Risk of coronary events in Japanese patients with both hypercholesterolemia and type 2 diabetes mellitus on low-dose simvastatin therapy: Implication from Japan Lipid Intervention Trial (J-LIT)

Oikawa, Shinichi; Kita, Toru; Mabuchi, Hiroshi; Matsuzaki, Masunori; Matsuzawa, Yuji; Nakaya, Noriaki; Saito, Yasushi; Sasaki, Jun; Shimamoto, Kazuaki; Itakura, Hiroshige

doi:10.1016/j.atherosclerosis.2006.04.017

Cited by 33Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsBlood Pressure and Hypertension Studies

Risk of coronary events in Japanese patients with both hypercholesterolemia and type 2 diabetes mellitus on low-dose simvastatin therapy: Implication from Japan Lipid Intervention Trial (J-LIT)

Oikawa, Shinichi, Kita, Toru, Mabuchi, Hiroshi, Matsuzaki, Masunori, Matsuzawa, Yuji, Nakaya, Noriaki, Saito, Yasushi, Sasaki, Jun +2 more·2007·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2006.04.017

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Abstract

Hypercholesterolemic patients with type 2 diabetes mellitus are at increased risk of coronary heart disease (CHD); however, direct evidence is very limited in Japanese patients. The J-LIT is the first nationwide study conducted to assess the relationship between serum lipid levels and development of coronary events in Japanese hypercholesterolemic patients. We analyzed the coronary events in the J-LIT study subjects by having type 2 diabetes or not. Of the total 41,801 subjects without prior CHD who received open-label simvastatin, 5mg/day, 6554 (male 40.2%, age 57.8+/-7.8) subjects had type 2 diabetes, while 35,247 (male 30.0%, age 57.8+/-7.9) did not. In this analysis, relative coronary event risks based on a 0.26 mmol/l (10mg/dl) increase in low density lipoprotein-cholesterol (LDL-C), were similar between hypercholesterolemic subjects with and without type 2 diabetes (17.3% versus 19.4%). Although all subjects were treated with simvastatin, the subjects with type 2 diabetes have significantly more coronary events compared to the subjects without type 2 diabetes (1.80/1000 and 0.76/1000 patient-years, respectively). Given the results above, to reduce the risk of coronary events in Japanese patients with both hypercholesterolemia and type 2 diabetes, careful and strict cholesterol management is needed in addition to the control of blood glucose.

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Significant reduction of cardiovascular events was seen in the statin-treated group that maintained LDL-C levels of < 120 mg/dL in the HOPE-3 study.
“Significant reduction of cardiovascular events was seen in the statin-treated group that maintained LDL-C levels of < 120 mg/dL.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [623]
LDL-C-lowering therapy using statins exhibits suppressive effects on cardiovascular events regardless of race.
“It has been proven by the study that LDL-C-lowering therapy using statins exhibits suppressive effects on cardiovascular events regardless of race623).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [623]
In managing dyslipidemia expressed by hypertriglyceridemia, the non-HDL-C level is more useful than the LDL-C level.
“However, in managing dyslipidemia expressed by hypertriglyceridemia, the non-HDL-C level is more useful than the LDL-C level. This has been reported in a number of studies177–179, 623, 624, 626, 627, 647).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [623]

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Authors: Oikawa, S., Kita, T., Mabuchi, H., Matsuzaki, M., Matsuzawa, Y., Nakaya, N., Saito, Y., Sasaki, J., Shimamoto, K., & Itakura, H.
Affiliations: Nippon Medical School (JP)
Kyoto University (JP)
Kanazawa University (JP)
Yamaguchi University (JP)
Sapporo Medical University (JP)
Ibaraki Christian University (JP)
Corresponding author: Oikawa, Shinichi
ORCID: Oikawa, Shinichi
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2007-04
Volume: 191
Issue: 2
Pages: 440-446
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2006.04.017
OpenAlex: W2082236682
Cited by: 33
References: 22
Citations by year: 2020: 1 · 2018: 4 · 2017: 1 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 1
FWCI: 2.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: coronary artery disease, hypercholesterolemia, type 2 diabetes, simvastatin, LDL cholesterol, statin therapy, cholesterol management, Japanese patients
MeSH terms: Adult, Aged, Coronary Disease, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Hypercholesterolemia, Japan, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Prospective Studies, Risk Factors, Time Factors, Triglycerides, Cohort Studies, Incidence, Proportional Hazards Models, Treatment Outcome, Risk Assessment, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Simvastatin, Asian People

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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Risk of coronary events in Japanese patients with both hypercholesterolemia and type 2 diabetes mellitus on low-dose simvastatin therapy: Implication from Japan Lipid Intervention Trial (J-LIT)

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