Cited by 287Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolismGenetics, Aging, and Longevity in Model Organisms

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Lysosomes and oxidative stress in aging and apoptosis

Kurz, Tino, Terman, Alexei, Gustafsson, Bertil, Brunk, Ulf T.·2008·Biochimica et Biophysica Acta (BBA) - General Subjects

DOI 10.1016/j.bbagen.2008.01.009

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Abstract

The lysosomal compartment consists of numerous acidic vesicles (pH approximately 4-5) that constantly fuse and divide. It receives a large number of hydrolases from the trans-Golgi network, while their substrates arrive from both the cell's outside (heterophagy) and inside (autophagy). Many macromolecules under degradation inside lysosomes contain iron that, when released in labile form, makes lysosomes sensitive to oxidative stress. The magnitude of generated lysosomal destabilization determines if reparative autophagy, apoptosis, or necrosis will follow. Apart from being an essential turnover process, autophagy is also a mechanism for cells to repair inflicted damage, and to survive temporary starvation. The inevitable diffusion of hydrogen peroxide into iron-rich lysosomes causes the slow oxidative formation of lipofuscin in long-lived postmitotic cells, where it finally occupies a substantial part of the volume of the lysosomal compartment. This seems to result in a misdirection of lysosomal enzymes away from autophagosomes, resulting in depressed autophagy and the accumulation of malfunctioning mitochondria and proteins with consequent cellular dysfunction. This scenario might put aging into the category of autophagy disorders.

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Authors: Kurz, T., Terman, A., Gustafsson, B., & Brunk, U. T.
Affiliations: Linköping University (SE)
Linköping University Hospital (SE)
Corresponding author: Brunk, Ulf T.
Venue: Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher: Elsevier BV
Published: 2008-11
Volume: 1780
Issue: 11
Pages: 1291-1303
ISSN: 0304-4165 (ISSN-L)
DOI: 10.1016/j.bbagen.2008.01.009
OpenAlex: W2056367295
Cited by: 287
References: 129
Citations by year: 2026: 13 · 2025: 11 · 2024: 9 · 2023: 7 · 2022: 13 · 2021: 14 · 2020: 14 · 2019: 21 · 2018: 13 · 2017: 13 · 2016: 21 · 2015: 11 · 2014: 23 · 2013: 16 · 2012: 15
FWCI: 2.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: lysosomes, oxidative stress, aging, apoptosis, autophagy, iron release, lipofuscin, lysosomal destabilization, hydrogen peroxide, mitochondrial dysfunction, lysosomal enzymes, necrosis, starvation survival
MeSH terms: Aging, Animals, Humans, Iron, Lysosomes, Mitosis, Apoptosis, Oxidative Stress

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Lysosomes and oxidative stress in aging and apoptosis

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