, G. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13065 · Cited by 50
Chen, Z., Wang, X., Du, S., Liu, Q., Xu, Z., Guo, Y., & Lin, X. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00900-6 · Cited by 59
Terracina, S. A., Petrella, C., Francati, S., Lucarelli, M., Barbato, C., Minni, A., Ralli, M., Greco, A., Tarani, L., Fiore, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415674 · Cited by 56
Li, J., Long, Q., Ding, H., Wang, Y., Luo, D., Li, Z., & Zhang, W. (2024) · Advanced Science · doi:10.1002/advs.202308677 · Cited by 47
Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging
Uddin, M. J., Farjana, M., Moni, A., Hossain, K. S., Hannan, M. A., & Ha, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158258 · Cited by 49
Roles of physical exercise in neurodegeneration: reversal of epigenetic clock
Xu, M., Zhu, J., Liu, X.-D., Luo, M.-Y., & Xu, N.-J. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00254-1 · Cited by 46
Martins, M. M., Branco, P. S., & Ferreira, L. M. (2023) · ChemistrySelect · doi:10.1002/slct.202300461 · Cited by 50
Artificial intelligence for dementia prevention
Newby, D., Orgeta, V., Marshall, C. R., Lourida, I., Albertyn, C. P., Tamburin, S., Raymont, V., Veldsman, M., Koychev, I., Bauermeister, S., et al. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13463 · Cited by 42
Insulin resistance in Alzheimer’s disease: The genetics and metabolomics links
Amin, A. M., Mostafa, H. M. A., & Khojah, H. M. J. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.12.016 · Cited by 45
Wang, X., Gao, M., Lu, X., Lei, Y., Sun, J., Ren, M., Xu, T., & Lin, H. (2024) · Journal of Environmental Management · doi:10.1016/j.jenvman.2024.123235 · Cited by 42
Resveratrol as a Therapeutic Agent in Alzheimer’s Disease: Evidence from Clinical Studies
Puranik, N., Kumari, M., Tiwari, S., Dhakal, T., & Song, M. (2025) · Nutrients · doi:10.3390/nu17152557 · Cited by 48
Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review
Jalili, C., Kiani, A., Gholami, M., Bahrehmand, F., Fakhri, S., Kakehbaraei, S., & Kakebaraei, S. (2023) · IET Nanobiotechnology · doi:10.1049/nbt2.12127 · Cited by 43
Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future
Ziętara, P., Dziewięcka, M., & Augustyniak, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010728 · Cited by 40
Therapeutic Potential of Targeting Mitochondria for Alzheimer’s Disease Treatment
Atlante, A., Amadoro, G., Latina, V., & Valenti, D. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226742 · Cited by 40
Tao, J., An, Y., Xu, L., Wang, Y., Wang, C., Li, P., Li, M., Yan, D., Wang, M., Zhong, G., et al. (2023) · Food & Function · doi:10.1039/d2fo03379h · Cited by 39
Mani, S., Dubey, R., Lai, I., Babu, M. A., Tyagi, S., Swargiary, G., Mody, D., Singh, M., Agarwal, S., Iqbal, D., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220700 · Cited by 43
Influence of human gut microbiome on the healthy and the neurodegenerative aging
Borrego-Ruiz, A., & Borrego, J. J. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112497 · Cited by 43
Interplay between Phytochemicals and the Colonic Microbiota
Kwon, C., Ediriweera, M. K., & Cho, S. K. (2023) · Nutrients · doi:10.3390/nu15081989 · Cited by 46
Resveratrol has an Overall Neuroprotective Role in Ischemic Stroke: A Meta-Analysis in Rodents
Liu, J., He, J., Huang, Y., & Hu, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.795409 · Cited by 36
Song, Z., Cheng, L., Liu, Y., Zhan, S., Wu, Z., & Zhang, X. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.10.019 · Cited by 37
Guan, Y., Li, L., Yang, R., Lü, Y., & Tang, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06605-0 · Cited by 41
Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease
Miziak, B., Błaszczyk, B., & Czuczwar, S. J. (2021) · Pharmaceuticals · doi:10.3390/ph14050458 · Cited by 35
Albanawany, N. M., Samy, D. M., Zahran, N. M., El‐Moslemany, R. M., Elsawy, S. M., & Nazel, M. W. A. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2105445 · Cited by 35
Ткаченко, Г. М., Buyun, L., Kołodziejska, R., Kamiński, P., & Kurhaluk, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188907 · Cited by 40
Uceda, S., Echeverry‐Alzate, V., Reiriz, M., Miguel, E. M., Pérez-Curiel, A., Gómez-Senent, S., & Beltrán-Velasco, A. I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713294 · Cited by 36
Nanocarriers for natural polyphenol senotherapeutics
Joma, N., Bielawski, P., Saini, A., Kakkar, A. K., & Maysinger, D. (2024) · Aging Cell · doi:10.1111/acel.14178 · Cited by 33
Shen, Y., Jiang, Y., Zhang, S., Zou, J., Gao, X., Song, Y., Zhang, Y., Hu, Y. P., Huang, Y., & Jiang, Q. (2022) · Foods · doi:10.3390/foods11040598 · Cited by 31
Joseph, A., Balakrishnan, A., Shanmughan, P., Maliakel, B. P., & Krishnakumar, I. M. (2022) · ACS Omega · doi:10.1021/acsomega.2c00116 · Cited by 31
Li, Z., Zhao, T., Shi, M., Wei, Y., Huang, X., Shen, J., Zhang, X., Xie, Z., Huang, P., Yuan, K., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1139558 · Cited by 33
Zhu, W. T., Zeng, X. F., Yang, H., Jia, M. L., Zhang, W., Liu, W., & Liu, S. Y. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s398046 · Cited by 30
Abtahi, N. A., Naghib, S. M., Haghiralsadat, F., Reza, J. Z., Hakimian, F., Yazdian, F. A., & Tofighi, D. (2021) · Nanotechnology Reviews · doi:10.1515/ntrev-2021-0119 · Cited by 31
Kang, N., Shi, Y., Song, J., Gao, F., Fan, M., Jin, W., Gao, Y., & Lv, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.868484 · Cited by 29
Hu, Y., Guo, H., Cheng, S., Sun, J., Du, J., Liu, X., Xiong, Y., Chen, L., Liu, C., Wu, C., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s434873 · Cited by 28
Neuro-Nutraceutical Polyphenols: How Far Are We?
Gentile, M. T., Camerino, I., Ciarmiello, L. F., Woodrow, P., Muscariello, L., Chiara, I. D., & Pacifico, S. (2023) · Antioxidants · doi:10.3390/antiox12030539 · Cited by 27
The Role of Reactive Oxygen Species in Alzheimer's Disease: From Mechanism to Biomaterials Therapy
Yu, Z., & Luo, F. H. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304373 · Cited by 30
New Uses of Melatonin as a Drug; A Review
Pohanka, M. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220105115755 · Cited by 27
Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?
Hieber, C., Grabbe, S., & Bros, M. (2023) · Biomolecules · doi:10.3390/biom13071085 · Cited by 30
Socała, K., Żmudzka, E., Lustyk, K., Zagaja, M. P., Brighenti, V., Costa, A., Andres‐Mach, M., Pytka, K., Martinelli, I., Mandrioli, J., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8101 · Cited by 29
The dual role of cellular senescence in human tumor progression and therapy
Ma, L., Yu, J., Fu, Y., He, X., Ge, S., Jia, R., Zhuang, A., Yang, Z. H., & Fan, X. (2024) · MedComm · doi:10.1002/mco2.695 · Cited by 30
Mountaki, C., Dafnis, I., Panagopoulou, E. A., Vasilakopoulou, P. B., Karvelas, M., Chiou, A., Karathanos, V. Τ., & Chroni, A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.022 · Cited by 28
Lin, L., Li, C., Li, T., Zheng, J., Shu, Y., Zhang, J., Shen, Y., & Ren, D. (2023) · Food Frontiers · doi:10.1002/fft2.210 · Cited by 28
How can we modulate aging through nutrition and physical exercise? An epigenetic approach
Rajado, A. T., Silva, N., Esteves, F., Brito, D. V. C., Binnie, A., Araújo, I. M., Nóbrega, C., Bragança, J., & Castelo‐Branco, P. (2023) · Aging · doi:10.18632/aging.204668 · Cited by 32
Dhiman, S., Mannan, A., Taneja, A., Mohan, M., & Singh, T. G. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122537 · Cited by 25
Shi, J., Lai, Z., Zhou, W., Yang, H., Zhang, T., Sun, J., Zhao, J., & Li, M. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00220-3 · Cited by 27
Khishvand, M. A., Yeganeh, E. M., Zarei, M., Soleimani, M., Mohammadi, M., & Mahjub, R. (2024) · BioMed Research International · doi:10.1155/2024/7877265 · Cited by 22
Jin, L. J., Nie, L., Deng, Y., Khana, G. J., & He, N. (2025) · Cell Proliferation · doi:10.1111/cpr.13804 · Cited by 24
Xu, J., Liu, J., Mi, Y., Zhao, T., Mu, D., Meng, Q., Wang, F., Li, N., & Hou, Y. W. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01219 · Cited by 22
Huang, W., Yu, L., Cai, W., & Ma, C. (2022) · Planta Medica · doi:10.1055/a-1923-4399 · Cited by 22
Zhao, J., Ye, L., Liu, Z., Cui, Y., Deng, D., Bai, S., Yang, L., Shi, Y., Liu, Z., & Zhang, R. (2022) · Nutrients · doi:10.3390/nu14214542 · Cited by 25
Emerging antioxidant therapies in Friedreich’s ataxia
Edzeamey, F. J., Ramchunder, Z., Pourzand, C., & Virmouni, S. A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1359618 · Cited by 23
Yusoff, A. A. M., & Khair, S. Z. N. M. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0080 · Cited by 23
Li, S., Zhao, J., Xi, Y., Ren, J., Zhu, Y., Lu, Y., & Dong, D. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.371366 · Cited by 21
Zeng, J., Wang, Y., Zhu, M., Wu, M., Zhou, Y., Wang, Q., Xu, Y., Lin, F., Wang, J., Li, Y., et al. (2023) · FEBS Journal · doi:10.1111/febs.16928 · Cited by 20
Цейликман, В. Э., Tseilikman, O. B., Karpenko, M. N., Traktirov, D. S., Obukhova, D. A., Shatilov, V. A., Zhukov, M. S., Валерьевич, М. Г., Yegorov, O. N., Aristov, M. R., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12112455 · Cited by 22
Wang, J., Liu, Y., Hu, J., & Chen, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1109576 · Cited by 24
Sun, X., Feng, S., Qin, B., Ye, J., Xie, L., Gui, J., & Sang, M. (2024) · Food & Function · doi:10.1039/d3fo03667g · Cited by 22
Potential Roles of Natural Antioxidants in Modulating Neurodegenerative Disease Pathways
Oyovwi, M. O., Agbonifo‐Chijiokwu, E., Ben‐Azu, B., Atere, A. D., Joseph, G. U., Godsday, O. U., & Udi, O. A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04874-w · Cited by 21
The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer’s Disease Treatment
Knight, E., Geetha, T., Broderick, T. L., & Babu, J. R. (2023) · Metabolites · doi:10.3390/metabo13030438 · Cited by 20
The potential benefits of polyphenols for corneal diseases
Feng, J., & Zhang, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115862 · Cited by 19
Resveratrol and Extra Virgin Olive Oil: Protective Agents Against Age-Related Disease
Morkovin, E. I., Litvinov, R., Koushner, A., & Babkov, D. A. (2024) · Nutrients · doi:10.3390/nu16244258 · Cited by 18
García‐Beltrán, O., Urrutia, P. J., & Núñez, M. T. (2023) · Antioxidants · doi:10.3390/antiox12020214 · Cited by 19
Research progress on pleiotropic neuroprotective drugs for traumatic brain injury
Zhao, Q., Li, H., Li, H., & Zhang, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1185533 · Cited by 18
Neuroprotective Effects of Microglial Membrane‐Derived Biomimetic Particles for Spinal Cord Injury
Wang, W., Li, S., Li, H., Guo, P., Lyu, C., Ye, P., Yang, W., Wang, J., Yu, D., Lu, G., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301592 · Cited by 18
Yu, Y., Li, S., Kong, L., Du, Y., Liu, Y., Zang, J., Guo, R., Zhang, L., Zhao, Z., Ju, R.-J., et al. (2023) · Journal of Liposome Research · doi:10.1080/08982104.2023.2290050 · Cited by 18
Hattori, Y., Kakino, Y., Hattori, Y., Iwashita, M., UCHIYAMA, H., Noda, K., Yoshimoto, T., Iida, H., & Ihara, M. (2024) · Journal of Stroke · doi:10.5853/jos.2023.02733 · Cited by 18
Parikh, D., & Shah, M. (2024) · Biomedical Analysis · doi:10.1016/j.bioana.2024.05.005 · Cited by 20
New Mechanisms of Action of Natural Antioxidants in Health and Disease II
Hrelia, S., & Angeloni, C. (2021) · Antioxidants · doi:10.3390/antiox10081200 · Cited by 17
The Potential Effects of Red Wine and Its Components on Neurocognitive Disorders: A Narrative Review
Boccardi, V., Tagliafico, L., Persia, A., Page, E., Ottaviani, S., Cremonini, A. L., Borgarelli, C., Pisciotta, L., Mecocci, P., Nencioni, A., et al. (2024) · Nutrients · doi:10.3390/nu16203431 · Cited by 18
Rosell‐Cardona, C., Griñán‐Ferré, C., Pérez‐Bosque, A., Polo, J., Pallàs, M., Amat, C., Moretó, M., & Miró, L. (2021) · Nutrients · doi:10.3390/nu13072369 · Cited by 17
Self-citation
Metadata
- Authors
- Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., & Pallàs, M.
- Affiliations
- Universitat de Barcelona (ES)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- Universitat Autònoma de Barcelona (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Semmelweis University (HU)
- ORCID
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 67
- Pages
- 101271
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W3126884725
- Cited by
- 208
- References
- 483
- Citations by year
- 2026: 15 · 2025: 33 · 2024: 52 · 2023: 47 · 2022: 38 · 2021: 22
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Ageing Research Reviews (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- Funders
- European Regional Development Fund (PCIN-2015-229, PID2019-106285RB)
- Spain Ministry of Science and Innovation
- Hungarian Science Foundation
- Semmelweis Egyetem (STIA-KFI-2020/132257/AOMBT/2020)
- Ministry of Economic Affairs and Digital Transformation
- Government of Catalonia (2017 SGR 106)
- Agencia Estatal de Investigación
- Ministerio de Economía y Competitividad
- Hungarian Scientific Research Fund (K 116525)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- resveratrol, neuroprotection, cognitive decline, Alzheimer's disease, Parkinson's disease, oxidative stress, reactive oxygen species, epigenetic modifications, aging, gut microbiota, dietary polyphenols, mitochondrial dysfunction, neuroinflammation, apoptosis, DNA damage, antioxidant activity
- MeSH terms
- Resveratrol, Aged, Alzheimer Disease, Antioxidants, Humans, Oxidative Stress, Neuroprotective Agents, Epigenesis, Genetic, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
