Age-Related Oxidative Stress Compromises Endosomal Proteostasis
Open accessAbstract
A hallmark of aging is an imbalance between production and clearance of reactive oxygen species and increased levels of oxidatively damaged biomolecules. Herein, we demonstrate that splenic and nodal antigen-presenting cells purified from aging mice accumulate oxidatively modified proteins with side-chain carbonylation, advanced glycation end products, and lipid peroxidation. Furthermore, we show that the endosomal accumulation of oxidatively modified proteins interferes with the efficient processing of exogenous antigens and degradation of macroautophagy-delivered proteins. In support of a causative role for oxidized products in the inefficient immune response, a decrease in oxidative stress improved the adaptive immune response to immunizing antigens. These findings underscore a previously unrecognized negative effect of age-dependent changes in cellular proteostasis on the immune response.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The second characteristic of aged cells is increased mitochondrial dysfunction and ensuing oxidative damage to proteins and DNA.
“The second characteristic of aged cells is increased mitochondrial dysfunction and ensuing oxidative damage to proteins and DNA.”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [103]
DC function in aged mice can be restored through administration of anti-oxidants.
“DC function in aged mice can be restored through administration of anti-oxidants [103].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [103]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works
Protein Misfolding, Functional Amyloid, and Human Disease
Chiti, F., & Dobson, C. M. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.101304.123901 · Cited by 6,435 · see citing works
Stadtman, E. R. (1992) · Science · doi:10.1126/science.1355616 · Cited by 2,701 · see citing works
Protein carbonyl groups as biomarkers of oxidative stress
Dalle‐Donne, I., Rossi, R., Giustarini, D., Milzani, A., & Colombo, R. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00003-2 · Cited by 2,353 · see citing works
Myeloperoxidase: friend and foe
Klebanoff, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204697 · Cited by 2,282 · see citing works
Aggresomes, inclusion bodies and protein aggregation
Kopito, R. R. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01852-3 · Cited by 1,906 · see citing works
Age-related changes in oxidized proteins.
Oliver, C. N., Ahn, B. W., Moerman, E. J., Goldstein, S., & Stadtman, E. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45598-6 · Cited by 1,306 · see citing works
Age-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,180 · see citing works
Sequence analysis of peptides bound to MHC class II molecules
Rudensky, A. Y., Preston‐Hurlburt, P., Hong, S., Barlow, A. K., & Janeway, C. A. (1991) · Nature · doi:10.1038/353622a0 · Cited by 1,073 · see citing works
The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity
Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059 · see citing works
Stadtman, E. R. (2006) · Free Radical Research · doi:10.1080/10715760600918142 · Cited by 1,056 · see citing works
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011 · see citing works
Misfolded proteins partition between two distinct quality control compartments
Kaganovich, D., Kopito, R., & Frydman, J. (2008) · Nature · doi:10.1038/nature07195 · Cited by 932 · see citing works
Microautophagy of Cytosolic Proteins by Late Endosomes
Sahu, R., Kaushik, S., Clement, C. C., Cannizzo, E. S., Scharf, B., Follenzi, A., Potolicchio, I., Nieves, E., Cuervo, A. M., & Santambrogio, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.12.003 · Cited by 902 · see citing works
Self-citationCellular strategies for controlling protein aggregation
Tyedmers, J., Mogk, A., & Bukau, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2993 · Cited by 885 · see citing works
Oxidative stress and metabolic syndrome
Roberts, C. K., & Sindhu, K. K. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.02.026 · Cited by 865 · see citing works
Autophagy and aging: The importance of maintaining "clean" cells
Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792 · see citing works
Self-citationAccumulation of Maillard reaction products in skin collagen in diabetes and aging.
Dyer, D. G., Dunn, J. A., Thorpe, S. R., Bailie, K., Lyons, T. J., McCance, D. R., & Baynes, J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116481 · Cited by 770 · see citing works
The phagocytes: neutrophils and monocytes
Dale, D. C., Boxer, L. A., & Liles, W. C. (2008) · Blood · doi:10.1182/blood-2007-12-077917 · Cited by 740 · see citing works
Itano, A. A., McSorley, S. J., Reinhardt, R. L., Ehst, B. D., Ingulli, E. G., Rudensky, A. Y., & Jenkins, M. K. (2003) · Immunity · doi:10.1016/s1074-7613(03)00175-4 · Cited by 719 · see citing works
Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species
Starkov, A. A., Fiskum, G. M., Chinopoulos, C., Lorenzo, B. J., Browne, S. E., Patel, M. S., & Beal, M. F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1899-04.2004 · Cited by 692 · see citing works
Aging and proinflammatory cytokines
Bruunsgaard, H., Pedersen, M., & Pedersen, B. K. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200105000-00001 · Cited by 690 · see citing works
Aging of the innate immune system
Shaw, A. C., Joshi, S., Greenwood, H., Panda, A., & Lord, J. M. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.05.003 · Cited by 647 · see citing works
Widespread protein aggregation as an inherent part of aging in C. elegans
David, D. C., Ollikainen, N., Trinidad, J. C., Cary, M. P., Burlingame, A. L., & Kenyon, C. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000450 · Cited by 627 · see citing works
Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance
Arndt, V., Dick, N., Tawo, R., Dreiseidler, M., Wenzel, D., Hesse, M., Fürst, D. O., Säftig, P., Saint, R. B., Fleischmann, B. K., et al. (2010) · Current Biology · doi:10.1016/j.cub.2009.11.022 · Cited by 572 · see citing works
Fratelli, M., Demol, H., Puype, M., Casagrande, S., Eberini, I., Salmona, M., Bonetto, V., Mengozzi, M., Duffieux, F., Miclet, E., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052592699 · Cited by 556 · see citing works
Barja, G., & Herrero, A. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.2.312 · Cited by 540 · see citing works
Haigis, M. C., & Yankner, B. A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.002 · Cited by 525 · see citing works
Oxidative stress and protein aggregation during biological aging
Squier, T. C. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00139-5 · Cited by 511 · see citing works
Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess
Wellen, K. E., & Thompson, C. B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.004 · Cited by 486 · see citing works
The wanderings of a free radical
Halliwell, B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.008 · Cited by 467 · see citing works
Superoxide dismutases and their impact upon human health
Johnson, F., & Giulivi, C. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.07.006 · Cited by 467 · see citing works
NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
Lamark, T., Kirkin, V., Dikic, I., & Johansen, T. (2009) · Cell Cycle · doi:10.4161/cc.8.13.8892 · Cited by 464 · see citing works
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
West, X. Z., Malinin, N. L., Merkulova, A. A., Tischenko, M., Kerr, B. A., Borden, E. C., Podrez, E. A., Salomon, R. G., & Byzova, T. V. (2010) · Nature · doi:10.1038/nature09421 · Cited by 431 · see citing works
Requena, J. R., Chao, C.-C., Levine, R. L., & Stadtman, E. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.69 · Cited by 415 · see citing works
Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
Alavez, S., Vantipalli, M. C., Zucker, D. J. S., Klang, I. M., & Lithgow, G. J. (2011) · Nature · doi:10.1038/nature09873 · Cited by 370 · see citing works
Role of Oxidant Species in Aging
Stadtman, E. R. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043365341 · Cited by 368 · cited 2× · see citing works
“…compartments with oxidatively damaged proteins and protein/lipid microaggregates could interfere with efficient Cell Reports 2, 136–149, July 26, 2012 ª2012 The Authors 145 endosomal proteostasis (Stadtman, 1992, 2004; Cloos and Christgau, 2004; Dunlop et al., 2008, 2009; Tyedmers et al., 2010).”
Regulation of Superoxide Anion Production by NADPH Oxidase in Monocytes/Macrophages
Cathcart, M. K. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000097769.47306.12 · Cited by 365 · see citing works
Oxidative stress, inflamm-aging and immunosenescence
Cannizzo, E. S., Clement, C. C., Sahu, R. K., Follo, C., & Santambrogio, L. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.06.005 · Cited by 303 · see citing works
Self-citationProteomic Identification of Carbonylated Proteins and Their Oxidation Sites
Madian, A. G., & Regnier, F. E. (2010) · Journal of Proteome Research · doi:10.1021/pr1002609 · Cited by 271 · see citing works
Chaperone-mediated autophagy: selectivity pays off
Cuervo, A. M. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.10.003 · Cited by 260 · cited 8× · see citing works
“…degree of oxidation still allows for the protein to be unfolded, which is a requirement for entry into the narrow catalytic chamber of the proteasome or the translocation channel that mediates substrate internalization into lysosomes via CMA (Dunlop et al., 2009; Cuervo, 2010; David et al., 2010).”
InfluentialSelf-citationOxidative Stress, Inflammaging, and Immunosenescence
Bauer, M. E., & la Fuente, M. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00004-6 · Cited by 229 · see citing works
Lysosome membrane lipid microdomains: novel regulators of chaperone‐mediated autophagy
Kaushik, S., Massey, A. C., & Cuervo, A. M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601283 · Cited by 216 · see citing works
Self-citationInnate and adaptive immunosenescence
Agarwal, S., & Busse, P. J. (2010) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2009.11.009 · Cited by 215 · see citing works
Is there more to aging than mitochondrial DNA and reactive oxygen species?
ALEXEYEV, M. F. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07269.x · Cited by 194 · see citing works
Pawelec, G., Derhovanessian, E., & Larbi, A. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.06.012 · Cited by 175 · see citing works
A causal link between respiration and senescence in Podospora anserina
Dufour, É., Boulay, J., Rincheval, V., & Sainsard‐Chanet, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070501997 · Cited by 170 · see citing works
Cloos, P. A., & Christgau, S. (2004) · Biogerontology · doi:10.1023/b:bgen.0000031152.31352.8b · Cited by 155 · see citing works
Endogenously Nitrated Proteins in Mouse Brain: Links to Neurodegenerative Disease
Sacksteder, C. A., Qian, W., Knyushko, T. V., Wang, H., Chin, M. H., Laćan, G., Melega, W. P., Camp, D., Smith, R. D., Smith, D., et al. (2006) · Biochemistry · doi:10.1021/bi060474w · Cited by 151 · see citing works
Isom, A., Barnes, S., Wilson, L. S., KIRK, M. C., Coward, L. U., & Darley-Usmar, V. M. (2004) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2004.03.013 · Cited by 140 · see citing works
Hydroxyl radical mediated damage to proteins, with special reference to the crystallins
Guptasarma, P., Balasubramanian, D., Matsugo, S., & Saito, I. (1992) · Biochemistry · doi:10.1021/bi00132a021 · Cited by 138 · see citing works
Monoclonal antibody detection of a major self peptide. MHC class II complex
Murphy, D. B., Rath, S., Pizzo, E., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.11.3483 · Cited by 129 · see citing works
Oxidized proteins: Mechanisms of removal and consequences of accumulation
Dunlop, R. A., Brunk, U. T., & Rodgers, K. J. (2009) · IUBMB Life · doi:10.1002/iub.189 · Cited by 124 · see citing works
Dendritic cells in human aging
AGRAWAL, A., Agrawal, S., & Gupta, S. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.11.007 · Cited by 122 · see citing works
p23, a simple protein with complex activities
Felts, S. J., & Toft, D. O. (2003) · Cell Stress and Chaperones · doi:10.1379/1466-1268(2003)008 · Cited by 116 · see citing works
Phagocytosis induces superoxide formation and apoptosis in macrophages
Park, J. (2003) · Experimental & Molecular Medicine · doi:10.1038/emm.2003.44 · Cited by 114 · see citing works
Takahashi, M., Ko, L., Kulathingal, J., Jiang, P., Sevlever, D., & Yen, S.-H. C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05736.x · Cited by 110 · see citing works
Chronological ageing and photoageing of dendritic cells
Grewe, M. (2001) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2001.00898.x · Cited by 106 · see citing works
The innate immune system and the clearance of apoptotic cells
Devitt, A., & Marshall, L. J. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0211095 · Cited by 103 · see citing works
Oxidative stress modulation and T cell activation
Larbi, A., Kempf, J., & Pawelec, G. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.004 · Cited by 102 · cited 4× · see citing works
“Likewise, adaptive immune responses are hindered by a decrease in the variety of the B and T cell repertoires, as well as their ability to clonally expand following antigen stimulation (Fratelli et al., 2002; Larbi et al., 2007).”
InfluentialFülöp, T., Larbi, A., Witkowski, J. M., Kotb, R. R., Hirokawa, K., & Pawelec, G. (2013) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2013010597 · Cited by 96 · see citing works
Mitochondrial Regulation of Oxygen Sensing
Chandel, N. S. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-60761-500-2_22 · Cited by 91 · see citing works
Polyglutamine protein aggregation and toxicity are linked to the cellular stress response
Cowan, K. J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg151 · Cited by 78 · see citing works
de la Fuente, M., Hernánz, Á., Guayerbas, N., Alvarez, P., & Alvarado, C. (2004) · PubMed · Cited by 70 · see citing works
MHC class II compartment subtypes: structure and function
Stern, L. J., Potolicchio, I., & Santambrogio, L. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.11.005 · Cited by 69 · see citing works
Self-citationCatabolic Insufficiency and Aging
Terman, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.005 · Cited by 58 · see citing works
Sharma, S., LUCIADOMINGUEZ, A., & Lustgarten, J. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.002 · Cited by 58 · see citing works
Mitochondrial stress signaling: a pathway unfolds
Broadley, S. A., & Hartl, F. U. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.11.003 · Cited by 56 · see citing works
Low‐Grade Inflammation with Aging Has Consequences for T‐Lymphocyte Signaling
Larbi, A., Dupuis, G., Douziech, N., Khalil, A., & Fülöp, T. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.016 · Cited by 50 · see citing works
Aging and Impairment of Innate Immunity
Nomellini, V., Gómez, C. R., & Kovacs, E. J. (2008) · KARGER eBooks · doi:10.1159/000136358 · Cited by 47 · see citing works
Biosynthesis and turnover of DOPA-containing proteins by human cells
Rodgers, K. J., Hume, P. M., Dunlop, R. A., & Dean, R. T. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.009 · Cited by 46 · see citing works
The impact of specific oxidized amino acids on protein turnover in J774 cells
Dunlop, R. A., Dean, R. T., & Rodgers, K. J. (2008) · Biochemical Journal · doi:10.1042/bj20070161 · Cited by 43 · see citing works
Ponnappan, S., Ovaa, H., & Ponnappan, U. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.01.002 · Cited by 38 · see citing works
Proteomic approaches to oxidative protein modifications implicated in the mechanism of aging
Toda, T., Nakamura, M., Morisawa, H., Hirota, M., Nishigaki, R., & Yoshimi, Y. (2010) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2010.00606.x · Cited by 37 · see citing works
Fujimoto, H., Kobayashi, H., & Ohno, M. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0491 · Cited by 36 · see citing works
Hung, L., Huang, K., Yang, D., Chang, D., Lai, J., & Ho, L. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.09.005 · Cited by 24 · see citing works
Rudensky, A. Y., Preston‐Hurlburt, P., Hong, S.-C., et al. (2016) · The Journal of Immunology · doi:10.1093/jimmunol/196.3.941 · Cited by 19 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Evolution of the immune system in humans from infancy to old age
Simon, A. K., Hollander, G. A., & McMichael, A. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.3085 · Cited by 1,796 · see citing works
Autophagy in major human diseases
Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108863 · Cited by 1,585 · see citing works
Self-citationSelective autophagy as a potential therapeutic target for neurodegenerative disorders
Scrivo, A., Bourdenx, M., Pampliega, O., & Cuervo, A. M. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30238-2 · Cited by 355 · see citing works
Self-citationAutophagy and the hallmarks of aging
Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101468 · Cited by 285 · see citing works
Self-citationInterplay of pathogenic forms of human tau with different autophagic pathways
Caballero, B., Wang, Y., Diaz, A., Tasset, I., Juste, Y. R., Stiller, B., Mandelkow, E., Mandelkow, E., & Cuervo, A. M. (2018) · Aging Cell · doi:10.1111/acel.12692 · Cited by 213 · see citing works
Self-citationAcetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
Caballero, B., Bourdenx, M., Luengo, E., Diaz, A., Sohn, P. D., Chen, X., Wang, C., Juste, Y. R., Wegmann, S., Patel, B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22501-9 · Cited by 223 · see citing works
Self-citationAutophagy and the immune function in aging
Cuervo, A. M., & Macian, F. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.05.006 · Cited by 112 · see citing works
Self-citationGardner, J. K., Mamotte, C. D. S., Jackaman, C., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.07.002 · Cited by 40 · see citing works
Krause, G. J., Diaz, A., Jafari, M., Khawaja, R. R., Agullo‐Pascual, E., Santiago‐Fernández, O., Richards, A. L., Chen, K., Dmitriev, P., Sun, Y., et al. (2022) · Aging Cell · doi:10.1111/acel.13713 · Cited by 35 · see citing works
Self-citation
- Authors
- Cannizzo, E. S., Clement, C. C., Morozova, K., Valdor, R., Kaushik, S., Almeida, L. N., Follo, C., Sahu, R., Cuervo, A. M., Macian, F., & Santambrogio, L.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Santambrogio, Laura
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 2
- Issue
- 1
- Pages
- 136-149
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC3408590
- OpenAlex
- W2123507662
- Cited by
- 95
- References
- 78
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 2 · 2023: 8 · 2022: 13 · 2021: 8 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 10 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 2
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Hispana (acceptedVersion, cc-by-nc-nd)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute on Aging (R01AG045223, P01AG031782, AG031782)
- National Institute of Allergy and Infectious Diseases (R01AI048833, AI48833, R01AI048832)
- Fogarty International Center (D43TW007129)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK041918, P01DK041918)
- National Center for Research Resources (S10RR019352)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- aging, oxidative stress, antigen-presenting cells, splenic B cells, protein carbonylation, advanced glycation end products, lipid peroxidation, antigen processing, macroautophagy, adaptive immune response, immunosenescence
- MeSH terms
- Aging, Animals, Cells, Cultured, Dendritic Cells, Homeostasis, Lymphatic System, Mice, Inbred CBA, Mice, Inbred C57BL, Models, Biological, Oxidation-Reduction, Protein Processing, Post-Translational, Proteins, Endosomes, Glycation End Products, Advanced, Reactive Oxygen Species, Oxidative Stress, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
