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Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol
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“Animal models and in vitro studies have shown that ANGPTL3 has an effect both on production as well as clearance of apoB (apolipoprotein B) containing lipoproteins.6,7”
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“A similar finding was observed in hepatocarcinoma cell lines treated with ANGPTL3 siRNA.7”
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Citations
Cites
Genome-scale CRISPR-Cas9 knockout screening in human cells
Shalem, O., Sanjana, N. E., Hartenian, E., Shi, X., Scott, D. A., Mikkelsen, T. S., Heckl, D., Ebert, B. L., Root, D. E., Doench, J. G., et al. (2014) · Science · doi:10.1126/science.1247005 · Cited by 5,234
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Dewey, F. E., Gusarova, V., Dunbar, R. L., O’Dushlaine, C., Schurmann, C., Gottesman, O., McCarthy, S., Van Hout, C. V., Bruse, S., Dansky, H. M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1612790 · Cited by 885
Self-citationCardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides
Graham, M. J., Lee, R. G., Brandt, T. A., Tai, L.-J., Fu, W., Peralta, R., Yu, R., Hurh, E., Paz, E., McEvoy, B. W., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701329 · Cited by 573
ANGPTL3 deficiency and protection against coronary artery disease
Stitziel, N. O., Khera, A. V., Wang, X., Bierhals, A. J., Vourakis, A. C., Sperry, A. E., Natarajan, P., Klarin, D., Emdin, C. A., Zekavat, S. M., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.02.030 · Cited by 467
Self-citationInactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion
Wang, Y., Gusarova, V., Banfi, S., Gromada, J., Cohen, J. C., & Hobbs, H. H. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m054882 · Cited by 189
Functional validation of new pathways in lipoprotein metabolism identified by human genetics
Bauer, R. C., Stylianou, I. M., & Rader, D. J. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32834469b3 · Cited by 36
Self-citation
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Cited by
Sorted by citations
Reeskamp, L. F., Millar, J. S., Wu, L., Jansen, H., van Harskamp, D., Schierbeek, H., Gipe, D. A., Rader, D. J., Dallinga-Thie, G. M., Hovingh, G. K., et al. (2021) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.120.315204 · Cited by 109
Self-citationDijk, W., Ruppert, P. M. M., Oost, L. J., & Kersten, S. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002426 · Cited by 72
Khan, S. U., Khan, M. U., Valavoor, S., Khan, M. S., Okunrintemi, V., Mamas, M. A., Leucker, T. M., Blaha, M. J., & Michos, E. D. (2020) · European Journal of Preventive Cardiology · doi:10.1177/2047487319871733 · Cited by 67
Metadata
- Authors
- Xu, Y.-X., Redon, V., Yu, H., Querbes, W., Pirruccello, J., Liebow, A., Deik, A., Trindade, K., Wang, X., Musunuru, K., Clish, C. B., Cowan, C., Fizgerald, K., Rader, D., & Kathiresan, S.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 268
- Pages
- 196-206
- ISSN
- 0021-9150
- PMC
- PMC5750127
- Cited by
- 105
- References
- 6
- Language
- en
- Licence
- Funders
- National Heart, Lung, and Blood Institute (R37-HL055323, RC2-HL101864, R33-HL120781)
- Massachusetts General Hospital (MGH)
- MGH
- Donovan Family Foundation
- Foundation Leducq (12-CDA-04)
- American Heart Association SDG (11SDG7670007)
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