Cited by 285Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model OrganismsUbiquitin and proteasome pathways

The DOI matches its Crossref record; 313 of the 316 references it cites were found in a registry or an index.

Autophagy and the hallmarks of aging

Open access

Kaushik, Susmita, Tasset, Inmaculada, Arias, Esperanza, Pampliega, Olatz, Wong, Esther, Martinez-Vicente, Marta, Cuervo, Ana Maria·2021·Ageing Research Reviews

DOI 10.1016/j.arr.2021.101468PMC PMC8616816

Open this paper in CoChat — free account

Abstract

Autophagy, an essential cellular process that mediates degradation of proteins and organelles in lysosomes, has been tightly linked to cellular quality control for its role as part of the proteostasis network. The current interest in identifying the cellular and molecular determinants of aging, has highlighted the important contribution of malfunctioning of autophagy with age to the loss of proteostasis that characterizes all old organisms. However, the diversity of cellular functions of the different types of autophagy and the often reciprocal interactions of autophagy with other determinants of aging, is placing autophagy at the center of the aging process. In this work, we summarize evidence for the contribution of autophagy to health- and lifespan and provide examples of the bidirectional interplay between autophagic pathways and several of the so-called hallmarks of aging. This central role of autophagy in aging, and the dependence on autophagy of many geroprotective interventions, has motivated a search for direct modulators of autophagy that could be used to slow aging and extend healthspan. Here, we review some of those ongoing therapeutic efforts and comment on the potential of targeting autophagy in aging.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.arr.2021.101468

Cites

313 of 313 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 201–313 of 313

Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles
Roberts, R. F., Tang, M. Y. H., Fon, E. A., & Durcan, T. M. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.07.020 · Cited by 121
The fine tuning of metabolism, autophagy and differentiation during in vitro myogenesis
Fortini, P., Ferretti, C., Iorio, E., Cagnin, M., Garribba, L., Pietraforte, D., Falchi, M., Pascucci, B., Baccarini, S., Morani, F., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.50 · Cited by 116
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
Hubbi, M. E., Gilkes, D. M., Hu, H., Gupta, K., Ahmed, I., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412840111 · Cited by 115
Subversion of Autophagy by Kaposi's Sarcoma-Associated Herpesvirus Impairs Oncogene-Induced Senescence
Leidal, A. M., Cyr, D. P., Hill, R. J., Lee, P. W. K., & McCormick, C. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.005 · Cited by 113
Glioblastoma ablates pericytes antitumor immune function through aberrant up-regulation of chaperone-mediated autophagy
Valdor, R., García‐Bernal, D., Riquelme, D., Martínez, C. M., Moraleda, J. M., Cuervo, A. M., Macián, F., & Martı́nez, S. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903542116 · Cited by 112
Self-citation
Metformin as a geroprotector: experimental and clinical evidence
Piskovatska, V., Stefanyshyn, N., Storey, K. B., Vaiserman, A. M., & Lushchak, O. V. (2018) · Biogerontology · doi:10.1007/s10522-018-9773-5 · Cited by 111
Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment
Castellazzi, M., Patergnani, S., Donadio, M., Giorgi, C., Bonora, M., Bosi, C., Brombo, G., Pugliatti, M., Seripa, D., Zuliani, G., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56614-5 · Cited by 111
Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes
Donati, A., Cavallini, G., Paradiso, C., Vittorini, S., Pollera, M., Gori, Z., & Bergamini, E. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.7.b288 · Cited by 110
Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7
Wang, B., Cai, Z., Tao, K., Zeng, W., Lu, F., Yang, R., Feng, D., Gao, G., & Yang, Q. (2016) · Autophagy · doi:10.1080/15548627.2016.1179401 · Cited by 107
Cellular and molecular mechanism for secretory autophagy
Kimura, T., Jia, J., Claude‐Taupin, A., Kumar, S. G., Choi, S. W., Gu, Y., Mudd, M. H., Dupont, N., Jiang, S., Peters, R. S., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1307486 · Cited by 102
Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells
Xu, Y., Zhang, Y., García‐Cañaveras, J. C., Guo, L., Kan, M., Yu, S., Blair, I. A., Rabinowitz, J. D., & Yang, X. (2020) · Science · doi:10.1126/science.abb4467 · Cited by 100
Autophagy Regulatory Network — A systems-level bioinformatics resource for studying the mechanism and regulation of autophagy
Türei, D., Földvári-Nagy, L., Fazekas, D., Módos, D., Kubisch, J., Kadlecsik, T., Demeter, A., Lenti, K., Csermely, P., Vellai, T., et al. (2015) · Autophagy · doi:10.4161/15548627.2014.994346 · Cited by 100
Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila
Schinaman, J. M., Rana, A., Ja, W. W., Clark, R. I., & Walker, D. W. (2019) · Scientific Reports · doi:10.1038/s41598-019-44106-5 · Cited by 99
Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegansPreprint
Wilhelm, T., Byrne, J., Medina, R., Kolundžić, E., Geisinger, J., Hajdůšková, M., Tursun, B., & Richly, H. (2017) · Genes & Development · doi:10.1101/gad.301648.117 · Cited by 98
Cell-Nonautonomous Regulation of Proteostasis in Aging and DiseasePreprint
Morimoto, R. I. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a034074 · Cited by 98
Humanin is an endogenous activator of chaperone-mediated autophagy
Gong, Z., Tasset, I., Díaz, A., Anguiano, J., Tas, E., Cui, L., Kuliawat, R., Liu, H., Kühn, B., Cuervo, A. M., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201606095 · Cited by 96
Self-citation
Crosstalk between exosomes and autophagy: A review of molecular mechanisms and therapies
Xing, H., Tan, J., Miao, Y., Lv, Y., & Zhang, Q. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16276 · Cited by 95
Age-Related Oxidative Stress Compromises Endosomal Proteostasis
Cannizzo, E. S., Clement, C. C., Morozova, K., Valdor, R., Kaushik, S., Almeida, L. N., Follo, C., Sahu, R., Cuervo, A. M., Macian, F., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.06.005 · Cited by 95
Self-citation
Sex differences in autophagy-mediated diseases: toward precision medicine
Shang, D., Wang, L., Klionsky, D. J., Cheng, H., & Zhou, R. (2020) · Autophagy · doi:10.1080/15548627.2020.1752511 · Cited by 92
Autophagy and Protein Secretion
Cavalli, G., & Cenci, S. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.01.015 · Cited by 91
Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue
Ghosh, A. K., Mau, T., O’Brien, M., Garg, S., & Yung, R. L. (2016) · Aging · doi:10.18632/aging.101083 · Cited by 88
Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE−/− mice
Peng, J., Yang, Q., Li, A., Li, R., Zuo, W., Liu, L., Ren, Z., Zheng, X., Tang, X., Li, G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13121 · Cited by 86
Autophagy suppresses melanoma tumorigenesis by inducing senescence
Liu, H., He, Z., & Simon, H. (2013) · Autophagy · doi:10.4161/auto.27163 · Cited by 85
Development of clinical trials to extend healthy lifespan
Justice, J. N., Niedernhofer, L., Robbins, P. D., Aroda, V. R., Espeland, M. A., Kritchevsky, S. B., Kuchel, G. A., & Barzilai, N. (2018) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000159 · Cited by 84
Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model
Muralimanoharan, S., Gao, X., Weintraub, S. T., Myatt, L., & Maloyan, A. (2016) · Autophagy · doi:10.1080/15548627.2016.1156822 · Cited by 83
Caspase activation regulates the extracellular export of autophagic vacuoles
Sirois, I., Groleau, J., Pallet, N., Brassard, N., Hamelin, K., Londoño, I., Pshezhetsky, A. V., Bendayan, M., & Hébert, M. (2012) · Autophagy · doi:10.4161/auto.19768 · Cited by 81
Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes
Martins‐Marques, T., Catarino, S., Zuzarte, M., Marques, C., Matafome, P. N., Pereira, P., & Girão, H. (2015) · Biochemical Journal · doi:10.1042/bj20141370 · Cited by 80
Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease
Congdon, E. E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00372 · Cited by 80
Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress
Singh, K., Matsuyama, S., Drazba, J. A., & Almasan, A. (2012) · Autophagy · doi:10.4161/auto.8.2.18600 · Cited by 78
Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans
Walters, R. O., Arias, E., Díaz, A., Burgos, E. S., Guan, F., Tiano, S., Mao, K., Green, C. L., Qiu, Y., Shah, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.065 · Cited by 77
Self-citation
Toward understanding genomic instability, mitochondrial dysfunction and aging
Fakouri, N. B., Hou, Y., Demarest, T. G., Christiansen, L. S., Okur, M. N., Mohanty, J. G., Croteau, D. L., & Bohr, V. A. (2019) · The FEBS Journal · doi:10.1111/febs.14663 · Cited by 77
Metabolic Shifts during Aging and Pathology
Ma, Y., & Li, J. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140041 · Cited by 75
Impaired Heat Shock Response in Cells Expressing Full-Length Polyglutamine-Expanded Huntingtin
Chafekar, S. M., & Duennwald, M. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037929 · Cited by 74
Intermittent fasting, a possible priming tool for host defense against SARS-CoV-2 infection: Crosstalk among calorie restriction, autophagy and immune response
Hannan, M. A., Rahman, M. A., Rahman, M. S., Sohag, A. A. M., Dash, R., Hossain, K. S., Farjana, M., & Uddin, M. J. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.07.001 · Cited by 74
Secretory Autophagy and Its Relevance in Metabolic and Degenerative Disease
González, C. D., Resnik, R., & Vaccaro, M. I. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00266 · Cited by 72
Alzheimer’s disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles
Gallart‐Palau, X., Guo, X., Serra, A., & Sze, S. K. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00623-4 · Cited by 72
Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy
Tan, S., Yu, C. Y., Sim, Z. W., Low, Z. S., Lee, B., See, F., Min, N., Gautam, A. S., Chu, J. J. H., Ng, K. W., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37400-1 · Cited by 65
Self-citation
Decline in protease activities with age in the nematode caenorhabditis elegans
Sarkis, G. J., Ashcom, J. D., Hawdon, J. M., & Jacobson, L. A. (1988) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(88)90001-2 · Cited by 65
Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease
Nardin, A., Schrepfer, E., & Ziviani, E. (2016) · Current Neuropharmacology · doi:10.2174/1570159x13666151030104414 · Cited by 61
Activation-induced autophagy is preserved in CD4+ T-cells in familial longevity
Raz, Y., Guerrero-Ros, I., Maier, A., Slagboom, P. E., Atzmon, G., Barzilai, N., & Macian, F. (2017) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx020 · Cited by 61
Emerging lysosomal pathways for quality control at the endoplasmic reticulum
Leonibus, C. D., Cinque, L., & Settembre, C. (2019) · FEBS Letters · doi:10.1002/1873-3468.13571 · Cited by 61
Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation
Mayeuf-Louchart, A., Lancel, S., Sebti, Y., Pourcet, B., Loyens, A., Delhaye, S., Duhem, C., Beauchamp, J., Ferri, L., Thorel, Q., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.073 · Cited by 61
Protein modification and maintenance systems as biomarkers of ageing
Vanhooren, V., Santos, A. N., Voutetakis, K., Petropoulos, I., Libert, C., Simm, A., Gonos, E. S., & Friguet, B. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.009 · Cited by 60
Autophagy deficient melanocytes display a senescence associated secretory phenotype that includes oxidized lipid mediators
Ni, C., Narzt, M., Nagelreiter, I., Zhang, C. F., Larue, L., Rossiter, H., Grillari, J., Tschachler, E., & Грубер, Ф. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.10.006 · Cited by 59
Exosomes produced by adipose-derived stem cells inhibit schwann cells autophagy and promote the regeneration of the myelin sheath
Yin, G., Yu, B., Liu, C., Lin, Y., Xie, Z., Hu, Y., & Lin, H. (2021) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2021.105921 · Cited by 59
Causes and consequences of DNA damage-induced autophagy
Juretschke, T., & Beli, P. (2021) · Matrix Biology · doi:10.1016/j.matbio.2021.02.004 · Cited by 59
The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan
Minnerly, J., Zhang, J., Parker, T., Kaul, T. K., & Jia, K. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006764 · Cited by 57
Reaction to Endoplasmic Reticulum Stress via ATF6 in Amyotrophic Lateral Sclerosis Deteriorates With Aging
Prell, T., Stubendorff, B., Le, T. T., Gaur, N., Tadić, V., Rödiger, A., Witte, O. W., & Großkreutz, J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00005 · Cited by 57
Can Enhanced Autophagy Be Associated with Human Longevity? Serum Levels of the Autophagy Biomarker Beclin-1 Are Increased in Healthy Centenarians
Emanuele, E., Minoretti, P., Sanchis‐Gomar, F., Pareja-Galeano, H., Yilmaz, Y. N., Garatachea, N., & Lucía, A. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1607 · Cited by 56
Microglial derived extracellular vesicles activate autophagy and mediate multi‐target signaling to maintain cellular homeostasis
den Broek, B. V., Pintelon, I., Hamad, I., Kessels, S., Haidar, M., Hellings, N., Hendriks, J. J. A., Kleinewietfeld, M., Brône, B., Timmerman, V., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12022 · Cited by 56
Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue
Kim, S.-N., Kwon, H.-J., Im, S.-W., Son, Y.-H., Akindehin, S., Jung, Y.-S., Lee, S. J., Rhyu, I. J., Kim, I. Y., Seong, J. K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07658-y · Cited by 55
Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians
Xiao, F.-H., Chen, X.-Q., Yu, Q., Ye, Y., Liu, Y.-W., Yan, D., Yang, L.-Q., Chen, G., Lin, R., Yang, L., et al. (2018) · Genome Research · doi:10.1101/gr.220780.117 · Cited by 55
The Use of Metformin to Increase the Human Healthspan
Piskovatska, V., Storey, K. B., Vaiserman, A. M., & Lushchak, O. V. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-42667-5_13 · Cited by 55
Mastering organismal aging through the endoplasmic reticulum proteostasis network
Taylor, R. C., & Hetz, C. A. (2020) · Aging Cell · doi:10.1111/acel.13265 · Cited by 55
Pomegranate Juice Enhances Healthy Lifespan in Drosophila melanogaster: An Exploratory Study
Balasubramani, S. P., Jayaram, M., Chatterjee, A., Patnaik, E., Kukkupuni, S. K., Nongthomba, U., & Venkatasubramanian, P. (2014) · Frontiers in Public Health · doi:10.3389/fpubh.2014.00245 · Cited by 54
Cardiac Morphogenesis: Specification of the Four-Chambered HeartPreprint
Christoffels, V. M., & Jensen, B. K. (2020) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037143 · Cited by 54
RAD6 Promotes Homologous Recombination Repair by Activating the Autophagy-Mediated Degradation of Heterochromatin Protein HP1
Chen, S., Wang, C., Sun, L., Wang, D.-L., Chen, L., Huang, Z., Yang, Q., Gao, J., Yang, X., Chang, J.-F., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01044-14 · Cited by 54
MiR-23a-depressed autophagy is a participant in PUVA- and UVB-induced premature senescence
Zhang, J.-A., Zhou, B.-R., Xu, Y., Chen, X., Liu, J., Gozali, M., Wu, D., Yin, Z.-Q., & Luo, D. (2016) · Oncotarget · doi:10.18632/oncotarget.9357 · Cited by 53
LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes
Nieto-Torres, J. L., Shanahan, S.-L., Chassefeyre, R., Chaiamarit, T., Zaretski, S., Landeras-Bueno, S., Verhelle, A., Encalada, S. E., & Hansen, M. (2021) · Current Biology · doi:10.1016/j.cub.2021.05.052 · Cited by 52
A New Vision of Mitochondrial Unfolded Protein Response to the Sirtuin Family
Weng, H., Ma, Y., Chen, L., Cai, G., Chen, Z., Zhang, S., & Ye, Q. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200123165002 · Cited by 51
Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics
Nie, T., Tao, K., Zhu, L., Huang, L. H., Hu, S., Yang, R., Xu, P., Mao, Z., & Yang, Q. (2020) · Autophagy · doi:10.1080/15548627.2020.1848128 · Cited by 51
Estrogen Signaling Dictates Musculoskeletal Stem Cell Behavior: Sex Differences in Tissue Repair
Knewtson, K. E., Ohl, N. R., & Robinson, J. L. (2021) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2021.0094 · Cited by 51
Telomerase Impinges on the Cellular Response to Oxidative Stress Through Mitochondrial ROS-Mediated Regulation of Autophagy
Green, P. D., Sharma, N. K., & Santos, J. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061509 · Cited by 50
Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1
Ali, M. Z., Devkota, S., Roh, J.-I., Lee, J., & Lee, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.094 · Cited by 49
Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy
Gao, B., Yu, W., Lv, P., Liang, X., Sun, S., & Zhang, Y. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165997 · Cited by 48
MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy
Hyttinen, J. M. T., Błasiak, J., Felszeghy, S., & Kaarniranta, K. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101260 · Cited by 48
Rapamycin activates mammalian microautophagy
Sato, M., Seki, T., Konno, A., Hirai, H., Kurauchi, Y., Hisatsune, A., & Katsuki, H. (2019) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2019.05.007 · Cited by 48
Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length
Wirth, A., Wolf, B., Huang, C.-K., Glage, S., Hofer, S. J., Bankstahl, M., Bär, C., Thum, T., Kahl, K. G., Sigrist, S. J., et al. (2021) · GeroScience · doi:10.1007/s11357-020-00310-0 · Cited by 47
Reducing lipofuscin accumulation and cardiomyocytic senescence of aging heart by enhancing autophagy
Li, W.-W., Wang, H.-J., Tan, Y.-Z., Wang, Y.-L., Yu, S.-N., & Li, Z.-H. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112585 · Cited by 47
Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging
Bejarano, E., Murray, J. W., Wang, X., Pampliega, O., Yin, D., Patel, B., Yuste, A., Wolkoff, A. W., & Cuervo, A. M. (2018) · Aging Cell · doi:10.1111/acel.12777 · Cited by 45
Self-citation
The role of epigenetics and non-coding RNAs in autophagy: A new perspective for thorough understanding
Talebian, S., Daghagh, H., Yousefi, B., Özkul, Y., Ilkhani, K., Seif, F., & Alivand, M. R. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111309 · Cited by 45
TORC1 specifically inhibits microautophagy through ESCRT-0
Hatakeyama, R., & VIRGILIO, C. D. (2019) · Current Genetics · doi:10.1007/s00294-019-00982-y · Cited by 44
An energetics perspective on geroscience: mitochondrial protonmotive force and aging
Berry, B. J., & Kaeberlein, M. R. (2021) · GeroScience · doi:10.1007/s11357-021-00365-7 · Cited by 44
Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults
Hart, C. R., Ryan, Z. C., Pfaffenbach, K. T., Dasari, S., Parvizi, M., Lalia, A. Z., & Lanza, I. R. (2019) · Aging · doi:10.18632/aging.102273 · Cited by 42
Inhibition of class I PI3K enhances chaperone-mediated autophagy
Endicott, S. J., Ziemba, Z., Beckmann, L. J., Boynton, D. N., & Miller, R. A. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202001031 · Cited by 42
Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy
Nie, D., Zhang, J., Zhou, Y., Sun, J., Wang, W., & Wang, J. H. (2021) · Stem Cells International · doi:10.1155/2021/6638249 · Cited by 41
Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia
Guadiana, S. M., Parker, A. K., Filho, G. F., Sequeira, A. R., Semple‐Rowland, S. L., Shaw, G., Mandel, R. J., Foster, T. C., Kumar, A., & Sarkisian, M. R. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00127 · Cited by 39
Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity
Breslin, L., Prosser, S. L., Cuffe, S., & Morrison, C. G. (2014) · Cell Cycle · doi:10.4161/15384101.2015.945868 · Cited by 39
Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy
Endicott, S. J., Boynton, D. N., Beckmann, L. J., & Miller, R. A. (2020) · Autophagy · doi:10.1080/15548627.2020.1725378 · Cited by 38
Autophagy Roles in Genome Maintenance
Ambrosio, S., & Majello, B. (2020) · Cancers · doi:10.3390/cancers12071793 · Cited by 38
Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy
Liu, W., Lin, H., Mao, Z., Zhang, L., Bao, K., Jiang, B., Xia, C., Li, W.-J., Hu, Z., & Li, J. (2020) · Aging · doi:10.18632/aging.102951 · Cited by 38
Human telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1
Shin, W. H., & Chung, K. C. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2641-7 · Cited by 37
Exosomes from mesenchymal stem cells expressing microribonucleic acid-125b inhibit the progression of diabetic nephropathy via the tumour necrosis factor receptor-associated factor 6/Akt axis
Cai, X., Zou, F., Xuan, R., & Lai, X. (2021) · Endocrine Journal · doi:10.1507/endocrj.ej20-0619 · Cited by 36
Interplay between Exosomes and Autophagy in Cardiovascular Diseases: Novel Promising Target for Diagnostic and Therapeutic Application
Tian, J., Popal, M. S., Zhao, Y., Liu, Y., Chen, K., & Liu, Y. (2018) · Aging and Disease · doi:10.14336/ad.2018.1020 · Cited by 35
Effects of caloric restriction on the antagonistic and integrative hallmarks of aging
Erbaba, B., Arslan-Ergül, A., & Adams, M. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101228 · Cited by 35
ATF4 ‐modified serum exosomes derived from osteoarthritic mice inhibit osteoarthritis by inducing autophagy
Wang, Y., He, S., Liang, X., Zhang, X., Li, S., & Li, T. (2020) · IUBMB Life · doi:10.1002/iub.2414 · Cited by 34
Stress-induced precocious aging in PD-patient iPSC-derived NSCs may underlie the pathophysiology of Parkinson’s disease
Zhu, L., Sun, C., Ren, J., Wang, G., Ma, R., Sun, L., Yang, D., Gao, S., Ning, K., Wang, Z., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1313-y · Cited by 31
Doxycycline Induces Mitophagy and Suppresses Production of Interferon-β in IPEC-J2 Cells
Yang, X., Zhu, L., Lin, J., Qinghua, Y., & Yang, Q. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00021 · Cited by 30
Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy
Sato, M., Ueda, E., Konno, A., Hirai, H., Kurauchi, Y., Hisatsune, A., Katsuki, H., & Seki, T. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.04.132 · Cited by 26
Facets of Autophagy Based Unconventional Protein Secretion–The Road Less Traveled
Padmanabhan, S., & Manjithaya, R. R. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.586483 · Cited by 25
Activation of the unfolded protein response in aged human lenses
TANG, H.-Z., & YANG, L.-M. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3417 · Cited by 22
Pomegranate juice and extract extended lifespan and reduced intestinal fat deposition in Caenorhabditis elegans
Zheng, J., Heber, D., Wang, M., Gao, C., Heymsfield, S. B., Martin, R. J., Greenway, F. L., Finley, J. W., Burton, J. H., Johnson, W. D., et al. (2017) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000570 · Cited by 22
Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
Young, A. R. J., Cassidy, L. D., & Narita, M. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.02.001 · Cited by 22
Emerging roles of transcriptional programs in autophagy regulation
Sakamaki, J.-I., Long, J. S., New, M. I., Acker, T. V., Tooze, S. A., & Ryan, K. M. (2017) · Transcription · doi:10.1080/21541264.2017.1372045 · Cited by 21
Sexual dimorphism in aging hematopoiesis: an earlier decline of hematopoietic stem and progenitor cells in male than female mice
So, E. Y., Jeong, E.-M., Wu, K. Q., Dubielecka, P. M., Reginato, A. M., Quesenberry, P. J., & Liang, O. D. (2020) · Aging · doi:10.18632/aging.202167 · Cited by 21
Autophagy regulates exosome secretion in rat nucleus pulposus cells via the RhoC/ROCK2 pathway
Hu, S., Zhang, Q., Meng, Q., Hu, A., Zou, J., & Li, X. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112239 · Cited by 20
The decrease of intraflagellar transport impairs sensory perception and metabolism in ageing
Zhang, Y., Zhang, X., Dai, Y., Song, M., Zhou, Y., Zhou, J. Y., Yan, X., & Shen, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-22065-8 · Cited by 20
Independent of Calorie Intake, Short-term Alternate-day Fasting Alleviates NASH, With Modulation of Markers of Lipogenesis, Autophagy, Apoptosis, and Inflammation in Rats
Elsayed, H. R. H., El-Nablaway, M., Khattab, B. A., Sherif, R., Elkashef, W. F., Abdalla, A. M., Nashar, E. M. E., Abd-Elmonem, M. M., & El‐Gamal, R. (2021) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554211041607 · Cited by 19
Effect of dietary restriction on the age-related changes in hormone-regulated protein breakdown
Del, R. A., Bombara, M., Fierabracci, Masini, M. A., Masiello, P., Pollera, M., & Bergamini, E. (1991) · Cited by 19
The role of extracellular vesicles in podocyte autophagy in kidney disease
Sun, B.-C., Zhai, S.-B., Zhang, L., & Sun, G. (2021) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-020-00594-z · Cited by 16
Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action
Pietrocola, F., Castoldi, F., Madeo, F., & Kroemer, G. (2020) · Autophagy · doi:10.1080/15548627.2020.1778293 · Cited by 15
The pluripotent role of exosomes in mediating non-coding RNA in ventricular remodeling after myocardial infarction
Qi, Z., Wu, D., Li, M., Yan, Z., Yang, X., Ji, N., Wang, Y., & Zhang, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117761 · Cited by 14
The Regulation of ROS‐ and BECN1‐Mediated Autophagy by Human Telomerase Reverse Transcriptase in Glioblastoma
Ding, X., Nie, Z., She, Z., Bai, X., Yang, Q., Wang, F., Wang, F., & Geng, X. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6636510 · Cited by 13
Ten-eleven translocation 1 regulates methylation of autophagy-related genes in human glioma
Fu, R., Ding, Y., Luo, J. D., Huang, K., Tang, X. J., Li, D. S., & Guo, S. W. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001024 · Cited by 13
Neoagarotetraose extends the lifespan of Caenorhabditis elegans through AMPK mediated signaling pathways and activation of autophagy
Wu, C., Liu, J., Ma, J., Yan, Q., & Jiang, Z. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104341 · Cited by 13
Involvement of autophagy in connexin 40 reduction in the late phase of traumatic brain injury in rats
Che, W., Guo, Y., Yang, W., Zheng, P., Zeng, J., & Tong, W. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.03.014 · Cited by 12
Effect of autophagy on cardiomyocyte membrane Cx43 acute remodeling in rats with ischemia-reperfusion.
Lü, Q., Li, W., Li, Z., Chen, Z., Fu, W., Jiang, Q., & Ding, S. (2019) · Europe PMC (PubMed Central) · Cited by 10
Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila
Jacomin, A., Gohel, R., Hussain, Z., Varga, Á., Maruzs, T., Eddison, M., Sica, M., Jain, A., Moffat, K. G., Johansen, T., et al. (2020) · Life Science Alliance · doi:10.26508/lsa.202000965 · Cited by 10
A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins
Catarino, S., Ribeiro‐Rodrigues, T., Ferreira, R. S., Ramalho, J. S., Abert, C., Martens, S., & Girão, H. (2020) · Cells · doi:10.3390/cells9040902 · Cited by 10
Effect of dietary restriction on the age-related changes in hormone-regulated protein breakdown
Roso, A. D., Bombara, M., Fierabracci, V., Masini, M., Masiello, P., Pollera, M., & Bergamini, E. (1991) · Aging Clinical and Experimental Research · doi:10.1007/bf03324052 · Cited by 8
The potentially conflicting cell autonomous and cell non-autonomous functions of autophagy in mediating tumor response to cancer therapy
Gewirtz, D. A., Tyutyunyk‐Massey, L., & Landry, J. W. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.048 · Cited by 8
Muscle Stem Cells: A Model System for Adult Stem Cell Biology
Cornelison, D., & Perdiguero, E. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6771-1_1 · Cited by 6
Overexpression of Beclin1 gene leads to reduction of telomerase activity in MDCK cells and enhances apoptosis
Taji, F., Abdoli, A., Baesi, K., Sheikholeslami, F., & Kouchesfahani, H. M. (2019) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_265_17 · Cited by 3

Flagged first, then by citations

3 of the 316 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Lopez-Otin, 2021, Hallm. Health Cell, 184, 1929
Martinez-Lopez, 2017, System-wide benefits of intermeal fasting by autophagy, Cell Metab., 26, 10.1016/j.cmet.2017.09.020 · DOI

Sorted by citations

Nonlinear dynamics of multi-omics profiles during human aging
Shen, X., Wang, C., Zhou, X., Zhou, W., Hornburg, D., Wu, S., & Snyder, M. P. (2024) · Nature Aging · doi:10.1038/s43587-024-00692-2 · Cited by 500
The different autophagy degradation pathways and neurodegeneration
Fleming, A., Bourdenx, M., Fujimaki, M., Karabiyik, C., Krause, G. J., Lopez, A., Martín‐Segura, A., Puri, C., Scrivo, A., Skidmore, J., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.017 · Cited by 500
Self-citation
From geroscience to precision geromedicine: Understanding and managing aging
Kroemer, G., Maier, A. B., Cuervo, A. M., Gladyshev, V. N., Ferrucci, L., Gorbunova, V., Kennedy, B. K., Rando, T. A., Seluanov, A., Sierra, F., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.011 · Cited by 395
Self-citation
Redox regulation: mechanisms, biology and therapeutic targets in diseases
Li, B., Ming, H., Qin, S., Nice, E. C., Dong, J., Du, Z., & Huang, C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02095-6 · Cited by 389
Molecular mechanisms of aging and anti-aging strategies
Li, Y., Tian, X., Luo, J., Bao, T., Wang, S., & Wu, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01663-1 · Cited by 380

See all 285

Authors: Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M.
Affiliations: Albert Einstein College of Medicine (US)
University of the Basque Country (ES)
National University of Singapore (SG)
ORCID: Kaushik, Susmita
Tasset, Inmaculada
Arias, Esperanza
Pampliega, Olatz
Wong, Esther
Martinez-Vicente, Marta
Cuervo, Ana Maria
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2021-12
Volume: 72
Pages: 101468
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2021.101468
PMC: PMC8616816
OpenAlex: W3203834151
Cited by: 285
References: 316
Citations by year: 2026: 49 · 2025: 70 · 2024: 66 · 2023: 65 · 2022: 35
FWCI: 6.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 303 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Ageing Research Reviews (acceptedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Glenn Foundation for Medical Research
Michael J. Fox Foundation for Parkinson's Research
Instituto de Salud Carlos III
Federación Española de Enfermedades Raras (PI20/00728)
Ministerio de Ciencia e Innovación
Rainwater Charitable Foundation
Fundación BBVA
National Institutes of Health (AG031782, P30DK041296, DK098408, AG017617, DK124308, AG054108, AG021904, NS100717, P30AG038072)
Grace Science Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: autophagy, hallmarks of aging, proteostasis, cell quality control, lysosomal degradation, lifespan extension, healthspan, geroprotective interventions, autophagy modulators
MeSH terms: Proteostasis, Aging, Autophagy, Humans, Longevity, Lysosomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autophagy and the hallmarks of aging

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks