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Daily ingestion of Akkermansia mucciniphila for one month promotes healthy aging and increases lifespan in old female mice

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Lactobacillus rhamnosus GG Colonization in Early Life Ameliorates Inflammaging of Offspring by Activating SIRT1/AMPK/PGC‐1α Pathway

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Association between Dysbiosis in the Gut Microbiota of Primary Osteoporosis Patients and Bone Loss

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Urinary metabolite signature in bipolar disorder patients during depressive episode

Chen, J., Xie, J., Zeng, L., Zhou, C., Zheng, P., & Xie, P. (2019) · Aging · doi:10.18632/aging.101805 · Cited by 40 · see citing works

Absence of gut microbiota affects lipid metabolism in the prefrontal cortex of mice

Chen, J., Xie, J., Zeng, B., Li, W., Bai, S., Zhou, C., Chen, W., Wei, H., & Xie, P. (2019) · Neurological Research · doi:10.1080/01616412.2019.1675021 · Cited by 38 · see citing works

Gut microbiota and metabonomics used to explore the mechanism of Qing’e Pills in alleviating osteoporosis

Xie, H., Hua, Z., Guo, M., Lin, S., Zhou, Y., Weng, Z., Wu, L., Chen, Z., Xu, Z., & Li, W. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2022.2056208 · Cited by 40 · see citing works

Murine Gut Microbiome Meta-analysis Reveals Alterations in Carbohydrate Metabolism in Response to Aging

You, X., Dadwal, U. C., Lenburg, M. E., Kacena, M. A., & Charles, J. F. (2022) · mSystems · doi:10.1128/msystems.01248-21 · Cited by 36 · see citing works

Impact of the Age of Cecal Material Transfer Donors on Alzheimer’s Disease Pathology in 5xFAD Mice

Valeri, F., Guilherme, M. D. S., He, F., Stoye, N. M., Schwiertz, A., & Endres, K. (2021) · Microorganisms · doi:10.3390/microorganisms9122548 · Cited by 32 · see citing works

Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice

Ke, S., Mitchell, S. J., MacArthur, M. R., Kane, A. E., Sinclair, D. A., Venable, E. M., Chadaideh, K. S., Carmody, R. N., Grodstein, F., Mitchell, J. R., et al. (2021) · Nutrients · doi:10.3390/nu13093290 · Cited by 27 · see citing works

The endocannabinoid system: a bridge between alzheimer’s disease and gut microbiota

Bisogno, T., Lauritano, A., & Piscitelli, F. (2021) · Life · doi:10.3390/life11090934 · Cited by 16 · see citing works

Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity

Monzó, C., Gkioni, L., Beyer, A., Valenzano, D. R., Grönke, S., & Partridge, L. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112722 · Cited by 16 · see citing works

Combining p-values from various statistical methods for microbiome data

Ham, H., & Park, T. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.990870 · Cited by 14 · see citing works

Voluntary Wheel Running in Old C57BL/6 Mice Reduces Age-Related Inflammation in the Colon but Not in the Brain

Ederer, M.-L., Günther, M., Best, L., Lindner, J., Kaleta, C., Witte, O. W., Simon, R., & Frahm, C. (2022) · Cells · doi:10.3390/cells11030566 · Cited by 14 · see citing works

The microbiota-gut-brain axis in Huntington's disease

Love, C. J., Masson, B. A., Gubert, C., & Hannan, A. J. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.06.005 · Cited by 14 · see citing works

Mutation accumulation and horizontal gene transfer inEscherichia colicolonizing the gut of old mice

Barreto, H. C., Frazão, N., Sousa, A., Konrad, A., & Gordo, I. (2020) · Communicative & Integrative Biology · doi:10.1080/19420889.2020.1783059 · Cited by 12 · see citing works

Interspecific interactions that affect ageing: Age-distorters manipulate host ageing to their own evolutionary benefits

Teulière, J., Bernard, C., & Bapteste, E. P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101375 · Cited by 12 · see citing works

Lipocalin 2 Deficiency Restrains Aging-Related Reshaping of Gut Microbiota Structure and Metabolism

Qiu, X., Chen, C., & Chen, X. (2021) · Biomolecules · doi:10.3390/biom11091286 · Cited by 12 · see citing works

Probiotic Lactobacilli Ameliorate Antibiotic-Induced Cognitive and Behavioral Impairments in Mice

Рашидовна, Я. Д., Novoselova, V., Alexandrova, A., Arslanova, A., Yakovleva, O. V., Shaidullov, I. F., Nikolaev, Y. A., El-Registan, G. I., Кудрин, В. С., & Ситдикова, Г. Ф. (2024) · Microbiology Research · doi:10.3390/microbiolres15030099 · Cited by 11 · see citing works

Evidence that the loss of colonic anti-microbial peptides may promote dysbiotic Gram-negative inflammaging-associated bacteria in aging mice

Forsyth, C. B., Shaikh, M. W., Engen, P. A., Preuss, F., Naqib, A. D., Palmen, B. A., Green, S. J., Zhang, L., Bogin, Z. R., Lawrence, K. M., et al. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1352299 · Cited by 11 · see citing works

Increasing spatial working memory in mice with Akkermansia muciniphila

Ahn, J., Kim, S., Han, E.-J., Hong, S., & Chung, H. (2025) · Communications Biology · doi:10.1038/s42003-025-07975-3 · Cited by 9 · see citing works

Modulation of the Epigenome by Nutrition and Xenobiotics during Early Life and across the Life Span: The Key Role of Lifestyle

Gabbianelli, R. (2018) · Lifestyle Genomics · doi:10.1159/000490751 · Cited by 9 · see citing works

The microbiome is associated with obesity-related metabolome signature in the process of aging

Binyamin, D., Turjeman, S., Asulin, N., Schweitzer, R., & Koren, O. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00811-w · Cited by 10 · see citing works

Effect of Senecio scandens ethanol extract on gut microbiota composition in mice

Yao, G., Zhang, H., Luo, G., Wang, Z., Zhao, H., Zhang, J., Dong, Y., Gao, Y., & Wu, S. (2021) · Archives of Microbiology · doi:10.1007/s00203-020-02144-y · Cited by 8 · see citing works

Heterochronic Fecal Microbiota Transfer Reverses Hallmarks of the Aging Murine Gut, Eye and BrainPreprint

Parker, A., Romano, S., Ansorge, R., Aboelnoer, A., Gall, G. L., Savva, G. M., Telatin, A., Jones, E. J., Baker, D., Rudder, S. J., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3811833 · Cited by 8 · see citing works

Dietary Selenium Deficiency Accelerates the Onset of Aging‐Related Gut Microbial Changes in Aged Telomere‐Humanized Mice, With Akkermansia muciniphila Being the Most Prominent and Alleviating Selenium Deficiency‐Induced Type 2 Diabetes

Huang, Y., Lu, H., Zhang, L., Olivier, A. K., Wu, T., Hsu, C., LeGrand, C., Zeng, H., Curran, S., Wang, Q., et al. (2025) · Aging Cell · doi:10.1111/acel.70130 · Cited by 7 · see citing works

Alterations of the gut microbiome and metabolic profile in CVB3-induced mice acute viral myocarditis

Kong, Q., Chen, L., Zeng, X., Lu, F., Huang, Y., & Wu, W. (2023) · BMC Microbiology · doi:10.1186/s12866-023-02863-4 · Cited by 7 · see citing works

Clostridium Difficile Infection: An Immunological Conundrum

Arredondo‐Hernández, R., Estrada, P. O., López‐Vidal, Y., & de León-Rosales, S. P. (2018) · Archives of Medical Research · doi:10.1016/j.arcmed.2018.11.002 · Cited by 6 · see citing works

The role of circulating metabolites and gut microbiome in hypertrophic scar: a two-sample Mendelian randomization study

Cheng, X., Cheng, B., Jin, R., Zheng, H., Zhou, J., & Shan, S. (2024) · Archives of Dermatological Research · doi:10.1007/s00403-024-03116-8 · Cited by 5 · see citing works

Deficiency of Gut-Enriched Lipase H Promotes Gut Aging and Reduces Lifespan in Drosophila

Sun, Y., Ma, H., Zhou, X., Huang, L., Yu, P. F., Qi, Y., Wei, G., & Ni, T. (2024) · Phenomics · doi:10.1007/s43657-024-00187-5 · Cited by 6 · see citing works

Fall of PARP3 restrains Lgr5+ intestinal stem cells proliferation and mucosal renovation in intestinal aging

Peng, X., Liu, H., Wang, J., Jiang, J., Chen, H., Tao, J., & Wu, B. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111796 · Cited by 4 · see citing works

Elemental sulfur upregulated testicular testosterone biosynthesis by associating with altered gut microbiota in mice

Bi, Y., Li, T., Pan, H., Guo, M., Chen, L., Qi, Q., Zhang, M., ZHANG, L., Yu, L., Wan, X., et al. (2020) · Biocell · doi:10.32604/biocell.2020.011208 · Cited by 4 · see citing works

Does young feces make the elderly live better? Application of fecal microbiota transplantation in healthy aging

LIAO, Y., Li, X., Li, Q., Wang, Y., TAN, X., & GONG, T. (2024) · Biocell · doi:10.32604/biocell.2024.050324 · Cited by 3 · see citing works

IL-1β knockout increases the intestinal abundancy of Akkermansia muciniphila

Bechberger, M., Eigenbrod, T., Boutin, S., Heeg, K. M., & Bode, K. A. (2023) · Beneficial Microbes · doi:10.1163/18762891-20220042 · Cited by 3 · see citing works

Longitudinal Analyses Reveal That Aging-related Alterations in the Intestinal Environment Lead to Gut Dysbiosis With the Potential to Induce ObesityPreprint

Nakanishi, Y., Nozu, R., Ueno, M., Hioki, K., Ishii, C., Murakami, S., Suzuki, K. M., Ka, Y., Ogura, T., Ito, A., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-119480/v1 · Cited by 2 · see citing works

Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal‐Like Epithelial State

Korcari, A., Tauc, H. M., Duggan, J., Wehbe, F., Darmanis, S., Modrusan, Z. D., Yun, J., Pappu, R., Garfield, D., Jasper, H., et al. (2026) · Aging Cell · doi:10.1111/acel.70495 · Cited by 1 · see citing works

Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging

Zhang, T., Niu, J., Hu, X., Hu, Z., Gao, Y., Liu, J., Chen, N., & Hu, Y. (2026) · Aging Cell · doi:10.1111/acel.70702 · Cited by 1 · see citing works

Analysis of the Difference of Intestinal Microbes in Muchuan Black-bone Chickens with Two Skin Colors

Liao, J., Shen, X., Long, W., Yu, S., Wang, G., Du, C., & Liang, Z. (2024) · Indian Journal of Animal Research · doi:10.18805/ijar.bf-1752 · Cited by 1 · see citing works

Defining the role of individual gut commensal microbes and host-microbe interactions

Ju, T. (2019) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-fhw9-mj96 · Cited by 1 · see citing works

Absence of gut microbiota affects lipid metabolism in the prefrontal cortex of micePreprint

Chen, J., Xie, J., Zeng, B., Li, W., Bai, S., Zhou, C., Chen, W., Wei, H., & Xie, P. (2021) · Research Square · doi:10.21203/rs.3.rs-96615/v2 · Cited by 1 · see citing works

"Smurf Mice": revolutionising our understanding of age-related and end-of-life animal physiologyPreprint

Cansell, C., Goepp, V., Bain, F., Todd, N., Douard, V., Monnoye, M., Zane, F., Sanchez, C., Pietrancosta, N., Rovère, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.14.659669 · Cited by 1 · see citing works

The Trend of Fermented Foods

Wang, S. S. (2018) · Annals of Advanced Biomedical Sciences · doi:10.23880/aabsc-16000106

Breaking down the barriers : The effects of aging, gut microbiota and bile acids on intestinal health

van der Lugt, B. (2021) · doi:10.18174/549523

Absence of gut microbiota affects lipid metabolism in the prefrontal cortex of micePreprint

Chen, J., Xie, J., Zeng, B., Li, W., Bai, S., Zhou, C., Chen, W., Wei, H., & Xie, P. (2021) · Research Square · doi:10.21203/rs.3.rs-96615/v1

Longitudinal analyses reveal that aging-related alterations in the intestinal environment promote HFD-induced obesityPreprint

Nakanishi, Y., Nozu, R., Ueno, M., Hioki, K., Ishii, C., Murakami, S., Suzuki, K. M., Ka, Y., Ogura, T., Ito, A., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3464296/v1

Oxisteróis e sua relação com a neuroinflamação na esclerose lateral amiotrófica

Lima, R. S. (2023) · doi:10.11606/d.46.2023.tde-12122023-105206

Additional file 1 of Alterations of the gut microbiome and metabolic profile in CVB3-induced mice acute viral myocarditis

Kong, Q., Chen, L., Zeng, X., Lu, F., Huang, Y., & Wu, W.-F. (2023) · Figshare · doi:10.6084/m9.figshare.22949319

Oxysterol Alterations in SOD1G93A ALS Rats: 25-Hydroxycholesterol and LPS-Binding Protein in Disease ProgressionPreprint

Lima, R. S., Santos, R. S., Chaves‐Filho, A. B., Trzan, I. F. L., Inague, A., de Faria, R. L., Dantas, L. S., Pinto, I. F. D., de Medeiros, M. H. G., Steiner, A. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.05.650333

Additional file 2 of Alterations of the gut microbiome and metabolic profile in CVB3-induced mice acute viral myocarditis

Kong, Q., Chen, L., Zeng, X., Lu, F., Huang, Y., & Wu, W. (2023) · Figshare · doi:10.6084/m9.figshare.22949322

Additional file 1 of Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6

Zhu, X., Shen, J., Feng, S., Huang, C., Wang, H., Huo, F., & Liu, H. (2023) · Figshare · doi:10.6084/m9.figshare.23265023

Additional file 2 of Age-related changes of microbiota in midlife associated with reduced saccharolytic potential: an in vitro study

Chen, J., Pi, X., Liu, W., Ding, Q., Wang, X., Jia, W., & Zhu, L. (2021) · Figshare · doi:10.6084/m9.figshare.14037361

Additional file 1 of Age-related changes of microbiota in midlife associated with reduced saccharolytic potential: an in vitro study

Chen, J., Pi, X., Liu, W., Ding, Q., Wang, X., Jia, W., & Zhu, L. (2021) · Figshare · doi:10.6084/m9.figshare.14037358

Bifidobacterium breve BBr60 Improves Metabolic Abnormalities by Regulating Gut Microbiota Balance in a High‐Fat Diet‐Induced Obese Mouse Model

Liao, Y., Yuan, X., Qin, A., Qi, Y., Shan, C., & Ma, J. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70972

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

Cuervo-Zanatta, D., Balasubramanian, H. B., Pasokh, A., & Zille, M. (2026) · FEBS Letters · doi:10.1002/1873-3468.70412

Live and Heat-Killed Lactiplantibacillus plantarum HY7715 Attenuate D-Galactose-Induced Aging-Related Brain Changes and Blood-Brain Barrier Disruption with Gut Microbiota Modulation in Mice

Baik, J., Gwon, H., Kim, J.-Y., Shim, J.-J., & Lee, J.-H. (2026) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2609.09057

Intestinal Permeability, Gut Inflammation, and Gut Immune System Response Are Linked to Aging-Related Changes in Gut Microbiota Composition: A Study in Female Mice

Gámez-Macías, P. E., Félix‐Soriano, E., Samblas, M., Sáinź, N., Moreno-Aliaga, M. J., & González‐Muniesa, P. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae045 · Cited by 56 · see citing works

Breaking down the barriers : The effects of aging, gut microbiota and bile acids on intestinal health

van der Lugt, B. (2021) · doi:10.18174/549523

Host transcriptional signatures associated with microbial sequence signals reveal age-related decline in intestinal homeostasis

Akinsuyi, O., Ojeda, A. E., Xhumari, J., Ruggles, J. V., de Freitas, A. S., & Roesch, L. F. W. (2026) · Future Microbiology · doi:10.1080/17460913.2026.2682676 · Cited by 1 · see citing works

Evidence that the loss of colonic anti-microbial peptides may promote dysbiotic Gram-negative inflammaging-associated bacteria in aging mice

Forsyth, C. B., Shaikh, M. W., Engen, P. A., Preuss, F., Naqib, A. D., Palmen, B. A., Green, S. J., Zhang, L., Bogin, Z. R., Lawrence, K. M., et al. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1352299 · Cited by 11 · see citing works

Interplay of the ENS and Microbiota With Murine Gut Epithelium‐Derived Organoids in Aging

Nguyen, T. T., Schapelhouman, D., Fischer, K., Chen, J., Dejung, M., Kielisch, F., Varga, J., Piepgras, J., Ahn, M., Tüscher, O., et al. (2026) · Aging Cell · doi:10.1111/acel.70608 · Cited by 1 · see citing works