Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197

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Resveratrol improves health and survival of mice on a high-calorie diet

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Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

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Obesity

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

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Mammalian Sirtuins: Biological Insights and Disease Relevance

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Berberine improves reproductive features in obese Caucasian women with polycystic ovary syndrome independently of changes of insulin sensitivity

Orio, F., Muscogiuri, G., Palomba, S., Savastano, S., Volpe, A., Orio, M., Colarieti, G., Sala, G. B. L., Colao, A. A. L., Marciano, F., et al. (2013) · e-SPEN Journal · doi:10.1016/j.clnme.2013.07.002 · Cited by 20

Natural constituents from food sources: potential therapeutic agents against muscle wasting

Shen, S., Yu, H., Gan, L., Yang, Y., & Lin, L. (2019) · Food & Function · doi:10.1039/c9fo00912d · Cited by 20

Supplemental Berberine in a High-Fat Diet Reduces Adiposity and Cardiac Dysfunction in Offspring of Mouse Dams with Gestational Diabetes Mellitus

Cole, L. K., Zhang, M., Chen, L., Sparagna, G. C., Vandel, M., Xiang, B., Dolinsky, V. W., & Hatch, G. M. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxaa408 · Cited by 18

Berberine hydrochloride protects against cytokine-induced inflammation through multiple pathways in undifferentiated C2C12 myoblast cells

Poudel, A., Zhou, J. Y., Mekala, N. K., Welchko, R. M., Rosca, M. G., & Li, L. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0653 · Cited by 17

Efficacy and safety of berberine in the treatment of type 2 diabetes with insulin resistance

Wang, Y., Aihua, Y., Li, S., Liu, B., Li, H., & Yan, Y. (2019) · Medicine · doi:10.1097/md.0000000000016947 · Cited by 18

Berberine elevates cardiolipin in heart of offspring from mouse dams with high fat diet-induced gestational diabetes mellitus

Cole, L. K., Sparagna, G. C., Vandel, M., Xiang, B., Dolinsky, V. W., & Hatch, G. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-95353-4 · Cited by 17

Dibenzofuran-induced mitochondrial dysfunction: Interaction with ANT carrier

Duarte, F. V., Gomes, A. P., Teodoro, J. S., Varela, A. T. I. F., Moreno, A. J., Rolo, A. P., & Palmeira, C. M. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.08.009 · Cited by 17

The significance of caloric restriction mimetics as anti-aging drugs

Nassar, K., El-mekawey, D., Elmasry, A. E., Refaey, M. S., El-Sayed Ghoneim, M., & Elshaier, Y. A. M. M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149354 · Cited by 16

Therapeutic Effects of Berberine in Metabolic Diseases and Diabetes Mellitus

Aram, K., Bahari, Z., Elliyeh, M., & Ghasemi, M. (2021) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-021-00159-0 · Cited by 16

In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine

Mahmoud, M. A., Ghareeb, D. A., Sahyon, H. A. E., El‐Shehawy, A. A., & Elsayed, M. M. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/2039897 · Cited by 15

Berberine improves dietary-induced cardiac remodeling by upregulating Kruppel-like factor 4-dependent mitochondrial function

Ding, L., Li, S., Wang, F., Xu, J. Y., Li, S., Wang, B., Kou, J., Wang, Y., & Cao, W. (2021) · Biological Chemistry · doi:10.1515/hsz-2020-0267 · Cited by 15

Effects of nutrients and diet on mitochondrial dysfunction: An opportunity for therapeutic approaches in human disease

Do, L. H., da Costa, R. T., & Solesio, M. E. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118493 · Cited by 13

Berberine Attenuates Acetamiprid Exposure-Induced Mitochondrial Dysfunction and Apoptosis in Rats via Regulating the Antioxidant Defense System

Phogat, A., Singh, J., Sheoran, R., Hasanpuri, A., Chaudhary, A., Bhardwaj, S., Antil, S., Kumar, V. J., Prakāsh, C., & Malik, V. (2024) · Journal of Xenobiotics · doi:10.3390/jox14030061 · Cited by 13

Addition of Berberine to Preservation Solution in an Animal Model of Ex Vivo Liver Transplant Preserves Mitochondrial Function and Bioenergetics from the Damage Induced by Ischemia/Reperfusion

Martins, R. M., Rolo, A. P., Teodoro, J. S., Furtado, E., Oliveira, R. C., Tralhão, J. G., & Palmeira, C. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010284 · Cited by 13

Coenzyme Q10 deficiency can be expected to compromise Sirt1 activity

DiNicolantonio, J. J., McCarty, M. F., & O’Keefe, J. H. (2022) · Open Heart · doi:10.1136/openhrt-2021-001927 · Cited by 11

Exposure to BDE-153 induces autophagy in HepG2 cells

Pereira, L. C., Duarte, F. V., Varela, A. T. I. F., Rolo, A. P., Palmeira, C. M., & Dorta, D. J. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.04.005 · Cited by 10

Pre- and Post-partum Berberine Supplementation in Dairy Goats as a Novel Strategy to Mitigate Oxidative Stress and Inflammation

Ghavipanje, N., Nasri, M. H. F., Farhangfar, S. H., Ghiasi, S. E., & Vargas‐Bello‐Pérez, E. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.743455 · Cited by 8

Interaction of plant alkaloid berberine with β-lactoglobulin: an account from spectroscopic, thermodynamic, and small-angle X-ray scattering studies aided by theoretical calculations

Saha, S., Bhattacharjee, S., & Chowdhury, J. (2023) · New Journal of Chemistry · doi:10.1039/d3nj03318j · Cited by 7

Berberine-Loaded Nanoparticles Combat Oxidative and Nitrosative Stress to Reprogram Macrophages in Rheumatoid Arthritis

Shukla, V., Umesh, & Purohit, A. (2024) · BioNanoScience · doi:10.1007/s12668-024-01637-0 · Cited by 7

Effects of berberine on high-fat/high-sucrose-induced nonalcoholic steatohepatitis in experimental rats

Eman, E., Hemat, E., Hanaa, H., & Safwat, Q. (2019) · Tanta Medical Journal · doi:10.4103/tmj.tmj_15_18 · Cited by 7

Mitochondrial Metabolism and Insulin Action

Turner, N. A. (2013) · InTech eBooks · doi:10.5772/56449 · Cited by 8

Dietary Plant Extracts in Improving Skeletal Muscle Development and Metabolic Function

Xiang, J., Du, ‬., & Wang, H. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2087669 · Cited by 9

Effects of Berberine on Hepatic Sirtuin 1-uncoupling Protein 2 Pathway in Non-alcoholic Fatty Liver Disease Rats Induced by High-fat Diet

Deng, Y., Zhang, Y., Yang, Q., Li, H., Liang, Y., He, Y., Li, Y., Wang, G.-L., Lin, C.-M., & Zhang, J. (2016) · Chinese Herbal Medicines · doi:10.1016/s1674-6384(16)60063-1 · Cited by 6

Standardized Siegesbeckia orientalis L. Extract Increases Exercise Endurance Through Stimulation of Mitochondrial Biogenesis

Kim, M., Kim, C., & Hwang, J. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2019.4485 · Cited by 6

Berberine: As A Therapeutic Target for Treating Obese Diabetes

Khan, H. (2016) · Journal of Diabetes Research and Therapy · doi:10.16966/2380-5544.e101 · Cited by 6

Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice

Morgado-Cáceres, P., Huerta, H., Bergman, C., Figueroa, R., Farías, P., Quiroz, G., Woehlbier, U., Mella, K., Díaz-Rivera, O., Linsambarth, S., et al. (2025) · Aging and Disease · doi:10.14336/ad.2025.0188 · Cited by 5

Potential dietary geroprotectors and their impact on key mechanisms of aging

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Biomarkers of Mitochondrial Dysfunction and Toxicity

Palmeira, C. M., Teodoro, J. S., Silva, R., & Rolo, A. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814655-2.00055-4 · Cited by 4

Construction of the gene network in the spinal cord injury treated by coptidis rhizoma based on network pharmacological and molecular docking

Wang, Y., Wang, Q., Yuan, H., Sai, M., Zuo, Z., & Wang, T. (2020) · Ibrain · doi:10.1002/j.2769-2795.2020.tb00050.x · Cited by 4

Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals

Teodoro, J. S., Duarte, F. V., Rolo, A. P., & Palmeira, C. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00028-0 · Cited by 4

Skeletal Muscle as a Therapeutic Target for Natural Products to Reverse Metabolic Syndrome

Mazibuko-Mbeje, S. E., Dludla, P. V., Nkambule, B. B., Obonye, N., & Louw, J. (2018) · InTech eBooks · doi:10.5772/intechopen.78687 · Cited by 3

Biomarkers of mitochondrial dysfunction and toxicity

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Synergy Effects of Metformin and Berberine on Glyoxal-induced Carbonyl Stress in Isolated Rat Liver Mitochondria

Rezaei, M., Kalantari‬, H., Mehrzadi, S., & Goudarzi, M. (2020) · Current Drug Therapy · doi:10.2174/1574885515666200214122055 · Cited by 3

Modulation of the mitochondrial function with polyphenols and other natural bioactive compounds to treat obesity

Gibert‐Ramos, A., Baselga‐Escudero, L., & Crescenti, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819621-2.00026-7 · Cited by 2

Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD

Wang, Q., Zeng, Z., Guo, L., Williams, K. E., Zhang, Y., Tang, H., Hu, H., Qin, G., Wang, K., & Wang, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1531302 · Cited by 2

Mitochondria as a target for safety and toxicity evaluation of nutraceuticals

Teodoro, J. S., Machado, I. F., Castela, A. C., Rolo, A. P., & Palmeira, C. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821038-3.00030-6 · Cited by 3

Targeted Reduction of Pathogenic Heteroplasmy Through Binding of G-Quadruplex DNAPreprint

Naeem, M. M., Maheshan, R., Costford, S. R., Kaufman, B. A., & Sondheimer, N. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/358101 · Cited by 2

The anti-aging mechanism of Berberine associated with metabolic control

Guo, X., Xiong, X., Lijun, Z., Zhong, G., & Zhu, X. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823679-6.00020-5 · Cited by 1

Berberine prevents against myocardial injury induced by acute β‐adrenergic overactivation in rats

Yang, Y., Jiang, S., Mu, Y., Liu, C., Han, Y., Jiang, J., & Wang, Y. (2024) · Journal of Applied Toxicology · doi:10.1002/jat.4659 · Cited by 1

PGC-1α: a potential therapeutic target for upper airway dilator muscle structure and dysfunction in OSA

An, X., Zhou, J., He, L., & Li, W. (2025) · Sleep And Breathing · doi:10.1007/s11325-025-03504-y · Cited by 1

Neuroprotective effect of berberine-loaded niosomes against brain injury in dyslipidemic rats: The interplay between oxidative stress, mitochondrial dysfunction and apoptotic signals

Mansour, M. F., Behairy, A., Khamis, T., Mohammed, H. A., Alsemeh, A. E., Eltaweel, A. M., & El-Emam, M. M. A. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2026.159716 · Cited by 1

Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction

Sato, M., Tanabu, D., Torigoe, D., Kadomatsu, T., Taniwaka, K., Ogata, Y., Shiiba, I., Suzuki, Y., Ito, N., Inatome, R., et al. (2026) · npj Aging · doi:10.1038/s41514-026-00366-w · Cited by 1

Mitochondrial Bioenergetic Assays as a Standard Protocol for Toxicological and Metabolic Assessment

Teodoro, J. S., Rolo, A. P., & Palmeira, C. M. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1091-6_16 · Cited by 1

Caloric restriction mimetics: effects of spermidine and berberine on healthy longevity and prevention of aging-associated diseases.

Murillo-Cancho, A. F., Martín‐Latorre, M. D. M., Lozano‐Paniagua, D., & Soriano, B. J. N. (2025) · Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria · doi:10.12873/451murillo · Cited by 1

New insights of active constituents from herbs and nutraceuticals and their mechanisms in obesity-induced insulin resistancePreprint

Lin, S., Wu, C., Li, X., Wang, Y., Lang, D.-Q., & Shen, C. (2023) · doi:10.22541/au.168112301.11759524/v1 · Cited by 1

Screening the Human Genome for New Mitochondrial and Longevity Regulators

Ling, A. J. Y. (2015) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

The Effects of a High Fat Diet on Mitochondrial Biogenesis and Inflammation in the Brain

Vervaecke, L. S., Davis, J. M., Carson, J., Murphy, A., & Thompson, R. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000495380.12776.95

Avaliação toxicológica e ecotoxicológica dos principais representantes de éteres de difenilas polibromadas (PBDEs)

Silva, M. P. (2019) · doi:10.11606/t.60.2019.tde-17102018-103418

Berberine Alleviates Adiposity and Cardiac Dysfunction in Offspring Exposed to Gestational Diabetes MellitusPreprint

Cole, L., Chen, L., Sparagna, G. C., Vandel, M., Xiang, B., Dolinsky, V. W., & Hatch, G. M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.20.209395

Potencjalne możliwości wykorzystania berberyny w przeciwdziałaniu insulinooporności i w cukrzycy typu 2

Mróz, M., Pastusiak, K., & Bogdański, P. (2021) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.2478/ahem-2021-0038

Mitohormesis

Machado, I. F., Teodoro, J. S., Castela, A. C., Palmeira, C. M., & Rolo, A. P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821562-3.00035-6

Role of Berberis SSP and Acetaminophen-Induced Acute Liver Injury

Kouchaki, S., Jeivad, F., Sepand, M. R., Amin, G., Gheshlaghi, G. H., Gholami, M., Ghaznavi, M. R. D., Rahimzadegan, M., & Sabzevari, O. (2023) · Pharmaceutical Chemistry Journal · doi:10.1007/s11094-023-02983-1

Alkaloids: “Dope or Medication?”

Steinberg, C. E. W. (2025) · Springer eBooks · doi:10.1007/978-3-031-97988-0_4

Natural Compounds and Mitochondrial Function

Khan, M. V., Rumman, M., Rabbani, G., Hussain, M. K., Ahmad, S., & Ahmad, N. (2025) · Springer eBooks · doi:10.1007/978-981-95-0125-0_6

Additional file 2 of The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review

Nie, Q., Li, M., Huang, C., Yongwei, Y., Liang, Q., Ma, X., Qiu, T., & jianhong, L. I. (2024) · Figshare · doi:10.6084/m9.figshare.26687729

Additional file 1 of The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review

Nie, Q., Li, M., Huang, C., Yongwei, Y., Liang, Q., Ma, X., Qiu, T., & Li, J. (2024) · Figshare · doi:10.6084/m9.figshare.26687726

DNM1L depletion leads to accelerated heteroplasmy shifting of m.10191C allele through ATG7-dependent pathways

Geng, M., Wang, D., Kavoosi, S., Kaufman, B. A., & Sondheimer, N. (2026) · Mitochondrion · doi:10.1016/j.mito.2026.102185

Berberin – Aktuelles aus der Diabetologie und Longevity-Forschung

Gröber, U., & Schütz, B. (2026) · Zeitschrift für Orthomolekulare Medizin · doi:10.1055/a-2880-1965

Berberine as a multi-hallmark modulator of aging: From AMPK and mitophagy to inflammaging and the SASP

Alanazi, S. M., Al‐kuraishy, H. M., Abdelaziz, A. M., Alasmari, E. M., Yousef, F. M., Mohamed, A. A., Salama, M. M., & Batiha, G. E. (2026) · Fitoterapia · doi:10.1016/j.fitote.2026.107497

Berberine suppressed sarcopenia insulin resistance through SIRT1-mediated mitophagy

Su, X., Yang, D., Hu, Y., Yuan, Y., & Song, L. (2023) · Open Life Sciences · doi:10.1515/biol-2022-0648 · Cited by 11

Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway

Xu, J. F., Zhang, Y., Yu, Z., Guan, Y., Lv, Y., Zhang, M., Zhang, M., Chen, L., Lv, X., & Guan, F. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022146 · Cited by 20

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation

Teodoro, J. S., Duarte, F. V., Gomes, A. P., Varela, A. T. I. F., Peixoto, F., Rolo, A. P., & Palmeira, C. M. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.09.002 · Cited by 112

Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle

Yao, S., Yuan, Y., Zhang, H., Meng, X., Jin, L., Yang, J., Wang, W., Ning, G., Zhang, Y., & Zhang, Z. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.028 · Cited by 41

Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine

Shan, Y., Zhang, S., Gao, B., Liang, S., Zhang, H., Yu, X., Zhao, J., Ye, L., Yang, Q., & Shang, W. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.591227 · Cited by 49